- Can Low-T Cause Migraines?
- Testosterone — What It Does And Doesn’t Do
- The Connection Between Low Testosterone and Headaches
Can Low-T Cause Migraines?
“One of the reliable side effects is that it impairs sperm, so if a man wants to have children, I don’t use it,” Dr. Alukal said. Testosterone is also not appropriate for men who have high red blood cell counts. And, there are mixed data on what role testosterone replacement can or should play among men with prostate cancer.
Merle L. Diamond, MD, associate director of the Diamond Headache Clinic in Chicago, always asks about a person’s libido during diagnosis. “Low testosterone has been reported as a cause of headache pain, and sometimes we will test for it,” she said.
And Jed Diamond, PhD, author of the book Men Alive: Stop Killer Stress With Simple Energy Healing Tools and director of the MenAlive men’s health program in Willits, Calif., noted that there’s no downside to measuring testosterone levels in men with headache or other health complaints. “This should be done as part of a regular checkup,” he said. “There are all sorts of health problems that are associated with low testosterone, and headache may be one of them. It’s feasible that treating low testosterone in people who are having headaches will improve them.”Low-T and Migraine Headaches: The Future
Although a lot of work remains to be done on this men’s health issue, the theory that low testosterone may play a role in the origin of headaches is not at all far-fetched.
“It makes sense because we know that migraines are caused by hormonal changes,” said Spyros G. Mezitis, MD, a New York-based endocrinologist. Still, he said, more study is needed before any blanket statements can be made about what role, if any, testosterone plays in causing or treating migraines in men.
Testosterone — What It Does And Doesn’t Do
Updated: August 29, 2019Published: July, 2015
When you think of testosterone, what comes to mind? Macho men? Aggressive, impatient, type A behavior? Road rage? Violence?
Testosterone’s role in bad behavior is largely a myth. What’s more, testosterone plays other important roles in health and disease that may surprise you. For example, did you know that testosterone is a key player in prostate cancer? Or, that women need testosterone, too? There’s more to testosterone than guys behaving badly.
Testosterone is the major sex hormone in males and plays a number of important roles, such as:
- The development of the penis and testes
- The deepening of the voice during puberty
- The appearance of facial and pubic hair starting at puberty; later in life, it may play a role in balding
- Muscle size and strength
- Bone growth and strength
- Sex drive (libido)
- Sperm production
Adolescent boys with too little testosterone may not experience normal masculinization. For example, the genitals may not enlarge, facial and body hair may be scant and the voice may not deepen normally.
Testosterone may also help maintain normal mood. There may be other important functions of this hormone that have not yet been discovered.
Signals sent from the brain to the pituitary gland at the base of the brain control the production of testosterone in men. The pituitary gland then relays signals to the testes to produce testosterone. A “feedback loop” closely regulates the amount of hormone in the blood. When testosterone levels rise too high, the brain sends signals to the pituitary to reduce production.
If you thought testosterone was only important in men, you’d be mistaken. Testosterone is produced in the ovaries and adrenal gland. It’s one of several androgens (male sex hormones) in females. These hormones are thought to have important effects on:
- Ovarian function
- Bone strength
- Sexual behavior, including normal libido (although evidence is not conclusive)
The proper balance between testosterone (along with other androgens) and estrogen is important for the ovaries to work normally. While the specifics are uncertain, it’s possible that androgens also play an important role in normal brain function (including mood, sex drive and cognitive function).
Did You Know?
Testosterone is synthesized in the body from cholesterol. But having high cholesterol doesn’t mean your testosterone will be high. Testosterone levels are too carefully controlled by the pituitary gland in the brain for that to occur.
The Perils of Too Much Testosterone
Having too much naturally-occurring testosterone is not a common problem among men. That may surprise you given what people might consider obvious evidence of testosterone excess: road rage, fighting among fathers at Little League games and sexual promiscuity.
Part of this may be due to the difficulty defining “normal” testosterone levels and “normal” behavior. Blood levels of testosterone vary dramatically over time and even during the course of a day. In addition, what may seem like a symptom of testosterone excess (see below) may actually be unrelated to this hormone.
In fact, most of what we know about abnormally high testosterone levels in men comes from athletes who use anabolic steroids, testosterone or related hormones to increase muscle mass and athletic performance.
Problems associated with abnormally high testosterone levels in men include:
- Low sperm counts, shrinking of the testicles and impotence (seems odd, doesn’t it?)
