Hydrocodone-acetaminophen 5-325 efectos secundarios

Contents

Lortab 5/325

Medically reviewed by Drugs.com. Last updated on Nov 5, 2018.

  • Overview
  • Side Effects
  • Dosage
  • Professional
  • Tips
  • Interactions
  • More

¿Qué es acetaminophen and hydrocodone?

Hydrocodone es un medicamento opioide para el dolor. Un opioide es a veces llamado un narcótico.

Acetaminophen es un calmante del dolor de menor potencia que aumenta el efecto de hydrocodone.

Acetaminophen and hydrocodone es una medicina combinada se usa para aliviar el dolor moderado a intenso.

Acetaminophen and hydrocodone puede también usarse para fines no mencionados en esta guía del medicamento.

¿Cuál es la información más importante que debo saber sobre acetaminophen and hydrocodone?

Esta medicina puede hacer mas lenta su respiración o pararla, y puede crear hábito. Use solamente la dosis que le prescribió su médico. Nunca comparta acetaminophen and hydrocodone con otra persona.

EL USO INCORRECTO DE UNA MEDICINA NARCÓTICA PUEDE CAUSAR ADICCIÓN, SOBREDOSIS O LA MUERTE, especialmente en un niño o en otra persona que use la medicina sin una prescripción médica.

No use esta medicina si usted ha usado un inhibidor de MAO en los últimos 14 días, como isocarboxazid, linezolid, inyección de azul de metileno, phenelzine, rasagiline, selegiline, o tranylcypromine.

Una sobredosis de acetaminophen puede causar daño al hígado o la muerte. Llame a su médico de inmediato si este medicamento causa dolor en la parte superior del estómago, orina oscura, ictericia (color amarillo de la piel u ojos), somnolencia severa, debilidad o respiración muy lenta.

Deje de tomar esta medicina y llame a su médico de inmediato si usted tiene enrojecimiento de la piel o sarpullido que se extiende y causa ampollas y descamación.

¿Qué debería discutir con el profesional del cuidado de la salud antes de tomar acetaminophen and hydrocodone?

Usted no debe usar esta medicina si es alérgico a acetaminophen (Tylenol) o hydrocodone, o si usted ha usado recientemente alcohol, sedantes, tranquilizantes, u otros medicamentos narcóticos.

No use esta medicina si usted ha tomado un inhibidor de MAO en los últimos 14 días. Una interacción peligrosa de medicamentos puede ocurrir. Los inhibidores de la MAO incluyen isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, y tranylcypromine.

Algunas medicinas pueden interactuar con hydrocodone y causar una condición seria llamada el síndrome de la serotonina. Asegúrese que su médico sepa si usted también toma medicina para la depresión, enfermedad mental, enfermedad de Parkinson, dolores de cabeza por migraña, infecciones graves, o la prevención de la náusea y el vómito. Pregúntele a su médico antes de hacer cualquier cambio de cómo o cuándo usted toma sus medicamentos.

Para asegurarse que esta medicina es segura para usted, dígale a su médico si usted tiene:

  • enfermedad del hígado, cirrosis, o si usted bebe más de 3 bebidas alcohólicas al día;

  • un historial de alcoholismo o adicción a las drogas;

  • diarrea, enfermedad inflamatoria intestinal, una obstrucción intestinal, estreñimiento severo;

  • enfermedad del riñón;

  • presión arterial baja, o si está deshidratado;

  • historial de herida en la cabeza, tumor cerebral, o accidente cerebrovascular;

  • asma, EPOC (COPD, por sus siglas en Inglés), apnea al dormir, u otro trastorno de la respiración; o

  • si usted usa un sedante como Valium (diazepam, alprazolam, lorazepam, Ativan, Klonopin, Restoril, Tranxene, Versed, Xanax, y otros).

Esta medicina puede causar problemas respiratorios con mayor probabilidad en adultos mayores y en personas que están enfermas, desnutridas o de alguna forma debilitadas.

Si usted usa medicina narcótica durante su embarazo, su bebé puede volverse dependiente de la medicina. Esto puede causar síntomas de abstinencia que pueden poner en riesgo la vida del bebé después de su nacimiento. Los bebés que nacen con dependencia a un medicamento que crea hábito pueden necesitar tratamiento médico por varias semanas. Dígale a su médico si usted está embarazada o planea quedar embarazada

Acetaminophen and hydrocodone puede pasar a la leche materna y causarle daño al bebé lactante. Usted no debe amamantar mientras usa esta medicina.

¿Cómo debo tomar acetaminophen and hydrocodone?

Siga las instrucciones en la etiqueta de su prescripción. Nunca tome acetaminophen and hydrocodone en cantidades mayores, o por más tiempo de lo recetado. Una sobredosis puede causar daño al hígado o la muerte. Dígale a su médico si su medicina ya no funciona tan bien como antes en aliviar su dolor.

