Nabumetone for back pain

Nabumetone (Oral)

nab-UE-me-tone

Oral route(Tablet)

NSAIDs cause an increased risk of serious or fatal cardiovascular thrombotic events, myocardial infarction, and stroke. Nabumetone is contraindicated in the setting of CABG surgery. NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events .

Medically reviewed by Drugs.com. Last updated on Dec 26, 2018.

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Commonly used brand name(s)

In the U.S.

  • Relafen

Available Dosage Forms:

  • Tablet

Therapeutic Class: Analgesic

Pharmacologic Class: NSAID

Chemical Class: Acetic Acid (class)

Uses for nabumetone

Nabumetone is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain and help relieve symptoms of arthritis (osteoarthritis and rheumatoid arthritis), such as inflammation, swelling, stiffness, and joint pain. Nabumetone does not cure arthritis and will help you only as long as you continue to take it .

Nabumetone is available only with your doctor’s prescription .

Before using nabumetone

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For nabumetone, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to nabumetone or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of nabumetone in the pediatric population. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of nabumetone in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution in patients receiving nabumetone .

Pregnancy

Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking nabumetone, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using nabumetone with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Ketorolac

Using nabumetone with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abciximab
  • Aceclofenac
  • Acemetacin
  • Acenocoumarol
  • Amiloride
  • Amineptine
  • Amitriptyline
  • Amitriptylinoxide
  • Amoxapine
  • Amtolmetin Guacil
  • Anagrelide
  • Apixaban
  • Ardeparin
  • Argatroban
  • Aspirin
  • Balsalazide
  • Bemiparin
  • Bendroflumethiazide
  • Benzthiazide
  • Betamethasone
  • Betrixaban
  • Bismuth Subsalicylate
  • Bivalirudin
  • Bromfenac
  • Budesonide
  • Bufexamac
  • Bumetanide
  • Cangrelor
  • Celecoxib
  • Certoparin
  • Chlorothiazide
  • Chlorthalidone
  • Choline Magnesium Trisalicylate
  • Choline Salicylate
  • Cilostazol
  • Citalopram
  • Clomipramine
  • Clonixin
  • Clopamide
  • Clopidogrel
  • Cortisone
  • Cyclopenthiazide
  • Cyclosporine
  • Dabigatran Etexilate
  • Dalteparin
  • Danaparoid
  • Deflazacort
  • Desipramine
  • Desirudin
  • Desmopressin
  • Desvenlafaxine
  • Dexamethasone
  • Dexibuprofen
  • Dexketoprofen
  • Diazoxide
  • Dibenzepin
  • Diclofenac
  • Diflunisal
  • Digoxin
  • Dipyridamole
  • Dipyrone
  • Dothiepin
  • Doxepin
  • Droxicam
  • Duloxetine
  • Edoxaban
  • Enoxaparin
  • Eplerenone
  • Epoprostenol
  • Eptifibatide
  • Escitalopram
  • Ethacrynic Acid
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Feverfew
  • Floctafenine
  • Flufenamic Acid
  • Fluocortolone
  • Fluoxetine
  • Flurbiprofen
  • Fluvoxamine
  • Fondaparinux
  • Furosemide
  • Ginkgo
  • Gossypol
  • Heparin
  • Hydrochlorothiazide
  • Hydrocortisone
  • Hydroflumethiazide
  • Ibuprofen
  • Iloprost
  • Imipramine
  • Indapamide
  • Indomethacin
  • Inotersen
  • Ketoprofen
  • Lepirudin
  • Levomilnacipran
  • Lithium
  • Lofepramine
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Magnesium Salicylate
  • Meadowsweet
  • Meclofenamate
  • Mefenamic Acid
  • Melitracen
  • Meloxicam
  • Mesalamine
  • Methotrexate
  • Methyclothiazide
  • Methylprednisolone
  • Metolazone
  • Milnacipran
  • Morniflumate
  • Nabumetone
  • Nadroparin
  • Naproxen
  • Nefazodone
  • Nepafenac
  • Niflumic Acid
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Nortriptyline
  • Olsalazine
  • Opipramol
  • Oxaprozin
  • Oxyphenbutazone
  • Paramethasone
  • Parecoxib
  • Parnaparin
  • Paroxetine
  • Pemetrexed
  • Pentosan Polysulfate Sodium
  • Pentoxifylline
  • Phenindione
  • Phenprocoumon
  • Phenylbutazone
  • Phenyl Salicylate
  • Piketoprofen
  • Piroxicam
  • Pixantrone
  • Polythiazide
  • Pralatrexate
  • Prasugrel
  • Prednisolone
  • Prednisone
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Protein C
  • Protriptyline
  • Reboxetine
  • Reviparin
  • Rivaroxaban
  • Rofecoxib
  • Salicylamide
  • Salicylic Acid
  • Salsalate
  • Sertraline
  • Sibutramine
  • Sodium Salicylate
  • Spironolactone
  • Sulfasalazine
  • Sulindac
  • Tacrolimus
  • Tenofovir Disoproxil Fumarate
  • Tenoxicam
  • Tianeptine
  • Tiaprofenic Acid
  • Ticagrelor
  • Ticlopidine
  • Tinzaparin
  • Tirofiban
  • Tolfenamic Acid
  • Tolmetin
  • Torsemide
  • Treprostinil
  • Triamterene
  • Trichlormethiazide
  • Trimipramine
  • Trolamine Salicylate
  • Valdecoxib
  • Venlafaxine
  • Vilazodone
  • Vorapaxar
  • Vortioxetine
  • Warfarin
  • Xipamide

