What is etodolac 400?

Etodolac

Generic Name: etodolac (ee toe DOE lak)
Brand Names: Lodine, Lodine XL

Medically reviewed by Sanjai Sinha, MD Last updated on Apr 10, 2019.

  • Overview
  • Side Effects
  • Dosage
  • Professional
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  • Interactions
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What is etodolac?

Etodolac is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.

Etodolac is used to treat mild to moderate pain, osteoarthritis, or rheumatoid arthritis.

Etodolac may also be used for purposes not listed in this medication guide.

Important information

Etodolac can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Etodolac may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using etodolac, especially in older adults.

Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or other medicines similar to etodolac (such as ibuprofen, ketoprofen, or naproxen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen. Do not drink alcohol while taking this medicine. Alcohol can increase the risk of stomach bleeding caused by etodolac. Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). This medicine can make your skin more sensitive to sunlight and sunburn may result.

Before taking this medicine

Etodolac can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Even people without heart disease or risk factors could have a stroke or heart attack while taking this medicine.

Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Etodolac may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using this medicine, especially in older adults.

You should not use etodolac if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

To make sure etodolac is safe for you, tell your doctor if you have:

  • heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke;

  • a history of heart attack, stroke, or blood clot;

  • a history of stomach ulcers or bleeding;

  • asthma;

  • liver or kidney disease; or

  • fluid retention.

Taking etodolac during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using etodolac.

Etodolac can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

The etodolac regular tablet is not approved for use by anyone younger than 18 years old. The extended-release form of etodolac is not approved for use by anyone younger than 6 years old.

How should I take etodolac?

Take etodolac exactly as it was prescribed for you. Follow all directions on your prescription label. Do not take this medicine in larger amounts or for longer than recommended. Use the lowest dose that is effective in treating your condition.

Do not crush, chew, or break an extended-release tablet. Swallow it whole.

It may take up to 2 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

If you use this medicine long-term, you may need frequent medical tests.

This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using etodolac.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking etodolac?

Avoid drinking alcohol. It may increase your risk of stomach bleeding.

Avoid taking aspirin or other NSAIDs while you are taking etodolac.

Ask a doctor or pharmacist before using any cold, allergy, or pain medication. Many medicines available over the counter contain aspirin or other medicines similar to etodolac. Taking certain products together can cause you to get too much of this type of medication. Check the label to see if a medicine contains aspirin, ibuprofen, ketoprofen, or naproxen.

Etodolac side effects

Get emergency medical help if you have signs of an allergic reaction to etodolac: sneezing, runny or stuffy nose; wheezing or trouble breathing; hives; swelling of your face, lips, tongue, or throat.

Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.

Stop using etodolac and call your doctor at once if you have:

  • changes in your vision;

  • the first sign of any skin rash, no matter how mild;

  • shortness of breath (even with mild exertion);

  • swelling or rapid weight gain;

  • signs of stomach bleeding – bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

  • liver problems – nausea, upper stomach pain, itching, tired feeling, flu-like symptoms, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  • kidney problems – little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath;

  • low red blood cells (anemia) – pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or

  • severe skin reaction – fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common etodolac side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Etodolac dosing information

Usual Adult Dose for Osteoarthritis:

Capsules or tablets: 300 mg orally 2 to 3 times a day or 400 mg orally twice a day or 500 mg orally twice a day. Total daily dose should not exceed 1200 mg.
Extended-release tablets: 400 to 1200 mg orally, given once daily.

Usual Adult Dose for Rheumatoid Arthritis:

Capsules or tablets: 300 mg orally 2 to 3 times a day or 400 mg orally twice a day or 500 mg orally twice a day. Total daily dose should not exceed 1200 mg.
Extended-release tablets: 400 to 1200 mg orally, given once daily.

Usual Adult Dose for Pain:

Capsules or tablets: 200 to 400 mg orally every 6 to 8 hours. Total daily dose should not exceed 1200 mg.

Usual Pediatric Dose for Juvenile Rheumatoid Arthritis:

Extended-release tablets:
6 to 16 years: dose based on weight, given orally once daily
For 20 to 30 kg, dose is 400 mg
For 31 to 45 kg, dose is 600 mg
For 46 to 60 kg, dose is 800 mg
For greater than 60 kg, dose is 1000 mg

What other drugs will affect etodolac?

Ask your doctor before using etodolac if you take an antidepressant such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone. Taking any of these medicines with an NSAID may cause you to bruise or bleed easily.

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • cyclosporine;

  • lithium;

  • methotrexate;

  • a blood thinner (warfarin, Coumadin, Jantoven);

  • heart or blood pressure medication, including a diuretic or “water pill”; or

  • steroid medicine (prednisone and others).

This list is not complete. Other drugs may interact with etodolac, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use etodolac only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2020 Cerner Multum, Inc. Version: 10.01.

Medical Disclaimer

More about etodolac

  • Side Effects
  • During Pregnancy or Breastfeeding
  • Dosage Information
  • Patient Tips
  • Drug Images
  • Drug Interactions
  • Support Group
  • Pricing & Coupons
  • En Español
  • 74 Reviews
  • Drug class: Nonsteroidal anti-inflammatory drugs
  • FDA Alerts (3)

Consumer resources

  • Etodolac Capsules and Tablets
  • Etodolac Extended-Release Tablets
  • Etodolac (Advanced Reading)

Other brands: Lodine, Lodine XL

Professional resources

  • Etodolac (AHFS Monograph)
  • … +4 more

Related treatment guides

  • Juvenile Rheumatoid Arthritis
  • Osteoarthritis
  • Pain
  • Rheumatoid Arthritis

How does this medication work? What will it do for me?

Etodolac belongs to the group of medications known as nonsteroidal anti-inflammatory drugs (NSAIDs). It is used for the short- and long-term relief of rheumatoid arthritis and osteoarthritis. It works by relieving pain and by reducing swelling and inflammation. It may take up to 2 weeks to see the full benefits of this medication.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does this medication come in?

200 mg
Each hard gelatin, light grey/dark grey, size No. 0 capsule imprinted “200” contains 200 mg of etodolac. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, lactose monohydrate, stearic acid and talc; capsule: black iron oxide, edible ink, gelatin, sodium lauryl sulfate as a processing aid, titanium dioxide and yellow iron oxide; ink: erythrosine aluminum lake, iron oxide yellow, n-butyl alcohol, propylene glycol, shellac, and titanium dioxide.

300 mg
Each hard gelatin, light grey/light grey, size No. 0 capsule imprinted “300” contains 300 mg of etodolac. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, lactose monohydrate, stearic acid and talc; capsule: black iron oxide, edible ink, gelatin, sodium lauryl sulfate as a processing aid, titanium dioxide and yellow iron oxide; ink: erythrosine aluminum lake, iron oxide yellow, n-butyl alcohol, propylene glycol, shellac, and titanium dioxide.

How should I use this medication?

The usual recommended dose for treatment of rheumatoid arthritis and osteoarthritis is 200 mg to 300 mg twice daily. Some people may find that 400 mg or 600 mg taken once daily in the evening works well. To minimize upset stomach and heartburn, take this medication immediately after a meal, or with food or milk.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take this medication?

