What is dymista used for?

Contents

How to use Dymista

Using your allergy nasal spray properly is important.

This short video shows you how to use Dymista.

Checklist of steps

  1. Blow your nose gently, if needed
  2. Shake the nasal spray gently
  3. Remove the cap
  4. Tilt your head forward
  5. Place the nozzle in one of your nostrils
  6. Point the nozzle away from the centre of your nose, towards the inside corner of your eye on the same side*
  7. While breathing in through your nose, firmly press the pump once
  8. Repeat steps 4–7 for your other nostril
  9. Wipe the nozzle and the inside of the cap
  10. Replace the cap

* You might find this easier if you use your opposite hand to hold the spray

Your nasal spray will come with instructions in the package. Always check the package insert for any specific instructions.

Common errors to avoid

  • Forgetting to prime the inhaler spray device before first use or if you haven’t used it for a while (14 days or more)
  • Skipping doses
  • Holding your head in the wrong position (should be tilted forward, not back)
  • Pushing the nozzle too hard or far into your nose
  • Blowing your nose hard after spraying (the medicine is lost)
  • Sniffing hard after spraying (the medicine ends up in your throat instead of your nose)
  • Using the medicine before saline sprays or irrigations, as they should be used first (saline can be used again after waiting at least
    an hour)

Other nasal spray types

See our complete How-to video library for other nasal sprays and how to use them.

Acknowledgement

Thanks to Ms Judi Wicking, asthma and respiratory educator, and the patient who participated in this film clip.

Development of this How-to video was supported by an untied educational grant from Meda Pharmaceuticals. The National Asthma Council Australia retained editorial control.

Dymista

How does this medication work? What will it do for me?

This combination product contains two medications: fluticasone and azelastine. Together, they are used to treat the nasal and eye symptoms of moderate-to-severe seasonal allergies for adults and children more than 12 years of age. This product is used when treatment with either antihistamines or nasal corticosteroids alone have not worked well enough to control the allergy symptoms.

Fluticasone is a corticosteroid. It reduces the body’s response to the allergy triggers. Azelastine is an antihistamine. It works by blocking the effect of the chemicals produced in the body in response to an allergy trigger. For most people, relief of allergy symptoms occurs within 30-45 minutes after administration, however fluticasone–azelastine needs to be used regularly to get the best results.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does this medication come in?

Each metered spray/actuation of white, homogeneous, redispersible suspension intended for intranasal administration delivers an average volume of 0.137 mL containing 137 mcg of azelastine hydrochloride and 50 mcg of fluticasone propionate. Nonmedicinal ingredients: disodium edetate, glycerol, microcrystalline cellulose, carmellose sodium, polysorbate 80, benzalkonium chloride, phenylethyl alcohol, and purified water.

How should I use this medication?

The recommended dose of this medication is 1 actuation (spray) into each nostril two times a day – one in the morning and one in the evening.

If you are using this medication for the first time or you have not used it for more than 7 days, you will need to “prime” the pump by spraying the pump in the air (away from you) 6 times or until a fine mist is sprayed from the bottle.

Before each use, gently blow your nose to clear your nostrils.

With the cap on, shake the medication well. Then remove the cap and follow these 4 steps to use the medication:

  • Tilt your head forward slightly and place the nozzle in one of your nostrils. Point the end of the nozzle towards the side of your nose.
  • Press the button firmly one time to spray the medication while you are breathing in through your nose. Remove the nozzle from your nose and breathe out through your mouth.
  • Repeat steps 1 and 2 for the other nostril.
  • Replace the dust cap.

Avoid getting the spray in your eyes. If you do, thoroughly rinse your eyes with water. Always put the cap back on after use.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor.

If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take this medication?

Do not use this medication if you:

  • are allergic to fluticasone, azelastine or any ingredients of the medication
  • have an untreated infection of the respiratory tract (fungal, bacterial or tuberculosis infection)

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • change in sense of taste or smell
  • crusting in the nose
  • drowsiness
  • dry or soreness inside the nose
  • headache
  • nose bleeds
  • runny nose
  • symptoms of upper respiratory tract infection (e.g., sore throat, fever, cough, stuffy nose, chills, feeling tired)

Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • bone or joint pain
  • signs of nasal ulcers (pain, burning or irritation)
  • signs of too much corticosteroid (e.g., rapid weight gain, sweating, thinning skin, dry skin, muscle weakness)
  • slowed growth (in adolescents)
  • symptoms of increased pressure in the eyes (e.g., decreased or blurred vision, eye pain, red eye, swelling of the eye)
  • symptoms of cataracts (e.g., visual glare, reduced vision)

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Drowsiness/reduced alertness: The antihistamine, azelastine, in this medication may affect the mental or physical abilities needed to drive or operate machinery. Avoid driving, operating machinery, or performing other hazardous tasks until you have determined how this medication affects you.

Growth in adolescents: Corticosteroids such as the fluticasone in this medication may slow down the growth of adolescents. Your doctor will monitor for this. Talk to your doctor if you have any concerns.

Infection: Corticosteroids such as the fluticasone in this medication can mask the signs of infection. You can also develop other infections such as a fungal throat infection or eye infection. Talk to your doctor as soon as possible if you develop any new symptoms.

Infections such as chickenpox and measles can be more serious in people taking medications such as fluticasone. If you are exposed to someone who has chickenpox or measles, contact your doctor.

Vision problems: Corticosteroids such as fluticasone may cause glaucoma or cataracts. Report any vision changes to your doctor immediately.

Wound healing: Corticosteroids such as fluticasone can impair the ability of wounds to heal. If you have ulcers in your nose, have had nasal surgery, or have had nasal trauma, talk to your doctor about how this medication will affect these conditions. Your doctor may recommend waiting until wounds have completely healed.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: Fluticasone passes into breast milk. It is not known if azilastine passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children less than 12 years of age.

What other drugs could interact with this medication?