Using nabumetone with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acebutolol
  • Alacepril
  • Atenolol
  • Azilsartan
  • Azilsartan Medoxomil
  • Benazepril
  • Betaxolol
  • Bisoprolol
  • Candesartan Cilexetil
  • Captopril
  • Carteolol
  • Carvedilol
  • Celiprolol
  • Dicumarol
  • Enalapril
  • Enalaprilat
  • Eprosartan
  • Esmolol
  • Fosinopril
  • Irbesartan
  • Labetalol
  • Levobunolol
  • Lisinopril
  • Losartan
  • Metipranolol
  • Metoprolol
  • Moexipril
  • Nadolol
  • Nebivolol
  • Olmesartan Medoxomil
  • Oxprenolol
  • Penbutolol
  • Perindopril Erbumine
  • Pindolol
  • Practolol
  • Propranolol
  • Quinapril
  • Ramipril
  • Sotalol
  • Spirapril
  • Telmisartan
  • Timolol
  • Trandolapril
  • Valsartan

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using nabumetone with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use nabumetone, or give you special instructions about the use of food, alcohol, or tobacco.

  • Tobacco

Other medical problems

The presence of other medical problems may affect the use of nabumetone. Make sure you tell your doctor if you have any other medical problems, especially:

  • Anemia or
  • Asthma or
  • Bleeding problems or
  • Blood clots or
  • Edema (fluid retention or body swelling) or
  • Heart attack, history of or
  • Heart disease (e.g., congestive heart failure) or
  • High blood pressure or
  • Kidney disease or
  • Liver disease (e.g., hepatitis) or
  • Stomach or intestinal ulcers or bleeding or
  • Stroke, history of—Use with caution. Nabumetone may make these conditions worse .
  • Aspirin sensitivity, history of—Nabumetone should NOT be used in patients with this condition .
  • Heart surgery (e.g., coronary artery bypass graft surgery)—Nabumetone should NOT be used to relieve pain right before or after the surgery .

Proper use of nabumetone

For safe and effective use of nabumetone, do not take more of it, do not take it more often, and do not take it for a longer time than ordered by your doctor. Taking too much of nabumetone may increase the chance of unwanted effects, especially in elderly patients .

