Polymyxin b sulfate dosage

Neomycin, Polymyxin B, Dexamethasone Ophthalmic Ointment by Bausch&Lomb

**THIS PRODUCT IS ON A MANUFACTURER BACK ORDER UNTIL MID-MARCH**

Neomycin + Polymyxin + Dexamethasone Ophthalmic
General Description:
This drug is an eye medication that is a combination of more than one antibiotic and a steroid anti-inflammatory. This medication is available in the form of drops/suspension as well as an ointment.
What is Neomycin, Polymyxin B, Dexamethasone Ophthalmic Ointment?

  • Two broad spectrum antibiotics and a steroid.

Reasons for prescribing eye medications:

  • To treat or prevent bacterial infections and inflammatory conditions involving the eye, conjunctiva, and eyelids

What dogs/cats should not take Neomycin, Polymyxin B, Dexamethasone Ophthalmic Ointment?

  • Cats can have a severe allergic reaction to the neomycin or polymyxin component in this eye medication
  • Animals with corneal ulcers as the steroid can delay healing
  • Animals with viral or fungal infections as the steroid can worsen or prolong the infection
  • Animals with a known hypersensitivity or allergy to this drug should not take this medication

Directions:

  • Read and follow the prescription label carefully.
  • Give the exact amount prescribed and only as often as directed.
  • Give this medication for as long as your veterinarian directs.
  • Do not skip doses or stop giving the medication without consulting your veterinarian.
  • Dose adjustments may be made based upon an assessment of how your dog or cats is responding clinically.
  • If your pet requires more than one medication in the same eye, administer the medications 5 minutes apart.
  • If your pet requires more than one medication, discuss with your veterinarian if it is preferable to administer drops before ointments.
  • If you are having difficulty applying the medication, contact your veterinarian
  • Call ahead for refills.
  • Ideally, give this medication at the same time(s) daily.

Administration of eye drops

  • Wash your hands before applying any eye medication
  • Check label directions and shake bottle if necessary
  • Remove excess discharge from around the eye with a moistened cloth
  • Remove the cap and avoid contaminating the tip of the medication bottle with the environment or your fingers
  • Tilt your pet’s head back so that they are looking up towards the ceiling
  • Gently hold the eyelids open and with the other hand holding the medication bottle, rest your hand above the eye
  • Be sure that the tip of the medication bottle is not pointed towards the eye in case of any sudden movements
  • Ensure that the tip of the medication bottle does not touch your pet’s eye, eyelids, or lashes
  • Apply the correct amount of drops into the eye
  • Continue to hold your pet’s head up and allow them to blink to distribute the drops over the entire eye
  • Place the cap back on the medication bottle and avoid contaminating the inside of the cap with your fingers
  • Wash your hands after applying any eye medication
  • Always praise and reward your pet to encourage cooperation

Administration of eye ointments

  • Wash hands prior before applying any eye medication
  • Check label directions
  • Remove excess discharge from around the eye with a moistened cloth
  • Remove the cap and avoid contaminating the tip of the medication tube with the environment or your fingers
  • Tilt your pet’s head back so that they are looking up towards the ceiling
  • Gently roll down the lower eyelid of the affected eye and while holding the medication tube, rest your hand above the eye
  • Be sure that the tip of the medication tube is not pointed towards the eye in case of any sudden movements
  • Ensure that the tip of the medication tube does not touch your pet’s eye, eyelids, or lashes
  • Holding the tube parallel to the eyelid, apply the correct amount of ointment along the inner edge of the lower lid
  • Gently hold the eyelids shut and massage to disperse the medication
  • Place the cap back on the medication tube and avoid contaminating the inside of the cap with your fingers
  • Wash your hands after applying any eye medication
  • Always praise and reward your pet to encourage cooperation

What if a dose is missed?
If a dose is missed, give it as soon as you can. If it is time already for the next dose, skip the missed dose and go back to the normal schedule. Do not give two doses at the same time.
What to tell/ask a veterinarian before giving Neomycin, Polymyxin B, Dexamethasone Ophthalmic Ointment?

Talk to your veterinarian about:

  • When your pet will need to be rechecked
  • What tests may need to be performed prior to and during treatment with this drug
  • What are the risks and benefits of using this drug

Tell your veterinarian about:

  • If your pet has experienced previous eye problems
  • If your pet has experienced side-effects on other drugs/products
  • If your pet has experienced digestive upset now or ever
  • If your pet has experienced liver or kidney disease now or ever
  • If your pet has experienced any other medical problems or allergies now or ever
  • All medicines and supplements that you are giving your pet or plan to give your pet, including those you can get without a prescription. Your veterinarian may want to check that all of your pet’s medications can be given together.
  • If your pet is pregnant, nursing or if you plan to breed your pet

Storage and Warnings:
Neomycin + Polymyxin + Dexamethasone Ophthalmic should be stored in a childproof container in a cool, dry place at room temperature away from heat and direct sunlight.
Keep this and all medication out of reach of children and pets.
Call your physician immediately if you accidentally take this product.
Potential side effects of Neomycin, Polymyxin B, Dexamethasone Ophthalmic Ointment:

  • This medication may cause the eye to sting for a short period after application.
  • This medication can cause hypersensitivity reactions resulting in marked redness and swelling of the tissues surrounding the eye.
  • This medication can affect and delay wound healing.
  • This medication can affect the regulation of animals with Cushing’s disease or diabetes mellitus.
  • Prolonged use of any antibiotic may lead to the development of bacterial resistance and overgrowth of other organisms.
  • If these symptoms persist or you notice anything else unusual, contact your veterinarian.

