- Why Should You Take Statins at Night?
- Statins and cholesterol
- Available prescriptions
- Statins that you should take at night
- Statins you can take in the morning
- What you need to know about taking statins
- Other ways to help reduce cholesterol
- Participants, methods, and results
- Breaking News: Statins Make You Fat!
- The uses and risks of Crestor
- Using Crestor — and all statins — safely
- What other drugs could interact with this medication?
- Rosuvastatin Side Effects
- In Summary
- For the Consumer
- For Healthcare Professionals
- Further information
- More about rosuvastatin
- Crestor Injury
Why Should You Take Statins at Night?
Statins and cholesterol
Statins are prescription medications that help to lower cholesterol. They specifically target low-density lipoprotein (LDL) cholesterol. That’s the bad kind.
When you have too much LDL cholesterol, it can build up in the walls of your arteries. This can lead to decreased blood flow. High LDL cholesterol is associated with an increased risk of coronary artery disease.
Statins work in two ways:
- They inhibit an enzyme that your body needs to produce cholesterol.
- They may also help reduce plaque that has built up in your arteries. This plaque is made up of cholesterol.
As a result, statins can help lower your risk of having a heart attack or stroke.
A variety of statins are available in brand name and generic form. Some common statins are:
Most statins should be taken once every 24 hours. Depending on the particular medication and dosage, you may need to take your statin twice a day.
Certain statins work better when taken with a meal. Others work best when they’re taken at night. This is because the cholesterol-making enzyme is more active at night. Also, the half-life, or the amount of time it takes for half the dose to leave your body, of some statins is short.
Statins that you should take at night
Some statins have half-lives of less than six hours. These statins are best taken at night.
Simvastatin is an example of a statin that works better if taken in the evening. Studies show that when simvastatin is taken at night, there’s a greater reduction in LDL cholesterol than when it’s taken in the morning.
Lovastatin should be taken with dinner. However, the extended-release version of lovastatin, Altoprev, should be taken at bedtime.
Fluvastatin has a half-life of about three hours, so it should also be taken at night.
Statins you can take in the morning
Studies show that some of the newer statins can be just as effective when taken in the morning. HMG-CoA reductase inhibitors such as atorvastatin and rosuvastatin are more potent than older statins. They have half-lives of at least 14 hours.
Extended-release fluvastatin, or Lescol XL, can be taken at any time of day.
What you need to know about taking statins
The most important thing you need to know is that statins aren’t all the same. That’s why you should thoroughly read the materials that come with your prescription. Follow directions carefully for maximum effectiveness.
Your doctor knows your personal medical issues and is your best source for information. Always ask if your statin should be taken with food or at a specific time of day.
If time of day isn’t an issue with your statin, choose the time you’re most likely to remember to take it. Statins work best when taken at the same time each day. Once it becomes part of your routine, you’re less likely to forget.
Some substances can interact with statins
With some statins, drinking grapefruit juice, or eating grapefruit, is a bad idea. Grapefruit juice can cause that statin to stay in your body much longer, and the drug can build up. This can increase the risk of muscle breakdown, liver damage, and even kidney failure. If your prescription label doesn’t mention grapefruit juice, be sure to ask your doctor about it.
Statins can also interact with other medications, so tell your doctor about all the drugs you take. That includes supplements, over-the-counter medications, and prescription drugs.
You may have side effects
Statins can be effective in getting your cholesterol under control, but they come with risks. Some common side effects include muscle and joint aches, nausea, and headache.
Serious risks include damage to your muscles, kidneys, and liver. If you have type 2 diabetes, statins may increase your blood sugar levels.
If you experience side effects, it’s important that you tell your doctor. Sometimes, switching to another statin can help.
Other ways to help reduce cholesterol
While statins can be very effective in lowering LDL cholesterol, you can also manage your cholesterol using alternative treatments or through lifestyle modifications.
Diet plays an important role in blood cholesterol levels. Your diet should be packed with fruits, vegetables, whole grains, and fish. Try to reduce your intake of saturated and trans fats, and increase your intake of omega-3 fatty acids. You should also go easy on salt and refined carbohydrates.