Etodolac should not be taken by anyone who:

  • is allergic to etodolac or to any of the ingredients of the medication
  • currently has or recently had inflammatory diseases of the stomach or intestines, such as stomach or intestinal ulcer or ulcerative colitis
  • has had an allergic reaction to acetylsalicylic acid (ASA) or other anti-inflammatory medications (e.g., asthma, itchy and runny nose, itchy skin rash, hives, or other allergic reactions)

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • constipation
  • diarrhea
  • drowsiness
  • heartburn
  • nausea
  • tiredness
  • vomiting

Although most of these side effects listed below don’t happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • abdominal pain
  • changes in the amount or colour of urine
  • difficult or painful swallowing
  • dizziness, loss of balance, or ringing in the ears
  • hearing problems
  • signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of self-harm)
  • skin rash
  • swelling in the feet or legs
  • symptoms of anemia (such as paleness, fatigue, or weakness)
  • symptoms of liver damage (such as yellow skin or eyes, abdominal pain, dark urine, pale stools, loss of appetite, nausea and vomiting, or itching)
  • unexpected weight changes
  • vision changes

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • signs of a severe allergic reaction (hives; difficulty breathing; swelling of the face, tongue, or throat)
  • symptoms of a bleeding ulcer (such as black tarry stools, blood in the stools, vomiting up of blood or material that looks like coffee grounds)
  • symptoms of a severe skin rash (such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort)
  • unusual or persistent bleeding or bruising

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Allergy: Some people who are allergic to other anti-inflammatory medications also experience allergic reactions to etodolac. Before you take etodolac, inform your doctor about any previous adverse reactions you have had to medications, especially other NSAIDs. Contact your doctor immediately if you experience signs of an allergic reaction, such as skin rash, itching, difficulty breathing, or swelling of the face and throat.

Anemia: As with other nonsteroidal anti-inflammatory drugs (NSAIDs), etodolac can cause a reduced red blood cell count (anemia) or make existing anemia worse. If you have a history of anemia, your doctor may recommend regular blood tests to determine your hemoglobin levels.

If you experience symptoms of reduced red blood cell count such as shortness of breath, feeling unusually tired or pale skin, contact your doctor as soon as possible.

Bleeding: NSAIDs such as etodolac may cause a reduced number of platelets in the blood, which can make it difficult to stop cuts from bleeding. If you notice any signs of bleeding, such as frequent nosebleeds, unexplained bruising, or black and tarry stools, notify your doctor as soon as possible. Your doctor will order routine blood tests to make sure potential problems are caught early.

Be sure to tell your doctor, dentist, or surgeon that you are taking this medication. You may be asked to stop taking this medication before surgery or dental procedures.

Drowsiness/reduced alertness: Drowsiness, dizziness, and lightheadedness have been reported by some people taking this medication. Do not drive vehicles or undertake other potentially hazardous activities until you have determined that this medication does not affect you in this way.

Fluid retention: As with many other NSAIDs, people have reported increased fluid retention while taking this medication. People who have heart failure, high blood pressure, kidney disease, who are recovering from surgical operations under general anesthesia, or have any other condition that might lead to fluid retention should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Kidney function: Kidney disease or reduced kidney function may cause this medication to build up in the body, causing side effects. If you have kidney problems, heart failure, or you are taking diuretics (e.g., hydrochlorothiazide, furosemide, indapamide) discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

As with other NSAIDs, etodolac may cause kidney damage. If you experience signs of decreased kidney function, such as decreased urine production, difficulty urinating or blood in the urine, contact your doctor as soon as possible.

Liver function: Some people taking NSAIDs such as etodolac have developed liver damage. Stop taking the medication and contact your doctor as soon as possible if you notice signs of liver damage, such as yellow eyes or skin, abdominal pain, itchy skin, pale stools, or dark urine. Your doctor may recommend regular liver function tests if you are taking this medication for a long period of time.

Potassium: NSAIDs such as etodolac can increase blood levels of potassium. You doctor will check your blood potassium levels while you are taking this medication. People with diabetes, kidney failure, or who are seniors, or are taking certain medications (e.g., ramipril, amiloride) should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Ulcers: NSAIDs such as etodolac may increase the risk of ulcers in the stomach and intestines. If you have had an ulcer, are at risk of experiencing an ulcer (e.g., are senior or smoke), or have medical conditions that make you prone to irritation of the stomach and intestines (e.g., diverticulitis, ulcerative colitis, Crohn’s disease), you should talk to your doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring or treatment is needed.

Stop taking the medication and seek immediate medical attention if you develop symptoms of a bleeding ulcer, such as dark tarry stools, blood in the stools, or vomiting up of blood or material that looks like coffee grounds.

Vision changes: Etodolac and other NSAIDs may cause blurred or reduced vision. Stop taking this medication if you experience changes in vision and contact your doctor to have an eye examination arranged.

Pregnancy: The safety of using this medication during pregnancy has not been established. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: It is not known if etodolac passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children.

Seniors: Seniors who take this medication should be closely monitored by their doctors. Seniors may be more likely to develop side effects and may require a lower dose due to decreased kidney and liver function.

What other drugs could interact with this medication?

There may be an interaction between etodolac and any of the following:

  • 5-ASA medications (e.g., mesalamine, olsalzine, sulfasalazine)
  • acetylsalicylic acid (ASA)
  • alcohol
  • aliskiren
  • aminoglycoside antibiotics (e.g., amikacin, gentamicin, tobramycin)
  • angiotensin-converting enzyme inhibitors (ACE inhibitors; e.g., enalapril, lisinopril, ramipril)
  • anticoagulants (e.g., apixaban, dabigatran, , rivaroxaban, warfarin)
  • beta-adrenergic blockers (e.g., atenolol, propranolol, sotalol)
  • bisphosphonates (e.g., alendronate, etidronate, risedronate)
  • celecoxib
  • cholestyramine
  • clopidogrel
  • colestipol
  • cyclosporine
  • dasatinib
  • deferasirox
  • desmopressin
  • digoxin
  • dipyridamole
  • diuretics (water pills; e.g., furosemide, hydrochlorothiazide, triamterene)
  • drospirenone
  • eplerenone
  • haloperidol
  • heparin
  • herbal products that affect blood clotting (e.g., cat’s claw, chamomile, fenugreek, evening primrose, feverfew, garlic, ginger, ginseng, glucosamine, turmeric)
  • hydralazine
  • latanoprost
  • lithium
  • low-molecular-weight heparins (e.g., dalteparin, enoxaparin, tinzaparin)methotrexate
  • other non-steroidal anti-inflammatory medications (NSAIDs; e.g., diclofenac, ibuprofen, naproxen)
  • obinutuzumab
  • omega-3 fatty acids
  • pentoxifylline
  • porfimer
  • quinolone antibiotics (e.g., ciprofloxacin, norfloxacin, ofloxacin)
  • selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, fluoxetine, paroxetine, sertraline)
  • serotonin-norepinephrine reuptake inhibitors (SNRIs; desvenlafaxine, duloxetine, venlafaxine)
  • sodium phosphates
  • tacrolimus
  • tenofovir
  • ticagrelor
  • ticlopidine
  • tipranavir
  • tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, trimipramine)
  • vancomycin
  • verteporfin
  • vitamin E

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material copyright MediResource Inc. 1996 – 2020. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Etodolac

Etodolac is a non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain, and to relieve symptoms of arthritis (osteoarthritis and rheumatoid arthritis), such as inflammation, swelling, stiffness, and joint pain.

