MS symptoms come and go

Paroxysmal is a term for any MS symptoms that begin suddenly and only last for a few seconds or a few minutes at most. However, these symptoms may reappear a few times or many times a day in similar short bursts. They may be painful and disrupt your everyday activities or they can just be annoying. The attacks usually stop after a few months.

Many symptoms of MS can come on in a paroxysmal way including:

  • trigeminal neuralgia which gives stabbing or burning sensations down the side of your face, usually on one side only
  • altered sensations in your skin such as itching, numbness, tingling, burning or aching
  • Lhermitte’s sign which feels like an electric shock down your neck and spine
  • shooting pains in the arms or legs which can be very brief but still take your breath away
  • spasms which may cause the sudden tightening of a limb, clawing of a hand, twitching or kicking out of a leg. Spasms may affect your trunk or your face muscles
  • problems with vision including double vision(diplopia) and Uhthoff’s phenomenon which is the temporary worsening of symptoms caused by an increase in temperature
  • swallowing difficulties (dysphagia)
  • slurring of speech (dysarthria)
  • weakness, usually in your legs or feet, which can cause unsteadiness or a fall
  • lack of coordination(ataxia) which may cause you to stumble or drop things
  • freezing of movement (akinesia) which is briefly being unable to move or only being able to move slowly or with extreme difficulty.


Multiple Sclerosis: Frequently Asked Questions

What is multiple sclerosis?

Multiple sclerosis (MS) is a central nervous system disorder-that is, it affects the brain and spinal cord and spares the nerves and muscles that leave the spinal cord. MS is an inflammatory disorder in which infection-fighting white blood cells enter the nervous system and cause injury. It is a demyelinating disorder because the myelin sheath that protects nerves is stripped off during inflammation. When this happens, the nerves cannot conduct electricity as well as they should, causing various symptoms. Symptoms may be the type that come and go over time (relapsing-remitting MS) or progress over time (progressive MS). MS can happen to just about anyone and is long-term.

How is MS diagnosed?

Multiple sclerosis is often difficult to diagnose because there is no single test or finding on an exam that makes the diagnosis and because the disorder varies from person to person. In most cases, there is a history of neurological symptoms that come and go over years. The neurological exam may show changes that suggest problems with the spinal cord or brain.

The magnetic resonance imaging (MRI) may show areas of abnormality that suggest MS, though the MRI in and of itself does not make the diagnosis. Spinal fluid testing may show that the immune system is active in and around the brain and spinal cord, supporting the diagnosis. Evoked potentials may assist in diagnosis. All of these need to be put together by the physician to determine if MS is the actual diagnosis. Even when all the tests are done, some people cannot be diagnosed for years after the beginning of symptoms.

What are some early symptoms of MS?

MS varies from person to person so there is no ‘standard’ set of symptoms for MS. However, we know that common symptoms of MS include:

  • Numbness or tingling in various parts of the body
  • Walking difficulties
  • Weakness of one or more body part
  • Fatigue
  • Visual blurring, and occasionally, double vision
  • Dizziness
  • Lhermitte’s phenomenon, a symptom in which people feel electrical tingling or shocks down their back, arms, or legs when they bend their neck forwards
  • Urinary symptoms, such as hesitancy when trying to urinate, or a feeling of urgency (when you have to go, you have to go)

There is no way to predict which symptoms one person might develop.

What is demyelination?

In MS, patients develop various areas in the brain and spinal cord where the myelin is stripped off of the nerves. These areas are called plaques or sometimes lesions. When the myelin is off, the electrical conduction of these nerves is altered. It is like getting a fuzzy signal on a television set. This event may affect any aspect of central nervous system functioning, causing symptoms. The symptoms may vary over time depending on how extensive the demyelination is and on factors such as fatigue and heat.

