Methylprednisolone and drinking alcohol

Medrol Dosepak (methylprednisolone) Drug Interactions

A total of 466 drugs are known to interact with Medrol Dosepak (methylprednisolone).

  • 77 major drug interactions
  • 352 moderate drug interactions
  • 37 minor drug interactions

Show all medications in the database that may interact with Medrol Dosepak (methylprednisolone).

Check for interactions

Type in a drug name to check for interactions with Medrol Dosepak (methylprednisolone).

Most frequently checked interactions

View interaction reports for Medrol Dosepak (methylprednisolone) and the medicines listed below.

  • Benadryl (diphenhydramine)
  • Celebrex (celecoxib)
  • Coumadin (warfarin)
  • Cymbalta (duloxetine)
  • Flexeril (cyclobenzaprine)
  • gabapentin
  • hydrocodone
  • ibuprofen
  • ibuprofen
  • Medrol (methylprednisolone)
  • naproxen
  • Norco (acetaminophen / hydrocodone)
  • omeprazole
  • prednisone
  • prednisone
  • tramadol
  • tramadol
  • Tylenol (acetaminophen)
  • Vitamin D3 (cholecalciferol)
  • Zyrtec (cetirizine)

Medrol Dosepak (methylprednisolone) alcohol/food interactions

There are 3 alcohol/food interactions with Medrol Dosepak (methylprednisolone)

Medrol Dosepak (methylprednisolone) disease interactions

There are 24 disease interactions with Medrol Dosepak (methylprednisolone) which include:

  • GI perforation
  • infections
  • prematurity
  • PUD
  • vaccination
  • (+) tuberculin test
  • cirrhosis
  • depression/psychoses
  • diabetes
  • electrolyte imbalance
  • fluid retention
  • hyperadrenocorticalism
  • hyperlipidemia
  • hypothyroidism
  • liver disease
  • MI
  • myasthenia gravis
  • myopathy
  • ocular herpes simplex
  • ocular toxicities
  • osteoporosis
  • scleroderma
  • strongyloidiasis
  • thromboembolism

More about Medrol Dosepak (methylprednisolone)

  • Side Effects
  • During Pregnancy or Breastfeeding
  • Dosage Information
  • Compare Alternatives
  • Support Group
  • Pricing & Coupons
  • En Español
  • 21 Reviews
  • Drug class: glucocorticoids
  • FDA Alerts (12)

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  • … +11 more

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.


Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.


Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.


Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.


No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

methylprednisolone (Rx)


Untreated serious infections

Documented hypersensitivity to drug or components (eg, lactose monohydrate from cow milk)

Intrathecal administration

Systemic fungal infection (except intra-articular injection in localized joint conditions)

IM route is contraindicated in idiopathic thrombocytopenic purpura

Premature infants (formulations containing benzyl alcohol only)

Traumatic brain injury (high doses)

Administration of live or live, attenuated vaccines is contraindicated in patients receiving immunosuppressive doses of corticosteroids


Use with caution in cirrhosis, ocular herpes simplex, hypertension, diverticulitis, hypothyroidism, myasthenia gravis, peptic ulcer disease, osteoporosis, ulcerative colitis, psychotic tendencies, renal insufficiency, pregnancy, diabetes mellitus, history of seizure disorders, multiple sclerosis, thromboembolic disorders, myocardial infarction

Long-term treatment: Risk of osteoporosis, myopathy, delayed wound healing

Minimal mineralocorticoid activity

Use in septic shock or sepsis syndrome not proven effective and may increase mortality in some patients including patients with elevated serum creatinine and patients who develop secondary infections

Clearance of corticosteroids may increase in hyperthyroid patients and decrease in hypothyroid ones; dose adjustments may be necessary

Patients receiving corticosteroids should avoid chickenpox or measles-infected persons if unvaccinated

Latent tuberculosis may be reactivated (patients with positive tuberculin test should be monitored)

Some suggestion (not fully substantiated) of slightly increased cleft palate risk if corticosteroids are used in pregnancy

May cause hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing syndrome, or hyperglycemia

Prolonged corticosteroid use may result in elevated IOP, glaucoma, or cataracts

Killed or inactivated vaccines may be administered; however, the response to such vaccines cannot be predicted

Immunization procedures may be undertaken in patients who are receiving corticosteroids as replacement therapy in physiologic doses (eg, for Addison’s disease)

Injection may result in dermal and/or subdermal changes forming depressions in the skin at injection site; to minimize incidence of dermal and subdermal atrophy, care must be exercised not to exceed recommended doses in injections; avoid injection into deltoid muscle due to high incidence of subcutaneous atrophy

