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Endocet vs Percocet: Main Differences and Similarities

Endocet and Percocet are two brand names for the combination of acetaminophen and oxycodone. This combination medication is often prescribed for moderate to severe pain that is not relieved with other therapies.

Acetaminophen is a nonsteroidal anti-inflammatory drug (NSAID) that treats pain and inflammation by decreasing the production of prostaglandins. Oxycodone is an opioid that binds to mu receptors in the brain. This combination produces a strong analgesic effects to relieve pain from injury, surgery, and other conditions.

Endocet

Endocet comes in strengths of 325 mg-2.5 mg, 325 mg-5 mg, 325 mg-7.5 mg, and 325 mg-10 mg of acetaminophen and oxycodone. The usual dose of Endocet is given every 6 hours as needed for pain. Common side effects of Endocet include constipation, nausea, and somnolence.

Percocet

Percocet is available in strengths of 325 mg-2.5 mg, 325 mg-5 mg, 325 mg-7.5 mg, and 325 mg-10 mg of acetaminophen and oxycodone. Percocet can be taken every 6 hours as needed for pain depending on a doctor’s prescription. Common side effects of Percocet include constipation, nausea, and somnolence.

Endocet vs Percocet Side by Side Comparison

Endocet and Percocet are identical medications used for pain. Their features can be found in the table below.

Endocet Percocet
Prescribed For
  • Moderate to severe pain
  • Moderate to severe pain
Drug Classification
  • Opioid
  • Opioid
Manufacturer
  • Endo Pharmaceuticals
  • Endo Pharmaceuticals
Common Side Effects
  • Constipation
  • Drowsiness
  • Dizziness
  • Headache
  • Nausea
  • Vomiting
  • Pruritus
  • Lethargy
  • Fatigue
  • Constipation
  • Drowsiness
  • Dizziness
  • Headache
  • Nausea
  • Vomiting
  • Pruritus
  • Lethargy
  • Fatigue
Is there a generic?
  • Yes, acetaminophen/oxycodone
  • Yes, acetaminophen/oxycodone
Is it covered by insurance?
  • Varies according to your provider
  • Varies according to your provider
Dosage Forms
  • Oral tablet
  • Oral tablet
Average Cash Price
  • $152 for a supply of 100, 2.5 mg capsules
  • $152 for a supply of 100, 2.5 mg capsules
SingleCare Discount Price
  • Endocet Price
  • Percocet Price
Drug Interactions
  • Alcohol
  • SSRI/SNRI antidepressants
  • Triptans
  • CNS depressants (opioids, antihistamines, antipsychotics, antianxiety agents, hypnotics, antiemetics, phenothiazines, tranquilizers)
  • Mixed agonist/antagonist analgesics (butorphanol, nalbuphine, pentazocine, buprenorphine)
  • Anticholinergics
  • MAO inhibitors
  • Tricyclic antidepressants
  • CYP3A4 and CYP2D6 inhibitors (macrolide antibiotics, azole-antifungal agents, protease inhibitors)
  • CYP3A4 inducers (rifampin, carbamazepine, phenytoin)
  • Muscle relaxants
  • Diuretics
  • Oral contraceptives
  • Beta blockers (propranolol)
  • Lamotrigine
  • Probenecid
  • Alcohol
  • SSRI/SNRI antidepressants
  • Triptans
  • CNS depressants (opioids, antihistamines, antipsychotics, antianxiety agents, hypnotics, antiemetics, phenothiazines, tranquilizers)
  • Mixed agonist/antagonist analgesics (butorphanol, nalbuphine, pentazocine, buprenorphine)
  • Anticholinergics
  • MAO inhibitors
  • Tricyclic antidepressants
  • CYP3A4 and CYP2D6 inhibitors (macrolide antibiotics, azole-antifungal agents, protease inhibitors)
  • CYP3A4 inducers (rifampin, carbamazepine, phenytoin)
  • Muscle relaxants
  • Diuretics
  • Oral contraceptives
  • Beta blockers (propranolol)
  • Lamotrigine
  • Probenecid
Can I use while planning pregnancy, pregnant, or breastfeeding?
  • Endocet is in Pregnancy Category C. While adverse effects have been reported in animals, not enough research has been performed in humans. Consult a doctor regarding steps to take while planning pregnancy. Endocet is not recommended while breastfeeding
  • Percocet is in Pregnancy Category C. While adverse effects have been reported in animals, not enough research has been performed in humans. Consult a doctor regarding steps to take while planning pregnancy. Percocet is not recommended while breastfeeding.

