What is brilinta for?


Brilinta is the brand name of the generic prescription drug ticagrelor.

It’s used, along with low doses of aspirin, to reduce the risk of a serious heart problem or stroke in people who’ve already had a heart attack or experience chest pain.

Brilinta belongs to a class of drugs called anti-platelets. It works by keeping platelets in the blood from clotting.

The Food and Drug Administration (FDA) approved Brilinta in 2011. It’s manufactured by AstraZeneca.

Brilinta Warnings

Brilinta contains a black-box warning because it can cause serious or life-threatening bleeding.

Before taking this medicine, tell your doctor if you have, or have ever had:

  • A condition that causes you to bleed more easily
  • A recent surgery or injury
  • A stomach ulcer
  • Bleeding in your intestines, stomach, or head
  • A stroke or mini-stroke
  • Polyps in your intestines, or any condition that can cause bleeding in the intestines
  • Liver disease
  • A lung disease, such as asthma or chronic obstructive pulmonary disease (COPD)
  • Allergies to medicines

Some other medicines may raise your risk of bleeding. Let your doctor know if you take any of the following:

  • Blood thinners, such as Coumadin (warfarin) or Eliquis (apixaban) or Xarelto (rivaroxaban)
  • Heparin
  • Other drugs to prevent or treat blood clots
  • Non-steroidal anti-inflammatory drugs (NSAIDs), such as Advil or Motrin (ibuprofen), Celebrex (celecoxib), or Aleve (naproxen)
  • Other anti-platelet drugs such as Plavix (clopidogrel)

Let your healthcare provider know you’re taking Brilinta before having any type of surgery, including a dental procedure.

You may need to stop taking the drug at least five days before your scheduled procedure.

Your healthcare provider will probably tell you not to take this medicine if you need to have heart bypass surgery right away.

Tell your doctor right away if you experience any of the following symptoms while taking Brilinta:

  • Severe, unexplained, long-lasting, or uncontrollable bleeding
  • Brown or pink urine
  • Black, red, or tarry stools
  • Vomit that’s bloody or looks like coffee grounds
  • Coughing up blood or blood clots

Avoid activities that may raise your risk of injury or bleeding while taking Brilinta. Use extra caution to prevent bleeding when shaving or brushing your teeth.

Brilinta also contains a black-box warning because taking high doses of aspirin with the drug may prevent it from working like it should.

Your doctor will most likely tell you to take a low dose (less than 100 milligrams) of aspirin during your treatment with Brilinta. Follow your doctor’s instructions carefully.

Don’t take more aspirin than your healthcare provider recommends. Many over-the-counter (OTC) medicines contain aspirin, so be sure to check all product labels.

Don’t stop taking Brilinta without first talking to your doctor. If you stop taking the medicine, your risk of a heart attack or stroke could increase.

Pregnancy and Brilinta

It’s not known whether Brilinta can harm an unborn baby. Tell your doctor if you’re pregnant or might become pregnant while taking this medicine.

It’s also not known whether the medicine passes into breast milk or could hurt a breastfeeding baby. Don’t breastfeed while taking Brilinta.

Brand Names: Brilinta (ticagrelor)

Generic Name: ticagrelor

  • What is ticagrelor (Brilinta (ticagrelor))?
  • What are the possible side effects of ticagrelor (Brilinta (ticagrelor))?
  • What is the most important information I should know about ticagrelor (Brilinta (ticagrelor))?
  • What should I discuss with my healthcare provider before taking ticagrelor (Brilinta (ticagrelor))?
  • How should I take ticagrelor (Brilinta (ticagrelor))?
  • What happens if I miss a dose (Brilinta (ticagrelor))?
  • What happens if I overdose (Brilinta (ticagrelor))?
  • What should I avoid while taking ticagrelor (Brilinta (ticagrelor))?
  • What other drugs will affect ticagrelor (Brilinta (ticagrelor))?
  • Where can I get more information (Brilinta (ticagrelor))?

