Pyrantel dosage for humans

Pyrantel Dosage

Medically reviewed by Drugs.com. Last updated on Dec 5, 2019.

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Applies to the following strengths: 144 mg/mL (50 mg/mL base); 180 mg; base 50 mg/mL

Usual Adult Dose for:

  • Enterobiasis
  • Pinworm Infection (Enterobius vermicularis)
  • Hookworm Infection (Necator or Ancylostoma)
  • Ascariasis
  • Trichostrongylosis
  • Moniliformis Infection

Usual Pediatric Dose for:

  • Enterobiasis
  • Pinworm Infection (Enterobius vermicularis)
  • Hookworm Infection (Necator or Ancylostoma)
  • Ascariasis
  • Trichostrongylosis
  • Moniliformis Infection

Additional dosage information:

  • Renal Dose Adjustments
  • Liver Dose Adjustments
  • Dose Adjustments
  • Precautions
  • Dialysis
  • Other Comments

Usual Adult Dose for Enterobiasis

11 mg/kg base (maximum 1 g) orally once. Repeat dose in 2 weeks.

Usual Adult Dose for Pinworm Infection (Enterobius vermicularis)

11 mg/kg base (maximum 1 g) orally once. Repeat dose in 2 weeks.

Usual Adult Dose for Hookworm Infection (Necator or Ancylostoma)

11 mg/kg base (maximum 1 g) orally daily for 3 days.

Usual Adult Dose for Ascariasis

11 mg/kg base (maximum 1 g) orally once.

Usual Adult Dose for Trichostrongylosis

11 mg/kg base (maximum 1 g) orally once.

Usual Adult Dose for Moniliformis Infection

11 mg/kg base (maximum 1 g) orally once. Repeat dose twice at 2 weeks intervals.

Usual Pediatric Dose for Enterobiasis

>=2 years: 11 mg/kg base (maximum 1 g) once. Repeat dose in 2 weeks.

Usual Pediatric Dose for Pinworm Infection (Enterobius vermicularis)

>=2 years: 11 mg/kg base (maximum 1 g) once. Repeat dose in 2 weeks.

Usual Pediatric Dose for Hookworm Infection (Necator or Ancylostoma)

>=2 years: 11 mg/kg base (maximum 1 g) orally daily for 3 days.

Usual Pediatric Dose for Ascariasis

>=2 years: 11 mg/kg base (maximum 1 g) orally once.

Usual Pediatric Dose for Trichostrongylosis

>=2 years: 11 mg/kg base (maximum 1 g) orally once.

Usual Pediatric Dose for Moniliformis Infection

>=2 years: 11 mg/kg base (maximum 1 g) orally once. Repeat dose twice at 2 weeks intervals.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Pyrantel is contraindicated in patients with hepatic disease.

Dose Adjustments

In the treatment of ascariasis, pyrantel may be used only if it has been determined that the worm load will not worsen obstruction.

Precautions

Pyrantel is contraindicated in patients with hepatic disease.
When one individual in a household has pinworms, the entire household should be treated unless otherwise advised. Pinworm infections are easily transmitted to others in the same household.
Pyrantel should be used with caution in patients with severe malnutrition or anemia. Supportive therapy is recommended for anemic, dehydrated, or malnourished patients prior to administration of the drug.
Other medications are known to antagonize the anthelmintic effect of pyrantel. Patients should be advised to consult with their physician before initiating any drug therapy while receiving pyrantel.

Dialysis

Data not available

Other Comments

The dose should be taken as a single oral dose. It may be taken alone or with milk or fruit juice.
Pyrantel pamoate 2.9 g is approximately equivalent to 1 g of pyrantel (base).

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Related questions

  • Pyrantel – what is the dosage for cats and kittens?