5. What do we know about multiple sclerosis?

There has been widespread research about MS over the past 50 years. We do not know the cause of MS, but do know that it is an inflammatory disorder of the central nervous system that occurs in people with a tendency to such a problem. We know that about 350,000 people in the United States have MS, about 1 in 1,000 people. We know that it is more common further north and south of the equator. Although we are still unsure exactly why this is. Females tend to get MS about three times as often as males, a rate similar to other immune diseases. MS is more common in Caucasians, but can occur in other populations. It is not contagious, nor is it infectious.

Did I do anything to bring on the MS or make it worse?

As far as we know there are no activities that specifically cause MS or make it worse. People with MS may not tolerate heat as well as they used to and may need to avoid particularly hot or humid situations. There is evidence that having infections makes having an exacerbation of MS more likely. There does not appear to be a link to trauma. However, emotional stress has been linked to a worsening of MS symptoms. Having MS is not the fault of people who have it; it can happen to anyone.

Is there anything new that we know about MS?

Multiple sclerosis is being studied actively in many research institutions around the world, and new knowledge is being added constantly. For example, we now know that even with early MS, the nerve fibers themselves (the axons) are affected more than we knew before. We know from MRI studies that new lesions (abnormal areas in the brain or spinal cord) occur about 5 to10 times as often as people with MS have new symptoms; that is, much of the disease occurs ‘under the radar scope’. We know that myelin repair occurs in the central nervous system all the time. Some groups feel there are different types of immune or pathological processes going on that we call MS, and perhaps MS may be many different disorders that we have lumped together.

8. Do any other diseases look like MS?

When neurologists evaluate MS they are also considering other diagnoses. While MS is the most likely cause of typical white matter changes and symptoms in an otherwise healthy young person, there are some other diseases that we consider and occasionally diagnose. These include a vitamin B12 deficiency that can cause an MS-like illness, and rarely, lupus, which may have symptoms that suggest MS. The MRI is very useful in ruling out many other disorders that could be confused with MS, and the blood tests and spinal fluid may also be helpful in diagnosing other diseases.

What does magnetic resonance imaging show in MS?

Magnetic resonance imaging has become the single most useful test for the diagnosis of MS; MRI is sensitive to brain changes which are seen in MS. Classically, the MRI shows lesions in the white matter deep in the brain near the fluid spaces of the brain (the ventricles). The test may also show changes in the cortex or near the cortex. MRI can also show changes in the brainstem and in the spinal cord.

There may be a loss of brain or spinal cord volume, a change which is called atrophy. Neurologists will occasionally use gadolinium, a heavy metal dye, to look at the brain more carefully. In a lesion that is active (a new plaque), this dye will leak out into the brain and show abnormalities. It is not clear how useful repeated MRIs are for following MS. However, many neurologists will repeat an MRI about a year after starting treatment for MS, or when there are unexplained changes in the patient’s course that make it important to take another look. In MS, the MRI may not make the diagnosis, as sometimes the changes are not specific for MS. Other times the appearance may be characteristic of MS.

What are evoked potentials, and what are they used for?

Evoked potentials are tests where different sets of nerves are stimulated, and the activity of the brain, spinal cord, or nerves is measured electrically. Visual evoked potentials are done by flashing a checkerboard image in front of the patient and recording the brain’s response at the back of the head. Auditory evoked responses are stimulated with a clicking noise in the ears, recording the brain’s response. Somatosensory evoked responses are recorded after stimulation of the nerves usually in the arms or legs and are a measure of the nerve activity coming up the nerves and into the spinal cord. In MS, these tests may be normal but may show changes such as slower electricity conduction along the nerve pathways. In MS, visual evoked potentials are the most useful as they may show evidence of injury to the optic nerve not suspected clinically.

What is the lumbar puncture (spinal tap) for?

The lumbar puncture helps to show signs of inflammation and immune system activity in and around the brain and spinal cord. The test is really the only direct measure of immune activity that we can use clinically. In people with MS, there may be an increase in white blood cells and antibody formation in the spinal fluid. There may be ‘oligoclonal’ bands, which are a measure of immune activity found in MS but also in other immune disorders. Spinal fluid helps to diagnose other diseases such as Lyme disease and lymphomas of the nervous system. Not everyone needs a lumbar puncture, but it can be very useful.