Make exercise a part of your daily routine and try to sit less. You can also lower your risk for heart disease by not smoking and maintaining a healthy weight.
While statins are often prescribed when your cholesterol can’t be controlled through diet and exercise alone, it never hurts to eat well and exercise more.
Brand Names: Crestor
Generic Name: rosuvastatin
- What is rosuvastatin (Crestor)?
- What are the possible side effects of rosuvastatin (Crestor)?
- What is the most important information I should know about rosuvastatin (Crestor)?
- What should I discuss with my healthcare provider before taking rosuvastatin (Crestor)?
- How should I take rosuvastatin (Crestor)?
- What happens if I miss a dose (Crestor)?
- What happens if I overdose (Crestor)?
- What should I avoid while taking rosuvastatin (Crestor)?
- What other drugs will affect rosuvastatin (Crestor)?
- Where can I get more information (Crestor)?
What is rosuvastatin (Crestor)?
Rosuvastatin reduces levels of “bad” cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of “good” cholesterol (high-density lipoprotein, or HDL).
Rosuvastatin is used in adults and children who are at least 8 years old, to lower cholesterol and triglycerides (types of fat) in the blood and to slow the build-up of plaque (fatty deposits) in blood vessels.
Rosuvastatin is also used to treat hereditary forms of high cholesterol, including the heterozygous type (inherited from one parent) and the homozygous type (inherited from both parents). For the heterozygous type, rosuvastatin can be used in children who are at least 8 years old. For the homozygous type, rosuvastatin can be used in children as young as 7 years old.
Rosuvastatin is also used to lower the risk of stroke, heart attack, and certain other heart complications in men 50 years and older and women 60 years and older who have risk factors for heart disease.
Rosuvastatin may also be used for purposes not listed in this medication guide.
What are the possible side effects of rosuvastatin (Crestor)?
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- unexplained muscle pain, tenderness, or weakness;
- confusion, memory problems; or
- liver problems–upper stomach pain, tired feeling, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes).
Common side effects may include:
- muscle aches; or
- nausea, stomach pain.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about rosuvastatin (Crestor)?
Do not use rosuvastatin if you are pregnant. It could harm the unborn baby.
You should not take rosuvastatin if you have liver disease, or if you breast-feeding a baby.
Participants, methods, and results
We randomised adults stable on 10 or 20 mg of simvastatin at night for primary or secondary prevention of coronary heart disease, stroke, or peripheral vascular disease, to dosings in the morning or evening for a period of eight weeks. We measured fasting blood lipid profiles at baseline and at eight weeks. We sampled blood between 8 30 and 9 30 am. Patients randomised to dosing in the morning were told not to omit it on the day of the follow up blood sample. The primary outcome measure was change in fasting total cholesterol concentration between baseline and follow up. We also measured the concentration of high density lipoprotein, alanine transaminase, low density lipoprotein, and triglyceride. We checked compliance by counting the number of tablets taken between the two visits.
We compared mean lipid concentrations between treatment groups in an intention to treat analysis using analysis of covariance with initial concentration as a covariate. We compared proportions with χ2 tests and means with unmatched t tests. The 5% level indicated statistical significance, and we analysed data in SPSS. To show a significant 4% change in mean cholesterol concentration with 80% power, assuming a mean coefficient of variation of 5.5% among patients, we needed 60 patients.
A computer search identified 96 patients who took simvastatin. We excluded 13 because they already took simvastin in the morning. Of the 83 eligible patients, 60 (72%) accepted. We randomised the 27 men and 33 women of mean age 66 (range 44-82) to taking the drug in the mornings or in the evenings. Thirty six patients took 10 mg a day and 24 took 20 mg a day. Sex and daily dose did not differ between groups (P > 0.6). A total of 57 patients completed the trial; one withdrew and two defaulted. In the intention to treat analysis, we assumed that the lipid profiles of these patients did not change between baseline and follow up. Change in blood lipids was normally distributed and switching taking simvastatin from in the evening to in the morning resulted in statistically significant increases in total and low density lipoprotein cholesterol (table). Compliance did not differ between the groups (mean number of tablets 1, standard deviation 5 for both groups; P = 0.9).