What is ticagrelor (Brilinta (ticagrelor))?

Ticagrelor prevents platelets in your blood from sticking together to form an unwanted blood clot that could block an artery.

Ticagrelor is used together with aspirin to lower your risk of having a stroke or serious heart problems after you’ve had a heart attack or severe chest pain (angina).

Ticagrelor may also be used for purposes not listed in this medication guide.

What are the possible side effects of ticagrelor (Brilinta (ticagrelor))?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • slow heartbeats;
  • nosebleeds, or any bleeding that will not stop;
  • shortness of breath even with mild exertion or while lying down;
  • easy bruising, unusual bleeding, purple or red spots under your skin;
  • red, pink, or brown urine;
  • black, bloody, or tarry stools; or
  • coughing up blood or vomit that looks like coffee grounds.

Common side effects may include:

  • bleeding; or
  • shortness of breath.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about ticagrelor (Brilinta (ticagrelor))?

You should not use ticagrelor if you have any active bleeding or a history of bleeding in the brain. Do not use this medicine just before heart bypass surgery.

Ticagrelor may cause you to bleed more easily, which can be severe or life-threatening. Call your doctor or seek emergency medical attention if you have bleeding that will not stop, black or bloody stools, red or pink urine, or if you cough up blood or vomit that looks like coffee grounds.

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact with ticagrelor.

Do not stop taking ticagrelor without first talking to your doctor, even if you have signs of bleeding. Stopping ticagrelor may increase your risk of a heart attack or stroke.

BRILINTA is used to lower your chance of having another heart attack or dying from a heart attack or stroke, but BRILINTA (and similar drugs) can cause bleeding that can be serious and sometimes lead to death. Instances of serious bleeding, such as internal bleeding, may require blood transfusions or surgery. While you take BRILINTA, you may bruise and bleed more easily and be more likely to have nosebleeds. Bleeding will also take longer than usual to stop.

Call your doctor right away if you have any signs or symptoms of bleeding while taking BRILINTA, including: severe, uncontrollable bleeding; pink, red, or brown urine; vomit that is bloody or looks like coffee grounds; red or black stool; or if you cough up blood or blood clots.

Do not stop taking BRILINTA without talking to the doctor who prescribes it for you. People who are treated with a stent, and stop taking BRILINTA too soon, have a higher risk of getting a blood clot in the stent, having a heart attack, or dying. If you stop BRILINTA because of bleeding, or for other reasons, your risk of a heart attack or stroke may increase. Tell all your doctors and dentists that you are taking BRILINTA. To decrease your risk of bleeding, your doctor may instruct you to stop taking BRILINTA 5 days before you have surgery. Your doctor should tell you when to start taking BRILINTA again, as soon as possible after surgery.

Take BRILINTA and aspirin exactly as instructed by your doctor. You should not take a dose of aspirin higher than 100 mg daily because it can affect how well BRILINTA works. Tell your doctor if you take other medicines that contain aspirin. Do not take new medicines that contain aspirin.

Do not take BRILINTA if you have a history of bleeding in the brain, are bleeding now, or are allergic to ticagrelor or any of the ingredients in BRILINTA.

Slow heart rhythm has been reported with BRILINTA.

BRILINTA can cause serious side effects, including bleeding and shortness of breath. Call your doctor if you have new or unexpected shortness of breath or any side effect that bothers you or that does not go away. Your doctor can decide what treatment is needed.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. BRILINTA may affect the way other medicines work, and other medicines may affect how BRILINTA works. Tell your doctor if you are breastfeeding or plan to breastfeed. You should not breastfeed while being treated with BRILINTA.

About 2 million to 3 million people take blood thinners every year. You may need them if you’ve already had a heart attack or a stroke, since they can lower your risk of having a second one.

You may also need this type of medicine if you have a heart or blood vessel disease, an irregular heart rhythm, lupus, or deep vein thrombosis. (DVT is a dangerous type of blood clot that often forms in the leg.) You also have a greater risk for blood clots if you’re overweight, recently had surgery, or have an artificial heart valve.