Are there different types of MS?

MS varies from patient to patient so that each individual has their own set of symptoms, problems, and their own course. There are people who have MS so mildly that they never even know that they have it. Of course, there are also others that have it severely. It is really a spectrum that ranges from mild to severe. An international panel of experts developed a classification of MS in 1999 that most neurologists use today:

  • Relapsing-remitting: Patients have attacks of symptoms/signs, with or without recovery, but between attacks have no interval worsening.
  • Secondary progressive: This is often after a few years of relapsing-remitting MS. The pattern changes from a relapsing pattern to progressive in between attacks, usually with fewer attacks.
  • Primary progressive: This involves a gradual onset from the beginning and no attacks.
  • Progressive relapsing: This is a rare form, and begins with a progressive course, while later developing attacks.
  • Fulminant: This is a rare form, and is very severe, rapidly progressive MS.

Is there such a thing as benign MS?

The term, “benign MS,” is not part of the international classification. It is used when people have had MS for many years without developing significant measurable disability. Recent studies have shown that it cannot be predicted early in the disease and so the term can only really be used retrospectively, after people have done very well with MS for many years.

What is an attack?

An MS attack is also known as a ‘relapse’, an ‘exacerbation,’ or a ’bout’ of MS. All of these terms mean the same thing–usually a worsening of MS symptoms or new MS symptoms lasting more than 48 hours and not due to infection or fever. An attack may be mild or severe; it may or may not correlate with MRI changes, though neurologists do not usually perform MRI imaging as part of an attack evaluation. Many patients have a daily variation of their symptoms; this is not an attack. Similarly, some patients may develop transient symptoms lasting only seconds such as twitching in an arm or a leg. This is also not an attack. Attacks are one marker of disease activity.

What is the prognosis (outlook) for MS?

Most people think that MS is a rapidly disabling disorder. This is not true for most people with MS. A recent study of people with MS in the Olmstead county area near the Mayo clinic showed that most people did well even without treatment. An older study showed that after 25 years without treatment most people were still able to walk. However, only a small percentage of people followed for years do not show some measurable signs of MS on examination.

Will the medications for MS make me feel better?

There are now 16 FDA-approved medications to control the course of MS, all for the treatment of relapsing-remitting MS. There are currently no FDA approved medications for the treatment of progressive MS. In general, the medications do not ‘make you feel better,’ but do reduce MS activity. People treated for MS are less likely to develop new attacks, have fewer new MRI changes, and tend not to progress as much as those on no treatment. So, while the medications may not make people feel better in the present, they do help prevent people from feeling worse in the future.

What is spasticity?

Spasticity is an increased muscle tension and tightness that may interfere with useful movements. It is often present when people have had MS for a few years, and tends to happen more often in the legs than in the rest of the body. Phasic spasms are rapid movements of limbs that occur suddenly, such as sudden flexing of a leg. Tonic spasms are a tightening of limbs in place. Spasticity may be painful and may interfere with walking, transferring, and sitting; in general, this is when spasticity is treated. While patients with spasticity may be weak, the two are not the same, and strength may be preserved in someone with spasticity.

Do people with MS get pain?

In the past, physicians thought that MS did not cause pain. However, recent studies have shown that up to one-third of people with MS will have pain related to their MS at some time during the course of their disease. This pain comes in a variety of forms, including trigeminal neuralgia, a syndrome involving sharp, stabbing pain in the side of the face or the jaw. It may come and go for days, weeks, or even longer. Medication may help with this. Some people develop back or neck pain, similar to the pain that many other people get. Some patients may get burning or tingling pain in the legs, arms, or body which may stay or come and go. Pain is part of MS and should be treated appropriately.

Do people with MS get bladder problems?