Lodine, the brand-name formulation of the drug, has been discontinued in the United States, and only the generic form of etodolac is available.

Etodolac works by reducing the levels of hormones that cause inflammation and pain in the body.

Etodolac may also be used for other purposes. Some examples of the off-label uses of this drug include the relief of:

  • Fibromyalgia symptoms
  • Gout symptoms
  • Symptoms of systemic lupus erythematosus (SLE or lupus)
  • Pain or inflammation caused by other conditions, such as back pain, knee pain, or foot pain.

Etodolac Warnings

This medicine can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use etodolac. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

Seek emergency medical help if you have symptoms of heart or circulation problems, such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

This medicine can also increase your risk of stomach or intestinal problems, including bleeding or perforation (formation of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking etodolac. Older adults may have an even greater risk of these serious gastrointestinal side effects.

Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or other medicines similar to etodolac, such as ibuprofen (Advil, Motrin, Mydol), ketoprofen (Actron, Orudis, Oruvail), or naproxen (Aleve).

If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin (Bayer, Bufferin), ibuprofen, ketoprofen, or naproxen.

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Etodolac can make your skin more sensitive to sunlight and sunburn may result.

Before taking etodolac, tell your doctor if you are allergic to any drugs, are a smoker, or if you have any of the following conditions:

  • A history of heart attack, stroke, or blood clot
  • Heart disease, congestive heart failure, high blood pressure
  • A history of stomach ulcers or bleeding
  • Liver or kidney disease
  • Asthma
  • Polyps in your nose
  • A bleeding or blood clotting disorder

If you have any of these conditions, you may need a dose adjustment or special tests to safely take etodolac.

Pregnancy and Etodolac

This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Taking etodolac during the last three months of pregnancy may harm the unborn baby. Do not take etodolac during pregnancy unless your doctor has told you to.

It is not known whether etodolac passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breastfeeding.

Do not give this medicine to a child younger than 6 years old without the advice of a doctor.

Cyclobenzaprine

  • Prepak Systems Inc.
  • Prescript Pharmaceuticals
  • Prescription Dispensing Service Inc.
  • Qualitest
  • Rebel Distributors Corp.
  • Redpharm Drug
  • Remedy Repack
  • Sandhills Packaging Inc.
  • Sandoz
  • Southwood Pharmaceuticals
  • Spectrum Pharmaceuticals
  • St Mary’s Medical Park Pharmacy
  • Stat Rx Usa
  • Stat Scripts LLC
  • Teva Pharmaceutical Industries Ltd.
  • UDL Laboratories
  • United Research Laboratories Inc.
  • Va Cmop Dallas
  • Vangard Labs Inc.
  • Victory Pharma
  • Vintage Pharmaceuticals Inc.
  • Watson Pharmaceuticals
  • Dosage forms

    Form Route Strength
    Capsule, extended release Oral 15 mg/1
    Capsule, extended release Oral 30 mg/1
    Kit 10 mg/1
    Kit Oral
    Kit Not applicable
    Tablet Oral 10 mg
    Capsule, film coated, extended release Oral 10 mg/1
    Capsule, film coated, extended release Oral 5 mg/1
    Powder Not applicable 1 g/1g
    Tablet Oral 10 mg/10mg
    Tablet Oral 10 mg/1
    Tablet Oral 5 mg/1
    Tablet Oral 7.5 mg/1
    Tablet, coated Oral 10 mg/1
    Tablet, film coated Oral 10 mg/1
    Tablet, film coated Oral 10 mg/301
    Tablet, film coated Oral 5 mg/1
    Kit Topical 5.6 g/5.6g
    Tablet, film coated Oral 7.5 mg/1
    Kit Topical
    Tablet Oral
    Kit Oral 0.25 g/0.25g
    Kit Oral 0.28 g/0.28g

    Prices

    Unit description Cost Unit
    Cyclobenzaprine hcl crystal 273.88USD g
    Cyclobenzaprine hcl powder 35.84USD g
    Fexmid 7.5 mg tablet 4.18USD tablet
    Flexeril 5 mg tablet 2.04USD tablet
    Flexeril 10 mg tablet 1.74USD tablet
    Cyclobenzaprine HCl 5 mg tablet 1.71USD tablet
    Cyclobenzaprine 5 mg tablet 1.64USD tablet
    Cyclobenzaprine HCl 10 mg tablet 0.47USD tablet
    Cyclobenzaprine 10 mg tablet 0.41USD tablet

    DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only. Patents Additional Data Available

    • Filed On Filed On

      The date on which a patent was filed with the relevant government.

      Learn more

    Properties

    State Solid Experimental Properties

    Property Value Source
    melting point (°C) 217 FDA Label
    water solubility Freely Soluble FDA Label
    logP 5.2 Not Available
    pKa 8.47 FDA Label

    Predicted Properties

    Property Value Source
    Water Solubility 0.00689 mg/mL ALOGPS
    logP 4.73 ALOGPS
    logP 4.61 ChemAxon
    logS -4.6 ALOGPS
    pKa (Strongest Basic) 9.76 ChemAxon
    Physiological Charge 1 ChemAxon
    Hydrogen Acceptor Count 1 ChemAxon
    Hydrogen Donor Count 0 ChemAxon
    Polar Surface Area 3.24 Å2 ChemAxon
    Rotatable Bond Count 3 ChemAxon
    Refractivity 102.62 m3·mol-1 ChemAxon
    Polarizability 32.95 Å3 ChemAxon
    Number of Rings 3 ChemAxon
    Bioavailability 1 ChemAxon
    Rule of Five Yes ChemAxon
    Ghose Filter Yes ChemAxon
    Veber’s Rule Yes ChemAxon
    MDDR-like Rule No ChemAxon

    Predicted ADMET features

    Property Value Probability
    Human Intestinal Absorption + 0.9941
    Blood Brain Barrier + 0.9512
    Caco-2 permeable + 0.8867
    P-glycoprotein substrate Substrate 0.7567
    P-glycoprotein inhibitor I Inhibitor 0.8563
    P-glycoprotein inhibitor II Inhibitor 0.6447
    Renal organic cation transporter Inhibitor 0.7955
    CYP450 2C9 substrate Non-substrate 0.7826
    CYP450 2D6 substrate Substrate 0.8918
    CYP450 3A4 substrate Substrate 0.7501
    CYP450 1A2 substrate Inhibitor 0.7324
    CYP450 2C9 inhibitor Non-inhibitor 0.9071
    CYP450 2D6 inhibitor Inhibitor 0.8933
    CYP450 2C19 inhibitor Non-inhibitor 0.9025
    CYP450 3A4 inhibitor Non-inhibitor 0.9158
    CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.6955
    Ames test Non AMES toxic 0.9132
    Carcinogenicity Non-carcinogens 0.8127
    Biodegradation Not ready biodegradable 0.8727
    Rat acute toxicity 2.9697 LD50, mol/kg Not applicable
    hERG inhibition (predictor I) Weak inhibitor 0.7531
    hERG inhibition (predictor II) Inhibitor 0.6767

    ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

    Spectra

    Mass Spec (NIST) Not Available Spectra

    Spectrum Spectrum Type Splash Key
    Predicted GC-MS Spectrum – GC-MS Predicted GC-MS Not Available
    Predicted MS/MS Spectrum – 10V, Positive (Annotated) Predicted LC-MS/MS Not Available
    Predicted MS/MS Spectrum – 20V, Positive (Annotated) Predicted LC-MS/MS Not Available
    Predicted MS/MS Spectrum – 40V, Positive (Annotated) Predicted LC-MS/MS Not Available
    Predicted MS/MS Spectrum – 10V, Negative (Annotated) Predicted LC-MS/MS Not Available
    Predicted MS/MS Spectrum – 20V, Negative (Annotated) Predicted LC-MS/MS Not Available
    Predicted MS/MS Spectrum – 40V, Negative (Annotated) Predicted LC-MS/MS Not Available

    Taxonomy

    Description This compound belongs to the class of organic compounds known as dibenzocycloheptenes. These are compounds containing a dibenzocycloheptene moiety, which consists of two benzene rings connected by a cycloheptene ring. Kingdom Organic compounds Super Class Benzenoids Class Dibenzocycloheptenes Sub Class Not Available Direct Parent Dibenzocycloheptenes Alternative Parents Trialkylamines / Organopnictogen compounds / Hydrocarbon derivatives Substituents Dibenzocycloheptene / Tertiary aliphatic amine / Tertiary amine / Organic nitrogen compound / Organopnictogen compound / Hydrocarbon derivative / Organonitrogen compound / Amine / Aromatic homopolycyclic compound Molecular Framework Aromatic homopolycyclic compounds External Descriptors organic tricyclic compound (CHEBI:3996)

    Targets

    Kind Protein Organism Humans Pharmacological action Yes Actions Antagonist General Function Virus receptor activity Specific Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodop… Gene Name HTR2A Uniprot ID P28223 Uniprot Name 5-hydroxytryptamine receptor 2A Molecular Weight 52602.58 Da Kind Protein Organism Humans Pharmacological action Unknown Actions Antagonist General Function Serotonin receptor activity Specific Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation… Gene Name HTR2B Uniprot ID P41595 Uniprot Name 5-hydroxytryptamine receptor 2B Molecular Weight 54297.41 Da Kind Protein Organism Humans Pharmacological action Unknown Actions Antagonist General Function Serotonin receptor activity Specific Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-… Gene Name HTR2C Uniprot ID P28335 Uniprot Name 5-hydroxytryptamine receptor 2C Molecular Weight 51820.705 Da Kind Protein Organism Humans Pharmacological action Unknown Actions Antagonist General Function Serotonin receptor activity Specific Function This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor … Gene Name HTR6 Uniprot ID P50406 Uniprot Name 5-hydroxytryptamine receptor 6 Molecular Weight 46953.625 Da Kind Protein Organism Humans Pharmacological action Unknown Actions Inhibitor General Function Serotonin:sodium symporter activity Specific Function Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into t… Gene Name SLC6A4 Uniprot ID P31645 Uniprot Name Sodium-dependent serotonin transporter Molecular Weight 70324.165 Da Kind Protein Organism Humans Pharmacological action Unknown Actions Inhibitor General Function Norepinephrine:sodium symporter activity Specific Function Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals. Gene Name SLC6A2 Uniprot ID P23975 Uniprot Name Sodium-dependent noradrenaline transporter Molecular Weight 69331.42 Da Kind Protein Organism Humans Pharmacological action Unknown Actions Antagonist General Function Serotonin receptor activity Specific Function This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor … Gene Name HTR7 Uniprot ID P34969 Uniprot Name 5-hydroxytryptamine receptor 7 Molecular Weight 53554.43 Da Kind Protein Organism Humans Pharmacological action Unknown Actions Inhibitor General Function Transmembrane signaling receptor activity Specific Function Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and … Gene Name TLR4 Uniprot ID O00206 Uniprot Name Toll-like receptor 4 Molecular Weight 95679.19 Da Kind Protein Organism Humans Pharmacological action Unknown Actions Inhibitor General Function Xanthine dehydrogenase activity Specific Function Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and N-methylphthalazinium, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal… Gene Name AOX1 Uniprot ID Q06278 Uniprot Name Aldehyde oxidase Molecular Weight 147916.735 Da

    Enzymes

    Kind Protein Organism Humans Pharmacological action Unknown Actions Substrate General Function Vitamin d3 25-hydroxylase activity Specific Function Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react… Gene Name CYP3A4 Uniprot ID P08684 Uniprot Name Cytochrome P450 3A4 Molecular Weight 57342.67 Da

    1. Wang RW, Liu L, Cheng H: Identification of human liver cytochrome P450 isoforms involved in the in vitro metabolism of cyclobenzaprine. Drug Metab Dispos. 1996 Jul;24(7):786-91.
    2. Witenko C, Moorman-Li R, Motycka C, Duane K, Hincapie-Castillo J, Leonard P, Valaer C: Considerations for the appropriate use of skeletal muscle relaxants for the management of acute low back pain. P T. 2014 Jun;39(6):427-35.

    Kind Protein Organism Humans Pharmacological action Unknown Actions Substrate General Function Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Specific Function Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un… Gene Name CYP1A2 Uniprot ID P05177 Uniprot Name Cytochrome P450 1A2 Molecular Weight 58293.76 Da Kind Protein Organism Humans Pharmacological action Unknown Actions Substrate Curator comments This enzyme relationship is reported to be weak in the literature and is unlikely to result in clinically significant drug interactions. General Function Steroid hydroxylase activity Specific Function Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic… Gene Name CYP2D6 Uniprot ID P10635 Uniprot Name Cytochrome P450 2D6 Molecular Weight 55768.94 Da

    1. Wang RW, Liu L, Cheng H: Identification of human liver cytochrome P450 isoforms involved in the in vitro metabolism of cyclobenzaprine. Drug Metab Dispos. 1996 Jul;24(7):786-91.
    2. FDA label, cyclobenzaprine

    Kind Protein Organism Humans Pharmacological action Unknown Actions Substrate General Function Protein homodimerization activity Specific Function UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the… Gene Name UGT1A4 Uniprot ID P22310 Uniprot Name UDP-glucuronosyltransferase 1-4 Molecular Weight 60024.535 Da Kind Protein Organism Humans Pharmacological action Unknown Actions Substrate General Function UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Specific Function Glucuronosyltransferase activity Gene Name UGT2B10 Uniprot ID P36537 Uniprot Name UDP-glucuronosyltransferase 2B10 Molecular Weight 60773.485 Da

    Carriers

    Details1. Serum albumin Kind Protein Organism Humans Pharmacological action Unknown Actions Substrate General Function Toxic substance binding Specific Function Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid… Gene Name ALB Uniprot ID P02768 Uniprot Name Serum albumin Molecular Weight 69365.94 Da

    1. Baig MH, Rahman S, Rabbani G, Imran M, Ahmad K, Choi I: Multi-Spectroscopic Characterization of Human Serum Albumin Binding with Cyclobenzaprine Hydrochloride: Insights from Biophysical and In Silico Approaches. Int J Mol Sci. 2019 Feb 3;20(3). pii: ijms20030662. doi: 10.3390/ijms20030662.

