Ofloxacin ophthalmic eye drops

Ofloxacin Ophthalmic Solution

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 11/20/2015

Ofloxacin (ofloxacin ophthalmic) solution is an antibiotic used to treat bacterial infections of the eyes. Common side effects of Ofloxacin include temporary blurred vision, eye stinging, burning, discomfort, itching, redness, dryness, tearing, sensitivity to light, pinkeye (conjunctivitis), facial swelling, eye pain, and infrequently, dizziness or nausea.

The usual starting dose of Ofloxacin is 1 to 2 drops every 2 to 4 hours in the affected eye(s), but is dependent on the condition being treated. Consult your doctor for details. Do not use other eye drops or medications during treatment with Ofloxacin unless otherwise directed by your doctor. Other drugs may interact with Ofloxacin. Tell your doctor all medications and supplements you take. Do not drive, use machinery, or do any activity that requires clear vision while taking Ofloxacin. This medication should be used during pregnancy only if clearly needed. Consult your doctor before using Oflaxacin before breastfeeding.

Our Ofloxacin (ofloxacin ophthalmic) solution Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Ofloxacin Ophthalmic Solution USP, 0.3% is a prescription sterile eye solution that helps treat infections caused by susceptible strains of bacteria in conjunctivitis and corneal ulcers. Customers may receive this drug under the names Ofloxacin, Ocuflox.

Uses

Ofloxacin Ophthalmic Solution treats bacterial eye infections and gives dogs and cats quick relief from pain, swelling, itching, and discomfort.

Possible Side Effects

The most frequently reported drug-related adverse reaction was transient ocular burning or discomfort. Other reported reactions include stinging, redness, itching, chemical conjunctivitis/keratitis, ocular/periocular/facial edema, foreign body sensation, photophobia, blurred vision, tearing, dryness, and eye pain. Rare reports of dizziness and nausea have been received.

Drug & Food Interactions

Always tell your veterinarian about all medications and supplements your pet is taking before using Ofloxacin Eye Drops.

Precautions

As with other anti-infectives, prolonged use may result in overgrowth of no susceptible organisms, including fungi. If superinfection occurs discontinue use and institute alternative therapy. Whenever clinical judgment dictates, the pet should be examined with the aid of magnification, such as slit lamp biomicroscopy and, where appropriate, fluorescein staining. Ofloxacin should be discontinued at the first appearance of a skin rash or any other sign of hypersensitivity reaction.

This drug is FDA-approved for human use. However, it is common practice for veterinarians to prescribe such drugs for use in dogs and cats.

NOTE: For Generic Medications, picture displayed may not depict actual product. Generic medications may vary from one order to the next by size, color and shape depending on manufacturer. Customers may receive the same drug under the names Ofloxacin, Ocuflox.

  1. Prescribing Information

See all items by Ofloxacin

Ofloxacin Ophthalmic Dosage

Medically reviewed by Drugs.com. Last updated on May 1, 2019.

  • Overview
  • Side Effects
  • Dosage
  • Professional
  • Pregnancy
  • More

Applies to the following strengths: 0.3%

Usual Adult Dose for:

  • Bacterial Conjunctivitis
  • Corneal Ulcers

Usual Pediatric Dose for:

  • Bacterial Conjunctivitis
  • Corneal Ulcers

Additional dosage information:

  • Renal Dose Adjustments
  • Liver Dose Adjustments
  • Precautions
  • Dialysis
  • Other Comments

Usual Adult Dose for Bacterial Conjunctivitis

Days 1 and 2: Instill 1 to 2 drops in the affected eye(s) every 2 to 4 hours.
Days 3 through 7: Instill 1 to 2 drops in the affected eye(s) 4 times a day.
Use: For the treatment of bacterial conjunctivitis due to susceptible strains of Staphylococcus aureus, S epidermidis, Streptococcus pneumoniae, Enterobacter cloacae, Haemophilus influenzae, Proteus mirabilis, Pseudomonas aeruginosa

Usual Adult Dose for Corneal Ulcers

Days 1 and 2: Instill 1 to 2 drops in the affected eye(s) every 30 minutes while awake and about 4 and 6 hours after retiring.
Days 3 through 7 to 9: Instill 1 to 2 drops in the affected eye(s) every hour while awake.
Days 7 to 9 through treatment completion: Instill 1 to 2 drops in the affected eye(s) 4 times a day.
Use: For the treatment of bacterial corneal ulcers due to susceptible strains of S aureus, S epidermidis, S pneumoniae, P aeruginosa, Serratia marcescens, Propionibacterium acnes