There may be an interaction between fluticasone-azelastine and any of the following:

  • aclidinium
  • alcohol
  • amphetamines (e.g., dextroamphetamine, lisdexamphetamine)
  • antihistamines (e.g., cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine)
  • antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
  • aripiprazole
  • atropine
  • azelastine
  • “azole” antifungals (e.g., itraconazole, ketoconazole, voriconazole)
  • baclofen
  • barbiturates (e.g., butalbital, pentobarbital phenobarbital)
  • belladonna
  • benzodiazepines (e.g., alprazolam, diazepam, lorazepam)
  • benztropine
  • betahistine
  • boceprevir
  • brimonidine
  • buspirone
  • ceritinib
  • chloral hydrate
  • clarithromycin
  • cobicistat
  • conivaptan
  • cyclobenzaprine
  • disopyramide
  • dofetilide
  • donepezil
  • dronabinol
  • flavoxate
  • galantamine
  • general anesthetics (medications used to put people to sleep before surgery)
  • glucagon
  • glycopyrrolate
  • HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delaviridine, efavirenz, etravirine, nevirapine)
  • HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
  • hyaluronidase
  • ipratropium
  • kava kava
  • ketotifen
  • lomitapide
  • magnesium sulfate
  • metoclopramide
  • metyrosine
  • mirabegron
  • mirtazapine
  • muscle relaxants (e.g., cyclobenzaprine, methocarbamol, orphenadrine)
  • nabilone
  • narcotic pain relievers (e.g., codeine, fentanyl, morphine, oxycodone)
  • nefazodone
  • nelfinavir
  • nicardipine
  • olopatadine
  • oxybutynin
  • pimozide
  • potassium chloride
  • pramipexole
  • rivastigmine
  • ropinirole
  • scopolamine
  • secretin
  • seizure medications (e.g., carbamazepine, clobazam, ethosuximide, felbamate, levetiracetam, phenobarbital, phenytoin, primidone, topiramate, valproic acid, zonisamide)
  • selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, duloxetine, fluoxetine, paroxetine, sertraline)
  • tapentadol
  • telaprevir
  • thalidomide
  • thiazide diuretics (water pills; e.g., hydrochlorothiazide, indapamide, metolazone)
  • tiotropium
  • tolterodine
  • tranylcypromine
  • tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, trimipramine)
  • tramadol
  • zolpidem
  • zopiclone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material copyright MediResource Inc. 1996 – 2020. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Dymista

azelastine and fluticasone nasal (Dymista)

Brand Names: Dymista

Generic Name: azelastine and fluticasone nasal

  • What is azelastine and fluticasone nasal (Dymista)?
  • What are the possible side effects of azelastine and fluticasone nasal (Dymista)?
  • What is the most important information I should know about azelastine and fluticasone nasal (Dymista)?
  • What should I discuss with my healthcare provider before using azelastine and fluticasone nasal (Dymista)?
  • How should I use azelastine and fluticasone nasal (Dymista)?
  • What happens if I miss a dose (Dymista)?
  • What happens if I overdose (Dymista)?
  • What should I avoid while using azelastine and fluticasone nasal (Dymista)?
  • What other drugs will affect azelastine and fluticasone nasal (Dymista)?
  • Where can I get more information (Dymista)?

What is azelastine and fluticasone nasal (Dymista)?

Azelastine and fluticasone nasal (for the nose) is a combination antihistamine and steroid medication used to treat sneezing, runny or stuffy nose, itching, and other nasal symptoms of allergies. This medicine is for use in adults and children who are at least 6 years old.

Azelastine and fluticasone nasal may also be used for purposes not listed in this medication guide.

What are the possible side effects of azelastine and fluticasone nasal (Dymista)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using the medicine and call your doctor at once if you have:

  • severe drowsiness;
  • severe or ongoing nosebleeds;
  • noisy breathing, runny nose, or crusting around your nostrils;
  • redness, sores, or white patches in your mouth or throat;
  • fever, chills, tiredness, body aches;
  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • any wound that will not heal; or
  • signs of low adrenal gland hormones–worsening tiredness or weakness, feeling light-headed, nausea, vomiting.

Steroid medicine can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using azelastine and fluticasone nasal.

Common side effects may include:

  • headache;
  • nosebleeds; or
  • altered sense of taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about azelastine and fluticasone nasal (Dymista)?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

More IMPORTANT SAFETY INFORMATION

  • DYMISTA can cause sleepiness or drowsiness. Do not drive, operate machinery, or do anything that needs you to be alert until you know how DYMISTA affects you.
  • Do not drink alcohol or take any other medicines that may cause you to feel sleepy while using DYMISTA. It can increase your chances of having serious side effects.

DYMISTA may cause serious side effects including:

  • Sleepiness or drowsiness
  • Nasal Problems. Symptoms of nasal problems may include: crusting in the nose, nosebleeds, runny nose, hole in the cartilage between your nose (nasal septal perforation). A whistling sound when you breathe may be a symptom of nasal septal perforation.
  • Slow wound healing. You should not use DYMISTA until your nose has healed if you have a sore in your nose, if you have had surgery on your nose, or if your nose has been injured.
  • Thrush (Candida), a fungal infection in your nose and throat. Tell your healthcare provider if you have any redness or white colored patches in your nose or mouth.
  • Eye problems, such as glaucoma or cataracts. Some people may have eye problems, including glaucoma and cataracts. You should have regular eye exams when using DYMISTA.
  • Immune system problems that may increase your risk of infections. DYMISTA may cause problems with the way your immune system protects your body against infection and increase your risk of infection. Avoid contact with people who have contagious diseases such as chickenpox or measles while you use DYMISTA. Symptoms of infection may include: fever, aches or pains, chills, feeling tired.
  • Adrenal Insufficiency. Adrenal insufficiency is a condition in which the adrenal glands do not make enough steroid hormones. Symptoms of adrenal insufficiency may include: tiredness, weakness, nausea, vomiting, low blood pressure.
  • Slowed or delayed growth in children. A child’s growth should be checked regularly while using DYMISTA.

Call your healthcare provider or get medical help right away if you have symptoms of any of the serious side effects listed above.

  • The most common side effects of DYMISTA include: changes in taste, nosebleeds, and headache.
  • Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of DYMISTA. For more information, ask your healthcare provider or pharmacist.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. DYMISTA and other medicines may affect each other, causing side effects.