Some people only need these meds for a few months. But if you have ongoing health problems, you may need to take them long term.

If you have atrial fibrillation, blood thinners can help keep you from having a stroke. That’s one of the most common reasons doctors prescribe it.


Clotting isn’t always a bad thing: When you cut yourself, it’s what seals your wound and keeps you from losing too much blood. Blood thinners prevent clotting. So, even tiny cuts or bruises will bleed a lot more if you take these drugs.

You should be very careful when taking part in activities that could cause any type of injury. Call your doctor right away if you fall or hit your head. Even if you don’t tear your skin, you could bleed internally.

Let your doctor know right away if you notice any signs of unusual bleeding, like:

  • Heavier-than-normal menstrual periods
  • Blood in your urine or stool
  • Bleeding from your gums or nose
  • Vomiting or coughing up blood
  • Dizziness
  • Weaknesses
  • A severe headache or stomach ache

If you take an anticoagulant like warfarin, you’ll need regular blood tests so your doctor can adjust your levels if needed. Ask him about other steps you should take to stay safe while you’re on this medication. Be careful with activities that can lead to head injuries. Any type of trauma is extremely dangerous if you’re taking a blood thinner.

If you get a dangerous bleeding problem while taking warfarin, doctors can turn to an “antidote” of vitamin K or a combination of prothrombin complex concentrate (PCC) and fresh frozen plasma to stop it. In addition, approval has been given for using a reversal agent like andexanet alfa (Andexxa) to reverse the anti-clotting effects of apixaban (Eliquis) and rivaroxaban (Xarelto) or idarucizumab (Praxbind) to reverse the anti-clotting effects of dabigatran etexilate (Pradaxa). in emergencies.

Eliquis (apixaban) and Xarelto (rivaroxaban) are both in a new group of anticoagulant drugs called novel oral anticoagulants (NOACs) used to prevent blood clots, stroke, and embolism, especially in people with atrial fibrillation. First approved by the FDA in 2011 and 2012, respectively, Eliquis and Xarelto quickly became two of the most popular blood thinners on the market.

Before these drugs, patients mostly relied on warfarin, which was introduced 64 years ago. Warfarin is still the most prescribed anticoagulant today, but NOACs as a whole have been quickly gaining ground. With several warfarin alternatives to choose from, patients and their physicians can now compare factors like cost, side effects, and hassle to decide which one is best for them.

How much do these anticoagulants cost?

NOACs, being relatively new, are only available as expensive brand-name drugs. The average retail price of either Eliquis or Xarelto is around $550 for a monthly supply. Warfarin, which is a generic, only costs $19 out of pocket. This might explain why warfarin is still the most popular anticoagulant despite being a hassle to take, which we’ll talk about next.

Drug name Average retail price Lowest GoodRx price
warfarin $18.59 $3.00
Eliquis $556.15 $458.07
Xarelto $553.65 $461.93

Will there be a generic version of Eliquis or Xarelto anytime soon?

The patents for Eliquis and Xarelto expire in 2023 and 2021, respectively. Only then will competitors be able to manufacture and sell generic alternatives.

Are Eliquis and Xarelto worth their price tag?

Warfarin treatment requires regular blood work to make sure the dosage is correct, and how much of the medicine needs to be taken depends on diet, exercise, and alcohol use. These are not considerations when taking NOACs, and for the most part, patients see this as a positive. It’s probably the main reason why many are willing to make the switch from warfarin.

To see how Eliquis and Xarelto compare to warfarin in terms of value and effectiveness, we took a look at survey responses collected by our partner website, Iodine.com. Iodine tells you what to expect from medications by combining real-life experience from thousands of people and expert guidance from pharmacists and the FDA.