Usual Pediatric Dose for Bacterial Conjunctivitis

1 year or older:
-Days 1 and 2: Instill 1 to 2 drops in the affected eye(s) every 2 to 4 hours.
-Days 3 through 7: Instill 1 to 2 drops in the affected eye(s) 4 times a day.
Use: For the treatment of bacterial conjunctivitis due to susceptible strains of S aureus, S epidermidis, S pneumoniae, E cloacae, H influenzae, P mirabilis, P aeruginosa

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Safety and efficacy have not been established in patients younger than 1 year.
Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-For topical ophthalmic use only (not for injection)
-Do not inject subconjunctivally; do not introduce directly into the anterior chamber of the eye.
-Consult the manufacturer product information for instillation instructions.
-If other topical ophthalmic agents are used, wait at least 10 minutes between instillations.
Patient advice:
-Do not wear contact lenses during therapy.
-Wash hands thoroughly before using this drug.
-Avoid contaminating the applicator tip with material from the eye, fingers, or any other source.
-Stop this drug and contact physician at first sign of rash or allergic reaction.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

More about ofloxacin ophthalmic

  • Side Effects
  • During Pregnancy or Breastfeeding
  • Compare Alternatives
  • Pricing & Coupons
  • En Español
  • 4 Reviews
  • Drug class: ophthalmic anti-infectives
  • FDA Alerts (1)

Consumer resources

  • Ofloxacin ophthalmic
  • Ofloxacin (Ophthalmic)
  • Ofloxacin Ophthalmic (Advanced Reading)

Other brands: Ocuflox

Professional resources

  • Ofloxacin eent (AHFS Monograph)
  • … +2 more

Related treatment guides

  • Corneal Ulcer
  • Conjunctivitis, Bacterial
  • Ophthalmic Surgery

PRECAUTIONS

General

As with other anti-infectives, prolonged use may result in overgrowth of non susceptible organisms, including fungi. If super infection occurs discontinue use and institute alternative therapy. Whenever clinical judgment dictates, the patient should be examined with the aid of magnification, such as slit lamp biomicroscopy and, where appropriate, fluorescein staining. Ofloxacin should be discontinued at the first appearance of a skin rash or any other sign of hypersensitivity reaction.

The systemic administration of quinolones, including ofloxacin, has led to lesions or erosions of the cartilage in weight-bearing joints and other signs of arthropathy in immature animals of various species. Ofloxacin, administered systemically at 10 mg/kg/day in young dogs (equivalent to 110 times the maximum recommended daily adult ophthalmic dose) has been associated with these types of effects.

Carcinogenesis, Mutagenesis, Impairment of Fertility

Long term studies to determine the carcinogenic potential of ofloxacin have not been conducted.

Ofloxacin was not mutagenic in the Ames test, in vitro and in vivo cytogenic assay, sister chromatid exchange assay (Chinese hamster and human cell lines), unscheduled DMA synthesis (UDS) assay using human fibroblasts, the dominant lethal assay, or mouse micronucleus assay. Ofloxacin was positive in the UDS test using rat hepatocyte, and in the mouse lymphoma assay.

In fertility studies in rats, ofloxacin did not affect male or female fertility or morphological or reproductive performance at oral dosing up to 360 mg/kg/day (equivalent to 4000 times the maximum recommended daily ophthalmic dose).

Pregnancy

Teratogenic Effects

Pregnancy Category C: Ofloxacin has been shown to have an embryocidal effect in rats and in rabbits when given in doses of 810 mg/kg/day (equivalent to 9000 times the maximum recommended daily ophthalmic dose) and 160 mg/kg/day (equivalent to 1800 times the maximum recommended daily ophthalmic dose).

These dosages resulted in decreased fetal body weight and increased fetal mortality in rats and rabbits, respectively. Minor fetal skeletal variations were reported in rats receiving doses of 810 mg/kg/day. Ofloxacin has not been shown to be teratogenic at doses as high as 810 mg/kg/day and 160 mg/kg/day when administered to pregnant rats and rabbits, respectively.