Especially tell your healthcare provider if you take:

  • ritonavir (Norvir®) or medicines that contain ritonavir (commonly used to treat HIV infection or AIDS)
  • ketoconazole, fluconazole, or itraconazole (for fungal infections)
  • Before using DYMISTA tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known if DYMISTA will harm your unborn baby.

Please see the Full Prescribing Information and Patient Information

APPROVED USES

DYMISTA is a prescription medicine used to treat symptoms of seasonal allergic rhinitis in people 6 years of age and older, who need treatment with both azelastine hydrochloride and fluticasone propionate. DYMISTA may help to reduce your nasal symptoms including stuffy nose, runny nose, itching, and sneezing.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.FDA.gov/medwatch or call 1-800-FDA-1088

Dymista 125/50 Nasal Spray

Generic Name: azelastine hydrochloride; fluticasone propionate
Product Name: Dymista 125/50 Nasal Spray

Indication: What Dymista 125/50 Nasal Spray is used for

Dymista 125/50 Nasal Spray is sprayed into the nose to treat allergic rhinitis (hayfever and other allergies) and rhinoconjunctivitis (allergy-induced symptoms in the nose and eyes) in adults and children 12 years and older where the use of a combination (intranasal antihistamine and glucocorticoid) is appropriate.

Dymista 125/50 Nasal Spray relieves the symptoms of allergies. For example, symptoms relating to the nose such as a runny nose, post nasal drip, sneezing, itchy or blocked nose; and symptoms relating to the eyes such as itchy, watery and red eyes.

Ask your doctor if you have any questions about why this medicine has been prescribed for you.

Your doctor may have prescribed it for another purpose.

This medicine is only available with a doctor’s prescription.

Action: How Dymista 125/50 Nasal Spray works

This medicine contains two active ingredients, azelastine hydrochloride and fluticasone propionate.

Azelastine hydrochloride belongs to a group of medicines called antihistamines. Antihistamines work by preventing the effects of substances such as histamine that the body produces as part of an allergic reaction. This reduces symptoms of an allergic rhinitis.

Fluticasone propionate belongs to a group of medicines called corticosteroids which are used to help reduce inflammation.

Due to the fast relief and the anti-inflammatory effect, Dymista 125/50 Nasal Spray is more effective on symptoms relating to the nose and eyes than either antihistamine or corticosteroid therapy alone.

One spray (137 mg) contains 125 µg of azelastine (as the hydrochloride) and 50 µg of fluticasone propionate.

This medicine also contains the inactive ingredients glycerol, microcrystalline cellulose, carmellose sodium, phenethyl alcohol, disodium edetate, benzalkonium chloride, polysorbate 80, and purified water.

Dose advice: How to use Dymista 125/50 Nasal Spray

Before you use Dymista 125/50 Nasal Spray

When you must not use it

Do not use the medicine if you have an allergy to azelastine hydrochloride or fluticasone propionate or any of the other ingredients listed here. Some of the symptoms of an allergic reaction to a medicine may include shortness of breath, wheezing or difficulty breathing; swelling of the face, lips, tongue or other parts of the body; rash, itching or hives on the skin.

Do not give this medicine to a child under the age of 12 years.

Do not use this medicine after the expiry date printed on the pack or if the packaging is torn or shows signs of tampering. If it has expired or is damaged, return it to your pharmacist for disposal.

Before you start to use it

Tell your doctor if you have allergies to any other medicines, foods, preservatives or dyes.

Tell your doctor if you have or have had any of the following medical conditions:

  • Recent injury or surgery to your nose or mouth;
  • Infection in your nose or sinus;
  • Ulcer or open sores in your nose;
  • Active or inactive tuberculosis;
  • Severe liver disease;
  • Increased/ high pressure in the eye (glaucoma) and/ or cataracts.

Tell your doctor if you are pregnant or planning to become pregnant. Your doctor can discuss with you the risks and benefits involved.

Tell your doctor if you are breastfeeding. It is not known if Dymista 125/50 Nasal Spray passes into the breast milk and could affect your baby. Your doctor can discuss with you the benefits and risks involved with using this medicine while you are breastfeeding.

If you have not told your doctor about any of the above, tell them before you start using the medicine.

Taking other medicines

Tell your doctor if you are taking any other medicines, including medicines that you can buy without a prescription from a pharmacy, supermarket or health food shop.

In particular, tell your doctor if you are taking:

  • A medicine or medicines that depress the central nervous system. Concurrent use with Dymista 125/50 Nasal Spray may cause sleepiness or drowsiness;
  • Ritonavir, an antiviral medicine;
  • Ketoconazole, an antifungal medicine;
  • Cimetidine, a medicine that inhibits stomach acid production.

These medicines may be affected by Dymista 125/50 Nasal Spray or may affect how well it works. You may need different amounts of your medicine, or you may need to use a different medicine. Your doctor or pharmacist will advise you.

Your doctor and pharmacist have more information on medicines to be careful with or avoid while using this medicine.

How to use Dymista 125/50 Nasal Spray

How to use it

Use only in your nose.

To prevent symptoms, start using the medicine:

  • Before the hayfever season, or;
  • Before coming in contact with something you know will cause your hayfever.

If you start using this medicine early, it will help reduce the severity of your symptoms.

If you do not understand the instructions, ask your doctor or pharmacist for help.

Preparing the spray
  • Gently blow your nose before using the medicine;
  • Shake the bottle for 5 seconds and then remove the protective cap;
  • The first time Dymista 125/50 Nasal Spray is used, prime the pump by squirting it into the air;
  • Prime the pump by putting two fingers on either side of the spray pump and place your thumb on the bottom of the bottle;
  • Press down and release the pump 6 times until a fine mist appears;
  • The pump is now primed and ready to use;
  • If the nasal spray has not been used for more than 7 days, you will need to prime the pump until a fine mist appears again.
Using the spray
  • Blow your nose to clear your nostrils;
  • Keep your head tilted downwards towards your toes. Do not tilt head backwards;
  • Hold the bottle upright and carefully insert the spray tip into one nostril;
  • Close another nostril with your finger, rapidly press down once and sniff gently at the same time;
  • Breathe out through your mouth;
  • Repeat in your other nostril;
  • Breathe in gently, and do not tilt your head back after dosing. This will stop the medicine going into your throat and causing an unpleasant taste;
  • After each use, wipe the spray tip with a clean tissue or cloth and then replace the protective cap.