Hydrocodone puede crear hábito, incluso a dosis regulares. Nunca comparta esta medicina con otra persona, especialmente con alguien con historial de abuso de drogas o adicción. EL USO INCORRECTO DE UNA MEDICINA NARCÓTICA PUEDE CAUSAR ADICCIÓN, SOBREDOSIS O LA MUERTE, especialmente en un niño o en otra persona que use la medicina sin una prescripción médica. Vender o regalar acetaminophen and hydrocodone es ilegal.

Mida la medicina líquida con la jeringa de medición que viene con su medicina, o con una cuchara o taza de medición especial. Si no tiene con qué medir la dosis de su medicina, pídale una cuchara o taza de medición a su farmacéutico.

Si necesita cirugía o pruebas médicas, dígale al cirujano por adelantado que usted está usando esta medicina. Quizás necesite dejar de usar la medicina por un breve tiempo.

No deje de usar esta medicina de forma repentina después de usarla por mucho tiempo, o podría tener síntomas desagradables de abstinencia. Pregúntele a su médico como dejar de tomar acetaminophen and hydrocodone de forma segura.

Guarde a temperatura ambiente lejos de la humedad y calor. Mantenga un record de la cantidad de medicina que ha usado de cada nuevo envase. Hydrocodone es una droga de potencial de abuso y usted debería saber si alguien está usando su medicina inapropiadamente o sin prescripción.

Siempre chequee la botella para asegurarse de que ha recibido las píldoras correctas (la misma marca y el tipo) recetado por su médico.

¿Qué sucede si dejo de tomar una dosis?

Ya que acetaminophen and hydrocodone se toma cuando se necesita, usted quizás no tiene un horario establecido para tomarla. Si usted está tomando el medicamento con regularidad, tome la dosis pasada tan pronto se acuerde. Sáltese la dosis pasada si ya casi es hora para la siguiente dosis. No use más medicina para compensar por la dosis pasada.

¿Qué sucede si tomo una sobredosis?

Busque atención médica de emergencia o llame a la línea de Poison Help al 1-800-222-1222. La sobredosis de acetaminophen and hydrocodone puede causar la muerte.

Las primeras señas de una sobredosis con acetaminophen incluyen pérdida del apetito, náusea, vómitos, dolor de estómago, sudores, y confusión o debilidad. Síntomas que ocurran luego pueden incluir dolor en la parte superior del estómago, orina oscura, y color amarillo de la piel o de la parte blanca de los ojos.

Los síntomas de una sobredosis puede también incluir somnolencia intensa, pupila puntiformes, piel fría y pegajosa, debilidad muscular, desmayo, pulso débil, estado de coma, labios azules, respiración poco profunda, o no respiración.

¿Qué debo evitar mientras tomo acetaminophen and hydrocodone?

Este medicamento puede perjudicar su pensamiento o reacciones. Evite manejar u operar maquinarias antes de saber cómo acetaminophen and hydrocodone le afectará. Mareos o somnolencia severa puede causar caídas u otros accidentes.

Pregúntele a su médico o farmacéutico antes de usar cualquiera otra medicina para el resfriado, alergias, el dolor, o para dormir. Acetaminophen (a veces es abreviado como APAP) se encuentra en muchas medicinas combinadas. El tomar ciertos productos juntos puede hacer que tome demasiado acetaminophen lo que puede conducir a una sobredosis fatal. Revise la etiqueta para ver si una medicina contiene acetaminophen o APAP.

Evite beber alcohol. Le puede aumentar su riesgo de daño al hígado mientras esté tomando acetaminophen.

¿Cuáles son los efectos secundarios posibles de acetaminophen and hydrocodone?

Busque atención médica de emergencia si usted tiene síntomas de una reacción alérgica: ronchas; dificultad para respirar; hinchazón de la cara, labios, lengua, o garganta.

En casos raros, acetaminophen puede causar una reacción severa de la piel que puede ser fatal. Ésto puede ocurrir aún si usted ha tomado acetaminophen anteriormente y no tuvo ninguna reacción. Deje de tomar esta medicina y llame a su médico de inmediato si usted tiene enrojecimiento de la piel o sarpullido que se extiende y causa ampollas y descamación. Si tiene este tipo de reacción, usted nunca más debe tomar alguna medicina que contiene acetaminophen.

Llame a su médico de inmediato si usted tiene:

  • respiración superficial, latido cardíaco lento;

  • sensación de desvanecimiento, como que se va a desmayar;

  • confusión, pensamiento o comportamiento fuera de lo normal;

  • convulsiones;

  • moretones o sangrado fáciles;

  • infertilidad, periodos menstruales ausentes;

  • impotencia, problemas sexuales, pérdida de interés en la actividad sexual;

  • problemas del hígado–náusea, dolor en la parte superior del estómago, picazón, pérdida del apetito, orina oscura, heces fecales de color arcilla, ictericia (color amarillo de la piel u ojos); o

  • niveles bajos de cortisol–náusea, vomito, pérdida del apetito, mareo, cansancio o debilidad que empeoran.