Nonteratogenic Effects

Additional studies in rats with doses up to 360 mg/kg/day during late gestation showed no adverse effect on late fetal development, labor, delivery, lactation, neonatal viability, or growth of the newborn. There are, however, no adequate and well-controlled studies in pregnant women. Ofloxacin ophthalmic solution should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Nursing Mothers

In nursing women a single 200 mg oral dose resulted in concentrations of ofloxacin in milk which were similar to those found in plasma. It is not known whether ofloxacin is excreted in human milk following topical ophthalmic administration. Because of the potential for serious adverse reactions from ofloxacin in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Pediatric Use

Safety and effectiveness in infants below the age of one year have not been established. Quinolones, including ofloxacin, have been shown to cause arthropathy in immature animals after oral administration; however, topical ocular administration of ofloxacin to immature animals has not shown any arthropathy. There is no evidence that the ophthalmic dosage form of ofloxacin has any effect on weight bearing joints.

Geriatric Use

No overall differences in safety or effectiveness have been observed between elderly and younger patients.

Ofloxacin ophthalmic

Generic Name: ofloxacin ophthalmic (oh FLOX a sin off THAL mik)
Brand Name: Ocuflox

Medically reviewed by Drugs.com on Apr 8, 2019 – Written by Cerner Multum

  • Overview
  • Side Effects
  • Dosage
  • Professional
  • Pregnancy
  • More

What is ofloxacin ophthalmic?

Ofloxacin is a fluoroquinolone (flor-o-KWIN-o-lone) antibiotic that fights bacteria in the body.

Ofloxacin ophthalmic (for use in the eyes) is used to treat bacterial infections of the eyes.

Ofloxacin ophthalmic is also used to treat an ulcer in the cornea of the eye.

Ofloxacin will not treat a viral or fungal infection of the eye.

Ofloxacin ophthalmic may also be used for purposes not listed in this medication guide.

Important Information

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use ofloxacin ophthalmic if you are allergic to ofloxacin or other fluoroquinolones (ciprofloxacin, gemifloxacin, levofloxacin, moxifloxacin, norfloxacin, and others).

Do not use this medicine to treat a viral or fungal infection in the eye. Ofloxacin ophthalmic is for use in treating only bacterial infections of the eye.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether ofloxacin ophthalmic passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.

Ofloxacin eye drops (solution) are not approved for use by anyone younger than 1 year old.

How should I use ofloxacin ophthalmic?

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Do not use this medicine while wearing contact lenses. Ofloxacin ophthalmic may contain a preservative that can discolor soft contact lenses. Wait at least 15 minutes after using this medicine before putting in your contact lenses.

Wash your hands before using the eye drops.

To apply the eye drops:

  • Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the tip down. Look up and away from the dropper and squeeze out a drop.

  • Close your eyes for 2 or 3 minutes with your head tipped down, without blinking or squinting. Gently press your finger to the inside corner of the eye for about 1 minute, to keep the liquid from draining into your tear duct.

  • Use only the number of drops your doctor has prescribed. If you use more than one drop, wait about 5 minutes between drops.

  • Wait at least 10 minutes before using any other eye drops your doctor has prescribed.

When treating a corneal ulcer, you may need to wake from sleep every 4 to 6 hours to use the medication. Follow your doctor’s dosing instructions very carefully. You may notice a whitish buildup on the ulcer. This is a sign that the medication is working and is not a harmful effect. This buildup should clear within a few days or weeks of treatment.

Do not touch the tip of the eye dropper or place it directly on your eye. A contaminated dropper can infect your eye, which could lead to serious vision problems.

Do not use the eye drops if the liquid has changed colors or has particles in it. Call your pharmacist for new medicine.

Store at room temperature away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

An overdose of ofloxacin ophthalmic is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

What should I avoid while using ofloxacin ophthalmic?

Avoid wearing contact lenses until you no longer have symptoms of the eye infection.

ofloxacin ophthalmic may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Do not use other eye medications unless your doctor tells you to.