How much to use

The recommended dose of Dymista 125/50 nasal spray is:

  • Adults and children 12 years and older: One spray into each nostril in the morning and evening;
  • Children under 12 years: This medicine is not recommended for children under 12 years.

Do not exceed the recommended dose.

Always use Dymista 125/50 Nasal Spray exactly as your doctor has told you. The instructions given by your doctor may differ from the information contained here.

If you are not sure of the correct dose or how to use this medicine, ask your doctor or pharmacist.

How long to use it

Dymista 125/50 Nasal Spray is suitable for long term use.

Continue using your medicine for as long as your doctor tells you to.

If you forget to use it

If you miss a dose, use Dymista 125/50 Nasal Spray when the next dose is due.

Do not use a double dose to make up for the dose that you missed.

If you are not sure what to do, ask your doctor or pharmacist.

If you have trouble remembering to use your medicine, ask your pharmacist for some hints.

If you have too much (overdose)

If you or someone else accidentally use too much Dymista 125/50 Nasal Spray on one occasion, there is nothing to worry about.

However, if you use too much of it over a long time (months or years), you may start to get unwanted side effects inside your nose and body.

Discuss any worries you may have about this with your doctor or pharmacist.

Immediately telephone your doctor or the Poisons Information Centre (telephone 131 126) if you think you or anyone else may have taken too much Dymista 125/50 Nasal Spray. Do this even if there are no signs or symptoms of discomfort or poisoning.

While you are using Dymista 125/50 Nasal Spray

Things you must do

If you are about to be started on any new medicine, remind your doctor and pharmacist that you are using this medicine.

Tell any other doctors, dentists, and pharmacists who treat you that you are using this medicine.

If you become pregnant while you are using this medicine, tell your doctor. Your doctor can discuss with you the risks of using it while you are pregnant.

Things you must not do

Do not give this medicine to anyone else, even if their symptoms seem to be the same as yours.

Do not use it to treat any other complaints unless your doctor tells you to.

Things to be careful of

Make sure you know how you react to Dymista 125/50 Nasal Spray before you drive, operate machinery, or do anything else that could be dangerous if you are tired, drowsy, dizzy or lightheaded. Dymista 125/50 Nasal Spray is unlikely to make you feel drowsy. However, if you are drowsy, do not drive a car or operate machinery.

Things that would be helpful for

If possible, avoid situations that you know will trigger your symptoms.

To prevent symptoms, start using this medicine:

  • Before the hayfever season, or;
  • Before coming into contact with something you know will cause your hayfever.

If you start using this medicine early, it will help reduce the severity of your symptoms.

After using Dymista 125/50 Nasal Spray

Storage

Keep Dymista 125/50 Nasal Spray in a cool dry place where the temperature stays below 25°C. Do not refrigerate or freeze this medicine.

Discard after 6 months of first opening the bottle.

Do not store this medicine or any other medicine in the bathroom or near a sink. Do not leave it on a window sill or in the car. Heat and dampness can destroy some medicines.

Keep the medicine where young children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Disposal

If your doctor tells you to stop using this medicine or the expiry date has passed, ask your pharmacist what to do with any medicine that is left over.

Schedule of Dymista 125/50 Nasal Spray

Dymista 125/50 Nasal Spray is a Schedule 4 – prescription only medicine.

Side effects of Dymista 125/50 Nasal Spray

Tell your doctor or pharmacist as soon as possible if you do not feel well while you are using Dymista 125/50 Nasal Spray. All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical attention if you get some of the side effects.

Do not be alarmed by this list of possible side effects. You may not experience any of them.

Ask your doctor or pharmacist to answer any questions you may have.

Tell your doctor or pharmacist if you notice any of the following and they worry you:

  • Irritated nose. This can cause mild stinging, itching or sneezing;
  • A bitter or unpleasant taste in your mouth;
  • Unpleasant smell;
  • Cough, dry throat or throat irritation;
  • Sore throat;
  • Nosebleeds;
  • Nausea;
  • Headache.

Tell your doctor or pharmacist as soon as possible if you notice any of the following:

  • Sleepiness or drowsiness;
  • Feeling weary, exhausted or weak;
  • Damage to the skin and mucous membrane in the nose;
  • Blurred vision or increased pressure in your eye.

If any of the following happen, stop using Dymista 125/50 Nasal Spray and tell your doctor immediately, or go to Accident and Emergency at your nearest hospital:

  • Sudden signs of allergy such as rash, itching or hives on the skin, swelling of the face, lips, tongue or other parts of the body, shortness of breath, wheezing or trouble breathing.

Tell your doctor or pharmacist if you notice anything that is making you feel unwell. Other side effects not listed above may also occur in some people.

For further information talk to your doctor.

SIDE EFFECTS

Systemic and local corticosteroid use may result in the following:

  • Somnolence
  • Local nasal effects, including epistaxis, nasal ulceration, nasal septal perforation, impaired wound healing, and Candida albicans infection
  • Glaucoma and cataracts
  • Immunosuppression
  • Hypothalamic-pituitary-adrenal (HPA) axis effects, including growth reduction

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect rates observed in practice.

Adults And Adolescents 12 Years Of Age And Older

The safety data described below in adults and adolescents 12 years of age and older reflect exposure to DYMISTA in 853 patients (12 years of age and older; 36% male and 64% female) with seasonal allergic rhinitis in 3 double-blind, placebo-controlled clinical trials of 2-week duration. The racial distribution for the 3 clinical trials was 80% white, 16% black, 2% Asian, and 1% other.