Busque atención médica de inmediato si tiene síntomas del síndrome de la serotonina, como: agitación, alucinaciones, fiebre, sudoración, sacudidas, latido cardíaco rápido, rigidez muscular, espasmo, pérdida de coordinación, náusea, vómito, o diarrea.

Efectos secundarios comunes incluyen:

  • somnolencia, dolor de cabeza;

  • malestar estomacal, estreñimiento;

  • visión borrosa; o

  • boca seca.

Esta lista no menciona todos los efectos secundarios y puede ser que ocurran otros. Llame a su médico para consejos médicos relacionados a efectos secundarios. Usted puede reportar efectos secundarios llamando al FDA al 1-800-FDA-1088.

¿Qué otras drogas afectarán a acetaminophen and hydrocodone?

Medicamentos narcóticos (opioides) pueden interactuar con muchas otras drogas y causar efectos secundarios peligrosos o mortales. Asegúrese que su médico sepa si usted también usa:

  • otros medicamentos narcóticos–medicina opioide para el dolor o medicina con receta para la tos;

  • drogas que le causen sueño o respiración lenta puede–una pastilla para dormir, relajante muscular, sedante, tranquilizante, o medicina antipsicótica; o

  • drogas que afectan los niveles de la serotonina en su cuerpo–medicina para la depresión, enfermedad de Parkinson, dolores de cabeza por migraña, infecciones graves, o la prevención de la náusea y el vómito.

Esta lista no está completa. Otras drogas pueden interactuar con acetaminophen and hydrocodone, incluyendo medicinas que se obtienen con o sin receta, vitaminas, y productos herbarios. No todas las interacciones posibles aparecen en esta guía del medicamento.

¿Dónde puedo obtener más información?

  • Su farmacéutico le puede dar más información sobre acetaminophen and hydrocodone.
  • Recuerde, mantenga ésta y todas las otras medicinas fuera del alcance de los niños, no comparta nunca sus medicinas con otros, y use este medicamento sólo para la condición por la que fue recetada.
  • Se ha hecho todo lo posible para que la información que proviene de Cerner Multum, Inc. (‘Multum’) sea precisa, actual, y completa, pero no se hace garantía de tal. La información sobre el medicamento incluida aquí puede tener nuevas recomendaciones. La información preparada por Multum se ha creado para uso del profesional de la salud y para el consumidor en los Estados Unidos de Norteamérica (EE.UU.) y por lo cual Multum no certifica que el uso fuera de los EE.UU. sea apropiado, a menos que se mencione específicamente lo cual. La información de Multum sobre drogas no sanciona drogas, ni diagnóstica al paciente o recomienda terapia. La información de Multum sobre drogas sirve como una fuente de información diseñada para la ayuda del profesional de la salud licenciado en el cuidado de sus pacientes y/o para servir al consumidor que reciba este servicio como un suplemento a, y no como sustituto de la competencia, experiencia, conocimiento y opinión del profesional de la salud. La ausencia en éste de una advertencia para una droga o combinación de drogas no debe, de ninguna forma, interpretarse como que la droga o la combinación de drogas sean seguras, efectivas, o apropiadas para cualquier paciente. Multum no se responsabiliza por ningún aspecto del cuidado médico que reciba con la ayuda de la información que proviene de Multum. La información incluida aquí no se ha creado con la intención de cubrir todos los usos posibles, instrucciones, precauciones, advertencias, interacciones con otras drogas, reacciones alérgicas, o efectos secundarios. Si usted tiene alguna pregunta acerca de las drogas que está tomando, consulte con su médico, enfermera, o farmacéutico.

Copyright 1996-2012 Cerner Multum, Inc. Version: 14.12. Revision Date: 9/29/2016 5:19:04 PM.

Further information

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More about Lortab (acetaminophen / hydrocodone)

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Norco 5-325

Generic Name: acetaminophen and hydrocodone

  • What is acetaminophen and hydrocodone?
  • What are the possible side effects of acetaminophen and hydrocodone?
  • What is the most important information I should know about acetaminophen and hydrocodone?
  • What should I discuss with my healthcare provider before taking acetaminophen and hydrocodone?
  • How should I take acetaminophen and hydrocodone?
  • What happens if I miss a dose?
  • What happens if I overdose?
  • What should I avoid while taking acetaminophen and hydrocodone?
  • What other drugs will affect acetaminophen and hydrocodone?
  • Where can I get more information?

What is acetaminophen and hydrocodone?

Hydrocodone is an opioid pain medication, sometimes called a narcotic. Acetaminophen is a less potent pain reliever that increases the effects of hydrocodone.