Lipid concentrations at baseline (mean and standard deviation) with mean and 95% confidence interval of the difference in the change after eight weeks of morning versus evening dosing (n=60)
*Analysis of covariance with adjustment for initial concentration.
Breaking News: Statins Make You Fat!
A new study highlights the false hope that consumers place in statin drugs to lower cholesterol levels. Results of the 10-year analysis showed that individuals prescribed statins for high cholesterol levels had a larger increase in body-mass index (BMI) than those who weren’t taking the drugs. These results once again call into question the wisdom of relying on statins to both reduce heart attack risk and extend life.
About 75% of the prescriptions for statins are written for people with no clinical evidence of cardiovascular disease (CVD). Statins have not been shown to increase life expectancy in these patients.
The list of statin drugs include:
The easy conclusion is that the majority of people on statin drugs are achieving no real benefit from them. In fact, by not focusing on effectively reducing heart disease risk through diet, lifestyle, and proper nutritional supplementation the reliance is costing many people their lives.
Statins do produce some benefits in reducing deaths due to a heart attack, but only in people with a history of a heart attack, stroke, or current signs and symptoms of existing CVD. Large studies in people without a history of heart attack or stroke who took statin drugs and lowered their cholesterol have shown they did not live any longer than the people in the placebo group.
In the largest and most thorough review of statins analyzed 11 clinical trials involving 65,229 participants and was published in the Archives of Internal Medicine in June 2010. The analysis provided the most reliable evidence available on the impact of statin therapy on all-cause mortality among high-risk individuals without prior CVD. The results showed that the use of statin therapy did not result in reduction in all-cause mortality in these high-risk patients.
These results are consistent with other quality reviews and call into question the widespread use of statins not only in high-risk patients without CVD, but also in patients with the only risk present being elevated LDL.
While drug companies and many doctors state that statins are so safe and effective they should be added to drinking water, the reality is that they are very expensive medicines, provide very limited benefit, and carry with them considerable risks for side effects. For example, a 2012 study by the Mayo Clinic found that the use of statins in postmenopausal women increased their risk for type 2 diabetes by 74%. Some of the other side effects noted with statins include the following:
- Liver problems and decreased liver function
- Interference with the manufacture of coenzyme Q10 (CoQ10), a key substance responsible for energy production within the body
- Rhabdomyolysis, the breaking down of muscle tissue, which can be fatal
- Nerve damage – the chances of nerve damage are 26 times higher in statin users than in the general population
- Cognitive (brain-related) impairment, such as memory loss, forgetfulness and confusion, has been seen in some statin users.
- Possible increased risk of cancer and heart failure with long-term use
- Increased muscle damage caused by exercise and reduced exercise capacity
- Worsening energy levels and fatigue after exertion in about 20% of cases
Researchers from a major global health initiative presented findings at the Society of General Internal Medicine Meeting on April 24, 2014 showing that statin users were consuming an extra 192 calories per day in 2009–2010 than they were in 1999–2000. This increase in calories was associated with a 6 to 11 pound weight gain in this time span. In contrast, there were no significant changes in eating habits or weight gain observed among statin nonusers.
The results were published in JAMA: Internal Medicine to coincide with the presentation. The new data raise concerns of a potential hazard with statins. Either the statins contribute directly to obesity by affecting metabolism or appetite in some manner or they led to “false reassurance” that led to poor dietary choices and a sedentary life.
The researchers used data from the National Health and Nutrition Examination Survey (NHANES) from 1999 and 2010, to calculate the impact of statins on calorie intake, weight gain, and BMI. During this time period, the proportion of patients taking statins increased from 7.5% in 1999 to 16.5% in 2010. Statin users tended to be older white males, less educated, had a diagnosis of diabetes, and a higher BMI than their counterparts not taking statins.