Increased dosage of rapidly acting corticosteroids indicated in patients on corticosteroid therapy subjected to any unusual stress before, during, and after the stressful situation

Not for use in the treatment of traumatic brain injury

Average and large doses of corticosteroids can cause elevation of blood pressure, salt and water retention, and increased excretion of potassium; dietary salt restriction and potassium supplementation may be necessary; all corticosteroids increase calcium excretion

Drug induced secondary adrenocortical insufficiency may be minimized by gradual reduction of dosage; relative insufficiency may persist for months after discontinuation of therapy; therefore, in situation of stress occurring during that period, hormone therapy should be reinstituted

Rarely, high doses of cyclically pulsed intravenous methylprednisolone (usually for the treatment of exacerbations of multiple sclerosis at doses of 1 g/day) can induce a toxic form of acute hepatitis; discontinue therapy if it occurs; since recurrence has occurred after re-challenge, avoid use in patients with a history of toxic hepatitis caused by methylprednisolone

With increasing doses of corticosteroids, the rate of occurrence of infectious complications increases; corticosteroids may also mask some signs of current infection; corticosteroids may exacerbate systemic fungal infections and should not be used in presence of such infections unless needed to control drug reactions; latent amebiasis or active amebiasis should be ruled out before initiating corticosteroid therapy patients who have spent time in tropics or patients with unexplained diarrhea

Lowest possible dose should be used to control condition under treatment; when reduction in dosage possible, reduction should be gradual

Risk/benefit decision must be made in each individual case as to dose and duration of treatment and as to whether daily or intermittent therapy should be used

Kaposi’s sarcoma reported in patients receiving corticosteroid therapy, most often for chronic conditions; discontinuation of therapy may result in clinical improvement

Although controlled clinical trials have shown corticosteroids to be effective in speeding the resolution of acute exacerbations of multiple sclerosis, they do not affect the ultimate outcome or natural history of the disease

Psychic derangements may appear when corticosteroids used, ranging from euphoria, insomnia, mood swings, personality changes, and severe depression, to frank psychotic manifestations; also, existing emotional instability or psychotic tendencies may be aggravated by corticosteroids

Give consideration to potential for hypersensitivity reactions to cow’s milk ingredients in Solumedrol; if appropriate, stop administration of injection solution Solumedrol and treat patient’s condition accordingly; alternative treatments, including use of corticosteroid formulations that do not contain ingredients produced from cow’s milk, should be considered for acute allergy management

Increased incidence of scleroderma reported in patients with systemic sclerosis; use caution

Epidural injection

  • Serious neurologic events, some resulting in death, have been reported with epidural injection
  • Specific events reported include, but are not limited to, spinal cord infarction, paraplegia, quadriplegia, cortical blindness, and stroke
  • These serious neurologic events have been reported with and without use of fluoroscopy
  • Safety and effectiveness of epidural administration of corticosteroids have not been established, and corticosteroids are not approved for this use

Methylprednisolone preserved with benzyl alcohol

  • Methylprednisolone preserved with benzyl alcohol should not be administered to neonates, infants, pregnant women, or breastfeeding women
  • Benzyl alcohol is associated with serious adverse events and death, particularly in pediatric patients (gasping syndrome, characterized by CNS depression, metabolic acidosis, and gasping respirations)

methylprednisolone (oral) (Medrol, Medrol Dosepak, MethylPREDNISolone Dose Pack)

Brand Names: Medrol, Medrol Dosepak, MethylPREDNISolone Dose Pack

Generic Name: methylprednisolone (oral)

  • What is methylprednisolone (Medrol, Medrol Dosepak, MethylPREDNISolone Dose Pack)?
  • What are the possible side effects of methylprednisolone (Medrol, Medrol Dosepak, MethylPREDNISolone Dose Pack)?
  • What is the most important information I should know about methylprednisolone (Medrol, Medrol Dosepak, MethylPREDNISolone Dose Pack)?
  • What should I discuss with my healthcare provider before taking methylprednisolone (Medrol, Medrol Dosepak, MethylPREDNISolone Dose Pack)?
  • How should I take methylprednisolone (Medrol, Medrol Dosepak, MethylPREDNISolone Dose Pack)?
  • What happens if I miss a dose (Medrol, Medrol Dosepak, MethylPREDNISolone Dose Pack)?
  • What happens if I overdose (Medrol, Medrol Dosepak, MethylPREDNISolone Dose Pack)?
  • What should I avoid while taking methylprednisolone (Medrol, Medrol Dosepak, MethylPREDNISolone Dose Pack)?
  • What other drugs will affect methylprednisolone (Medrol, Medrol Dosepak, MethylPREDNISolone Dose Pack)?
  • Where can I get more information (Medrol, Medrol Dosepak, MethylPREDNISolone Dose Pack)?