Drug name Worth it Worked well Big hassle
warfarin 61% 54% 21%
Eliquis 47% 58% 21%
Xarelto 45% 45% 9%

A little bit about the scores above: People taking or who have taken a medication are asked to rate their experience with it, or how worth it the medication is, taking into account upsides and downsides. They are also asked to rate how well they think the medication works (effectiveness) and how much of a hassle it is.

Although 21% of people who’ve taken warfarin thought it was a big hassle, more than half thought the benefits of the medication made up for it overall. Eliquis and Xarelto have similar worth it scores, but Xarelto seems to be less of a hassle. All three treatments scored close together when it came to how effective people thought they were, but even then, only half of the participants thought anticoagulants worked well in general.

It’s worth noting that all anticoagulants carry the risk of bleeding-related side effects such as unexpected nosebleeds, bruising, blue or purple toes, and even internal bleeding (with signs like dark urine or bloody stools). People taking Eliquis and Xarelto are also more likely to experience nausea or upset stomach.

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What are people are saying about their anticoagulants?

Digging into Iodine’s user tips for the three medications can give us an idea of what people really think about their anticoagulants:

This 69-year-old man thinks warfarin was somewhat of a hassle: “If you’re taking Coumadin (warfarin), find an anticoagulant clinic to help you through the process. It’ll be worth every mile you have to drive to get there versus taking the newer drugs, such as Xarelto.”

A 67-year-old woman is a champion for blood monitoring on warfarin: “For anyone whining about ‘inconvenience’—Warfarin is the only anticoagulant that can be tested (at a lab, hospital, or home), so you and your doctor know exactly where your coagulation status is. I always know right where I am, and if I am at serious risk for either a clot OR a bleed.”

On the flip side, here’s a 65-year-old woman who loves the freedom of Eliquis: “My body stopped reacting properly to Coumadin so I was switched to Eliquis. So nice. No monthly blood draws, less bleeding when I get a cut. I can eat my favorite greens to my heart’s content. With insurance, only $10 a month—the Eliquis, not the greens!”

This 75-year-old man taking Eliquis does not think it’s worth it due to side effects and cost: “Much too expensive and with Medicare, users will reach ‘donut hole’ costs. Bleeding from small wounds and bruising are excessive.”

A 73-year-old man likes the low hassle of Xarelto, and luckily has it covered by Medicare: “Works well for me, saves many trips to control Coumadin which I used before. I think it is safe, my doctors say it is. Is not cheap but Medicare covers it with $33 copay (per month).”

So which anticoagulant is best for me?

It depends. If cost is the main deciding factor, your doctor will probably start you off on warfarin. If you find the regular blood monitoring, changes in diet or unwanted side effects hard to deal with, you may want to switch to another anticoagulant.

Ask your doctor about warfarin versus NOACs, and always check your health insurance plan to see which medications are covered and what they cost. NOACs like Eliquis, Xarelto, Pradaxa, and Savaysa are all only available as brand-name medications but could be covered by your insurance.

For more information on anticoagulants and warfarin alternatives, compare warfarin, Eliquis and Xarelto on Iodine.com.

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  • Ask the Expert: Common Questions About Alcohol and Blood Thinners

    1. How dangerous is it to drink alcohol if I’m on a blood thinner?

    According to the U.S. Department of Health and Human Services and U.S. Department of Agriculture, moderate drinking is one drink per day for women and up to two drinks per day for men.

    There are a number of factors that determine how dangerous moderate alcohol consumption is while taking blood thinners. Unfortunately, these factors are different for everyone.

    For the most part, moderate alcohol consumption is safe for people while taking blood thinners as long as you have no major medical problems and are in overall good health. It’s important to confirm this with your healthcare provider.

    2. What are the risks of drinking alcohol when on my medication?

    If you have chronic medical problems associated with either your liver or kidneys, it will affect the metabolism (or break down) of the blood thinner. This may make your blood too thin and put you at higher risk of life-threatening bleeding complications.