- Heart muscle damage and increased risk of heart attack
- Prostate enlargement with difficulty urinating
- Liver disease
- Fluid retention with swelling of the legs and feet
- Weight gain, perhaps related in part to increased appetite
- High blood pressure and cholesterol
- Increased muscle mass
- Increased risk of blood clots
- Stunted growth in adolescents
- Uncharacteristically aggressive behavior (although not well studied or clearly proven)
- Mood swings, euphoria, irritability, impaired judgment, delusions
Among women, perhaps the most common cause of a high testosterone level is polycystic ovary syndrome (PCOS). This disease is common. It affects 6% to 10% of premenopausal women.
The ovaries of women with PCOS contain multiple cysts. Symptoms include irregular periods, reduced fertility, excess or coarse hair on the face, extremities, trunk and pubic area, male-pattern baldness, darkened, thick skin, weight gain, depression and anxiety. One treatment available for many of these problems is spironolactone, a diuretic (water pill) that blocks the action of male sex hormones.
Women with high testosterone levels, due to either disease or drug use, may experience a decrease in breast size and deepening of the voice, in addition to many of the problems men may have.
Too Little Testosterone
In recent years, researchers (and pharmaceutical companies) have focused on the effects of testosterone deficiency, especially among men. In fact, as men age, testosterone levels drop very gradually, about 1% to 2% each year — unlike the relatively rapid drop in estrogen that causes menopause. The testes produces less testosterone, there are fewer signals from the pituitary telling the testes to make testosterone, and a protein (called sex hormone binding globulin (SHBG) increases with age. All of this reduces the active (free) form of testosterone in the body. More than a third of men over age 45 may have reduced levels of testosterone than might be considered normal (though, as mentioned, defining optimal levels of testosterone is tricky and somewhat controversial).
Symptoms of testosterone deficiency in adult men include:
- Reduced body and facial hair
- Loss of muscle mass
- Low libido, impotence, small testicles, reduced sperm count and infertility
- Increased breast size
- Hot flashes
- Irritability, poor concentration and depression
- Loss of body hair
- Brittle bones and an increased risk of fracture
Some men who have a testosterone deficiency have symptoms or conditions related to their low testosterone that will improve when they take testosterone replacement. For example, a man with osteoporosis and low testosterone can increase bone strength and reduce his fracture risk with testosterone replacement.
As surprising as it may be, women can also be bothered by symptoms of testosterone deficiency. For example, disease in the pituitary gland may lead to reduced testosterone production from the adrenal glands disease. They may experience low libido, reduced bone strength, poor concentration or depression.
There are times when low testosterone is not such a bad thing. The most common example is probably prostate cancer. Testosterone may stimulate the prostate gland and prostate cancer to grow. That’s why medications that lower testosterone levels (for example, leuprolide) and castration are common treatments for men with prostate cancer. Men taking testosterone replacement must be carefully monitored for prostate cancer. Although testosterone may make prostate cancer grow, it is not clear that testosterone treatment actually causes cancer.
Diseases and Conditions That Affect Testosterone
Men can experience a drop in testosterone due to conditions or diseases affecting the:
- Testes – direct injury, castration, infection, radiation treatment, chemotherapy, tumors
- Pituitary and hypothalamus glands – tumors, medications (especially steroids, morphine or related drugs and major tranquilizers, such as haloperidol), HIV/AIDS, certain infections and autoimmune conditions
Genetic diseases, such as Klinefelter syndrome (in which a man has an extra x-chromosome) and hemochromatosis (in which an abnormal gene causes excessive iron to accumulate throughout the body, including the pituitary gland) can also affect testosterone.
Women may have a testosterone deficiency due to diseases of the pituitary, hypothalamus or adrenal glands, in addition to removal of the ovaries. Estrogen therapy increases sex hormone binding globulin and, like aging men, this reduces the amount of free, active testosterone in the body.
Currently, testosterone therapy is approved primarily for the treatment of delayed male puberty, low production of testosterone (whether due to failure of the testes, pituitary or hypothalamus function) and certain inoperable female breast cancers.
However, it is quite possible that testosterone treatment can improve symptoms in men with significantly low levels of active (free) testosterone, such as:
- Generalized weakness
- Low energy
- Disabling frailty
- Problems with sexual function
- Problems with cognition.
However, many men with normal testosterone levels have similar symptoms so a direct connection between testosterone levels and symptoms is not always clear. As a result, there is some controversy about which men should be treated with supplemental testosterone.
Testosterone therapy may make sense for women who have low testosterone levels and symptoms that might be due to testosterone deficiency. (It’s not clear if low levels without symptoms are meaningful; treatment risks may outweigh benefits.) However, the wisdom and effectiveness of testosterone treatment to improve sexual function or cognitive function among postmenopausal women is unclear.