What is methylprednisolone (Medrol, Medrol Dosepak, MethylPREDNISolone Dose Pack)?

Methylprednisolone is a steroid that prevents the release of substances in the body that cause inflammation.

Methylprednisolone is used to treat many different inflammatory conditions such as arthritis, lupus, psoriasis, ulcerative colitis, allergic disorders, gland (endocrine) disorders, and conditions that affect the skin, eyes, lungs, stomach, nervous system, or blood cells.

Methylprednisolone may also be used for purposes not listed in this medication guide.


round, white, imprinted with MEDROL 2


oval, orange, imprinted with Medrol 8


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Methylprednisolone 16 mg 683820918

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Methylprednisolone 32 mg 683820919

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Methylprednisolone 4 mg 683820916

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Methylprednisolone 4 mg-BAR

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Methylprednisolone 4 mg-GRE

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Methylprednisolone 4 mg-WAT

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Methylprednisolone 8 mg 683820917

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What are the possible side effects of methylprednisolone (Medrol, Medrol Dosepak, MethylPREDNISolone Dose Pack)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • shortness of breath (even with mild exertion), swelling, rapid weight gain;
  • bruising, thinning skin, or any wound that will not heal;
  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • severe depression, changes in personality, unusual thoughts or behavior;
  • new or unusual pain in an arm or leg or in your back;
  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • seizure (convulsions); or
  • low potassium–leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling.

Steroids can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.

Common side effects may include:

  • fluid retention (swelling in your hands or ankles);
  • dizziness, spinning sensation;
  • changes in your menstrual periods;
  • headache;
  • mild muscle pain or weakness; or
  • stomach discomfort, bloating.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about methylprednisolone (Medrol, Medrol Dosepak, MethylPREDNISolone Dose Pack)?

You should not use this medicine if you have a fungal infection anywhere in your body.


Methylprednisolone is the generic form of the brand-name drug Solu-Medrol, a corticosteroid that relieves inflammation and improves problems caused by a decrease in adrenal gland function.

The medicine is used to treat a variety of conditions, including:

  • Multiple sclerosis
  • Certain types of arthritis
  • Intestinal disorders such as ulcerative colitis
  • Severe allergies
  • Asthma
  • Flares of chronic obstructive pulmonary disease (COPD)
  • Lupus
  • Skin disorders such as psoriasis
  • Blood, kidney, eye, and thyroid problems
  • Cancer

The Food and Drug Administration (FDA) approved methylprednisolone in 1957.

Solu-Medrol is manufactured by Pharmacia and Upjohn Company, a division of Pfizer, Inc.

Methylprednisolone Warnings

Before taking methylprednisolone, tell your doctor if you have or have had:

  • A fungal infection or any other type of infection
  • Allergies to medicines or foods
  • A history of bleeding problems
  • Congestive heart failure or a recent heart attack
  • High blood pressure
  • Kidney or liver problems
  • Low potassium levels
  • Diabetes
  • Seizures
  • An underactive thyroid
  • Adrenal gland problems
  • Fluid retention
  • Mental or mood disorders
  • Eye conditions such as glaucoma, cataracts, or a herpes infection of the eye
  • A recent diagnosis of chickenpox, measles, or shingles
  • Human immunodeficiency virus (HIV)
  • Tuberculosis (TB)
  • Stomach or intestinal problems such as ulcers or ulcerative colitis
  • Inflammation of the esophagus
  • A recent intestinal surgery
  • A recent head trauma
  • Recent vaccinations
  • Weak bones or muscle problems

Also, be sure to tell your physician if you’re taking the drug mifepristone (Mifeprex) before starting on methylprednisolone.

Some forms of Solu-Medrol solution may contain benzyl alcohol. This may cause serious or life-threatening harm in newborns or infants.

Talk to your doctor before giving this medicine to a baby.

Corticosteroids such as methylprednisolone may cause serious harm if they’re administered into the spine with an epidural. These medicines are not approved for this type of use.

Methylprednisolone may lower your body’s ability to fight infections. Try to avoid contact with people who are sick or have infections.

Talk to your doctor before receiving any vaccination while on methylprednisolone. Also, if you haven’t had chickenpox, measles, or shingles, avoid contact with anyone who does.

If you have diabetes, methylprednisolone may affect your blood sugar levels. Check your blood sugar often, and talk to your doctor before you alter any doses of your diabetes medications.

Corticosteroids such as methylprednisolone may affect growth in kids and teens. Talk to your doctor if you’re concerned about this potential side effect.