    ×Unlock Data

    There is additional data available for commercial users including Adverse Effects, Contraindications, and Blackbox Warnings. Contact us to learn more about these and other features.

    Learn more

    Drug created on June 13, 2005 07:24 / Updated on February 02, 2020 04:08

    Etodolac 400 mg narcotic etodolac tablets 500 mg

    Etodolac lodine 600mg

    No drug can preserve or regenerate beta cells when blood sugars are rising over 140 mg/dl for long periods of time, etodolac 400 mg narcotic because sustained high blood sugars cause glucotoxicity–poisoning of beta cells. Domestic orders are shipped via FedEx Home Delivery (1-5 days), etodolac warfarin 3mg FedEx 2 Day Air, FedEx Standard Overinight, USPS First Class (2-5 days) and USPS Priority (2-3 days). The invention further discloses preparation of gabapentin and isolation of gabapentin in polymorphic Form II with high yield and purity. The main risk factors for impaired glucose tolerance due to corticosteroids are the dose of steroid and duration of treatment. My website is in the very same niche as yours and my visitors would truly benefit from some of the information you present here. I have virtually no knowledge of coding but I was hoping to start my own blog in the near future. Primary Immunodeficiency Diseases Due to Defects in Lymphocytes. Mais beaucoup de gens préfèrent à l’antiquité faire des achats dans les pharmacies ordinaires, buy arcoxia canada au lieu d’aller à la boutique en ligne. CPB and postoperative values were compared with baseline by using a paired Student’s t-test. Man unterscheidet verschiedene körpereigene Prostaglandine, mobic 20mg nebenwirkungen sie bilden Gruppen wie PGD, PGE und PGF und teilen sich zusätzlich in Untergruppen. Only 23 of the 662 (3.5%) athletes tested between 8 – 28 June 2015 declared the personal use of meldonium, which included 13 competition winners. You don’t have to live with the symptoms of RLS disrupting your night. (show more) umn class: Standard non-polar; Column length: 2 m; Column type: Packed; Start T: 200 C; CAS no: 50486; Active phase: OV-1; Substrate: Chromosorb G; Data type: Kovats RI; Authors: Dubsky, mestinon 10mg bula H.; Hana, K.; Komarkova, M.; Rittich, B., Pouziti kovatsovych indexu pri toxikologickych analysach, Chem. I’ve not experienced any of the symptoms that anyone has experienced but I have had a few problems in the ‘bedroom department’. Mildronate increases aerobic capabilities of athletes through carnitine-lowering effect. Ergotisme : quelques cas de spasmes artériels avec ischémie des extrémités ont été observés (addition d’effets vasculaires). In the second year, an open-label design was used and patients could select either suppressive or episodic therapy or discontinue treatment and participation. Because he won’t eat ANYTHING, I have to put the pills at the back of his tongue and hold his mouth shut until he swallows. i visited different hospital but they gave me list of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. licheniformis strain C8 was susceptible to 4.0 mg/liter erythromycin. Telavancin: (Moderate) Concurrent or sequential use of telavancin with other potentially nephrotoxic drugs such as Angiotensin-converting enzyme inhibitors (ACE inhibitors) may lead to additive nephrotoxicity. Addleman has progressed with treatment and has apparently been compliant with all institutional rules since 1989.

    Etodolac 400 mg with alcohol

    Escitalopram in premenstrual dysphoric disorder during luteal phase.

    Identification

    Are you a new drug developer? Contact us to learn more about our customized products and solutions. Stay in the know! As part of our commitment to providing the most up-to-date drug information, we will be releasing #DrugBankUpdates with our newly added curated drug pages. #DrugBankUpdates Name Etodolac Accession Number DB00749 (APRD00067) Type Small Molecule Groups Approved, Investigational, Vet approved Description

    Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis.

    Structure 3D Download Similar Structures

    Structure for Etodolac (DB00749)

    × Close Synonyms External IDs AY 24236 / AY-24-236 / AY-24,236 / AY-24236 / NIH-9918 Product Images Prescription Products

    Name Dosage Strength Route Labeller Marketing Start Marketing End
    Unlock Additional Data
    Etodolac Capsule 300 mg Oral Aa Pharma Inc 1997-08-21 Not applicable Canada
    Etodolac Capsule 200 mg Oral Aa Pharma Inc 1997-08-21 Not applicable Canada
    Lodine Tablet, film coated 500 mg/1 Oral Wyeth Pharmaceuticals Inc. 2006-03-30 2006-09-21 US
    Lodine Tablet, film coated 400 mg/1 Oral Wyeth Pharmaceuticals Inc. 2006-03-30 2006-09-21 US
    Lodine Tablet 500 mg/1 Oral Physicians Total Care, Inc. 1996-10-01 2011-05-31 US
    Lodine Capsule 300 mg/1 Oral Wyeth Pharmaceuticals Inc. 2006-03-30 2006-09-21 US
    Lodine Tablet 400 mg/1 Oral Physicians Total Care, Inc. 1993-10-15 2011-05-31 US
    Lodine Capsule 200 mg/1 Oral Wyeth Pharmaceuticals Inc. 2006-03-30 2006-09-21 US
    Lodine Capsule 300 mg/1 Oral Physicians Total Care, Inc. 1994-01-03 2002-06-30 US
    Ultradol – Cap 200mg Capsule Oral Procter And Gamble 1995-12-31 2002-07-23 Canada

    Additional Data Available

    • Application Number Application Number

      A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

      Learn more

    • Product Code Product Code

      A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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    Generic Prescription Products

    Name Dosage Strength Route Labeller Marketing Start Marketing End
    Unlock Additional Data
    Etodolac Tablet, film coated, extended release 400 mg/1 Oral Proficient Rx LP 2001-02-09 Not applicable US
    Etodolac Tablet, extended release 600 mg/1 Oral Taro Pharmaceuticals U.S.A., Inc. 2003-03-13 Not applicable US
    Etodolac Tablet 500 mg/1 Oral Genpharm Ulc 2015-11-01 2015-11-24 US
    Etodolac Tablet, coated 400 mg/1 Oral bryant ranch prepack 2015-04-20 Not applicable US
    Etodolac Capsule 200 mg/1 Oral Av Kare, Inc. 2017-01-05 Not applicable US
    Etodolac Tablet, film coated, extended release 500 mg/1 Oral St. Mary’s Medical Park Pharmacy 2018-03-14 Not applicable US
    Etodolac Capsule 300 mg/1 Oral Denton Pharma, Inc. Dba Northwind Pharmaceuticals 2019-02-18 Not applicable US
    Etodolac Tablet 400 mg/1 Oral Sandoz Inc 1997-04-11 2009-11-11 US
    Etodolac Tablet, film coated 400 mg/1 Oral Amneal Pharmaceuticals NY LLC 2018-06-11 Not applicable US
    Etodolac Capsule 300 mg/1 Oral Taro Pharmaceuticals U.S.A., Inc. 1998-04-30 Not applicable US