Medical Disclaimer

More about pyrantel

  • Side Effects
  • During Pregnancy or Breastfeeding
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  • En Español
  • 8 Reviews
  • Drug class: anthelmintics

Consumer resources

  • Pyrantel
  • Pyrantel Pamoate Chewable Tablets
  • Pyrantel Pamoate Tablets
  • Pyrantel Pamoate Suspension
  • Pyrantel (Advanced Reading)

Other brands: Pin-X, Reese’s Pinworm Medicine, Pinworm Medicine, Ascarel, Pin-Away

Professional resources

  • Pyrantel Pamoate (AHFS Monograph)

Related treatment guides

  • Pinworm Infection (Enterobius vermicularis)
  • Ascariasis
  • Enterobiasis
  • Hookworm Infection (Necator or Ancylostoma)
  • Moniliformis Infection
  • Trichostrongylosis

Group: anthelminthic agent
Chewable tablet 250 mg (as embonate)
Oral suspension 50 mg (as embonate)/ml

General information

A pyrimidine derivative that depolarizes the neuromuscular junctions of susceptible nematodes. The paralysed worms are subsequently expelled in the faeces.

It is poorly absorbed from the gastrointestinal tract. Most is excreted unchanged in the faeces. The absorbed fraction is partially metabolized in the liver and the residuum is excreted in the urine.

Clinical information

Uses

Treatment of hookworm infections, ascariasis, enterobiasis and trichostrongyliasis.

Dosage and administration

Adults and children: a single dose of 10 mg/kg is sufficient to eliminate many cases of hookworm infection, ascariasis, enterobiasis and trichostrongyliasis.

Patients with enterobiasis, however, should receive a second dose after 2-4 weeks and all members of the household should be treated concurrently.

Heavy hookworm infections are relatively resistant and three further doses should be given on consecutive days.

Regular administration of a single dose of 2.5 mg/kg three or four times a year in mass treatment control programmes has been reported to reduce the prevalence of ascariasis substantially.

Contraindications

• Known hypersensitivity.

Precautions

Lower doses should be administered when liver function is impaired.

Drug interactions

Pyrantel and piperazine have antagonistic effects. They should never be given concurrently.

Use in pregnancy

Safe use in pregnancy has not been established. Although high priority should be accorded to the treatment of pregnant women, pyrantel should preferably not be administered during the first trimester.

Adverse effects

Mild gastrointestinal disturbance, headache, dizziness, drowsiness, insomnia and rash are occasionally reported.

Overdosage

Emesis or gastric lavage may be of value if undertaken within a few hours of ingestion.

Storage

Pyrantel preparations should be stored in tightly closed containers, protected from light.

Pyrantel

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

What is pyrantel pamoate?

Pyrantel pamoate (brand names Nemex®, Nemex 2®) is an anthelmintic, or dewormer. It is used to treat intestinal roundworm, hookworm, and stomach worm parasites in dogs.

The use of pyrantel pamoate to treat intestinal parasites in cats is off label or extra-label. This medication is also used off label to treat roundworms and hookworms in small mammals such as rabbits and rodents.

Many drugs are commonly prescribed for off label use in veterinary medicine. In these instances, follow your veterinarian’s directions and cautions very carefully.

Pyrantel pamoate is also found in a variety of combination products for the treatment of intestinal parasites and/or heartworm.

How is pyrantel pamoate given?

Pyrantel pamoate is available as a capsule, chewable tablet, and liquid suspension. Pyrantel pamoate should be given by mouth with or without food.

Liquid forms must be shaken well before use. Measure the dosage carefully. Follow the dosing instructions provided by your veterinarian.

This medication should take effect within 1 to 2 hours; however, effects may not be noticeably visible and therefore laboratory tests may need to be done to evaluate this medication’s effectiveness.

What if I miss giving my pet the medication?

If you miss a dose, give it when you remember, and then wait the amount of time between doses recommended by your veterinarian before dosing again. Never give your pet two doses at once or give extra doses.

It is very important to give the medication for the length of time your veterinarian has recommended.

Are there any potential side effects?