Summary

Endocet and Percocet contain the same active ingredients, acetaminophen and oxycodone. As a potent opioid combination, Endocet and Percocet can help relieve moderate to severe pain.

Both Endocet and Percocet come in similar dosage forms. They can both be taken multiple times throughout the day as needed for pain. However, the maximum recommended daily dose of acetaminophen is 4000 mg. This is because acetaminophen can cause liver damage at high doses.

Acetaminophen and oxycodone can cause side effects such as constipation and nausea. As a Schedule II drug, this combination also has a high risk for abuse and dependence. Those who abuse acetaminophen and oxycodone report feelings of euphoria which can lead to addiction.

It is important to discuss these medications with a doctor. This information should be reviewed with a doctor to determine the best treatment option for you.

When comparing oxycodone vs. Percocet or asking “is oxycodone Percocet,” it’s also helpful to have an understanding of what Percocet is on its own. Percocet is a combination of oxycodone and acetaminophen. Acetaminophen is a pain reliever available in over-the-counter medicines like Tylenol. The combination element of Percocet makes it a very effective pain reliever. Acetaminophen on its own is less potent than an opioid, but when paired with the oxycodone it increases the effectiveness.

Opioids can lead to an overdose, despite their therapeutic benefits, so it’s important for people to be vigilant when taking them and ensure they take them only as prescribed. Some of the negative side effects of opioids can include nausea, vomiting, confusion, dizziness, and constipation. Opioids can also depress the respiratory system, which can lead to breathing problems.

With oxycodone vs. Percocet, there’s another layer of risk. Percocet has acetaminophen which can cause liver damage and acute liver failure when too much is taken for a certain period. People who take Percocet have to be aware of the dosage of opioids they’re taking and the amount of acetaminophen.

Since oxycodone doesn’t contain acetaminophen, the primary risk to be aware of is the use of opioids.

To compare oxycodone vs. Percocet:

  • Oxycodone can be prescribed on its own and is an opioid pain medicine, while Percocet is a combination narcotic with an opioid element that is oxycodone and also acetaminophen, which is the same as Tylenol
  • Percocet is considered one of the strongest pain medicines available because of the different modes of pain relief it offers in a single dose
  • Percocet can be taken every six hours, while Oxycodone can be taken every four to six hours usually, depending on the strength.
  • With oxycodone, the risk of overdose can occur primarily because of respiratory depression
  • Both oxycodone and Percocet are highly addictive, and both are a Schedule II controlled substance

So, is oxycodone Percocet? No, but oxycodone is one of the primary active ingredients in Percocet.

If you or a loved one live with addiction or are using drugs recreationally and want to stop, The Recovery Village® can help. Reach out to one of our representatives today to learn how you can start on your path to recovery.

Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.

Are there Significant Differences Between Percocet and Norco?

Percocet and Norco are medications prescribed to patients with moderate to moderately severe pain commonly associated with injury, surgery, or dental procedures. Although these painkillers may be used to treat similar conditions, there are a few small differences in their chemical composition and how they impact addiction.

Percocet vs. Norco

Percocet and Norco are both combination drugs that contain an opioid painkillers and acetaminophen (a pain reliever and fever reducer). This combination allows the drugs to effectively treat different types of pain simultaneously. The opioid found in Percocet is oxycodone, while in Norco is the opioid ingredient is hydrocodone. Published research indicates that Percocet and Norco treat pain equally.1-3

Percocet and Norco have half-lives of approximately 4 hours. Both drugs are used to treat the acute onset of pain and can be expected to provide pain relief for anywhere between 4-6 hours.