In the 3 placebo controlled clinical trials of 2-week duration, 3411 patients with seasonal allergic rhinitis were treated with 1 spray per nostril of DYMISTA, azelastine hydrochloride nasal spray, fluticasone propionate nasal spray, or placebo, twice daily. The azelastine hydrochloride and fluticasone propionate comparators use the same vehicle and device as DYMISTA and are not commercially marketed. Overall, adverse reactions were 16% in the DYMISTA treatment groups, 15% in the azelastine hydrochloride nasal spray groups, 13% in the fluticasone propionate nasal spray groups, and 12% in the placebo groups. Overall, 1% of patients in both the DYMISTA and placebo groups discontinued due to adverse reactions.

Table 1 contains adverse reactions reported with frequencies greater than or equal to 2% and more frequently than placebo in patients treated with DYMISTA in the seasonal allergic rhinitis controlled clinical trials.

Table 1: Adverse Reactions with ≥ 2% Incidence and More Frequently than Placebo in Placebo- Controlled Trials of 2 Weeks Duration with DYMISTA in Adult and Adolescent Patients With Seasonal Allergic Rhinitis

In the above trials, somnolence was reported in < 1% of patients treated with DYMISTA (6 of 853) or vehicle placebo (1 of 861) .

Pediatric Patients 6-11 Years Of Age

The safety data described below in children 6-11 years of age reflect exposure to DYMISTA in 152 patients (6-11 years of age; 57% male and 43% female) with seasonal allergic rhinitis in one doubleblind, placebo-controlled clinical trial of 2-week duration. The racial distribution for the clinical trial was 69% white, 31% black, 2% Asian and 2% other.

In the placebo-controlled clinical trial of 2-week duration, patients with seasonal allergic rhinitis were treated with 1 spray per nostril of DYMISTA or placebo, twice daily. Overall, adverse reactions were 16% in the DYMISTA treatment group, and 12% in the placebo group. Overall, 1% of patients in both the DYMISTA and placebo groups discontinued due to adverse reactions.

Table 2 contains adverse reactions reported with frequencies greater than or equal to 2% and more frequently than placebo in patients treated with DYMISTA in the seasonal allergic rhinitis controlled clinical trial.

Table 2: Adverse Reactions with ≥ 2% Incidence and More Frequently than Placebo in Placebo- Controlled Trials of 2 Weeks Duration with DYMISTA in Children 6 to 11 Years of Age With Seasonal Allergic Rhinitis

In the above trial, somnolence was not reported .

Long-Term (12-Month) Safety Trial In Adults And Adolescents 12 Years Of Age And Older

In the 12-month open-label, active-controlled clinical trial, 404 Asian patients (240 males and 164 females) with perennial allergic rhinitis or vasomotor rhinitis were treated with DYMISTA, 1 spray per nostril twice daily.

In the 12-month, open-label, active-controlled, long-term safety trial in adults and adolescents 12 years of age and older, 404 patients with perennial allergic rhinitis or vasomotor rhinitis were treated with DYMISTA 1 spray per nostril twice daily and 207 patients were treated with fluticasone propionate nasal spray, 2 sprays per nostril once daily. Overall, adverse reactions were 47% in the DYMISTA treatment group and 44% in the fluticasone propionate nasal spray group. The most frequently reported adverse reactions ( ≥ 2%) with DYMISTA were headache, pyrexia, cough, nasal congestion, rhinitis, dysgeusia, viral infection, upper respiratory tract infection, pharyngitis, pain, diarrhea, and epistaxis. In the DYMISTA treatment group, 7 patients (2%) had mild epistaxis and 1 patient ( < 1%) had moderate epistaxis. In the fluticasone propionate nasal spray treatment group 1 patient ( < 1%) had mild epistaxis. No patients had reports of severe epistaxis. Focused nasal examinations were performed and no nasal ulcerations or septal perforations were observed. Eleven of 404 patients (3%) treated with DYMISTA and 6 of 207 patients (3%) treated with fluticasone propionate nasal spray discontinued from the trial due to adverse events.

Long-Term (3-Month) Safety Trial In Pediatric Patients 6-11 Years Of Age

In the 3-month, open label, active-controlled, safety trial in pediatric patients 6-11 years of age 264 patients (128 patients ≥ 6 to < 9 years of age, and 136 patients ≥ 9 to < 12 years of age) with allergic rhinitis (based on the Investigator’s assessment) were treated with DYMISTA, 1 spray per nostril twice daily and 89 patients (44 patients ≥ 6 to < 9 years of age, and 45 patients ≥ 9 to < 12 years of age) were treated with fluticasone propionate nasal spray, 1 spray per nostril twice daily. Overall, adverse reactions were 40% in the DYMISTA treatment group and 36% in the fluticasone propionate nasal spray group. The most frequently reported adverse reactions ( ≥ 2%) with DYMISTA were epistaxis, headache, oropharyngeal pain, vomiting, upper abdominal pain, cough, pyrexia, otitis media, upper respiratory tract infection, diarrhea, nausea, otitis externa, and urticaria. In the DYMISTA treatment group 23 patients (9%) had mild epistaxis and 3 patients (1%) had moderate epistaxis. In the fluticasone propionate nasal spray treatment group 8 patients (9%) had mild epistaxis. No patients had reports of severe epistaxis. Focused nasal examinations were performed and no ulcerations or septal perforations were observed. Four of 264 patients (2%) treated with DYMISTA and 3 of 89 (3%) treated with fluticasone propionate nasal spray discontinued from the trial due to adverse events. There were two reports of somnolence, one severe, among children taking DYMISTA .