In 1999–2000, statin users consumed 2,000 calories a day and ate 71.7 grams per day of fat, interestingly both of these intakes were significantly less than that consumed by individuals not taking statins., However, by 2009–2010 there was a significant increase in the number of calories consumed and the amount of fat eaten by statin users, whereas in the group not taking statins the daily calorie and fat intake actually dropped a little but was not statistically significant. Over time, the dietary changes in the statin group led to significant increases in both BMI and weight gain.
Table 1. Caloric and Fat Intake by Statin Use Between 1999 and 2010
|Statin users||No statins|
|Caloric intake (kcal/day)|
|Fat intake (g/day)|
These results indicate that statin use may have affected diet and lifestyle choices, or it may also show that statins have an underlying effect that promotes obesity. Given the fact that the use of statins is associated with an increased risk of type 2 diabetes, there could be a biological basis for the noted observation – the promotion of insulin resistance.
This study is quite interesting and is worthy of serious follow up by actually monitoring the effect of statin use in patients over time. The take away message for me is that statins are NOT addressing the major causes of CVD and may be creating serious health issues of their own.
In order to provide you the best guidelines to reduce your risk for CVD, I am offering a free PFD download on my book on Cholesterol and Heart Health – What the Drug Companies Won’t Tell You and Your Doctor Doesn’t Know. Just click here. Feel free to forward it to any friend or family member that can benefit from it.
Redberg RF. Statins and weight gain. JAMA Intern Med 2014; available at: https://archinte.jamanetwork.com/journal.aspx.
The uses and risks of Crestor
As with most drugs, some people will have an adverse reaction to Crestor.
One study showed that 1.4 percent of patients stopped using it because of adverse reactions.
More than 2 percent of patients experienced:
- myalgia, or muscle pain
- abdominal pain
- weakness or lack of energy
People who should not use Crestor include:
- those who are allergic to rosuvastatin
- patients with liver disease
- pregnant or breastfeeding mothers
If a woman is taking Crestor and she becomes pregnant, she should inform her doctor at once, as there may be a risk to the fetus or the infant.
The following people should make sure their doctors know before being prescribed Crestor:
- patients with kidney or liver disease
- people with diabetes
- patients with a thyroid disorder
- people who consume more than two alcoholic drinks each day
Patients should tell their doctor immediately if they experience:
- unexplained weakness, muscle pain, or tiredness
- loss of appetite
- upper abdominal pain
- dark urine
All these are signs and symptoms of rare but potentially serious side effects.
Patients taking Crestor have a very slight risk of developing rhabdomyolysis. This involves a breakdown of the skeletal muscles that release certain proteins, including myoglobin into the bloodstream.
Myoglobin can damage the kidneys and cause kidney failure.
Anybody who may be developing rhabdomyolysis should stop taking Crestor immediately.
Alcohol can raise triglyceride levels and the chance of liver damage, so it should be avoided when using Crestor.
Statins will be less effective if the patient does not follow a cholesterol-lowering diet plan. Patients must avoid foods that are high in cholesterol and fat.
Other medications may increase the risk of medical problems and complications if taken together with Crestor.
Examples include cyclosporine, gemfibrozil, drugs that contain niacin, fenoribrate, and some HIV medications. Other examples include atazanavir, ritonavir, lopinavir or ritonavir, and saquinavir.
Are statins a good idea?
Statins are one of the medications that doctors find it hardest to persuade patients to adhere to.
Share on PinterestFor best effect, Crestor should be used with a healthy diet and regular exercise.
Patients often stop taking them because of bad publicity. Some studies have suggested that statins are not as helpful as commonly believed, for example, in reducing the risk of thrombolytic events.
However, medical professionals are concerned that by not using statins, patients could be putting themselves at risk of heart disease.
The FDA stated in 2009 that the risks of Crestor are comparable with the risk of using other statins. Statins have been linked to a higher risk of myopathy and rhabdomyolysis, and, rarely, liver problems.