Your doctor will likely perform frequent laboratory tests while you take methylprednisolone. Be sure to keep all appointments with your health care provider.

This medicine may interfere with skin allergy tests. Be sure to tell your physician you’re taking methylprednisolone before having this type of test.

Tell your doctor you’re taking this medicine before having any type of surgery, including a dental procedure.

Pregnancy and Methylprednisolone

It’s not known whether methylprednisolone will harm an unborn baby.

Talk to your doctor if you’re pregnant or plan to become pregnant before taking this drug.

It’s also not known if the medicine passes into breast milk or could harm a breastfeeding baby. Talk to your physician before using this drug while breastfeeding.

Methylprednisolone and Alcohol

Methylprednisolone can cause dizziness. Alcohol use may worsen the dizziness side effects associated with this drug, so you should limit alcohol consumption while taking it.

Alcohol use with methylprednisolone has also been shown to increase risk for stomach bleeding.

Methylprednisolone Versus Prednisone

Although they have similar names, methylpredisolone and prednisone are different drugs and can’t and shouldn’t be used interchangeably.

Talk with your doctor or pharmacist if you have any questions about your medication.

Methylprednisolone Coupons and Prices

Looking to save money on a prescription for methylprednisolone? SingleCare, a leading online service for prescription, dental, and vision discounts, has partnered with most major pharmacies around the country to help you save up to 80 percent off prescription costs. Click on “Free Coupon” below and sign up to get your free SingleCare pharmacy savings card. You’ll receive a coupon by email or text to get the best price at a local participating pharmacy near you.

Is It Safe to Mix Prednisone (Steroids) and Alcohol?

The effects of mixing prednisone and other steroids and alcohol substances have been debated over time. Large amounts of steroids and alcohol may lead to gastrointestinal problems such as bleeding or ulcers. However, some steroids include alcohol in the mix to make them work effectively. If addiction is a concern, know that the larger the amounts taken, the higher the tolerance and the more dangerous it is. For more information about the dangers of steroid and alcohol use, contact us.

Risks of Mixing Prednisone and Alcohol

Corticosteroids, such as prednisone, may be prescribed for a number of reasons. Prednisone is a strong anti-inflammatory medication that is normally produced naturally in the body. When the body is inflamed, the addition of this drug can help it return to normal. However, if someone is addicted to steroid and alcohol, it could cause damage in the end. Treatment for addiction to steroid and alcohol abuse is important, as both substances are harmful to the body when overused.

The importance of not drinking alcohol with steroids may be due to the underlying condition, more than due to the drug being taken. Steroids often treat endocrine disorders, which can react poorly to alcohol use. It is important to stay away from the use of steroids (or to be monitored while taking steroids) if you have some conditions, such as thyroid disorders, diabetes, osteoporosis, myasthenia gravis, tuberculosis, stomach ulcers, diverticulitis, congestive heart failure, high blood pressure, and others. It is not known if prednisone alone will cause damage to unborn children, but alcohol can. The combination may result in unknown consequences.

It is possible to develop a dependency on prednisone steroids and alcohol. Prednisone mimics a natural chemical in the body, so if it is stopped too quickly you may have withdrawal symptoms. Long-term use of steroids such as prednisone can result in many problems, such as the thinning of the skin, bruising easily, and having changes in the location of fat on the body. This is partially due to changes in hormonal levels during the drug’s use.

Have you been drinking?

Can you drink alcohol while taking methylprednisolone tablets?

Methylprednisolone is a corticosteroid, is similar to a natural hormone produced by your adrenal glands. It is often used to replace this chemical when your body does not make enough of it. It relieves inflammation and is used to treat certain forms of arthritis; skin, blood, kidney, eye, thyroid, and intestinal disorders; severe allergies and asthma. Methylprednisolone is also used to treat certain types of cancer.

It may be quite okay to drink the occasional glass of alcohol while taking methylprednisolone especially if your dose is low and you’re not taking it for long-term treatment of a chronic condition such as arthritis or adrenal insufficiency.

Methylprednisolone suppresses the immune system which makes it useful to treat symptoms of certain autoimmune disorders like multiple sclerosis, Crohn’s disease, and rheumatoid arthritis.

Alcohol also suppresses the immune system so it would be a good idea to avoid alcohol as much as possible if being treated for an autoimmune disease as the combination could be problematic if you were to develop an infection.

Alcohol and methylprednisolone can each irritate the digestive tract and cause peptic ulcers. Combining the two may be problematic if you are prone to indigestion or stomach upset.

Always check with your doctor if it safe to drink alcohol as though know your medical history.

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