    Even if you have a normally functioning liver and kidneys, alcohol can limit your liver’s ability to metabolize other compounds. It can also limit your kidneys in excreting the broken down toxins or drugs, like your prescribed blood thinner. This can lead to the same harmful effect of excessive anticoagulation.

    3. What are some signs I should call a doctor?

    Being on any blood thinner will increase your risk of bleeding. Traumatic injuries are one of the most common causes of bleeding, but sometimes you can bleed spontaneously.

    Red flag signs include a large amount of visible blood loss in the urine, stool, vomit, or from some physical injury. Seek medical care promptly to stop the bleeding and provide resuscitation as needed.

    There are rare circumstances of internal bleeding that may or may not be associated with a traumatic injury. They can be hard to identify and act on since it may not be obvious at first, but injuries to the head are a high risk and should be examined by a healthcare provider.

    Other common symptoms of internal bleeding include:

    • dizziness
    • weakness
    • fatigue
    • fainting
    • abdominal swelling
    • altered mental state
    • severely low blood pressure (this is a medical emergency, and you must seek medical care immediately)

    You also may notice small bruises on your skin appear when little blood vessels get injured from everyday activities. This isn’t usually a major concern unless it’s extensive or there’s marked discoloration.

    4. How does alcohol consumption affect my high cholesterol or risk of other cardiovascular issues?

    Moderate alcohol consumption has notable and significant health benefits, but not everyone agrees. There are a number of risks associated with any amount of alcohol consumption.

    A 2011 meta-analysis that included 84 prior research studies found that alcohol drinkers have a reduced number of cardiovascular and stroke deaths, as well as decreased development of coronary artery disease (CAD) and non-fatal stroke compared with non-drinkers.

    The lowest risk of CAD deaths was found in alcohol drinkers consuming approximately one to two alcoholic equivalents. A more neutral effect was found with stroke deaths and non-fatal strokes. This meta-analysis is the foundation of the current alcohol consumption guidelines.

    Moderate consumption of alcohol, mainly in red wines, has been found to cause a small increase in your HDL (good) cholesterol.

    5. Are some blood thinners different than others in this regard, or is it all the same risk?

    There is more than one kind of blood thinner and they work in different pathways within the body.

    One of the oldest blood thinners still in widespread use is warfarin (Coumadin). Of all the blood thinners available today, warfarin is more strongly affected by excessive alcohol consumption. However, moderate consumption does not significantly affect the metabolism of warfarin.

    Within the last few years, a new class of blood thinners was developed. They offer a number of benefits over warfarin, but they do have some disadvantages. Speak with your healthcare provider about the benefits and risks.

    Of these relatively new blood thinners, there are direct thrombin inhibitors, such as dabigatran (Pradaxa), and factor Xa inhibitors, such as rivaroxaban (Xarelto), apixaban (Eliquis), and edoxaban (Savaysa). Their mechanism of action isn’t affected by alcohol consumption. It’s relatively safe to consume alcohol as long as you are in good overall health and have confirmed with your healthcare provider.

    Talk to your healthcare provider to find out which blood thinner you qualify for.

    6. Are there tools or resources available to help me reduce my alcohol intake?

    Having the restraint to consume only moderate amounts of alcohol may be challenging for some individuals. It’s not recommended that you start drinking alcohol if you don’t normally.

    For those who have a problem with alcoholism, there are resources and tools to help reduce alcohol intake. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) is one of the many institutes of the National Institute of Health (NIH), and is an exceptional resource, consolidating all things related to alcohol.

    If you know you are vulnerable to alcohol abuse, don’t put yourself in an environment that will tempt excessive intake.

    Of course, healthcare providers are here to assist and support you along the way.