Acetaminophen and hydrocodone is a combination medicine used to relieve moderate to severe pain.

Acetaminophen and hydrocodone may also be used for purposes not listed in this medication guide.

What are the possible side effects of acetaminophen and hydrocodone?

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

Call your doctor at once if you have:

  • noisy breathing, sighing, shallow breathing;
  • a light-headed feeling, like you might pass out;
  • liver problems–nausea, upper stomach pain, tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • low cortisol levels– nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Serious side effects may be more likely in older adults and those who are overweight, malnourished, or debilitated.

Long-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.

Common side effects include:

  • dizziness, drowsiness, feeling tired;
  • nausea, vomiting, stomach pain;
  • constipation; or
  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about acetaminophen and hydrocodone?

MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.

An overdose of acetaminophen can damage your liver or cause death. Call your doctor at once if you have pain in your upper stomach, loss of appetite, dark urine, or jaundice (yellowing of your skin or eyes).

Taking opioid medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.

Fatal side effects can occur if you use opioid medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.

Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

Hydrocodone

  • Prepak Systems Inc.
  • Provident Pharmaceuticals LLC
  • Qualitest
  • Ranbaxy Laboratories
  • Rebel Distributors Corp.
  • Redpharm Drug
  • Remedy Repack
  • Sandhills Packaging Inc.
  • Sandoz
  • Schwarz Pharma Inc.
  • Seatrace Pharmaceuticals Inc.
  • Southwood Pharmaceuticals
  • Sovereign Pharmaceuticals Ltd.
  • St Mary’s Medical Park Pharmacy
  • Stat Rx Usa
  • Sun Pharmaceutical Industries Ltd.
  • Superior Pharmeceuticals
  • Talbert Medical Management Corp.
  • Teamm Pharmaceuticals Inc.
  • UCB Pharma
  • UDL Laboratories
  • United Research Laboratories Inc.
  • Va Cmop Dallas
  • Veratex Corp.
  • Victory Pharma
  • Vintage Pharmaceuticals Inc.
  • Vistapharm Inc.
  • Watson Pharmaceuticals
  • Wockhardt Ltd.
  • WraSer Pharmaceuticals
  • Xanodyne Pharmaceuticals Inc.
  • Zyber Pharmaceuticals
  • Dosage forms

    Form Route Strength
    Suspension Oral
    Tablet Oral
    Capsule Oral
    Elixir Oral
    Solution Oral
    Tablet Oral
    Tablet Oral 5 mg/1
    Tablet, film coated Oral
    Tablet, extended release Oral 100 mg/1
    Tablet, extended release Oral 120 mg/1
    Tablet, extended release Oral 20 mg/1
    Tablet, extended release Oral 40 mg/1
    Tablet, extended release Oral 80 mg/1
    Syrup Oral
    Syrup Oral
    Kit Oral
    Cream Topical
    Capsule, extended release Oral
    Tablet, extended release Oral
    Suspension, extended release Oral
    Tablet, extended release Oral 15 mg/1
    Tablet, extended release Oral 30 mg/1
    Tablet, extended release Oral 45 mg/1
    Tablet, extended release Oral 60 mg/1
    Tablet, extended release Oral 90 mg/1
    Tablet, coated Oral
    Liquid Oral
    Capsule, extended release Oral 10 mg/1
    Capsule, extended release Oral 15 mg/1
    Capsule, extended release Oral 20 mg/1
    Capsule, extended release Oral 30 mg/1
    Capsule, extended release Oral 40 mg/1
    Capsule, extended release Oral 50 mg/1

    Prices

    Unit description Cost Unit
    Hydrocodone-Acetaminophen 7.5-500 mg/15ml Solution 473ml Bottle 60.97USD bottle
    Hydrocodone-Ibuprofen 7.5-200 mg tablet 1.13USD tablet
    Hydrocodone-Acetaminophen 10-750 mg tablet 1.1USD tablet
    Hydrocodone-Acetaminophen 7.5-325 mg tablet 0.63USD tablet
    Hydrocodone-Acetaminophen 10-325 mg tablet 0.57USD tablet
    Hydrocodone-Acetaminophen 5-325 mg tablet 0.57USD tablet
    Hydrocodone-Acetaminophen 10-660 mg tablet 0.53USD tablet
    Hydrocodone-Acetaminophen 10-500 mg tablet 0.5USD tablet
    Hydrocodone-Acetaminophen 10-650 mg tablet 0.47USD tablet
    Hydrocodone-Acetaminophen 7.5-500 mg tablet 0.47USD tablet
    Hydrocodone-Acetaminophen 2.5-500 mg tablet 0.43USD tablet
    Hydrocodone-Acetaminophen 7.5-750 mg tablet 0.43USD tablet
    Hydrocodone-Acetaminophen 5-500 mg tablet 0.4USD tablet
    Hydrocodone-Acetaminophen 7.5-650 mg tablet 0.16USD tablet
    Hydrocodone-Homatropine 5-1.5 mg/5ml Syrup 0.15USD ml

    DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only. Patents Additional Data Available

    • Filed On Filed On

      The date on which a patent was filed with the relevant government.