When used for severe or continuing arthritis, nabumetone must be taken regularly as ordered by your doctor in order for it to help you. Nabumetone usually begins to work within one week, but in severe cases up to two weeks or even longer may pass before you begin to feel better. Also, several weeks may pass before you feel the full effects of nabumetone.

You may take nabumetone with or without food .

Dosing

The dose of nabumetone will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of nabumetone. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For osteoarthritis and rheumatoid arthritis:
      • Adults—At first, 1000 milligrams (mg) once a day, in the morning or evening, or 500 mg twice a day, in the morning and evening. Your doctor may increase the dose, if necessary, up to a total of 2000 mg a day.
      • Children—Use and dose must be determined by your doctor .

Missed dose

If you miss a dose of nabumetone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions while using nabumetone

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood and urine tests may be needed to check for unwanted effects .

Nabumetone may raise your risk of having a heart attack or stroke. This is more likely in people who already have heart disease. People who use nabumetone for a long time might also have a higher risk .

Nabumetone may cause bleeding in your stomach or intestines. These problems can happen without warning signs. This is more likely if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, if you are over 60 years old, if you are in poor health, or if you are using certain other medicines (a steroid or a blood thinner) .

Serious skin reactions can occur during treatment with nabumetone. Check with your doctor right away if you have any of the following symptoms while taking nabumetone: blistering, peeling, loosening of skin, chills, cough, diarrhea, fever, itching, joint or muscle pain, red skin lesions, sore throat, sores, ulcers, or white spots in mouth or on lips, or unusual tiredness or weakness .

Possible warning signs of some serious side effects that can occur during treatment with nabumetone may include swelling of the face, fingers, feet, and/or lower legs; severe stomach pain, black, tarry stools, and/or vomiting of blood or material that looks like coffee grounds; unusual weight gain; yellow skin or eyes; decreased urination; unusual bleeding or bruising; and/or skin rash. Also, signs of serious heart problems could occur such as chest pain, tightness in chest, fast or irregular heartbeat, unusual flushing or warmth of skin, weakness, or slurring of speech. Stop taking nabumetone and check with your doctor immediately if you notice any of these warning signs .

Nabumetone may also cause a serious type of allergic reaction called anaphylaxis. Although this is rare, it may occur more often in patients who are allergic to aspirin or to any of the nonsteroidal anti-inflammatory drugs. Anaphylaxis requires immediate medical attention. The most serious signs of this reaction are very fast or irregular breathing, gasping for breath, wheezing, or fainting. Other signs may include changes in color of the skin of the face; very fast but irregular heartbeat or pulse; hive-like swellings on the skin; and puffiness or swellings of the eyelids or around the eyes. If these effects occur, get emergency help at once .

Using nabumetone while you are pregnant can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away .

Nabumetone may make your skin more sensitive to sunlight. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds .

Before having any kind of surgery or medical tests, tell your doctor that you are taking nabumetone. It may be necessary for you to stop treatment for a while, or to change to a different nonsteroidal anti-inflammatory drug before your procedure .

Nabumetone side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  • Headache
  • itching skin
  • nausea
  • rash
  • stomach pain
  • swelling

Less common

  • Burning feeling in chest or stomach
  • indigestion
  • stomach upset
  • swelling or inflammation of the mouth
  • tenderness in stomach area
  • vomiting

Rare

  • Bleeding gums
  • blistering, peeling, loosening of skin
  • bloody or black, tarry stools
  • bloody or cloudy urine
  • burning upper abdominal pain
  • changes in vision
  • chest pain
  • chills
  • clay-colored stools
  • constipation
  • cough
  • dark-colored urine
  • diarrhea
  • difficult or labored breathing
  • difficulty swallowing
  • dizziness
  • dry cough
  • dry mouth
  • fast heartbeat
  • fever
  • fluid-filled skin blisters
  • general feeling of tiredness or weakness
  • greatly decreased frequency of urination or amount of urine
  • high blood pressure
  • hives or welts
  • increased sensitivity of skin to sunlight
  • increased thirst
  • joint pain, stiffness, or swelling
  • large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs
  • light-colored stools
  • loss of appetite
  • muscle pain
  • pain in lower back or side
  • pinpoint red spots on skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • rapid breathing
  • red irritated eyes
  • red skin lesions, often with a purple center
  • redness or other discoloration of skin
  • severe or continuing stomach pain
  • severe sunburn
  • shortness of breath
  • skin thinness
  • sore throat
  • sores, ulcers, or white spots in mouth or on lips
  • stomach bloating, burning, or cramping
  • swelling of face, fingers, feet or lower legs
  • tightness in chest
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vaginal bleeding
  • vomiting of blood or material that looks like coffee grounds
  • weight gain or loss
  • wheezing
  • yellow eyes or skin