Postmarketing Experience

The following spontaneous adverse events have been reported with DYMISTA or one of the components (azelastine and fluticasone). Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Cardiac disorders: atrial fibrillation, increased heart rate, palpitations

Eye disorder: blurred vision, cataracts, conjunctivitis, dryness and irritation, eye swelling, glaucoma, increased intraocular pressure, vision abnormal, xerophthalmia

Gastrointestinal disorders: nausea, vomiting

General disorders and administration site condition: aches and pain, application site irritation, chest pain, edema of face and tongue, fatigue, tolerance

Immune system disorders: anaphylaxis/anaphylactoid reactions which in rare instances were severe, hypersensitivity reactions

Musculoskeletal and connective tissue disorders: growth suppression

Nervous system disorders: disturbance or loss of smell and/ or taste, dizziness, involuntary muscle contractions, paresthesia, parosmia

Psychiatric disorders: anxiety, confusion, nervousness

Renal and urinary disorders: urinary retention

Respiratory, thoracic and mediastinal disorders: bronchospasm, cough, dysphonia, dyspnea, hoarseness, nasal septal perforation, nasal discomfort, nasal dryness, nasal sores, nasal ulcer, sore throat, throat dryness and irritation, voice changes, wheezing

Skin and subcutaneous tissue disorder: angioedema, erythema, face swelling, pruritus, rash, urticaria

Vascular disorder: hypertension

Read the entire FDA prescribing information for Dymista (Azelastine Hydrochloride and Fluticasone Propionate)

Dymista Nasal Spray
(120 Sprays)

Delivery & Shipping Information

UK Orders

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As well as keeping customers informed at every stage of the journey, DPD believe in maximising choice and convenience. That’s why DPD provide access to a suite of options both on the day of delivery and the night before, allowing customers to take delivery of their goods in a way that suits. If you wish to reschedule, you can:

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  • Upgrade delivery to By 12

Please note: DPD do not deliver on Saturdays, Sundays or Bank Holidays – this should be taken into account when ordering.

Once a package has been shipped with DPD we advise that you are bound to the terms and conditions of their use together with the terms and conditions contained herein.

You have the right to cancel your order up to the point when your treatment is dispatched. The pharmacist must destroy any medication within 30 days of it being returned, even un-opened boxes, so we are not able to offer refunds once your treatment has been dispatched.

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BFPO Postcodes

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Remote Areas

Please be aware that Royal Mail Guaranteed services are not available to all customers in the UK, especially those that live in remote postcodes. Royal Mail advise customers of the following:

We deliver within two working days by 5.30pm to the following postcodes areas:
GY1 Herm (Channel Islands)
GY9 Sark (Channel Islands)
GY10
HS2
PA60 – 75, 78
ZE2, 3

We deliver within three working days by 5.30pm to the following postcode areas:
KW16 – non-Town
KW17
PH30, 41 – 44

Please note: This applies to our ‘Special Delivery’ and ‘Saturday Guaranteed’ services.

International Orders

We are currently unable to ship orders outside of the UK.

We are unable to ship orders to mailing or forwarding houses for onwards shipping to locations outside of the UK.

Dymista: New Spray for Allergic Rhinitis

Dymista is a nasal spray used to control the symptoms of hay fever and allergic rhinitis (allergic nasal inflammation). The spray treats a runny and blocked nose, sneezing and itching. Relief of symptoms usually starts within 30 minutes of using Dymista. Dymista is most effective when the spray is used regularly for at least a few days.

Ingredients and action

Dymista combines two medicines in one treatment. It is has a dual action. It contains a fast acting antihistamine called azelastine and a steroid called fluticasone.

Azelastine usually starts to work within 30 to 60 minutes. It takes a few days of regular use for the steroid part of the spray to reduce inflammation. Symptom control is likely to be fast and to improve over a few days, providing Dymista is used regularly.

The antihistamine effect of Dymista wears off over 12 to 24 hours and the steroid effects usually wear off over a few days after use of the spray is stopped.

Other allergic rhinitis sprays and treatments

There are alternative nasal sprays to Dymista for the treatment of allergic rhinitis, some of which contain antihistamines and others steroids, in separate sprays. Dymista combines the long acting antihistamine azelastine present in Rhinolast nasal sprays with the glucocorticoid fluticasone present in Pirinase and Flixonase nasal sprays.

These alternative nasal sprays should NOT be used at the same time (concomitantly) with Dymista.

Studies show Dymista usually works more quickly than steroid nasal sprays and improved symptom relief continues with sustained use of Dymista.

You should discuss treatment options with your doctor or pharmacists. Alternative nasal sprays to Dymista may control allergic rhinitis symptoms adequately and may be preferred, particularly by patients who have mild or occasional symptoms or patients have responded well to these sprays before.

People who are using both an antihistamine nasal spray and a steroid nasal spray may find it more convenient and cost effective to use Dymista. Dymista is a single combined treatment.

Dymista nasal spray acts directly on the nasal membranes, reducing inflammation and sensitivity. Studies show eye symptoms, such as inflammation, watering and itching, also improve when Dymista is used.

Dymista does not replace antihistamine tablets and is not primarily a treatment for dry itchy or inflamed eyes. However, if allergic rhinitis symptoms are well controlled by Dymista, it is possible other allergic rhinitis treatment, such as antihistamine tablets and eye drops, may no longer be needed.

You must NOT use other hay fever nasal sprays whilst you are using Dymista.

Dymista side effects and cautions

Serious side effects are unlikely. The commonest side effects are; nosebleed, headache, a bitter taste in the mouth, and an unpleasant smell. For more detail, see the manufacturer’s patient information leaflet supplied with Dymista sprays. All patients must read this leaflet before using Dymista.

  • Dymista should NOT to be used with other nasal sprays for allergic rhinitis. These may contain the same of similar ingredients and you may get a double dose.
  • Consult a doctor if allergic rhinitis symptoms are not controlled after using Dymista for 7 days.
  • Consult a doctor if symptoms are worsening or if bleeding or ulceration of the nose occurs.
  • Dymista should NOT be used continuously from more than 3 months without the approval of a doctor.

Dymista could impair your ability to drive or operate machinery, particularly if used in combination with sedating medications, such as some antihistamine tablets.

Dosage and usage

Dymista is most effective when used regularly on a twice daily basis for as long as needed. The usual dose is one puff in each nostril twice daily. If used irregularly or on an occasional basis, Dymista will be less effective.

The manufacturer’s patient information leaflet supplied with Dymista describes how to use the spray (spray technique).

Further information: NHS – Hay fever

What is Dymista used for?

  • Preventing and treating symptoms of moderate to severe hay fever (seasonal allergic rhinitis).
  • Preventing and treating symptoms of moderate to severe nasal allergies that occur throughout the year (perennial allergic rhinitis), for example due to pet allergies or dust mite allergies.

Dymista nasal spray is suitable for adults and adolescents aged 12 years and over. Your doctor may prescribe it if your symptoms haven’t been controlled by using an antihistamine or corticosteroid nasal spray on its own.