Ofloxacin ophthalmic side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe burning, stinging, or irritation after using this medicine;

  • eye pain;

  • eye swelling, redness, severe discomfort, crusting or drainage (may be signs of infection); or

  • severe skin reaction–fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

  • blurred vision;

  • eye pain or

  • mild burning, stinging, or other discomfort;

  • eye redness, itching, or watering;

  • red or puffy eyelids;

  • your eyes being more sensitive to light; or

  • eye dryness, feeling like something is in your eye.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Ofloxacin ophthalmic dosing information

Usual Adult Dose for Bacterial Conjunctivitis:

Days 1 and 2: Instill 1 to 2 drops in the affected eye(s) every 2 to 4 hours.
Days 3 through 7: Instill 1 to 2 drops in the affected eye(s) 4 times a day.
Use: For the treatment of bacterial conjunctivitis due to susceptible strains of Staphylococcus aureus, S epidermidis, Streptococcus pneumoniae, Enterobacter cloacae, Haemophilus influenzae, Proteus mirabilis, Pseudomonas aeruginosa

Usual Adult Dose for Corneal Ulcers:

Days 1 and 2: Instill 1 to 2 drops in the affected eye(s) every 30 minutes while awake and about 4 and 6 hours after retiring.
Days 3 through 7 to 9: Instill 1 to 2 drops in the affected eye(s) every hour while awake.
Days 7 to 9 through treatment completion: Instill 1 to 2 drops in the affected eye(s) 4 times a day.
Use: For the treatment of bacterial corneal ulcers due to susceptible strains of S aureus, S epidermidis, S pneumoniae, P aeruginosa, Serratia marcescens, Propionibacterium acnes

Usual Pediatric Dose for Bacterial Conjunctivitis:

1 year or older:
-Days 1 and 2: Instill 1 to 2 drops in the affected eye(s) every 2 to 4 hours.
-Days 3 through 7: Instill 1 to 2 drops in the affected eye(s) 4 times a day.
Use: For the treatment of bacterial conjunctivitis due to susceptible strains of S aureus, S epidermidis, S pneumoniae, E cloacae, H influenzae, P mirabilis, P aeruginosa

Usual Pediatric Dose for Corneal Ulcers:

1 year or older:
-Days 1 and 2: Instill 1 to 2 drops in the affected eye(s) every 30 minutes while awake and about 4 and 6 hours after retiring.
-Days 3 through 7 to 9: Instill 1 to 2 drops in the affected eye(s) every hour while awake.
-Days 7 to 9 through treatment completion: Instill 1 to 2 drops in the affected eye(s) 4 times a day.
Use: For the treatment of bacterial corneal ulcers due to susceptible strains of S aureus, S epidermidis, S pneumoniae, P aeruginosa, S marcescens, P acnes

What other drugs will affect ofloxacin ophthalmic?

It is not likely that other drugs you take orally or inject will have an effect on ofloxacin used in the eyes. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2018 Cerner Multum, Inc. Version: 6.01.

Medical Disclaimer

About ofloxacin eye drops

Type of medicine Antibacterial eye drops
Used for Eye infections in adults and children
Also called Exocin®
Available as Eye drops

Ofloxacin eye drops are used to treat bacterial eye infections. They work by helping to kill the bacteria which are causing the infection.

Eye infections are a common cause of conjunctivitis. In conjunctivitis, your eye becomes inflamed, feels gritty, and may water more than usual. The white of your eye may look red, and your eyelids may become swollen and stuck together with a discharge when you wake up in the morning. Only one eye may be infected to begin with, but it often spreads to both eyes. Most cases of infective conjunctivitis clear within a week or so without treatment. For more severe infections, or for infections which do not clear on their own, an antibiotic eye drop such as ofloxacin can be used.

Before using ofloxacin eye drops

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start using ofloxacin eye drops it is important that your doctor knows:

  • If you are pregnant or breast-feeding.
  • If you have ever had an allergic reaction to an antibiotic, or to any eye drops.
  • If you have a heart condition or an unusual heart rhythm.
  • If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.

How to use ofloxacin eye drops

  1. Wash your hands well before you use the drops.
  2. Remove the cap.
  3. Tilt your head back a little and pull the lower lid of your eye downwards to form a pocket.
  4. Hold the bottle upside down near to your eye. Try not to touch your eye as you do this.
  5. Apply enough pressure to the bottle to release one drop into your eye.
  6. Close your eye for a minute or two, and press gently on the side of your nose where the corner of your eye meets your nose. This helps to stop the drop from draining away and keeps it in your eye.
  7. Repeat the process in your other eye if you have been told to use the drops in both eyes.
  8. Replace the cap.