The benefits are also similar to those offered by other statins. The FDA notes that the balance between the risks and the benefits is acceptable.
For best results, patients who use statins should also follow a diet that is low in saturated fats and cholesterol, and they should get regular physical exercise.
The following serious adverse reactions are discussed in greater detail in other sections of the label:
- Rhabdomyolysis with myoglobinuria and acute renal failure and myopathy (including myositis)
- Liver enzyme abnormalities
Clinical Studies Experience
Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in clinical practice.
In the CRESTOR controlled clinical trials database (placebo or active-controlled) of 5394 patients with a mean treatment duration of 15 weeks, 1.4% of patients discontinued due to adverse reactions. The most common adverse reactions that led to treatment discontinuation were:
- abdominal pain
The most commonly reported adverse reactions (incidence ≥2%) in the CRESTOR controlled clinical trial database of 5394 patients were:
- abdominal pain
Adverse reactions reported in ≥2% of patients in placebo-controlled clinical studies and at a rate greater than placebo are shown in Table 1. These studies had a treatment duration of up to 12 weeks.
Table 1: Adverse Reactions1 Reported in ≥2% of Patients Treated with CRESTOR and > Placebo in Placebo-Controlled Trials (% of Patients)
Other adverse reactions reported in clinical studies were abdominal pain, dizziness, hypersensitivity (including rash, pruritus, urticaria, and angioedema) and pancreatitis. The following laboratory abnormalities have also been reported: dipstick-positive proteinuria and microscopic hematuria ; elevated creatine phosphokinase, transaminases, glucose, glutamyl transpeptidase, alkaline phosphatase, and bilirubin; and thyroid function abnormalities.
In the METEOR study, involving 981 participants treated with rosuvastatin 40 mg (n=700) or placebo (n=281) with a mean treatment duration of 1.7 years, 5.6% of subjects treated with CRESTOR versus 2.8% of placebo-treated subjects discontinued due to adverse reactions. The most common adverse reactions that led to treatment discontinuation were: myalgia, hepatic enzyme increased, headache, and nausea .
Adverse reactions reported in ≥2% of patients and at a rate greater than placebo are shown in Table 2.
Table 2: Adverse Reactions1 Reported in ≥2% of Patients Treated with CRESTOR and > Placebo in the METEOR Trial (% of Patients)
|Adverse Reactions||CRESTOR 40 mg
|ALT >3x ULN2||2.2||0.7|
| 1 Adverse reactions by MedDRA preferred term.
2 Frequency recorded as abnormal laboratory value.
In the JUPITER study, 17,802 participants were treated with rosuvastatin 20 mg (n=8901) or placebo (n=8901) for a mean duration of 2 years. A higher percentage of rosuvastatin-treated patients versus placebo-treated patients, 6.6% and 6.2%, respectively, discontinued study medication due to an adverse event, irrespective of treatment causality. Myalgia was the most common adverse reaction that led to treatment discontinuation.
In JUPITER, there was a significantly higher frequency of diabetes mellitus reported in patients taking rosuvastatin (2.8%) versus patients taking placebo (2.3%). Mean HbA1c was significantly increased by 0.1% in rosuvastatin-treated patients compared to placebo-treated patients. The number of patients with a HbA1c >6.5% at the end of the trial was significantly higher in rosuvastatin-treated versus placebo-treated patients .
Adverse reactions reported in ≥2% of patients and at a rate greater than placebo are shown in Table 3.
Table 3: Adverse Reactions1 Reported in ≥2% of Patients Treated with CRESTOR and > Placebo in the JUPITER Trial (% of Patients)
|Adverse Reactions||CRESTOR 20 mg
|1 Treatment-emergent adverse reactions by MedDRA preferred term.|
Pediatric Patients With Heterozygous Familial Hypercholesterolemia
In a 12-week controlled study in boys and postmenarcheal girls 10 to 17 years of age with heterozygous familial hypercholesterolemia with CRESTOR 5 to 20 mg daily , elevations in serum creatine phosphokinase (CK) >10 x ULN were observed more frequently in rosuvastatin compared with placebo-treated children. Four of 130 (3%) children treated with rosuvastatin (2 treated with 10 mg and 2 treated with 20 mg) had increased CK >10 x ULN, compared to 0 of 46 children on placebo.