Taking Percocet or Norco can help you feel happy and relaxed. These drugs have similar common side effects that include:

  • Drowsiness
  • Confusion
  • Dizziness
  • Nausea
  • Vomiting
  • Lethargy
  • Dry mouth
  • Impaired motor skills
  • Euphoria

Studies have shown that Percocet is more likely to cause nausea, dizziness, drowsiness, fatigue, and headache.2 Other research shows that people taking Norco experience constipation and stomach pain more frequently than people using Percocet.1 Both drugs depress the central nervous system and can lead to more serious side effects if taken at higher dosages. In a double-blind study, results concluded that a combination of oxycodone and ibuprofen caused the best pain relief with the fewest adverse effects.3 Overdose of either drug can result in dangerous symptoms that can include decreased breathing, low blood pressure, organ failure, and even death.

Addiction of Percocet and Norco

Percocet and Norco interact with opioid receptors in your body, altering the way you feel and respond to pain. Like other opioids, these drugs both have a high potential for abuse that can lead to addiction. Percocet is more powerful when compared to Norco. Not surprisingly, there is a higher risk of abuse with Percocet, as is generally the case with more potent opioids.4 As such, Percocet and Norco should only be taken as instructed by your doctor. You should take these drugs only for as long as they are prescribed, in the amounts prescribed, and no more frequently than prescribed.

Some of the common signs that someone has a dependence on opioids are:

  • Changing social groups
  • Lack of interest in activities
  • Isolation from friends and family
  • Poor hygiene
  • Dramatic mood changes
  • Missing work or appointments
  • Hyperactivity
  • Being tired

Treatment Options

Addiction to Percocet or Norco should be treated with the assistance of substance abuse professionals. Due to the harmful physical and psychological symptoms you can experience during withdrawal, it is recommended to undergo detox in a medical facility or detox center where you will be safe and comfortable. Certain medications can be given to you during detox to help minimize cravings and reduce withdrawal symptoms.

After detox, you will transition to a facility for rehab. Treatment programs commonly consist of individual counseling, group counseling, family counseling, and alternative therapies. Behavioral therapy is often an important part of treatment and it will help you address the underlying causes of your abuse to Percocet or Norco. This will provide you with the coping tools needed to prevent future relapse. Aftercare treatment is also an important part of successful long-term recovery. You will also benefit from participation in addiction support groups, many of which hold meetings at local hospitals, places of worship, and community centers.

Sources

Endocet is a combination medicine that contains the drugs oxycodone and acetaminophen. It’s used to relieve moderate to severe pain.

Oxycodone is a narcotic drug that works in the brain to change how your body feels pain.

Acetaminophen is a pain reliever and fever reducer that increases the effects of oxycodone.

The U.S. Food and Drug Administration (FDA) approved the combination of oxycodone and acetaminophen in 1980. Endocet is manufactured by Endo Pharmaceuticals.

Endocet Warnings

Endocet contains a black box warning because acetaminophen use can lead to severe and sometimes fatal liver failure.

Most liver problems in these situations happen in people who take more than 4,000 milligrams (mg) of acetaminophen a day and use more than one product containing acetaminophen.

Don’t take Endocet or acetaminophen in any other product beyond the amounts your doctor recommends.

Be sure to ask a healthcare professional about any cold, pain, allergy, or sleep medicine you’re considering taking.

Many of these products contain acetaminophen, which is sometimes abbreviated as “APAP”

Tell your doctor right away if you experience any of the following symptoms while taking Endocet:

  • Yellowing of the skin or eyes
  • Nausea
  • Pain in your upper stomach
  • Itching
  • Loss of appetite
  • Dark-colored urine
  • Clay-colored stools

Don’t take Endocet if you’ve recently used alcohol, sedatives, tranquilizers, or other narcotic drugs.

Tell your doctor if you drink more than three alcoholic beverages a day, or if you have a history of alcoholism or drug addiction.

This medicine may be habit-forming. Don’t share Endocet with another person.

Before taking Endocet, tell your doctor if you have, or have ever had:

  • Liver disease or cirrhosis
  • Diarrhea or severe constipation
  • Inflammatory bowel disease
  • A bowel obstruction
  • A colostomy or ileostomy
  • Kidney disease
  • Low blood pressure
  • A head injury, brain tumor, or stroke
  • A breathing disorder, such as asthma, chronic obstructive pulmonary disease (COPD), or sleep apnea
  • Allergies to medications

Also, let your doctor know if you’re dehydrated or get dehydrated easily before taking this medicine.