Side effects to pyrantel pamoate may include nausea, vomiting, lack of appetite, and diarrhea. If vomiting occurs after receiving a dose on an empty stomach, give the dose with food.

Lack of appetite, diarrhea and vomiting may occur due to the elimination of parasites. Contact your veterinarian if these signs become severe or continue to be a problem.

This short-acting medication should stop working within 24 hours, although effects can be longer in pets with liver or kidney disease.

Are there any risk factors for this medication?

Pyrantel pamoate should not be used in pets that:

  • are allergic to it
  • are severely weakened or frail

It is considered safe to use in nursing animals and should be used with caution (follow the dosing instructions carefully) in pregnant animals.

Are there any drug interactions I should be aware of?

Certain drugs may interact with pyrantel pamoate including levamisole, morantel, and piperazine. Exposure to organophosphates (pesticides) while taking pyrantel pamoate should be avoided. It is important to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking.

Is there any monitoring that needs to be done with this medication?

Monitor to ensure that the medication is working and monitor for adverse effects.

How do I store pyrantel pamoate?

Pyrantel pamoate tablets should be stored in a tightly sealed container, protected from light, and at room temperature. Liquid suspensions should not be exposed to direct sunlight.

What should I do in case of emergency?

Pyrantel pamoate can be toxic when given regularly over a period of months. If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.

Contributors: Rania Gollakner, BS, DVM © Copyright 2018 LifeLearn Inc. Used and/or modified with permission under license.

To Your Health

Q. Is it OK to give worm medicine to children if you only suspect worms but don’t have evidence of it? When my kids complain of a tickly-like sensation on their rectal area, I deworm my family and dog (the pharmacist told me it was safe for dogs) with Combantrin according to their weight.

A. Combantrin (the generic name is pyrantel pamoate) is often the first medication used to treat pinworms, hookworms, and roundworms because it is available without a prescription. Another advantage of pyrantel is that adults and children more than 2 years of age can all take the same dose. Of all types of worms, pinworm is by far the most common, and the most innocuous. The symptoms you describe fit with pinworm infection. See “To Your Health” in the Dec. 13, 2003, Austin Chronicle for more information on pinworms.

Contrary to popular belief, pinworms do not infect dogs or cats, and children who get pinworms do not get them from dogs or cats. Any long, thin worm segments associated with dogs are likely to be tapeworms; hookworms and roundworms look quite different from pinworms or small tapeworms. A species of pinworm does infect horses, but since parasites usually adapt themselves to their host, apparently these pinworms are not transmitted to humans.

Due to the economic rewards of keeping valuable thoroughbred horses in excellent health, such horses have been used as experimental animals to refine worming techniques. Such studies should help us understand the safety of pinworm medication and how to most effectively control pinworms in humans. The question of how often pyrantel can safely be used to deworm your family may be answered by an article published in Veterinary Parasitology in 1996. Daily administration of pyrantel appears to be safe for both yearling foals and adult horses. Both daily and monthly administration controlled the pinworm egg count in adult horses, but both failed in younger horses. If this observation in horses can be transferred to humans, it appears that keeping children completely free of pinworms is a difficult task even when medications like pyrantel are used continuously. Your present practice of treating your family when any of them exhibits symptoms seems ideal.

It may be unnecessary to treat the dog along with the rest of the family if you only suspect pinworms and have no suspicion of roundworm or hookworm infection. You can spot roundworms in your dog’s feces, and you should carefully protect your children from contact with your dog if roundworms are found. Dogs can be infected with roundworms and pass them on to humans through their feces, but it takes approximately two weeks after being passed for the eggs of this parasite to become infective to humans. If humans inadvertently ingest roundworm eggs, the eggs hatch in the human’s intestinal tract, and then the immature roundworms, rather than maturing into adult worms, migrate to other tissues (lungs, liver, brain, etc) and become a serious condition. With this risk in mind, many cities have passed “pooper scooper” laws that require owners to immediately clean up their pet’s feces from public property.

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