The following adverse reactions have been identified during postapproval use of CRESTOR: arthralgia, fatal and non-fatal hepatic failure, hepatitis, jaundice, thrombocytopenia, depression, sleep disorders (including insomnia and nightmares), peripheral neuropathy, interstitial lung disease and gynecomastia. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
There have been rare reports of immune-mediated necrotizing myopathy associated with statin use .
There have been rare postmarketing reports of cognitive impairment (e.g., memory loss, forgetfulness, amnesia, memory impairment, and confusion) associated with statin use. These cognitive issues have been reported for all statins. The reports are generally nonserious, and reversible upon statin discontinuation, with variable times to symptom onset (1 day to years) and symptom resolution (median of 3 weeks).
Read the entire FDA prescribing information for Crestor (Rosuvastatin Calcium)
Using Crestor — and all statins — safely
Updated: April 16, 2019Published: March, 2014
Some simple steps can help minimize or avoid muscle problems from Crestor and other cholesterol-lowering drugs.
All drugs have side effects. The trick is to weigh the potential for serious side effects against the gain you can get from the medication. The balance sheet for Crestor and other statins looks like this: These drugs cut the risk of heart attack, angina (chest pain), stroke, and death from cardiovascular disease by 30%. They cause muscle pain in under 5% of the people who take them, and these pains often stop by themselves even with continued statin use. The chance of rhabdomyolysis, a potentially deadly breakdown of muscle tissue, is less than one per million statin prescriptions.
Some people are more prone to muscle problems from Crestor and other statins than others. You are in this category if you
- are over age 80
- have a small body frame or are frail
- have kidney disease
- drink a lot of grapefruit juice
- take other medications (for a list, ask your doctor or pharmacist.)
If any of these apply to you, it’s prudent to start with a low-dose statin and slowly work your way up to what’s needed to get your cholesterol to a safe level while having your doctor closely monitor you for problems.
Muscle pains and aches are part of everyday life for some. Figuring out if these are due to a statin can be tricky.
Statin-related muscle problems usually appear within a few weeks of starting the drug. Be aware of muscle pain, cramps, stiffness, spasms, and weakness that can’t be explained by arthritis, recent strenuous exercise, a fever, a fall, or other common causes. If any of these occur, tell your doctor right away — don’t wait until your next scheduled appointment. He or she might lower your statin dose, take you off another medication that could be reacting with the statin, or stop the statin altogether. Sometimes just taking a break, then restarting the same statin at the same dose is enough to make the problem disappear. Your doctor might also suggest switching to another statin.
The advantage of having seven statins on the market is that each one has a unique chemical composition. These differences mean that one statin may cause you trouble while another may work flawlessly for you. In addition to Crestor, the other statins are Lescol (fluvastatin), Lipitor (atorvastatin), Mevacor (lovastatin), Livalo (pitavastatin), Pravachol (pravastatin), and Zocor (simvastatin).
While it’s impossible to differentiate what pain is truly caused by a statin and what are the normal aches and pains of getting older, it’s important to report unexplainable muscle pain to your doctor.
Image: © BackyardProduction/Thinkstock
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Seniors: If you are older than 65 years of age, your doctor will likely monitor you closely for muscle-related side effects.
What other drugs could interact with this medication?
There may be an interaction between rosuvastatin and any of the following:
- antacids (if taken within 2 hours of taking rosuvastatin)
- calcium carbonate
- hepatitis C antivirals (e.g., daclatasvir, dasabuvir, ledipasvir, ombitasvir, paritaprevir, simeprevir, sofosbuvir)
- HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
- niacin (nicotinic acid)
- proton pump inhibitors (e.g., lansoprazole, omeprazole, pantoprazole)
- other “statin” anti-cholesterol medications (e.g., atorvastatin, lovastatin, simvastatin)
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
All material copyright MediResource Inc. 1996 – 2020. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Crestor
Seniors: If you are older than 65 years of age, your doctor will likely monitor you closely for muscle-related side effects.