Symptoms of overdose

  • Agitation
  • blurred vision
  • coma
  • confusion
  • depression
  • hostility
  • irregular, fast or slow, or shallow breathing
  • irritability
  • muscle twitching
  • nervousness
  • pain or discomfort in chest, upper stomach, or throat
  • pale or blue lips, fingernails, or skin
  • pounding in the ears
  • seizures
  • severe stomach pain
  • slow heartbeat
  • stupor
  • unusual drowsiness, dullness, or feeling of sluggishness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Acid or sour stomach
  • belching
  • bloated full feeling
  • continuing ringing or buzzing or other unexplained noise in ears
  • excess air or gas in stomach or intestines
  • hearing loss
  • indigestion
  • mild diarrhea
  • passing gas

Less common

  • Increased sweating
  • sleepiness or unusual drowsiness
  • sleeplessness
  • trouble sleeping
  • unable to sleep

Rare

  • Anxiety
  • burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
  • feeling of constant movement of self or surroundings
  • general feeling of discomfort or illness
  • increased appetite
  • lack or loss of strength
  • lightheadedness
  • sensation of spinning
  • shakiness in legs, arms, hands, feet
  • trembling or shaking of hands or feet

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 2019 Truven Health Analytics, Inc. All Rights Reserved.

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More about nabumetone

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  • 69 Reviews
  • Drug class: Nonsteroidal anti-inflammatory drugs
  • FDA Alerts (3)

Consumer resources

  • Nabumetone

Other brands: Relafen, Relafen DS

Professional resources

  • Nabumetone (AHFS Monograph)
  • … +2 more

Related treatment guides

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  • Frozen Shoulder
  • Muscle Pain
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About nabumetone

Type of medicine A non-steroidal anti-inflammatory drug (NSAID)
Used for Relief of pain and inflammation in adults with arthritis
Also called Relifex®
Available as Tablets

Anti-inflammatory painkillers like nabumetone are also called non-steroidal anti-inflammatory drugs (NSAIDs), or sometimes just ‘anti-inflammatories’. Nabumetone is prescribed for people with osteoarthritis or rheumatoid arthritis. It eases pain and reduces inflammation.

Nabumetone works by blocking the effect of natural substances called cyclo-oxygenase (COX) enzymes. These enzymes help to make other chemicals in the body, called prostaglandins. Some prostaglandins are produced at sites of injury or damage, and cause pain and inflammation. By blocking the effect of COX enzymes, fewer prostaglandins are produced, which means pain and inflammation are eased.

Before taking nabumetone

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking nabumetone it is important that your doctor knows:

  • If you have ever had a stomach or duodenal ulcer, or if you have an inflammatory bowel disorder such as Crohn’s disease or ulcerative colitis.
  • If you have asthma or any other allergic disorder.
  • If you are pregnant, trying for a baby, or breast-feeding.
  • If you have any problems with the way your liver works, or if you have any problems with the way your kidneys work.
  • If you have a heart condition or a problem with your blood vessels or circulation.
  • If you have high blood pressure.
  • If you have any blood clotting problems.
  • If you have a connective tissue disorder such as systemic lupus erythematosus. This is an inflammatory condition which is also called lupus or SLE.
  • If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
  • If you have ever had an allergic reaction to any other NSAID (such as aspirin, naproxen, ibuprofen, and indometacin), or to any other medicine.