Some people with MS will have problems with bladder function due to injury to the nerves that tell the bladder and the sphincters what to do and to the nerves that help the bladder sense when it is full. The most common symptom of bladder problems in MS is urgency, a feeling that “when you have to go, you have to go.” Sometimes people find that it is hard to start going, for the urine to flow. Some people cannot tell when they have to go, or may have accidents (incontinence).

Many of these symptoms can be treated either with medication or with approaches such as self-catheterization, which allows the bladder to be emptied whenever it needs to be. People with MS and bladder problems are at a higher risk of urinary tract infections. Bladder problems in MS may range from being a nuisance to being a major problem that needs to be addressed.

Is fatigue part of MS?

Fatigue, a sensation of being tired all the time, is very common in MS. Most patients with MS feel tired more than they used to, despite getting sleep at night. While fatigue in MS can be due to a lack of sleep or poor sleep, it is often just one of the symptoms of MS. It may be due to activation of the immune system, like fighting off an infection. It may be due to having to work harder to re-route information in the brain because of the MS. In any case, it can be treated. Taking naps helps with afternoon fatigue.

Regular exercise actually improves fatigue symptoms. Avoiding very heavy meals may help. Making sure that night-time sleep is good is also useful. There are medications that have been shown to be helpful in MS-related fatigue.

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Multiple Sclerosis (MS) Symptoms

The most common first symptoms of MS are:

  • numbness and tingling in one or more extremities, in the trunk, or on one side of the face
  • weakness, tremor, or clumsiness in the legs or hands
  • partial loss of vision, double vision, eye pain, or areas of visual alteration

Other common symptoms include the following.


Fatigue is a common and often the most debilitating symptom of MS. It may occur in several different forms:

  • activity-related fatigue
  • fatigue due to deconditioning (not being in good shape)
  • depression
  • lassitude—also known as “MS fatigue”

The fatigue associated with MS is often worse in the late afternoon.

Bladder and bowel dysfunction

Bladder and bowel dysfunction can be ongoing or intermittent problems in MS. Bladder frequency, waking up at night to void, and bladder accidents can be symptoms of this problem. Bowel dysfunction can result in constipation, bowel urgency, loss of control, and irregular bowel habits.


Weakness in multiple sclerosis can be related to an exacerbation or a flare-up, or can be an ongoing problem.

Cognitive changes

Cognitive changes related to MS can be obvious or very subtle. They may include memory loss, poor judgment, decreased attention span, and difficulty reasoning and solving problems.

Acute and chronic pain

Like symptoms of weakness, pain in MS can be acute or chronic. Burning sensations and electric shock–like pain can occur spontaneously or in response to being touched.

Muscle spasticity

MS spasticity can affect your mobility and comfort. Spasticity can be defined as spasms or stiffness and may involve pain and discomfort.


Both clinical depression and a similar, less severe emotional distress are common in people with MS. About 50 percent of people with MS experience depression at some time during their illness.

Since revealing her diagnosis in late 2018, Selma Blair has solidified herself as an inspirational and realistic representation of life with multiple sclerosis—a chronic disease that, as Selma bravely shares on Instagram, can cause an series of side effects from muscle spasms, to a “glitchy” brain, to insomnia. Most recently, the illness called for a treatment so intense that it left Selma bald (and owning it!). But these recent symptoms are not necessarily the first signs of multiple sclerosis in women—or what sent Selma to the doc in the first place.

At first, Selma thought she was just suffering from a pinched nerve—it wasn’t until she fell in front of her doctor that she was diagnosed with multiple sclerosis. However, Blair, 47, thinks she’s had the disease for much longer. “I have probably had this incurable disease for 15 years at least,” she wrote on her original Instagram revelation in October.

Unfortunately, since there’s no one single test for multiple sclerosis, “the diagnosis can be missed, delayed or even incorrect,” according to the National Multiple Sclerosis Society. But in the wise words of your third grade teacher: knowledge is power. Knowing the signs of multiple sclerosis in women can help make you that much more prepared to take action if you notice something seems off down the line.