How does Dymista work?

Dymista nasal spray contains two active ingredients, azelastine hydrochloride (an antihistamine) and fluticasone propionate (a type of medicine that reduces inflammation called a corticosteroid or steroid).

Azelastine works by preventing the actions of histamine – a substance produced by the body when it reacts to a foreign substance, such as pollen or pet fur (these are known as allergens). Histamine causes a chain reaction that results in allergic symptoms such as itchy eyes, sneezing and a runny nose. Azelastine blocks histamine receptors and so stops this chain reaction.

Fluticasone is absorbed into the cells of the nasal lining and works by stopping these cells from releasing chemicals that trigger allergic and inflammatory reactions. It relieves symptoms such as a blocked or runny nose, sneezing and sinus discomfort. It can also help relieve associated eye symptoms like red, itchy and watery eyes.

The azelastine starts relieving nasal symptoms within 15 minutes of using the nasal spray. However, it can take a few days for the fluticasone to build up to its full effect.

How do I use Dymista nasal spray?

  • For allergies like hay fever it’s best to start using Dymista a few days before you expect to get symptoms, for example before the start of the pollen season, or if you know you’re going to be in contact with pets that give you the allergy. You should then keep using it regularly all the time you’re still being exposed to the allergen, for example throughout the pollen season, to keep the nasal inflammation under control.
  • Adults and adolescents aged 12 years and over should use one spray into each nostril twice a day, morning and evening.
  • If you forget to use your nasal spray use it as soon as you remember, unless it’s nearly time for your next dose. In this case just leave out the forgotten dose and take the next dose as normal. Don’t use a double dose to make up for a missed dose.
  • Follow the instructions provided with the nasal spray. You should shake the bottle gently before use.
  • Take care to avoid getting the spray in your eyes.
  • Before you use the spray for the first time the bottle needs to be primed by pressing down and releasing the pump six times. Hold the bottle upright and away from you while you are doing this. If the nasal spray hasn’t been used for more than seven days you should reprime it before use by pressing and releasing the pump once.
  • Any remaining nasal spray should be discarded six months after the spray is first opened, because it could be contaminated with dirt or germs. Write the date you open your nasal spray on the bottle so you know when to throw it away. Dispose of carefully, preferably by returning to your pharmacy.

Who shouldn’t use Dymista spray?

  • People who are allergic to any ingredients of the spray. Check the ingredients listed in the leaflet that comes with the spray if you know you have specific allergies.
  • Dymista is not recommended for children under 12 years of age, as its safety and effectiveness have not been established in this age group.

Who might need extra monitoring while using Dymista spray?

  • People with an infection in the nasal passages or sinuses (the infection should be treated).
  • People who have recently had nasal surgery, nasal ulcers or an injury to the nose (this medicine should not be used until the nose has healed).
  • People with tuberculosis affecting the lungs.
  • People who are or have recently been using any other product containing a corticosteroid, including creams, ointments, tablets, asthma medicines, eye drops or other nasal sprays or drops.
  • People with severe liver disease.

Can I use Dymista nasal spray while pregnant or breastfeeding?

  • Not unless it’s prescribed by your doctor. Make sure your doctor knows if you’re pregnant or breastfeeding before using Dymista spray. Some nasal sprays can be used by pregnant or breastfeeding women who can’t tolerate their hay fever symptoms, as only minimal amounts of the medicine pass into the bloodstream after using the nasal spray. However, they should only be used if absolutely necessary and only if prescribed by your doctor so that you can be monitored if required. Ask your doctor for further advice.

What are the possible side effects of Dymista nasal spray?

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects known to be associated with Dymista. Just because a side effect is stated here doesn’t mean that all people using Dymista will experience that or any side effect.

Very common (affect more than 1 in 10 people)

  • Nosebleeds.

Common (affect between 1 in 10 and 1 in 100 people)

  • Headache.
  • Unpleasant taste and smell.

Uncommon (affect between 1 in 100 and 1 in 1000 people)

  • Nasal discomfort, eg stinging or itching.
  • Sneezing.
  • Nasal dryness.
  • Cough.
  • Dry throat.
  • Throat irritation.

Rare (affect between 1 in 1000 and 1 in 10,000 people)

  • Dry mouth.

Very rare (affect fewer than 1 in 10,000 people)

  • Dizziness.
  • Feeling sleepy, tired or weak.
  • Feeling sick.
  • Perforation of the nasal septum.
  • Allergic reactions such as rash, itching, hives or swelling of the face or tongue.
  • Cataracts, raised pressure in the eye or glaucoma. Tell your doctor if you notice any changes in your vision while using Dymista.

If corticosteroid nasal sprays are used in high doses for long periods of time, they do have the potential to cause side effects similar to those associated with corticosteroids taken by mouth, such as mental health problems, slowed growth in children and adolescents, and decreased functioning of the adrenal glands (glands that produce natural steroid hormones). However, these types of side effect are extremely unlikely to occur with this nasal spray, because the amount of fluticasone absorbed into the bloodstream from the nose is very low. As a precaution, the lowest effective dose needed to control your symptoms should always be used, and for the shortest possible time.

If your child is prescribed Dymista nasal spray for long periods of time your doctor may want to monitor their height to make sure their growth is not being affected. Your doctor can give you more advice about this.

Read the leaflet that comes with the medicine or talk to your doctor or pharmacist if you want any more information about the possible side effects of Dymista nasal spray. If you think you or your child have experienced a side effect, did you know you can report this using the yellow card website?

Can I use other medicines with Dymista nasal spray?

Tell your doctor or pharmacist if you’re already using any other medicines, including those bought without a prescription and herbal medicines, before you start using Dymista as well.

This is particularly important if you are or have recently been using any other medicines that contain corticosteroids, for example tablets, injections, eye or nose drops, creams, asthma inhalers, or other similar nasal sprays. There may be a higher risk of side effects if you’re using more than one type of steroid medication – you may need to be monitored by your doctor.