You shouldn’t take Endocet if you’ve taken a monoamine oxidase inhibitor (MAOI) in the last two weeks. These drugs include:

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. Stop taking Endocet and call your doctor immediately if you develop skin redness, or a rash that spreads and causes peeling and blistering.

Tell your healthcare provider you’re taking Endocet before having any type of surgery, including a dental procedure.

This drug can cause false results on certain urine tests. Be sure to tell all healthcare professionals who treat you that you’re taking Endocet. Never take any illicit substances while you’re taking Endocet.

If you’ve taken Endocet for a long period of time, don’t stop taking the medicine suddenly. Ask your doctor how to come off the drug gradually, to avoid unpleasant withdrawal symptoms.

Pregnancy and Endocet

It’s not known whether Endocet can harm an unborn baby.

Taking oxycodone during pregnancy may cause your baby to become dependent on the drug.

It can also lead to life-threatening withdrawal symptoms in newborns.

Tell your doctor if you’re pregnant, or might become pregnant, before taking this medicine.

Endocet may pass into breast milk and hurt a breastfeeding baby. Talk to your doctor before breastfeeding while taking this medicine.

acetaminophen and oxycodone (Endocet, Endocet 10/325, Endocet 2.5/325)

Generic Name: acetaminophen and oxycodone

  • What is acetaminophen and oxycodone?
  • What are the possible side effects of acetaminophen and oxycodone?
  • What is the most important information I should know about acetaminophen and oxycodone?
  • What should I discuss with my healthcare provider before taking acetaminophen and oxycodone?
  • How should I take acetaminophen and oxycodone?
  • What happens if I miss a dose?
  • What happens if I overdose?
  • What should I avoid while taking acetaminophen and oxycodone?
  • What other drugs will affect acetaminophen and oxycodone?
  • Where can I get more information?

What is acetaminophen and oxycodone?

Oxycodone is an opioid pain medication, sometimes called a narcotic. Acetaminophen is a less potent pain reliever that increases the effects of oxycodone.

Acetaminophen and oxycodone is a combination medicine used to relieve moderate to severe pain.

Acetaminophen and oxycodone may also be used for purposes not listed in this medication guide.

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634810628_PB

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Acetaminophen-oxycodone 131070045

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Acetaminophen-oxycodone 325 mg-10 mg 131070046

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Acetaminophen-Oxycodone 325 mg-10 mg-MAL

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Acetaminophen-Oxycodone 325 mg-5 mg-AMN

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Acetaminophen-Oxycodone 325 mg-7.5 mg-MAL

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Acetaminophen-oxycodone 325-10 mg 428580104

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Acetaminophen-oxycodone 325-5 mg 428580102

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Acetaminophen-oxycodone 325-7.5 mg 428580103

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Endocet 325 mg-10 mg

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Endocet 7.5-325 mg

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Percocet 325-5 mg

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Roxicet

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What are the possible side effects of acetaminophen and oxycodone?

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

Call your doctor at once if you have:

  • noisy breathing, sighing, shallow breathing;
  • a light-headed feeling, like you might pass out;
  • weakness, tiredness, fever, unusual bruising or bleeding;
  • confusion, unusual thoughts or behavior;
  • problems with urination;
  • liver problems–nausea, upper stomach pain, tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • low cortisol levels– nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Serious side effects may be more likely in older adults and those who are overweight, malnourished, or debilitated.

Long-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.

Common side effects include:

  • dizziness, drowsiness, feeling tired;
  • feelings of extreme happiness or sadness;
  • nausea, vomiting, stomach pain;
  • constipation; or
  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about acetaminophen and oxycodone?

MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.

An overdose of acetaminophen can damage your liver or cause death. Call your doctor at once if you have pain in your upper stomach, loss of appetite, dark urine, or jaundice (yellowing of your skin or eyes).

Taking opioid medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.

Fatal side effects can occur if you use opioid medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.

Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

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