    Additional Data Available

    • Application Number Application Number

      A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

      Learn more

    • Product Code Product Code

      A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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    Mixture Products International/Other Brands Bodopine (Yuan Chou) / Dolarit (Drogsan) / Dolchis (Korea United Pharm) / Doloc (Unifarma) / Dualgan (ITF) / Eccoxolac (Meda) / Edolar Fort (Pfizer) / Edopain (Incepta) / Edopain ER (Incepta) / Elac (Royal) / Elderin (Lek) / Eric (U.C. Pharma) / Esodax (Münir Sahin) / ETL (Senton) / Etodin (Nobel) / Etodin Fort (Ulkar) / Etodol (Yuhan) / Etodon (Shinlon) / Etoflam (Standard Chem) / Etol Fort (Nobel) / Etolac (Alkaloid) / Etomax (Ipca) / Etomax-ER (Ipca) / Etonox (Charoen Bhaesaj) / Etopan (Winthrop Pharmaceuticals) / Etopin (U-Liang) / Lodine XL (Wyeth) Categories UNII 2M36281008 CAS number 41340-25-4 Weight Average: 287.3535
    Monoisotopic: 287.152143543 Chemical Formula C17H21NO3 InChI Key NNYBQONXHNTVIJ-UHFFFAOYSA-N InChI InChI=1S/C17H21NO3/c1-3-11-6-5-7-12-13-8-9-21-17(4-2,10-14(19)20)16(13)18-15(11)12/h5-7,18H,3-4,8-10H2,1-2H3,(H,19,20) IUPAC Name 2-{1,8-diethyl-1H,3H,4H,9H-pyranoindol-1-yl}acetic acid SMILES CCC1=C2NC3=C(CCOC3(CC)CC(O)=O)C2=CC=C1

    Pharmacology

    Indication

    For acute and long-term management of signs and symptoms of osteoarthritis and rheumatoid arthritis, as well as for the management of pain.

    Associated Conditions

    • Juvenile Idiopathic Arthritis (JIA)
    • Osteoarthritis (OA)
    • Pain, Acute
    • Rheumatoid Arthritis

    Pharmacodynamics

    Etodolac is an anti-inflammatory agent with analgesic and antipyretic properties. It is used to treat osteoarthritis, rheumatoid arthritis and control acute pain. The therapeutic effects of etodolac are achieved via inhibition of the synthesis of prostaglandins involved in fever, pain, swelling and inflammation. Etodolac is administered as a racemate. As with other NSAIDs, the S-form has been shown to be active while the R-form is inactive. Both enantiomers are stable and there is no evidence of R- to S- conversion in vivo.

    Mechanism of action

    Similar to other NSAIDs, the anti-inflammatory effects of etodolac result from inhibition of the enzyme cycooxygenase (COX). This decreases the synthesis of peripheral prostaglandins involved in mediating inflammation. Etodolac binds to the upper portion of the COX enzyme active site and prevents its substrate, arachidonic acid, from entering the active site. Etodolac was previously thought to be a non-selective COX inhibitor, but it is now known to be 5 – 50 times more selective for COX-2 than COX-1. Antipyresis may occur by central action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat loss.

    Target Actions Organism
    AProstaglandin G/H synthase 2 inhibitor Humans
    UProstaglandin G/H synthase 1 inhibitor Humans
    URetinoic acid receptor RXR-alpha other Humans

    Unlock Additional Data Additional Data Available Adverse Effects

    Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

    Learn more Additional Data Available Contraindications

    Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

    Learn more Additional Data Available Blackbox Warnings

    Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

    Learn more Absorption

    Based on mass balance studies, the systemic bioavailability of etodolac from either the tablet or capsule formulation is at least 80%.

    Volume of distribution

    • 390 mL/kg

    Protein binding

    > 99% bound, primarily to albumin

    Metabolism

    • Etodolac 6-Hydroxyetodolac
    • Etodolac 7-Hydroxyetodolac
    • Etodolac Etodolac acyl glucuronide

    Route of elimination

    It is not known whether etodolac is excreted in human milk; however, based on its physical-chemical properties, excretion into breast milk is expected. Etodolac is extensively metabolized in the liver. The hydroxylated-etodolac metabolites undergo further glucuronidation followed by renal excretion and partial elimination in the feces (16% of dose). Approximately 1% of a etodolac dose is excreted unchanged in the urine with 72% of the dose excreted into urine as parent drug plus metabolite.

    Half life

    Terminal t1/2, 7.3 ± 4.0 hours. Distribution t1/2, 0.71 ± 0.50 hours

    Clearance Toxicity

    Selective COX-2 inhibitors have been associated with increased risk of serious cardiovascular events (e.g. myocardial infarction, stroke) in some patients. Current data is insufficient to assess the cardiovascular risk of etodolac. Etodolac may increase blood pressure and/or cause fluid retention and edema. Risk of GI toxicity including bleeding, ulceration and perforation. Risk of direct renal injury, including renal papillary necrosis. Anaphylactoid and serious skin reactions (e.g. exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis) have been reported. Common adverse events include abdominal pain, constipation, diarrhea, dyspepsia, flatulence, GI bleeding, GI perforation, nausea, peptic ulcer, vomiting, renal function abnormalities, anemia, dizziness, edema, liver function test abnormalities, headache, prolonged bleeding time, pruritus, rash, tinnitus. Symptoms of overdose include lethargy, drowsiness, nausea, vomiting, and epigastric pain.

    Affected organisms

    • Humans and other mammals

    Pathways

    Pathway Category
    Etodolac Action Pathway Drug action

    Pharmacogenomic Effects/ADRs Not Available

    Interactions

    Drug Interactions This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

    • All Drugs
    • Approved
    • Vet approved
    • Nutraceutical
    • Illicit
    • Withdrawn
    • Investigational
    • Experimental
    Drug Interaction
    Unlock Additional Data
    (R)-warfarin The risk or severity of bleeding and hemorrhage can be increased when Etodolac is combined with (R)-warfarin.
    (S)-Warfarin The risk or severity of bleeding and hemorrhage can be increased when Etodolac is combined with (S)-Warfarin.
    1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic Acid The risk or severity of hypertension can be increased when Etodolac is combined with 1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic Acid.
    1-benzylimidazole The risk or severity of hypertension can be increased when Etodolac is combined with 1-benzylimidazole.
    2,5-Dimethoxy-4-ethylamphetamine The risk or severity of hypertension can be increased when Etodolac is combined with 2,5-Dimethoxy-4-ethylamphetamine.
    2,5-Dimethoxy-4-ethylthioamphetamine The risk or severity of hypertension can be increased when Etodolac is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.
    4-Bromo-2,5-dimethoxyamphetamine The risk or severity of hypertension can be increased when Etodolac is combined with 4-Bromo-2,5-dimethoxyamphetamine.
    4-hydroxycoumarin The risk or severity of bleeding and hemorrhage can be increased when Etodolac is combined with 4-hydroxycoumarin.
    4-Methoxyamphetamine The risk or severity of hypertension can be increased when Etodolac is combined with 4-Methoxyamphetamine.
    5-methoxy-N,N-dimethyltryptamine The risk or severity of hypertension can be increased when Etodolac is combined with 5-methoxy-N,N-dimethyltryptamine.