Rosuvastatin Side Effects
Medically reviewed by Drugs.com. Last updated on Jan 12, 2019.
- Side Effects
Commonly reported side effects of rosuvastatin include: myalgia. Other side effects include: asthenia. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to rosuvastatin: oral tablet
Along with its needed effects, rosuvastatin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking rosuvastatin:
- Dark-colored urine
- muscle cramps or spasms
- muscle pain, stiffness, tenderness, wasting, or weakness
- unusual tiredness or weakness
Incidence not known
- Abdominal or stomach pain
- clay-colored stools
- skin rash
- unpleasant breath odor
- vomiting of blood
- yellow eyes or skin
Some side effects of rosuvastatin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Body aches or pain
- difficulty with moving
- dry or sore throat
- pain in the joints
- runny nose
- tender, swollen glands in the neck
- trouble swallowing
- voice changes
- Accidental injury
- accumulation of pus, swollen, red, or tender area of infection near a tooth
- acid or sour stomach
- arm, back, or jaw pain
- bladder pain
- bloated or full feeling
- bloody or cloudy urine
- blurred vision
- burning feeling in the chest or stomach
- burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
- chest pain or discomfort
- chest tightness or heaviness
- difficult or labored breathing
- difficult, burning, or painful urination
- dry mouth
- excess air or gas in the stomach or intestines
- excessive muscle tone
- fast, irregular, pounding, or racing heartbeat or pulse
- feeling faint
- feeling of constant movement of self or surroundings
- feeling of warmth or heat
- feeling sad or empty
- flushed, dry skin
- flushing or redness of the skin especially on the face and neck
- fruit-like breath odor
- general feeling of discomfort or illness
- increased hunger
- increased thirst
- increased urination
- itching skin
- lack of appetite
- lack or loss of strength
- loss of appetite
- loss of consciousness
- loss of interest or pleasure
- muscle tension or tightness
- neck pain
- nerve pain
- pain or swelling in the arms or legs without any injury
- pain or tenderness around the eyes and cheekbones
- pain, swelling, or redness in the joints
- pale skin
- passing gas
- pounding in the ears
- sensation of spinning
- slow heartbeat
- stomach pain, discomfort, tenderness, or upset
- stuffy nose
- swelling of the hands, ankles, feet, or lower legs
- trouble concentrating
- trouble sleeping
- unexplained weight loss
- unusual bleeding or bruising
For Healthcare Professionals
Applies to rosuvastatin: oral capsule, oral tablet
The most frequently reported side effects included headache, myalgia, abdominal pain, asthenia, and nausea.
Very common (10% or more): Myalgia (up to 12.7%), arthralgia (10.1%)
Rare (less than 0.1%): Myopathy, rhabdomyolysis, myositis
Frequency not reported: Immune-mediated necrotizing myopathy, tendon disorders, creatine phosphokinase increased
Common (1% to 10%): Abdominal pain, nausea, constipation
Rare (less than 0.1%): Pancreatitis
Frequency not reported: Diarrhea
Common (1% to 10%): Headache, dizziness
Very rare (less than 0.01%): Polyneuropathy, memory loss
Postmarketing reports: Cognitive impairment, forgetfulness, amnesia, memory impairment, peripheral neuropathy
Rare (0.01% to 0.1%): Hepatic transaminases/enzymes increased
Very rare (less than 0.01%): Jaundice, hepatitis
Frequency not reported: Bilirubin increased
Postmarketing reports: Fatal hepatic failure, nonfatal hepatic failure
Uncommon (0.1% to 1%): Rash, pruritus, urticaria
Rare (less than 0.1%): Angioedema
Frequency not reported: Stevens-Johnson syndrome
Frequency not reported: Acute renal failure
Very rare (less than 0.01%): Hematuria
Frequency not reported: Proteinuria, myoglobinuria, sexual dysfunction
Common (1% to 10%): Asthenia
Frequency not reported: Edema, glutamyl transpeptidase increased, alkaline phosphatase increased
Frequency not reported: Cough, dyspnea, interstitial lung disease
Frequency not reported: Confusion, depression, insomnia, nightmares, sleep disorders/disturbances
Very rare (less than 0.01%): Gynecomastia
Frequency not reported: Thyroid function abnormalities
Common (1% to 10%): Diabetes mellitus
Frequency not reported: Glucose elevated, HbA1c increased
Rare (less than 0.1%): Thrombocytopenia
Rare (less than 0.1%): Hypersensitivity reaction
1. Cerner Multum, Inc. “UK Summary of Product Characteristics.” O 0
2. Cerner Multum, Inc. “Australian Product Information.” O 0
3. “Product Information. Crestor (rosuvastatin).” AstraZeneca Pharma Inc, Mississauga, ON.