Real quick: What is multiple sclerosis again?

Multiple sclerosis (MS) is a disease of the central nervous system, which affects the brain and spinal cord. MS basically blocks the messages that flow between the brain and the body, often resulting in vision problems, muscle weakness, coordination issues, numbness, and thinking or memory problems, according to the National Institutes of Health.

Selma is just one 2.3 million people worldwide who suffer from MS, according to the National MS Society. There’s no cure for the disease, though treatments and disease-modifying therapies can slow or delay the progression of symptoms.

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While 15 years seems like a long time to go undiagnosed, it’s entirely possible—that’s because MS symptoms can be hard to nail down. “A lot of the symptoms are kind of non-specific,” says Jonathan Howard, M.D., a neurologist at NYU Langone’s Multiple Sclerosis Comprehensive Care Center—that means many symptoms aren’t only seen in MS patients.

In fact, it’s not uncommon for doctors to misdiagnose patients, ultimately delaying their treatment, says Amit Sachdev, M.D., an assistant professor and director of the Division of Neuromuscular Medicine at Michigan State University.

If you’re experiencing any of these concerning multiple sclerosis symptoms, check in with your doctor to figure out what’s up. (But don’t go into defcon-5 just yet; many other health issues could be to blame.)

1. Your foot keeps falling asleep.

Normally, you only get that prickly pins-and-needles feeling when you’ve put pressure on your leg for too long, temporarily cutting off blood flow. But if you find that your arms, legs, hands, or feet feel numb, burning, or tingly out of nowhere, that can be a sign of MS, Segil says.

2. You’re tired, like, all the time.

You’re inevitably going to come across those days when you just can’t even. But sudden spells of severe exhaustion that last for weeks and mess with your ability to function normally on a day-to-day basis might be an indication that MS is destroying the nerves and fibers in your spinal column.

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“People with MS describe their fatigue as overwhelming, making even simple tasks difficult,” says Costello. “It is often out of proportion with your activity, is not relieved by sleep, and is worsened if you become overheated.”

3. You stop getting your period.

Any illness that affects your immune system, including multiple sclerosis, may cause amenorrhea, or the loss of your period, says Segil. Missing a period every so often is not a big deal—everything from stress to traveling to the flu can temporarily throw your reproductive system out of sync—but if your period is gone for more than three months in a row or your cycle becomes erratic, it’s time to talk to a doctor.

4. You have trouble swallowing or speaking sometimes.

Issues with speech and swallowing typically go hand-in-hand (their medical names are actually dysphagia and dysarthrias), per the National MS Society.

As far as speech goes, damaged areas of the brain can affect speech patterns, causing slurring or a more nasal sound to your voice.

Your brain is also largely in control of swallowing (tbh, your brain is in control of pretty much everything)—and yeah, not being able to swallow properly should definitely raise a red flag.

5. You’ve been especially clumsy lately.

“People often think they just have bad balance but having weakness in one or both of your limbs could be a sign that something is wrong with your motor nerves,” Segil says. So if you find yourself tripping, stumbling, feeling unsteady, or falling frequently for no reason, get to a doctor ASAP.

6. You’re having trouble multitasking, or you’ve been really moody.

About 60 percent or more of those diagnosed with MS experience some form of cognitive or emotional distress, according to Kathleen Costello, a nurse practitioner and associate vice president of healthcare access at the National Multiple Sclerosis Society.

Those with MS can suffer from impaired recall, difficulty with depression, irritability, sudden mood swings, and uncontrollable fits of crying or laughter.

7. You’re feeling some pretty weird sensations.

Sensory issues are a strange but common sign of multiple sclerosis. “My patients often say that their body just feels different, on a sensory level, from one part to the next,” Segil explains. “For example, when they put on their shirt, it feels differently sliding over their chest than it does going over their stomach.”