Can this drug be given with other drugs?

  • Do not give new food or medications without first talking to your veterinarian.
  • If your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian.

Overdosing?
Contact your veterinarian immediately if you pet has accidentally ingested this medication or has received more than the prescribed amount
What else should I know about Neomycin, Polymyxin B, Dexamethasone Ophthalmic Ointment?
Notify your veterinarian if your animal’s condition does not improve or worsens despite this treatment.
As with all prescribed medicines, Neomycin + Polymyxin + Dexamethasone Ophthalmic should only be given to the pet for which it was prescribed.
It should be given only for the condition for which it was prescribed. Never use skin or ear medications in the eye.

This is just a summary of information about Neomycin + Polymyxin + Dexamethasone Ophthalmic. If you have any questions or concerns about Neomycin + Polymyxin + Dexamethasone Ophthalmic or the condition it was prescribed for, please contact your veterinarian.

Polytrim

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 8/6/2018

Polytrim (polymyxin B sulfate and trimethoprim ophthalmic solution) is an antibiotic indicated in the treatment of surface bacterial infections of the eye, including acute bacterial conjunctivitis, and blepharoconjunctivitis, caused by susceptible strains of the following microorganisms: Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus viridans, Haemophilus influenzae and Pseudomonas aeruginosa. Polytrim is available in generic form. Common side effects of Polytrim include:

  • eye irritation (redness, burning, stinging, or itching), and
  • hypersensitivity reactions (eyelid swelling, itching, increased redness, tearing, or rash)

In mild to moderate infections, instill a dose of one drop of Polytrim in the affected eye(s) every three hours (maximum of 6 doses per day) for a period of 7 to 10 days. Polytrim may interact with other drugs. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Polytrim; it is unknown how it would affect a fetus. It is unknown if Polytrim passes into breast milk. Consult your doctor before breastfeeding.

Our Polytrim (polymyxin B sulfate and trimethoprim ophthalmic solution) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Polymyxin B / Trimethoprim Ophthalmic Dosage

Medically reviewed by Drugs.com. Last updated on Jan 20, 2020.

  • Overview
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  • Dosage
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Applies to the following strengths: 10000 units-1 mg/mL

Usual Adult Dose for:

  • Bacterial Conjunctivitis
  • Blepharoconjunctivitis

Usual Pediatric Dose for:

  • Bacterial Conjunctivitis
  • Blepharoconjunctivitis

Additional dosage information:

  • Renal Dose Adjustments
  • Liver Dose Adjustments
  • Precautions
  • Dialysis
  • Other Comments

Usual Adult Dose for Bacterial Conjunctivitis

Instill 1 drop in the affected eye(s) every 3 hours for 7 to 10 days.
Maximum dose: 6 doses/day
Uses: For the treatment of mild to moderate surface ocular bacterial infections (including acute bacterial conjunctivitis) and blepharoconjunctivitis due to susceptible strains of Staphylococcus aureus, S epidermidis, Streptococcus pneumoniae, viridans streptococci, Haemophilus influenzae, Pseudomonas aeruginosa

Usual Pediatric Dose for Bacterial Conjunctivitis

2 months or older: Instill 1 drop in the affected eye(s) every 3 hours for 7 to 10 days.
Maximum dose: 6 doses/day
Uses: For the treatment of mild to moderate surface ocular bacterial infections (including acute bacterial conjunctivitis) and blepharoconjunctivitis due to susceptible strains of S aureus, S epidermidis, S pneumoniae, viridans streptococci, H influenzae, P aeruginosa

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:
Known hypersensitivity to either active component or to any of the ingredients
Safety and efficacy have not been established in patients younger than 2 months.
Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Not for injection into the eye
Storage requirements:
-Store at 15C to 25C (59F to 77F); protect from light.
Patient advice:
-Avoid contaminating the applicator tip with material from the eye, fingers, or any other source.
-Discontinue use and contact physician if redness, irritation, swelling, or pain persists/worsens.
-Do not wear contact lenses if you have signs/symptoms of ocular bacterial infections.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

More about polymyxin b / trimethoprim ophthalmic

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  • En Español
  • 18 Reviews
  • Drug class: ophthalmic anti-infectives

Consumer resources

  • Polymyxin B and trimethoprim ophthalmic
  • Trimethoprim and Polymyxin B
  • Polymyxin b and trimethoprim Ophthalmic (Advanced Reading)

Other brands: Polytrim

Professional resources

  • Trimethoprim and Polymyxin B (Wolters Kluwer)
  • … +1 more

Related treatment guides

  • Blepharoconjunctivitis
  • Conjunctivitis, Bacterial

WARNINGS

NOT FOR INJECTION INTO THE EYE. If a sensitivity reaction to POLYTRIM® occurs, discontinue use. POLYTRIM® Ophthalmic Solution is not indicated for the prophylaxis or treatment of ophthalmia neonatorum.