      Learn more

    Properties

    State Solid Experimental Properties

    Property Value Source
    melting point (°C) 198 °C PhysProp

    Predicted Properties

    Property Value Source
    Water Solubility 0.797 mg/mL ALOGPS
    logP 2.13 ALOGPS
    logP 1.96 ChemAxon
    logS -2.6 ALOGPS
    pKa (Strongest Acidic) 18 ChemAxon
    pKa (Strongest Basic) 8.61 ChemAxon
    Physiological Charge 1 ChemAxon
    Hydrogen Acceptor Count 4 ChemAxon
    Hydrogen Donor Count 0 ChemAxon
    Polar Surface Area 38.77 Å2 ChemAxon
    Rotatable Bond Count 1 ChemAxon
    Refractivity 82.74 m3·mol-1 ChemAxon
    Polarizability 32.05 Å3 ChemAxon
    Number of Rings 5 ChemAxon
    Bioavailability 1 ChemAxon
    Rule of Five Yes ChemAxon
    Ghose Filter Yes ChemAxon
    Veber’s Rule Yes ChemAxon
    MDDR-like Rule No ChemAxon

    Predicted ADMET features

    Property Value Probability
    Human Intestinal Absorption + 1.0
    Blood Brain Barrier + 0.9984
    Caco-2 permeable + 0.8621
    P-glycoprotein substrate Substrate 0.8253
    P-glycoprotein inhibitor I Inhibitor 0.6425
    P-glycoprotein inhibitor II Non-inhibitor 0.8664
    Renal organic cation transporter Inhibitor 0.6604
    CYP450 2C9 substrate Non-substrate 0.8546
    CYP450 2D6 substrate Substrate 0.8997
    CYP450 3A4 substrate Substrate 0.8168
    CYP450 1A2 substrate Non-inhibitor 0.8207
    CYP450 2C9 inhibitor Non-inhibitor 0.9412
    CYP450 2D6 inhibitor Inhibitor 0.6629
    CYP450 2C19 inhibitor Non-inhibitor 0.8402
    CYP450 3A4 inhibitor Non-inhibitor 0.7625
    CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.8675
    Ames test Non AMES toxic 0.7735
    Carcinogenicity Non-carcinogens 0.9419
    Biodegradation Not ready biodegradable 0.984
    Rat acute toxicity 3.0914 LD50, mol/kg Not applicable
    hERG inhibition (predictor I) Weak inhibitor 0.9024
    hERG inhibition (predictor II) Non-inhibitor 0.8165

    ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

    Spectra

    Mass Spec (NIST) (10.3 KB) Spectra

    Taxonomy

    Description This compound belongs to the class of organic compounds known as morphinans. These are polycyclic compounds with a four-ring skeleton with three condensed six-member rings forming a partially hydrogenated phenanthrene moiety, one of which is aromatic while the two others are alicyclic. Kingdom Organic compounds Super Class Alkaloids and derivatives Class Morphinans Sub Class Not Available Direct Parent Morphinans Alternative Parents Phenanthrenes and derivatives / Isoquinolones and derivatives / Tetralins / Coumarans / Anisoles / Aralkylamines / Alkyl aryl ethers / Piperidines / Trialkylamines / KetonesOxacyclic compounds / Azacyclic compounds / Organopnictogen compounds / Organic oxides / Hydrocarbon derivatives show 5 more Substituents Morphinan / Phenanthrene / Isoquinolone / Tetralin / Coumaran / Anisole / Alkyl aryl ether / Aralkylamine / Piperidine / BenzenoidKetone / Tertiary amine / Tertiary aliphatic amine / Oxacycle / Ether / Azacycle / Organoheterocyclic compound / Amine / Hydrocarbon derivative / Organooxygen compound / Organonitrogen compound / Organic oxide / Organic nitrogen compound / Organopnictogen compound / Carbonyl group / Organic oxygen compound / Aromatic heteropolycyclic compound show 17 more Molecular Framework Aromatic heteropolycyclic compounds External Descriptors organic heteropentacyclic compound (CHEBI:5779)