    Additional Data Available

    • Extended Description Extended Description

      Extended description of the mechanism of action and particular properties of each drug interaction.

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    • Severity Severity

      A severity rating for each drug interaction, from minor to major.

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    • Evidence Level Evidence Level

      A rating for the strength of the evidence supporting each drug interaction.

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    • Action Action

      An effect category for each drug interaction. Know how this interaction affects the subject drug.

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    Food Interactions

    • Avoid alcohol.
    • Food increases the peak plasma concentration of extended-release tablets with no effect on extent of absorption.
    • Food increases the time to peak concentration of regular release oral formulations by 1.4 to 3.8 hours with no effect on extent of absorption.
    • Take with food to reduce gastric irritation.

    Synthesis Reference US4585877 General References Not Available External Links Human Metabolome Database HMDB0014887 KEGG Drug D00315 KEGG Compound C06991 PubChem Compound 3308 PubChem Substance 46505184 ChemSpider 3192 BindingDB 50016799 ChEBI 4909 ChEMBL CHEMBL622 Therapeutic Targets Database DAP000778 PharmGKB PA449550 RxList RxList Drug Page Drugs.com Drugs.com Drug Page Wikipedia Etodolac ATC Codes M01AB08 — Etodolac

    • M01AB — Acetic acid derivatives and related substances
    • M01A — ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    • M01 — ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
    • M — MUSCULO-SKELETAL SYSTEM

    AHFS Codes

    • 28:08.04.92 — Other Nonsteroidal Antiimflammatory Agents

    FDA label (290 KB)

    Clinical Trials

    Clinical Trials

    Phase Status Purpose Conditions Count
    1 Completed Treatment Fasting 4
    1 Completed Treatment Fed 1
    1 Completed Treatment Healthy Volunteers 1
    2 Active Not Recruiting Treatment HCC 1
    2 Recruiting Prevention Neoplasms, Colorectal 1
    2 Recruiting Prevention Neoplasms, Pancreatic 1
    2 Terminated Treatment Prostatic Neoplasms 1
    3 Completed Treatment Acute Delayed Onset Muscle Soreness (DOMS) 1
    3 Completed Treatment Ankle Sprains 1
    3 Completed Treatment Back Pain Lower Back 1
    3 Completed Treatment Post Operative Pain 1
    3 Not Yet Recruiting Treatment Pain, Acute 1
    3 Unknown Status Prevention Neoplasms, Colorectal 1
    4 Completed Treatment Medicaments Substances in Therapeutic Use 1
    Not Available Completed Not Available Rheumatoid Arthritis 1
    Not Available Completed Treatment Knee Osteoarthritis (Knee OA) 1
    Not Available Unknown Status Prevention Primary Operable Breast Cancer 1

    Pharmacoeconomics

    Manufacturers

    • Aaipharma llc
    • Apotex inc
    • Endo pharmaceuticals inc
    • Genpharm inc
    • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
    • Mylan pharmaceuticals inc
    • Sandoz inc
    • Taro pharmaceutical industries ltd
    • Teva pharmaceuticals usa inc
    • Watson laboratories inc
    • Wyeth pharmaceuticals inc
    • Point holdings inc
    • Watson laboratories inc florida
    • Actavis elizabeth llc
    • Apotex inc etobicoke site
    • Mylan laboratories inc
    • Ranbaxy laboratories ltd

    Packagers

    • Actavis Group
    • Apotex Inc.
    • Apotheca Inc.
    • A-S Medication Solutions LLC
    • Atlantic Biologicals Corporation
    • Bristol-Myers Squibb Co.
    • Bryant Ranch Prepack
    • Corepharma LLC
    • DHHS Program Support Center Supply Service Center
    • Direct Dispensing Inc.
    • Dispensing Solutions
    • Diversified Healthcare Services Inc.
    • Eon Labs
    • H.J. Harkins Co. Inc.
    • Innoviant Pharmacy Inc.
    • Ivax Pharmaceuticals
    • Kaiser Foundation Hospital
    • Keltman Pharmaceuticals Inc.
    • Lake Erie Medical and Surgical Supply
    • Letco Medical Inc.
    • Major Pharmaceuticals
    • Murfreesboro Pharmaceutical Nursing Supply
    • Mylan
    • Novopharm Ltd.
    • Nucare Pharmaceuticals Inc.
    • Ohm Laboratories Inc.
    • Palmetto Pharmaceuticals Inc.
    • Par Pharmaceuticals
    • Patheon Inc.
    • PD-Rx Pharmaceuticals Inc.
    • Physicians Total Care Inc.
    • Preferred Pharmaceuticals Inc.
    • Prepak Systems Inc.
    • Prescript Pharmaceuticals
    • Ranbaxy Laboratories
    • Rebel Distributors Corp.
    • Redpharm Drug
    • Remedy Repack
    • Resource Optimization and Innovation LLC
    • Southwood Pharmaceuticals
    • St Mary’s Medical Park Pharmacy
    • Stat Rx Usa
    • Taro Pharmaceuticals USA
    • Teva Pharmaceutical Industries Ltd.
    • Torpharm Inc.

    Dosage forms

    Form Route Strength
    Capsule Oral 200 mg
    Capsule Oral 300 mg
    Capsule, gelatin coated Oral 300 mg/1
    Tablet Oral 400 mg/1
    Tablet Oral 500 mg/1
    Tablet, coated Oral 400 mg/1
    Tablet, coated Oral 500 mg/1
    Tablet, extended release Oral 400 mg/1
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    Tablet, extended release Oral 600 mg/1
    Tablet, film coated, extended release Oral 400 mg/1
    Tablet, film coated, extended release Oral 500 mg/1
    Tablet, film coated, extended release Oral 600 mg/1
    Capsule Oral 200 mg/1
    Capsule Oral 300 mg/1
    Tablet, film coated Oral 400 mg/1
    Tablet, film coated Oral 500 mg/1
    Kit Oral
    Capsule Oral

    Prices

    Unit description Cost Unit
    Etodolac CR 600 mg 24 Hour tablet 2.76USD tablet
    Lodine 400 mg tablet 2.65USD tablet
    Lodine 500 mg tablet 1.8USD tablet
    Etodolac CR 500 mg 24 Hour tablet 1.6USD tablet
    Etodolac 500 mg tablet 1.52USD tablet
    Etodolac 400 mg tablet 1.5USD tablet
    Etodolac CR 400 mg 24 Hour tablet 1.46USD tablet
    Etodolac 300 mg capsule 1.31USD capsule
    Apo-Etodolac 200 mg Capsule 0.8USD capsule
    Apo-Etodolac 300 mg Capsule 0.8USD capsule

    DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only. Patents Not Available Mass Spec (NIST) Not Available Spectra Description This compound belongs to the class of organic compounds known as indolyl carboxylic acids and derivatives. These are compounds containing a carboxylic acid chain (of at least 2 carbon atoms) linked to an indole ring. Kingdom Organic compounds Super Class Organoheterocyclic compounds Class Indoles and derivatives Sub Class Indolyl carboxylic acids and derivatives Direct Parent Indolyl carboxylic acids and derivatives Alternative Parents 3-alkylindoles / Benzenoids / Pyrroles / Heteroaromatic compounds / Oxacyclic compounds / Monocarboxylic acids and derivatives / Dialkyl ethers / Carboxylic acids / Azacyclic compounds / Organopnictogen compoundsOrganonitrogen compounds / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds show 4 more Substituents Indolyl carboxylic acid derivative / 3-alkylindole / Indole / Benzenoid / Pyrrole / Heteroaromatic compound / Oxacycle / Azacycle / Monocarboxylic acid or derivatives / EtherDialkyl ether / Carboxylic acid / Carboxylic acid derivative / Organic oxide / Organopnictogen compound / Organooxygen compound / Organonitrogen compound / Organic oxygen compound / Organic nitrogen compound / Carbonyl group / Hydrocarbon derivative / Aromatic heteropolycyclic compound show 12 more Molecular Framework Aromatic heteropolycyclic compounds External Descriptors monocarboxylic acid, organic heterotricyclic compound (CHEBI:4909)

    Binding Properties

    × Details Binding Properties1. Prostaglandin G/H synthase 2 Kind Protein Organism Humans Pharmacological action Yes Actions Inhibitor General Function Prostaglandin-endoperoxide synthase activity Specific Function Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and… Gene Name PTGS2 Uniprot ID P35354 Uniprot Name Prostaglandin G/H synthase 2 Molecular Weight 68995.625 Da

    1. Chen WS, Liu JH, Wei SJ, Liu JM, Hong CY, Yang WK: Colon cancer cells with high invasive potential are susceptible to induction of apoptosis by a selective COX-2 inhibitor. Cancer Sci. 2003 Mar;94(3):253-8.
    2. Chen WS, Wei SJ, Liu JM, Hsiao M, Kou-Lin J, Yang WK: Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, etodolac. Int J Cancer. 2001 Mar 15;91(6):894-9.
    3. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.
    4. Kusuhara H, Komatsu H, Sumichika H, Sugahara K: Reactive oxygen species are involved in the apoptosis induced by nonsteroidal anti-inflammatory drugs in cultured gastric cells. Eur J Pharmacol. 1999 Nov 3;383(3):331-7.
    5. Svendsen KB, Bech JN, Sorensen TB, Pedersen EB: A comparison of the effects of etodolac and ibuprofen on renal haemodynamics, tubular function, renin, vasopressin and urinary excretion of albumin and alpha-glutathione-S-transferase in healthy subjects: a placebo-controlled cross-over study. Eur J Clin Pharmacol. 2000 Aug;56(5):383-8.
    6. Wilson JE, Chandrasekharan NV, Westover KD, Eager KB, Simmons DL: Determination of expression of cyclooxygenase-1 and -2 isozymes in canine tissues and their differential sensitivity to nonsteroidal anti-inflammatory drugs. Am J Vet Res. 2004 Jun;65(6):810-8.

    Kind Protein Organism Humans Pharmacological action Unknown Actions Inhibitor General Function Prostaglandin-endoperoxide synthase activity Specific Function Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gas… Gene Name PTGS1 Uniprot ID P23219 Uniprot Name Prostaglandin G/H synthase 1 Molecular Weight 68685.82 Da Kind Protein Organism Humans Pharmacological action Unknown Actions Other General Function Zinc ion binding Specific Function Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expressi… Gene Name RXRA Uniprot ID P19793 Uniprot Name Retinoic acid receptor RXR-alpha Molecular Weight 50810.835 Da

    1. Kolluri SK, Corr M, James SY, Bernasconi M, Lu D, Liu W, Cottam HB, Leoni LM, Carson DA, Zhang XK: The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis. Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2525-30. Epub 2005 Feb 7.

    Kind Protein Organism Humans Pharmacological action Unknown Actions Substrate General Function Steroid hydroxylase activity Specific Function Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un… Gene Name CYP2C9 Uniprot ID P11712 Uniprot Name Cytochrome P450 2C9 Molecular Weight 55627.365 Da Kind Protein Organism Humans Pharmacological action Unknown Actions Substrate General Function Retinoic acid binding Specific Function UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 2 lacks trans… Gene Name UGT1A9 Uniprot ID O60656 Uniprot Name UDP-glucuronosyltransferase 1-9 Molecular Weight 59940.495 Da

    1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1.

    Kind Protein Organism Humans Pharmacological action Unknown Actions Substrate General Function Retinoic acid binding Specific Function UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative reg… Gene Name UGT1A3 Uniprot ID P35503 Uniprot Name UDP-glucuronosyltransferase 1-3 Molecular Weight 60337.835 Da

    1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1.

    Kind Protein Organism Humans Pharmacological action Unknown Actions Substrate General Function Protein kinase c binding Specific Function UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative reg… Gene Name UGT1A10 Uniprot ID Q9HAW8 Uniprot Name UDP-glucuronosyltransferase 1-10 Molecular Weight 59809.075 Da

    1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1.

    Kind Protein Organism Humans Pharmacological action Unknown Actions Substrate General Function Glucuronosyltransferase activity Specific Function UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.Its unique specificity for 3,4-catechol estrogens and estriol su… Gene Name UGT2B7 Uniprot ID P16662 Uniprot Name UDP-glucuronosyltransferase 2B7 Molecular Weight 60694.12 Da

    1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1.

    Details1. Serum albumin Kind Protein Organism Humans Pharmacological action Unknown General Function Toxic substance binding Specific Function Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid… Gene Name ALB Uniprot ID P02768 Uniprot Name Serum albumin Molecular Weight 69365.94 Da

    Transporters

    ×

    Property Measurement pH Temperature (°C)
    IC 50 (nM) 50000 N/A N/A 10991954

    Details Binding Properties1. Solute carrier family 22 member 6 Kind Protein Organism Humans Pharmacological action Unknown Actions Inhibitor General Function Sodium-independent organic anion transmembrane transporter activity Specific Function Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one … Gene Name SLC22A6 Uniprot ID Q4U2R8 Uniprot Name Solute carrier family 22 member 6 Molecular Weight 61815.78 Da

    1. Mulato AS, Ho ES, Cihlar T: Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1. J Pharmacol Exp Ther. 2000 Oct;295(1):10-5.

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    Drug created on June 13, 2005 07:24 / Updated on February 02, 2020 00:19

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