PRECAUTIONS

General

As with other antimicrobial preparations, prolonged use may result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs, appropriate therapy should be initiated.

Carcinogenesis, Mutagenesis, Impairment Of Fertility

Carcinogenesis

Long-term studies in animals to evaluate carcinogenic potential have not been conducted with polymyxin B sulfate or trimethoprim.

Mutagenesis

Trimethoprim was demonstrated to be non-mutagenic in the Ames assay. In studies at two laboratories no chromosomal damage was detected in cultured Chinese hamster ovary cells at concentrations approximately 500 times human plasma levels after oral administration; at concentrations approximately 1,000 times human plasma levels after oral administration in these same cells, a low level of chromosomal damage was induced at one of the laboratories. Studies to evaluate mutagenic potential have not been conducted with polymyxin B sulfate.

Impairment Of Fertility

Polymyxin B sulfate has been reported to impair the motility of equine sperm, but its effects on male or female fertility are unknown.

No adverse effects on fertility or general reproductive performance were observed in rats given trimethoprim in oral dosages as high as 70 mg/kg/day for males and 14 mg/kg/day for females.

Pregnancy

Teratogenic Effects

Animal reproduction studies have not been conducted with polymyxin B sulfate. It is not known whether polymyxin B sulfate can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity.

Trimethoprim has been shown to be teratogenic in the rat when given in oral doses 40 times the human dose. In some rabbit studies, the overall increase in fetal loss (dead and resorbed and malformed conceptuses) was associated with oral doses 6 times the human therapeutic dose.

While there are no large well-controlled studies on the use of trimethoprim in pregnant women, Brumfitt and Pursell, in a retrospective study, reported the outcome of 186 pregnancies during which the mother received either placebo or oral trimethoprim in combination with sulfamethoxazole. The incidence of congenital abnormalities was 4.5% (3 of 66) in those who received placebo and 3.3% (4 of 120) in those receiving trimethoprim and sulfamethoxazole. There were no abnormalities in the 10 children whose mothers received the drug during the first trimester. In a separate survey, Brumfitt and Pursell also found no congenital abnormalities in 35 children whose mothers had received oral trimethoprim and sulfamethoxazole at the time of conception or shortly thereafter.

Because trimethoprim may interfere with folic acid metabolism, trimethoprim should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Nonteratogenic Effects

The oral administration of trimethoprim to rats at a dose of 70 mg/kg/day commencing with the last third of gestation and continuing through parturition and lactation caused no deleterious effects on gestation or pup growth and survival.

Nursing Mothers

It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when POLYTRIM® Ophthalmic Solution is administered to a nursing woman.

Pediatric Use

Safety and effectiveness in children below the age of 2 months have not been established (see WARNINGS).

Geriatric Use

No overall differences in safety or effectiveness have been observed between elderly and other adult patients.

Polymyxin B; Trimethoprim eye drops, solution

What is this medicine?

POLYMYXIN B and TRIMETHOPRIM (pol i MIX in B and trye METH oh prim) eye drops treat certain eye infections caused by bacteria.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Polytrim

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • wear contact lenses

  • an unusual or allergic reaction to polymyxin B, trimethoprim, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

This medicine is used in the eye. Follow the directions on the prescription label. Wash your hands before and after use. Tilt your head back slightly. Pull your lower eyelid down gently to form a pouch. Do not touch the tip of the dropper to your eye, fingertips, or other surface. Squeeze the prescribed number of drops into the pouch. Close the eye gently to spread the drops. Use your medicine at regular intervals. Do not take your medicine more often than directed. Use all of your medicine as directed even if you think your are better. Do not skip doses or stop your medicine early.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children and infants for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What may interact with this medicine?

Interactions are not expected. Do not use any other eye products without advice of your doctor or health care professional.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Check with your doctor or health care professional if your condition does not get better after 5 days, or if it gets worse.

If you wear contact lenses, ask when you can use your lenses again.

A burning or stinging reaction that does not go away may mean you are allergic to this product. Stop use and call your doctor or health care professional.

To prevent the spread of infection, do not share eye products or other personal items with anyone else.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • burning, stinging, or swelling

  • change in vision or blurred vision that will not go away

  • eye pain

  • itching and redness

  • rash

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • temporary blurred vision after applying

  • temporary watering or stinging

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature 15 to 25 degrees C (59 to 77 degrees F). Protect from light. To prevent the spread of infection, it is best to throw away any unused eye drops after you finish the course of treatment. Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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