    Targets

    Binding Properties

    ×

    Property Measurement pH Temperature (°C)
    Ki (nM) 9.5 N/A N/A 22439881

    Details Binding Properties1. Mu-type opioid receptor Kind Protein Organism Humans Pharmacological action Yes Actions Agonist General Function Voltage-gated calcium channel activity Specific Function Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone… Gene Name OPRM1 Uniprot ID P35372 Uniprot Name Mu-type opioid receptor Molecular Weight 44778.855 Da Kind Protein Organism Humans Pharmacological action Yes Actions Agonist General Function Opioid receptor activity Specific Function G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine n… Gene Name OPRD1 Uniprot ID P41143 Uniprot Name Delta-type opioid receptor Molecular Weight 40368.235 Da Kind Protein Organism Humans Pharmacological action Unknown Actions Ligand General Function Opioid receptor activity Specific Function Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma m… Gene Name SIGMAR1 Uniprot ID Q99720 Uniprot Name Sigma non-opioid intracellular receptor 1 Molecular Weight 25127.52 Da

    1. Olson KM, Duron DI, Womer D, Fell R, Streicher JM: Comprehensive molecular pharmacology screening reveals potential new receptor interactions for clinically relevant opioids. PLoS One. 2019 Jun 6;14(6):e0217371. doi: 10.1371/journal.pone.0217371. eCollection 2019.

    Enzymes

    Kind Protein Organism Humans Pharmacological action Unknown Actions Substrate General Function Steroid hydroxylase activity Specific Function Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic… Gene Name CYP2D6 Uniprot ID P10635 Uniprot Name Cytochrome P450 2D6 Molecular Weight 55768.94 Da Kind Protein Organism Humans Pharmacological action Unknown Actions Substrate General Function Vitamin d3 25-hydroxylase activity Specific Function Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react… Gene Name CYP3A4 Uniprot ID P08684 Uniprot Name Cytochrome P450 3A4 Molecular Weight 57342.67 Da Kind Protein Organism Humans Pharmacological action Unknown Actions Substrate General Function Steroid hydroxylase activity Specific Function Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un… Gene Name CYP2B6 Uniprot ID P20813 Uniprot Name Cytochrome P450 2B6 Molecular Weight 56277.81 Da

    1. FDA Label: Hydrocodone Tab ER

    Kind Protein Organism Humans Pharmacological action Unknown Actions Substrate General Function Steroid hydroxylase activity Specific Function Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im… Gene Name CYP2C19 Uniprot ID P33261 Uniprot Name Cytochrome P450 2C19 Molecular Weight 55930.545 Da

    1. FDA Label: Hydrocodone Tab ER

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    There is additional data available for commercial users including Adverse Effects, Contraindications, and Blackbox Warnings. Contact us to learn more about these and other features.

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    Drug created on June 13, 2005 07:24 / Updated on February 02, 2020 04:27

    Lortab

    Medically reviewed by Sanjai Sinha, MD Last updated on Feb 10, 2019.

    • Overview
    • Side Effects
    • Dosage
    • Professional
    • Tips
    • Interactions
    • More

    What is Lortab?

    Lortab contains a combination of acetaminophen and hydrocodone. Hydrocodone is an opioid pain medication. An opioid is sometimes called a narcotic. Acetaminophen, also called Tylenol, is a less potent pain reliever that increases the effects of hydrocodone.

    Lortab is used to relieve moderate to severe pain.

    Lortab may also be used for purposes not listed in this medication guide.

    Important information

    Hydrocodone can slow or stop your breathing. Never use Lortab in larger amounts, or for longer than prescribed. Narcotic pain medicine may be habit-forming, even at regular doses. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

    MISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.

    Do not use Lortab if you have used a MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

    An overdose of acetaminophen can damage your liver or cause death. Call your doctor at once if you have nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of your skin or eyes).

    Stop taking Lortab and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

    Before taking Lortab

    You should not use Lortab if you are allergic to acetaminophen (Tylenol) or hydrocodone, or if you have recently used alcohol, sedatives, tranquilizers, or other narcotic medications.

    Do not use Lortab if you have taken a MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

    Some medicines can interact with hydrocodone and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take medicine for depression, mental illness, Parkinson’s disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.

    To make sure Lortab is safe for you, tell your doctor if you have:

    • liver disease, cirrhosis, or if you drink more than 3 alcoholic beverages per day;

    • a history of alcoholism or drug addiction;

    • diarrhea, inflammatory bowel disease, bowel obstruction, severe constipation;

    • kidney disease;

    • low blood pressure, or if you are dehydrated;

    • a history of head injury, brain tumor, or stroke;

    • asthma, COPD, sleep apnea, or other breathing disorders; or

    • if you use a sedative like Valium (diazepam, alprazolam, lorazepam, Ativan, Klonopin, Restoril, Tranxene, Versed, Xanax, and others).

    Lortab is more likely to cause breathing problems in older adults and people who are severely ill, malnourished, or otherwise debilitated.

    If you use narcotic medicine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant.

    Acetaminophen and hydrocodone can pass into breast milk and may harm a nursing baby. You should not breast-feed while using Lortab.

    How should I take Lortab?

    Take Lortab exactly as prescribed. Follow all directions on your prescription label. Never take this medicine in larger amounts, or for longer than prescribed. An overdose can damage your liver or cause death. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

    Hydrocodone may be habit-forming, even at regular doses. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription. Selling or giving away Lortab is against the law.