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Some side effects may not be reported. You may report them to the FDA.
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Crestor is a prescription drug designed to control unhealthy cholesterol levels in the bloodstream. Everyone has “good” (HDL) and “bad” (LDL) cholesterol levels. When bad cholesterol is too high, it can cause a variety of health problems, including heart attacks‚ strokes‚ and arteriosclerosis. You can improve cholesterol levels by eating a better diet, but some believe this is not always enough in severe situations – which is why cholesterol drugs were created.
One of the most popular cholesterol medications is Crestor, a synthetic lipid-lowering medication approved for treating hypercholesterolemia. The drug, manufactured by AstraZeneca and approved by the FDA in 2003, is classified as a statin, which means it works by inhibiting cholesterol production by the liver. Originally, the drug was to be used to treat a limited population with bad cholesterol and a history of heart attack, but use of the drug was expanded by the FDA in 2010 to allow for use in healthy patients to reduce their risk for heart attacks, strokes, and deaths.
Crestor was prescribed to improve good and bad cholesterol levels, but many users experienced side effects – some of which were severe. It is expected that all drugs will produce some side effects, but in the case of Crestor, some of those side effects were deadly.
Crestor and Kidney Damage
Many Crestor users suffered kidney damage and studies show the risk of kidney damage could be a much as 75% higher for Crestor users. Other studies show general risks of using Crestor are as much as 7% higher than with other cholesterol drugs.
The drug has also been linked to Rhabdomyolysis, a disease that breaks down muscle tissue. There is evidence that muscle tissue eventually clogged the kidneys in some users, further boosting their risk for renal failure.
One study, published in March 2015 in the journal BMJ, showed people taking higher doses of statins like Crestor were 34% more likely to be hospitalized for acute kidney injury within the first 120 days of treatment, compared to those taking lower doses. Researchers speculated the increased risk was related to the breakdown of muscle tissue.
In addition to kidney disease, Crestor can trigger a number of other side effects, including:
• Back Pain
• Muscle pain
• Flu syndrome
• Urinary tract infection
• Pharyngitis (a specific kind of sore throat)
• Fatigue and lack of energy
• Abdominal pain
• Memory loss and confusion
Many former users of Crestor also claim they developed type 2 diabetes after using the drug.
Crestor Users Take Legal Action
A growing number of former Crestor users throughout the country are now pursuing legal action against AstraZeneca, alleging the drug manufacturer failed to adequately research Crestor or warn doctor and consumers of the potential risks associated with the drug. Many claimed if they’d known the risks of taking the drug they would not have prescribed or used it.
According to legal claims, AstraZeneca:
• Knew or should have known about the risks associated with Crestor
• Concealed information from consumers and the medical community
• Ignored available information and fraudulently concealed the risk of diabetes
Lawsuits also allege there should have been warnings placed on Crestor labels once the risks were known or the drug should have been recalled.
In 2004, the consumer advocacy group Public Citizen filed a petition with the FDA demanding Crestor be recalled from the market because of its severe side effects and the availability of safer alternatives. The group believes the drug would have never been approved had AstraZeneca disclosed the risks earlier.