Getting the most from your treatment

  • Before you start the treatment, read the manufacturer’s printed information leaflet from the pack. The manufacturer’s leaflet will give you more information about the drops, and a full list of side-effects which you may experience from using them.
  • If your eyes have an obvious discharge or ‘crust’, it can help if you bathe them with cool clean water before using ofloxacin.
  • Use the drops regularly, exactly as your doctor tells you to. If the infection is severe, this is likely to be every 2-4 hours for the first two days. (Just use the drops while you are awake – you do not need to wake yourself up during the night to put them in.) On day three, reduce the frequency down to four times a day.
  • If your symptoms do not improve within a few days, or if they become worse, speak again with your doctor.
  • When you first put the drops into your eye, it may cause blurred vision. This should quickly clear, but make sure you can see clearly again before you drive or use machines or tools.
  • Take care to avoid spreading the infection from one eye to the other, and to other members of your family. Washing your hands regularly (particularly after touching your eyes), and not sharing towels or pillows will help to prevent the infection from spreading.
  • If the tip of the bottle touches your eye(s) when putting the drops in, it is a good idea to squeeze out two or three drops straightaway on to some tissue and rinse the tip with salt water.
  • Eye infections, or using ofloxacin eye drops, may cause your eyes to become more sensitive to sunlight than usual. Wearing sunglasses may help to protect your eyes.
  • If you are using any other eye drops, leave at least five minutes between applying each preparation. This is to prevent more liquid going into your eye than it can handle. Otherwise the drops will overflow from your eye and not have the intended effect.
  • Even when your eye appears normal again, there may still be some bacteria present. It is important to continue to use the drops for a further 48 hours once your eye appears normal. This will help to make sure that all the bacteria have been killed. It is likely that you may need to use the drops for about a week, but you should not use them for any longer than 10 days.
  • Do not wear contact lenses until your symptoms have completely gone. Wait for 24 hours after the last dose of eye drops before using your lenses again.

Can ofloxacin eye drops cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with ofloxacin eye drops. You will find a full list in the manufacturer’s information leaflet supplied with the drops. Speak with your doctor if any of the following continue or become troublesome.

Common ofloxacin eye drop side-effects What can I do if I experience this?
Eye irritation or discomfort This is usually mild and does not last for long
Blurred vision If this happens, do not drive until you can see clearly again

If you experience any other symptoms which you think may be due to the drops, speak with your doctor or pharmacist.

How to store ofloxacin eye drops

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.
  • Throw away the bottle after you have finished the course of treatment, even if there is some liquid left. Never keep opened bottles of eye drops to use later.

Important information about all medicines

The drops are for use in the eyes only. If someone swallows some, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.

This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.

If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are using.

If you buy any medicines check with a pharmacist that they are suitable to take with your other medicines.

Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

If you have any questions about this medicine ask your pharmacist.

Ofloxacin Eye Drops
Rx

Ofloxacin Eye Drops for Dogs and Cats

Prescription Ofloxacin Eye Drops stop bacterial eye infections in their tracks and give dogs and cats quick relief from pain, swelling, itching and discomfort.

  • Prescribed for bacterial eye infections
  • Broad-spectrum antibiotic treatment
  • For cats and dogs
  • Easy to use dropper top bottle

Bacterial eye infections can cause a host of problems for your dog or cat including swelling, pain, itching, and light sensitivity. And these infections can easily spread between pets. To treat bacterial eye infections, veterinarians often prescribe Ofloxacin Eye Drops, a broad-spectrum topical antibiotic. The active ingredient, Ofloxacin, belongs to a class of medicines called quinolone antibiotics which work at the genetic level to stop bacteria from multiplying so the infection doesn’t spread and quickly dies. Ofloxacin is only for bacterial eye infections and is not effective on other types of infections. The dropper top on the bottle helps direct the drops right into your pet’s eyes. To learn what pet parents think about Ofloxacin Eye Drops, click the “Reviews” tab above.

What you should know about Ofloxacin Eye Drops:

  • Talk to your pet’s veterinarian before using this product.
  • Follow dosing directions exactly – don’t give your pet more medication than directed and don’t skip doses.
  • Read the label carefully for information about storage, possible side effects, and drug interactions.

For additional information about Ofloxacin Eye Drops, click the “More Information” and “Package Insert” tabs above.

Resistance is a major concern when giving antibiotics. Resistance occurs when bacteria survive and mutate and are then able to survive even after antibiotics are given. To help avoid any resistance, it is important to give antibiotics as they are prescribed for as long as they are prescribed even if your pet is looking and feeling better.

About the author

Leave a Reply

Your email address will not be published. Required fields are marked *