The following medicines may slow the breakdown of any fluticasone that’s absorbed into your bloodstream from your nose and so may increase the risk of side effects on the rest of the body:

  • protease inhibitors such as ritonavir for HIV infection (Dymista nasal spray is not recommended for people who are taking ritonavir)
  • telaprevir for hepatitis C
  • the antifungals ketoconazole and itraconazole. Make sure your doctor knows you’re using Dymista if you’re prescribed one of these, because long courses of treatment with these antifungals should be avoided.

If you find Dymista isn’t reducing your allergy symptoms you should get advice from your doctor or pharmacist. It may be OK to use a nasal decongestant or allergy eye drops with Dymista, assuming these are appropriate for you, however don’t use other corticosteroid or antihistamine nasal sprays alongside Dymista.

What other medicines contain the same active ingredients?

There are currently no other medicines in the UK that contain both azelastine and fluticasone as the active ingredients.

The following medicines contain just fluticasone:

  • Avamys nasal spray.
  • Boots allergy relief nasal spray.
  • Flixonase aqueous nasal spray.
  • Flixonase nasule drops.
  • Nasofan nasal spray.
  • Pirinase hayfever nasal spray.

Fluticasone is also the active ingredient in Cutivate cream and ointment for eczema and Flixotide inhalers for asthma.

Optilast eye drops and Rhinolast nasal spray both contain just azelastine.

Last updated 04.08.2017

Helen Marshall, BPharm, MRPharmS Helen Marshall, BPharm, MRPharmS A UK registered pharmacist with a background in hospital pharmacy.

Dymista Nasal Spray

Generic Name: azelastine and fluticasone nasal (AY zel AS teen and floo TIK a sone)
Brand Names: Dymista

Medically reviewed by P. Thornton, DipPharm Last updated on Dec 14, 2018.

  • Overview
  • Side Effects
  • Dosage
  • Professional
  • Interactions
  • More

What is Dymista?

Dymista nasal spray contains a combination of azelastine and fluticasone. Azelastine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Fluticasone is a steroid that prevents the release of substances in the body that cause inflammation.

Dymista nasal spray is used to treat nasal symptoms such as congestion, sneezing, and runny nose caused by seasonal allergies.

Dymista nasal spray is for use in adults and children who are at least 6 years old.

Important Information

You should not use Dymista if you are allergic to azelastine (Astelin, Astepro, Optivar) or fluticasone (Advair, Cutivate, Flovent, Flonase, Veramyst), or if you are also taking ritonavir (Norvir, Kaletra).

Before using Dymista, tell your doctor if you have glaucoma or cataracts, diabetes, herpes simplex virus of your eyes, tuberculosis or any other infection, sores or ulcers inside your nose, or if you have recently had injury of or surgery on your nose.

It may take up to several days of using Dymista nasal spray before your symptoms improve. Tell your doctor if your symptoms do not improve after a week of treatment.

Fluticasone can lower blood cells that help your body fight infections. Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using steroid medication.

Do not share Dymista with other people, even if they have the same symptoms you have. Do not give this medicine to a child younger than 12 years old without medical advice. Steroid medication can affect growth in children. Talk with your doctor if you think your child is not growing at a normal rate while using this medication.

Before taking this medicine

To make sure Dymista is safe for you, tell your doctor if you have ever had:

  • sores or ulcers inside your nose;

  • an injury of or surgery on your nose;

  • chickenpox or measles;

  • tuberculosis or any other infection or illness;

  • herpes infection of your eyes; or

  • glaucoma or cataracts.

It is not known whether Dymista will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Using azelastine and fluticasone nasal while you are breast-feeding may cause your breast milk to taste bitter. If you breast-feed while using this medicine, watch for signs that your baby is not nursing as well. Talk to your doctor about the best way to feed your baby.

How should I use Dymista?

Use Dymista exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Shake the medicine bottle gently just before each use.

Avoid getting Dymista in your eyes or mouth.

If the medicine gets in your eyes, rinse with water for 10 minutes and then call your doctor.

Do not allow a young child to use this medicine without help from an adult.

Store Dymista nasal spray in an upright position at room temperature. Do not freeze or refrigerate.

Throw away the medicine after you have used 120 sprays, even if there is still medicine left in the bottle.

Dymista dosing information

Usual Adult Dose for Allergic Rhinitis:

1 spray in each nostril twice a day
Uses: Relief of symptoms of seasonal allergic rhinitis

Usual Pediatric Dose for Allergic Rhinitis:

6 years and older:
1 spray in each nostril twice a day.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

An overdose of Dymista is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

Using too much of this medicine long term can lead to thinning skin, easy bruising, changes in body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.

What should I avoid while using Dymista?

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Drinking alcohol with this medicine can increase certain side effects.

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chickenpox or measles. These conditions can be serious or even fatal in people who are using Dymista.

Dymista side effects

Get emergency medical help if you have signs of an allergic reaction to Dymista: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using the medicine and call your doctor at once if you have:

  • severe drowsiness;

  • severe or ongoing nosebleeds;

  • noisy breathing, runny nose, or crusting around your nostrils;

  • redness, sores, or white patches in your mouth or throat;

  • fever, chills, tiredness, body aches;

  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;

  • any wound that will not heal; or

  • signs of low adrenal gland hormones – worsening tiredness or weakness, feeling light-headed, nausea, vomiting.

Steroid medicine can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.

Common Dymista side effects may include:

  • headache;

  • nosebleeds; or

  • altered sense of taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Dymista?

Using Dymista with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your other medicines, especially:

  • ritonavir (Norvir, Kaletra); or

  • antifungal medicine – fluconazole, itraconazole, ketoconazole.

This list is not complete. Other drugs may interact with azelastine and fluticasone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Dymista only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2020 Cerner Multum, Inc. Version: 3.01.

Medical Disclaimer

More about Dymista (azelastine / fluticasone nasal)

  • Side Effects
  • During Pregnancy
  • Dosage Information
  • Drug Interactions
  • Pricing & Coupons
  • En Español
  • 99 Reviews
  • Drug class: nasal antihistamines and decongestants
  • FDA Approval History

Consumer resources

  • Dymista
  • Dymista (Advanced Reading)

Professional resources

  • Dymista (FDA)

Related treatment guides

  • Allergic Rhinitis

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