    Dr. Harb Harb is a non-invasive cardiologist working within the Northwell Health System in New York, specifically at the North Shore University Hospital, affiliated with Hofstra University. He completed medical school at the University of Iowa Carver College of Medicine in Iowa City, Iowa, internal medicine at the Cleveland Clinic in Cleveland, Ohio, and cardiovascular medicine at Henry Ford Health System in Detroit, Michigan. Dr. Harb moved to New York City, choosing a career path in academic medicine as an assistant professor at the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell. There, he teaches and works with cardiovascular and medical trainees as well as medical students. He is a Fellow of the American College of Cardiology (FACC) and American board-certified in general cardiology, echocardiography, and stress-testing, and nuclear cardiology. He is a registered physician in vascular interpretation (RPVI). Lastly, he obtained graduate education in public health and business administration to contribute to national healthcare reform research and implementation.

    Is Alcohol a Blood Thinner?

    So what should you know about alcohol and blood thinners if you’re taking them or you have a loved one who is?

    Blood thinners can be a life-saving class of drugs, but they do have risks, and you should be aware of warnings related to alcohol and blood thinners if you’re taking them.

    The consensus is that an occasional drink or moderate drinking is okay in terms of alcohol and blood thinners, but anything more than that could be risky. Regardless of what you read on the warning label regarding alcohol and blood thinners, it’s also important to make sure you ask your physician. Even if most people can combine a moderate amount of alcohol and blood thinners, you might have something, in particular, that would prevent you from being able to do that safely.

    Even if you do combine alcohol and blood thinners, it’s essential not to drink large amounts because of the risks as well as the many interactions between the two that we don’t fully understand right now.

    If you drink heavily or just any more than an occasional drink and you’re combining alcohol and blood thinners you’re at a greater risk of what’s called a significant bleeding accident. Combining alcohol and blood thinners may also lead to internal bleeding.

    If you regularly combine alcohol and blood thinners and then you were to have a relatively common accident, as an example, it could lead to an increased level of bleeding that could require emergency care.

    If you have a problem with alcohol, you should disclose this to your physician before they prescribe you a blood thinner and they can provide you with options and work with you on ways to address your drinking before you take blood thinners.

    The risks of alcohol and blood thinners are even more dangerous if you also take an over-the-counter medicine or something that also has an interaction with blood thinners. These are all things that should be discussed with your doctor.

    Something else to consider within the conversation of alcohol and blood thinners is the fact that while moderate drinking may be okay, the term moderate can mean something different to different people.

    Sometimes the best rule of thumb with alcohol and blood thinners is to abstain from alcohol altogether.

    Brilinta vs Plavix: Main Differences and Similarities

    Brilinta (ticagrelor) and Plavix (clopidogrel) are two antiplatelet medications that can be used to prevent clots from forming in the blood. Both medications are indicated to reduce the risk of heart and stroke in patients with acute coronary syndrome (ACS) or a history of myocardial infarction (MI or heart attack).

    Brilinta is known to be more potent than Plavix and is, therefore, considered a superior medication, at least for the first year after an ACS diagnosis. Despite this difference, both medications belong to the same class of medications known as P2Y12 platelet inhibitors. They work in similar ways with some differences to take note of.

    Brilinta is the brand name for ticagrelor. While it can be used to prevent heart attack, stroke, and death from vascular complications, it can also prevent blood clots from stent placements after an ACS event. There is currently no generic available and thus, the price may be higher than other drugs.

    Brilinta is available as a 60 mg or 90 mg oral tablet. It is usually started with a single 180 mg oral dose following an ACS event. It is then taken as 90 mg twice daily for one year and then decreased to 60 mg twice daily. Brilinta should be taken with a daily aspirin dose of 75 to 100 mg.

    If Brilinta is taken simultaneously with a 40 mg daily dose of simvastatin or lovastatin, the risk of statin-related events, such as muscle pain, may be increased. Brilinta should also be monitored when using other drugs such as opioids or digoxin, which can affect absorption. Dose adjustments may need to be made in severe liver impairment as well.


    Plavix is also known by its generic name, clopidogrel. Plavix is indicated to reduce heart attack and stroke for patients with ACS or a previous heart attack or stroke. Unlike Brilinta, the generic of Plavix is approved and available for purchase.