How to take nabumetone

  • Before you start the treatment, read the manufacturer’s printed information leaflet from inside the pack. It will give you more information about nabumetone, and it will also provide you with a full list of the side-effects which you could experience from taking it.
  • The usual dose is 0.5-1 g daily, taken as one or two 500 mg tablets. You will be asked to take the tablets at the end of the day. If your doctor prescribes a higher dose than this for you, you will be asked to take a dose in the morning as well. This will be in addition to the dose you take in the evening. Take nabumetone exactly as your doctor tells you to.
  • You should take nabumetone after a meal, or with a snack. Taking the tablets with some food will help to protect your stomach from side-effects such as indigestion and stomach irritation.
  • If you forget to take a dose, don’t worry, just take the next dose when it is due. Do not take two doses together to make up for a missed dose.

Getting the most from your treatment

  • Your doctor will try to prescribe you the lowest dose for the shortest time in order to reduce the risk of side-effects. If you need to take nabumetone over a period of time, your doctor may want to prescribe another medicine along with it to protect your stomach from irritation.
  • Try to keep any regular appointments with your doctor. This is so your doctor can check on your progress.
  • If you have asthma, symptoms such as wheeze or breathlessness can be made worse by anti-inflammatories such as nabumetone. If this happens to you, you should stop taking nabumetone and see a doctor as soon as possible.
  • There is known to be a small increased risk of heart and blood vessel problems in people taking some anti-inflammatory painkillers long-term. Your doctor will explain this to you and will prescribe the lowest suitable dose for the shortest time in order to reduce the risk. Do not take more than the recommended dose.
  • If you buy any medicines, check with a pharmacist that they are suitable for you to take. This is because you should not take nabumetone with any other anti-inflammatory painkiller, some of which are available in cold and flu remedies which can be bought ‘over the counter’.
  • If you are due to have an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.

Can nabumetone cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with nabumetone. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer’s printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer’s information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following continue or become troublesome.

Common nabumetone side-effects (these affect less than 1 in 10 people) What can I do if I experience this?
Feeling sick or being sick (vomiting), indigestion, stomach discomfort, wind Stick to simple meals, and remember to take your doses after a meal. If the discomfort continues, speak with your doctor
Diarrhoea Drink plenty of water
Constipation Try to eat a well-balanced diet and drink several glasses of water each day
Ear disorders, increased blood pressure, itchy rash, swollen hands or feet Speak with your doctor if you are concerned about any of these

Important: if you experience any of the following less common but possibly serious symptoms, stop taking nabumetone and contact a doctor for advice straightaway:

  • If you have any breathing difficulties such as wheeze or breathlessness.
  • If you have any signs of an allergic reaction such as swelling around your mouth or face, or a severe itchy skin rash.
  • If you pass blood or black stools, bring up blood, or have severe stomach pains.

If you experience any other symptoms which you think may be due to the tablets, speak with your doctor or pharmacist for further advice.

How to store nabumetone

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

Important information about all medicines

Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.

This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.

Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

If you have any questions about this medicine ask your pharmacist.

Are you currently using nabumetone?

Read the Medication Guide provided by your pharmacist before you start using nabumetone and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually once or twice daily with a full glass of water (8 ounces or 240 milliliters). Do not lie down for at least 10 minutes after taking this drug. To prevent stomach upset, take it with food, milk, or an antacid.

Dosage is based on your medical condition and response to treatment. To minimize side effect risks (such as stomach bleeding), use this medication at the lowest effective dose for the shortest possible length of time. Do not increase your dose or take it more often than prescribed. For chronic conditions such as arthritis, continue taking it as directed by your doctor. Discuss the risks and benefits with your doctor or pharmacist.

In certain conditions (such as arthritis), it may take up to 2 weeks when this drug is taken regularly before you notice the full benefits.

If you are taking this drug on an “as needed” basis (not on a regular schedule), remember that pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

Tell your doctor if your condition worsens.

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