People with normal testosterone levels are sometimes treated with testosterone at the recommendation of their doctors or they obtain the medication on their own. Some have recommended it as a “remedy” for aging. For example, a study from Harvard Medical School in 2003 found that even among men who started out with normal testosterone results noted loss of fat, increased muscle mass, better mood, and less anxiety when receiving testosterone therapy. Similar observations have been noted among women. However, the risks and side effects of taking testosterone when the body is already making enough still discourages widespread use.
The Bottom Line
Testosterone is so much more than its reputation would suggest. Men and women need the proper amount of testosterone to develop and function normally. However, the optimal amount of testosterone is far from clear.
Checking testosterone levels is as easy as having a blood test. The difficult part is interpreting the result. Levels vary over the course of the day. A single low level may be meaningless in the absence of symptoms, especially if it was normal at another time. We need more research to know when to measure testosterone, how best to respond to the results and when it’s worthwhile to accept the risks of treatment.
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The Connection Between Low Testosterone and Headaches
The quantity of testosterone in the body defines and develops male characteristics, such as voice, depth, facial hair, large muscles, and sperm production. And while levels of this hormone start declining after age 30, lower-than-normal testosterone levels can affect sex drive, muscle strength, and bone density. Get your hormone levels checked by an endocrinologist.
Migraines and persistent headaches also often accompany low T. Here we look into the possible connection between low T and headaches, and whether one causes the other:
Migraines and The Estrogen Effect:
Estrogen and progesterone (testosterone’s female counterpart) levels fluctuate during menstruation, pregnancy and menopause. These fluctuations have widely been known to be a common causative factor of migraine and other cluster headaches in women, often stopping entirely post-menopause; when estrogen production stops.
However, despite representing opposite gender characteristics, testosterone and estrogen are present in both men and women. It is this estrogen-testosterone imbalance that may contribute towards migraine in men with low testosterone levels. In such cases, estrogen production increases, while testosterone levels reduce or remain the same. Testosterone replacement therapy, which is commonly used for low T treatment, has been proposed for treating migraines in men and women.
Multiple studies have focused on the effect of low testosterone and high estrogen levels on migraine and generalized headaches in men, along with the effect of Low T therapy on migraine treatment. Some of the most popular include:
- A 2018 Leiden University Medical Centre, Netherlands study , in which researchers took blood samples from 39 men of similar age and health; 17 of whom already suffered from regular migraines. According to the results, estrogen levels in migraine sufferers were 50% higher than their non-migraine peers, despite having similar, normal levels of testosterone.
- A 2012 study published in the post-reproductive health journal Maturitas observed the effect of testosterone therapy in pre- and postmenopausal women with migraines. According to the results, implanting small testosterone pellets under the skin relieved the condition equally in both groups.
The Other Scenario:
While reduced production in male reproductive organs is the prime cause of low T, a small number of men with migraine and low T may have low levels of the hormone due to an abnormality in the pituitary gland, which is responsible for hormone production and regulation. This increases the likelihood of other hormonal deficiencies being the prime cause of migraines instead of, or in addition to, testosterone deficiency.
The Migraine Benefits of Low-T Treatment:
While more research is needed before the mass employment of testosterone therapy for treating migraines in men and some women, the treatment can help relieve migraines in the following ways:
- Increasing serotonin levels (a substance that facilitates communication within the brain).
- Improving brain blood flow by widening blood vessels in the brain; a common cause of migraine.
- Reducing swelling in the brain.
- Resuming normal electrical activity in the brain by stopping Cortical Spreading Depression (CSD).
Careful consideration is required before opting for low T therapy due to multiple possible health risks for men:
- Increased risk of prostate cancer, heart attack, stroke, and death
- Fertility issues due to reduced sperm production
- Breast and prostate enlargement
- Blood clots in veins
- Acne and oily skin
- Testicle shrinkage
- Sleep apnea
In women, the therapy has the following side-effects:
- Facial and body hair
- Male-pattern hair loss
- Oily skin and acne
- Deep voice
Despite the above-stated risks, low T therapy remains a highly effective medical treatment for stabilizing testosterone levels. If you suspect a testosterone-estrogen imbalance to be the cause of your migraines, consult with your doctor for a proper diagnosis, and whether low T therapy is for you.
You can also book an appointment with a top Endocrinologist in Lahore, Karachi and Islamabad through oladoc.com, or call our helpline at 042-3890-0939 for assistance to find the RIGHT Doctor for your hormonal concerns.
About the Writer:
Yashfa Marrium is a freelance writer and health enthusiast. You can reach her at
Disclaimer: The contents of this article are intended to raise awareness about common health issues and should not be viewed as sound medical advice for your specific condition. You should always consult with a licensed medical practitioner prior to following any suggestions outlined in this article or adopting any treatment protocol based on the contents of this article.