    Measure liquid Lortab with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

    If you need surgery or medical tests, tell the doctor ahead of time that you are using Lortab. You may need to stop using the medicine for a short time.

    Do not stop using Lortab suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

    Store at room temperature away from moisture and heat. Keep track of the amount of medicine used from each new bottle. Hydrocodone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

    Always check your bottle to make sure you have received the correct pills (same brand and type) of medicine prescribed by your doctor.

    Since Lortab is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

    Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen and hydrocodone can be fatal.

    The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

    Overdose symptoms may also include extreme drowsiness, pinpoint pupils, cold and clammy skin, muscle weakness, fainting, weak pulse, slow heart rate, coma, blue lips, shallow breathing, or no breathing

    What should I avoid while taking Lortab?

    This medication may impair your thinking or reactions. Avoid driving or operating machinery until you know how Lortab will affect you. Dizziness or severe drowsiness can cause falls or other accidents.

    Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

    Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen.

    Lortab side effects

    Get emergency medical help if you have signs of an allergic reaction to Lortab: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

    In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking Lortab and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen.

    Call your doctor at once if you have:

    • shallow breathing, slow heartbeat;

    • a light-headed feeling, like you might pass out;

    • confusion, unusual thoughts or behavior;

    • seizure (convulsions);

    • easy bruising or bleeding;

    • infertility, missed menstrual periods;

    • impotence, sexual problems, loss of interest in sex;

    • liver problems – nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

    • low cortisol levels – nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.

    Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

    Common Lortab side effects include:

    • drowsiness, headache;

    • upset stomach, constipation;

    • blurred vision; or

    • dry mouth.

    This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    What other drugs will affect Lortab?

    Narcotic (opioid) medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:

    • other narcotic medications – opioid pain medicine or prescription cough medicine;

    • drugs that make you sleepy or slow your breathing – a sleeping pill, muscle relaxer, sedative, tranquilizer, or antipsychotic medicine; or

    • drugs that affect serotonin levels in your body – medicine for depression, Parkinson’s disease, migraine headaches, serious infections, or prevention of nausea and vomiting.

    This list is not complete. Other drugs may interact with acetaminophen and hydrocodone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

    Hydrocodone Addiction and Abuse

    What Is Hydrocodone Addiction?

    Hydrocodone is a prescription Opioid painkiller, typically prescribed to treat moderate to severe pain. Unlike natural Opiates morphine and codeine, hydrocodone is a semi-synthetic opioid. Generally, doctors may decide to write a hydrocodone (brand name Vicodin®) prescription to treat short-term pain following dental surgery or for injury-related pain. However, due to the addictive nature of Opioids, regular use of hydrocodone can be habit-forming. Once the body becomes dependent on hydrocodone to feel normal, trying to quit taking them will result in symptoms of withdrawal. To mitigate withdrawal, individuals should treat their hydrocodone addiction through detox and rehab.

    In as little as five days of prescribed use, the risk for developing a chronic hydrocodone addiction increases significantly.

    Hydrocodone Addiction and Its Effects on the Body

    Hydrocodone, like other opioids, works by binding to pain receptors (known specifically as mu opioid receptors) in the brain. Once hydrocodone binds to these receptors, pain signals are weakened or blocked entirely. Mu opioid receptors are also responsible for the positive reinforcement aspect of drug-taking. Feel-good sensations of euphoria produced by opioids are likewise introduced here and encourage people to take the drug again. Often, when people try to quit or reduce the amount of hydrocodone they’re taking, they discover how dependent their bodies have become on the painkiller. After repeated use, opioids’ action in the frontal cortex weaken the individual’s ability to control decision-making and regulate mood.

    While hydrocodone is typically taken orally, some who abuse the drug crush the pills and either snort or inject the powder.

    Because most people with a hydrocodone addiction begin by misusing a prescription given to them by their doctor, it can be difficult to see the signs of addiction. Prescription drug abuse involves taking pills more often than prescribed, continuing to take them beyond their prescribed timeframe, and taking them in a way other than how they were intended (such as snorting or injecting them).

    Addiction is diagnosed on a spectrum from mild to moderate to severe. Some signs of hydrocodone addiction include taking more than intending to and prioritizing drug use over personal or professional responsibilities. As an individual’s tolerance to the effects of hydrocodone builds, people will need higher doses to keep withdrawal symptoms at bay.