    Plavix comes as a 75 mg or 300 mg oral tablet. It is typically dosed similar to Brilinta with an initial loading dose. After an initial dose of 300 mg after an ACS event, a dose of 75 mg is taken daily. Plavix should be taken daily with a dose of aspirin to further reduce the risk of vascular events.

    When taken with other drugs such as opioids, Plavix may have decreased exposure and thus, a reduced therapeutic effect. Drug interactions should be taken into consideration in order to receive maximum benefits. If exposure to Plavix is increased, the risk of bleeding also increases.

    Brilinta vs Plavix Side by Side Comparison

    Brilinta and Plavix are two blood thinners that have similar indications. They also have some differences in side effects and drug interactions. These similarities and differences can be found below.

    Brilinta Plavix
    Prescribed For
    • Reduce the rate of cardiovascular death, heart attack, and stroke in patients with ACS or history of an MI
    • Reduce the rate of stent thrombosis
    • Reduce the rate of cardiovascular death, heart attack, and stroke in patients with ACS or history of an MI
    • Reduce the risk of heart attack and stroke in patients with a recent stroke or heart attack or known peripheral arterial disease
    Drug Classification
    • P2Y12 platelet inhibitor
    • P2Y12 platelet inhibitor
    • AstraZeneca
    • Sanofi
    • Bristol-Myers Squibb
    Common Side Effects
    • Unusual bleeding
    • Bruising
    • Bleeding gums
    • Heavy menstruation
    • Nose bleeds
    • Shortness of breath
    • Unusual bleeding
    • Bruising
    • Bleeding gums
    • Heavy menstruation
    • Nose bleeds
    • Shortness of breath
    Is there a generic?
    • No generic available
    • Yes
    • Clopidogrel
    Is it covered by insurance?
    • Varies according to your provider
    • Varies according to your provider
    Dosage Forms
    • Oral tablet
    • Oral tablet
    Average Cash Price
    • $427 (per 60 tablets)
    • $237 (per 30 tablets)
    SingleCare Discount Price
    • Brilinta Price
    • Plavix Price
    Drug Interactions
    • CYP3A4 inhibitors
    • CYP3A4 inducers
    • Opioids
    • Simvastatin
    • Lovastatin
    • Digoxin
    • Opioids
    • NSAIDs
    • Warfarin
    • SSRIs
    • SNRIs
    • Repaglinide
    Can I use while planning pregnancy, pregnant, or breastfeeding?
    • Brilinta is in Pregnancy Category C. Consult a physician regarding taking Brilinta while pregnant or breastfeeding
    • Plavix is in Pregnancy Category B. Consult a doctor regarding steps to take if planning pregnancy or breastfeeding.


    Brilinta and Plavix are two antiplatelet medications that can reduce the risk of heart attack and stroke in certain people with ACS or a previous heart attack. Compared to Plavix, Brilinta has more potent effects against blood clotting. Not only does it have more potent effects, but the effects also last longer. Brilinta may, however, have slightly higher bleeding side effects, though the benefits greatly outweigh the risk. One downside may be the higher price of Brilinta with no generic available yet.

    Other notable differences can be found in their side effects and drug interactions. Dyspnea, or shortness of breath, has been commonly reported as a side effect of Brilinta. Because Brilinta is metabolized extensively by the CYP3A4 enzyme, it does interact with CYP3A4 inhibitors and inducers. For someone taking simvastatin or lovastatin, they may have a higher risk of muscle pain. On the other hand, Plavix is mainly metabolized by the CYP2C19 enzyme. Therefore, the absorption of Plavix may be affected by drugs like SSRIs or SNRIs.

    Despite both medications having several differences, they can essentially treat similar conditions. After all, they both belong to the same class of medications. Because of their potential risks and differences, it is recommended to discuss both of these medications with your doctor. Your overall condition will be an important factor when deciding which treatment option will work better for you.

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