Half of people diagnosed with MS also have chronic pain, which is usually coupled with involuntary spasms, inexplicable weakness, or stiffness in the muscles. “It is often described as heaviness or like the limb is worn out,” says Costello. The legs are usually the first extremity to bear the brunt of the muscular woes, but the back is also a typical problem area.

8. You can’t distinguish between colors anymore.

If you previously had a good eye for color, don’t brush this off, Segil says. “It’s called optic neuritis and it happens because of a loss of insulation around the optic nerves in the brain; it’s one of the primary symptoms of multiple sclerosis,” he explains.

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But it’s not just color-related: MS can also manifest as partial blindness, color blindness, blind spots, or blindness only in one eye. “Some people describe this as looking through a smudged contact lens, or looking through a screen or through water,” says Costello. “It may also be associated with pain or a pulling sensation during eye movement.”

The onset of MS-related vision problems is usually slow, since the deterioration of the eyes happens over time. Optic neuritis can also happen on its own—without necessarily being associated with multiple sclerosis—as a result of an infection, a vitamin deficiency, or other autoimmune diseases.

9. You’re forgetting everything.

If you’ve forgotten your bestie’s birthday, lost your keys five times in one week, and rewashed the same clean laundry twice, you might worry you have early-onset Alzheimer’s disease.

The good news is that Alzheimer’s is extremely rare in young women. The bad news is that problems with short-term memory or other cognitive issues can be MS symptoms in women.

10. You’re always drinking water, but you rarely have to pee.

Being able to hydrate all day without visiting the ladies room may seem like an awesome talent, but it’s not a good thing. It’s a hallmark of multiple sclerosis, especially if you’re stopped up for more than 24 hours, Segil says.

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However, any big change in urinary frequency can be an MS symptom in women, and is often how people end up getting diagnosed, he adds. Sometimes it’s the opposite, and you have to pee all the time.

“Many people with MS report a sense of ‘gotta-go’ bladder urgency or may need to use the restroom more frequently,” says Costello. “Sometimes they are even awakened during the night by the urge to urinate.” Dysfunctional bathroom habits and bowel problems occur in about 80 percent of people with MS, and the inability to hold in your pee is often accompanied by constipation, diarrhea, and uncontrollable bowel movements as well.

11. You randomly get dizzy or nauseated.

One of the earliest MS symptoms in women is extreme dizziness or vertigo caused by nerve damage that messes with your motor, sensory, and coordination systems, making you feel disoriented, unsteady, dizzy, or even nauseated.

12. You’re having trouble texting or typing.

“One of the first things we often see in MS patients is the inability to text, type, use a cellphone or tablet, or do other things that require fine motor control,” Segil says. As multiple sclerosis advances, it can cause “lesions,” or areas of damage on your nervous system. If you get a lesion on the back region of the brain, it can hurt your manual dexterity, he explains.

13. You’re having trouble getting aroused.

Sexual arousal starts in the central nervous system—so your brain actually has to send messages to your sexual organs to get them revved up. But in MS, since the brain-body connection isn’t working properly, your body might not get the memo that you’re ready for action, according to the National MS Society.

Sexual problems are actually pretty common among women with MS—as many as 72 percent of female patients are affected by sexual issues including reduced sensation in the vaginal or clitoral area (or painfully heightened sensations), along with vaginal dryness.

14. You can’t tell if something’s hot or cold.

An inability to sense temperature changes with your hands is another symptom of MS-induced nerve damage, Segil says.

15. You’ve tested negative for every other disease, but you still feel ill.

“Multiple sclerosis is considered one of the ‘great masqueraders’, along with lupus, because its symptoms are so easily attributed to other causes or illnesses,” Segil says. “Because the symptoms depend entirely on which nerves are affected, no two patients will present the same.”

For many women, this means that they only get an accurate diagnosis of MS after their doctors have ruled everything else out. Fortunately, an MRI scan can spot the telltale “lesions” of the disease, so don’t be afraid to ask about getting tested for it, he adds.

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