    Immediate Effects of Hydrocodone Misuse and Abuse Include:

    • Blurry vision
    • Confusion
    • Constipation
    • Diarrhea
    • Dry mouth
    • Euphoria
    • Itchy skin
    • Lightheadedness
    • Nausea
    • Nodding in and out of consciousness
    • Pinpoint pupils
    • Reduced breathing rate
    • Seizures
    • Sleepiness
    • Slowed heartbeat
    • Slurred speech
    • Vomiting
    • Warm, flushed skin

    Long-term abuse of hydrocodone not only changes the way the brain functions but can have lasting effects on mood and thought patterns. People who have abused hydrocodone for a prolonged period of time are likely to suffer insomnia, liver or kidney disease, depression, and anxiety. Some mental disorders, like insomnia and depression, can be treated through therapy and medication like antidepressants. However, damage done to the liver and kidneys is difficult to reverse, as well as treat.

    Taking too much hydrocodone can result in an overdose. When the body is unable to process all of the opioids in its system, breathing and heart rates can plummet. In just a few minutes, someone overdosing on hydrocodone may stop breathing, depriving their brains of oxygen (also known as hypoxia).

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    (855) 826-4464

    Types of Hydrocodone

    In addition to Vicodin, other brand name versions of hydrocodone include Norco® and Lortab®. Each iteration contains hydrocodone and non-opioid pain reliever, acetaminophen. Hydrocodone without acetaminophen is sold under brand name Zohydro®. Some individuals with a hydrocodone addiction have a specific brand they prefer, despite all opioids having similar effects if taken in large enough quantities (including morphine, codeine, and Heroin). Researchers say this type of preference has practical and psychological foundations.

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    Vicodin

    (5mg, 7.5mg, or 10mg combined with 300mg acetaminophen)

    What Vicodin looks like: white tablets with dosage amount debossed on one side and “VICODIN” (may also have ES or HP) on the other.

    Each Vicodin tablet has 300 mg of acetaminophen and comes in three different dosage levels of hydrocodone—5 mg, 7.5 mg and 10 mg. It is generally prescribed for one tablet taken every 4 to 6 hours, though addicts may take much higher doses.

    In 2011, up to 131 million Americans were prescribed Vicodin, often in unnecessary strengths and quantity. In 2014, lawmakers recognized the increasing danger of hydrocodone combination products and changed them from Schedule III to Schedule II controlled substances. Then, the Food and Drug Administration (FDA) announced that all manufacturers cease marketing products with more than 325mg of acetaminophen due to increased risk of liver damage and accidental acetaminophen overdose when taking acetaminophen daily. Previous formulations included 500 mg to 750 mg of acetaminophen per pill.

    Norco

    (7mg, 10mg combined with 325 mg acetaminophen)

    What Norco looks like: white tablets with orange specks with “WATSON” debossed on one side and 913 on the other, light orange tablets with “NORCO® 729” on one side and bisected on the other, and yellow tablets with “NORCO 539” debossed on one side and bisected on the other.

    Though Vicodin is by far the most common hydrocodone prescription, Norco is still commonly used. It is most often prescribed in two strengths: 7.5 mg or 10 mg of hydrocodone combined with 325 mg of acetaminophen.

    Prior to the FDA lowering acceptable levels of acetaminophen in medication, Norco had the least amount of acetaminophen. Subsequently, some addicts chose Norco over other prescription painkillers to avoid the increased risk of consuming too much acetaminophen. Currently however, it has the highest percentage of acetaminophen of the hydrocodone variants.

    (5mg, 7.5mg, 10mg combined with 325mg acetaminophen)

    What Lortab looks like: tablets in multiple colors depending on strength (white with pink, green, or blue specks, or wholly pink) with “ucb” debossed on one side and a number (901, 902, 903, 910) on the other.

    Lortab is a brand name version of hydrocodone similar to brands Norco® and Lorcet®.

    Zohydro

    (10mg, 15mg, 20mg, 30mg, 40mg, 50mg)

    What Zohydro looks like: white, light green, dark blue, or dark brown capsules with “Z3## mg” in black ink.

    Zohydro was the first purely hydrocodone medication approved by the FDA in 2013. The agency approved the medication against the advice of its scientific advisory board, which voted 11-2 to deny Zohydro’s approval. The addition of acetaminophen is thought to lower hydrocodone’s risk of abuse, causing many to question the FDA’s decision to approve Zohydro.

    Because pure hydrocodone has a higher risk of abuse than found in Vicodin, Norco, and Lortab, it is generally only prescribed for severe pain. This medication is designed to treat individuals with severe, chronic pain who are opioid tolerant and have not found relief with alternate treatment options.

    Hydrocodone Addiction Statistics

    million

    In 2014, doctors wrote 120 million hydrocodone prescriptions.

    pills per patient

    After hydrocodone (Vicodin) was moved from a Schedule III to a Schedule II substance, there was a 7 pill per patient prescribing rate increase in the U.S.

    million

    In 2015, 12.5 million Americans used hydrocodone in the past year; 2 million were addicted to prescription painkillers.

    Find Help Today

    If you or someone you love is struggling with addiction to hydrocodone, now is the time to get help. Contact a treatment expert to find out more about what options are available to start a new life free from addiction.

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