Humulin r regular insulin

Contents

Humulin R

PATIENT INFORMATION

HUMULIN® R
Regular Insulin Human Injection, Usp (RDNA Origin) 100 Units Per Ml (U-100)

WARNING

THIS LILLY HUMAN INSULIN PRODUCT DIFFERS FROM ANIMAL-SOURCE INSULINS BECAUSE IT IS STRUCTURALLY IDENTICAL TO THE INSULIN PRODUCED BY YOUR BODY’S PANCREAS AND BECAUSE OF ITS UNIQUE MANUFACTURING PROCESS.

ANY CHANGE OF INSULIN SHOULD BE MADE CAUTIOUSLY AND ONLY UNDER MEDICAL SUPERVISION. CHANGES IN STRENGTH, MANUFACTURER, TYPE (E.G., REGULAR, NPH, ANALOG), SPECIES, OR METHOD OF MANUFACTURE MAY RESULT IN THE NEED FOR A CHANGE IN DOSAGE.

SOME PATIENTS TAKING HUMULIN® (HUMAN INSULIN, rDNA ORIGIN) MAY REQUIRE A CHANGE IN DOSAGE FROM THAT USED WITH OTHER INSULINS. IF AN ADJUSTMENT IS NEEDED, IT MAY OCCUR WITH THE FIRST DOSE OR DURING THE FIRST SEVERAL WEEKS OR MONTHS.

Diabetes

Insulin is a hormone produced by the pancreas, a large gland that lies near the stomach. This hormone is necessary for the body’s correct use of food, especially sugar. Diabetes occurs when the pancreas does not make enough insulin to meet your body’s needs.

To control your diabetes, your doctor has prescribed injections of insulin products to keep your blood glucose at a near-normal level. You have been instructed to test your blood regularly for glucose. Studies have shown that some chronic complications of diabetes such as eye disease, kidney disease, and nerve disease can be significantly reduced if the blood sugar is maintained as close to normal as possible. Proper control of your diabetes requires close and constant cooperation with your doctor. Despite diabetes, you can lead an active and healthy life if you eat a balanced diet, exercise regularly, and take your insulin injections as prescribed by your doctor.

Always keep an extra supply of insulin as well as a spare syringe and needle on hand. Always wear diabetic identification so that appropriate treatment can be given if complications occur away from home.

Regular Human Insulin

Description

Humulin is synthesized in a special non-disease-producing laboratory strain of Escherichia coli bacteria that has been genetically altered to produce human insulin. Humulin R consists of zinc-insulin crystals dissolved in a clear fluid. It takes effect within 30 minutes and has a duration of activity of approximately 4 to 12 hours. The time course of action of any insulin may vary considerably in different individuals or at different times in the same individual. As with all insulin preparations, the duration of action of Humulin R (insulin (human recombinant)) is dependent on dose, site of injection, blood supply, temperature, and physical activity. Humulin R (insulin (human recombinant)) is a sterile solution and is for subcutaneous injection. It should not be used intramuscularly. The concentration of Humulin R (insulin (human recombinant)) is 100 units/mL (U-100).

Identification

Human insulin from Eli Lilly and Company has the trademark Humulin. Your doctor has prescribed the type of insulin that he/she believes is best for you.

DO NOT USE ANY OTHER INSULIN EXCEPT ON YOUR DOCTOR’S ADVICE AND DIRECTION.

Always check the carton and the bottle label for the name and letter designation of the insulin you receive from your pharmacy to make sure it is the same as prescribed by your doctor. There are two Humulin R (insulin (human recombinant)) formulations: Humulin R (insulin (human recombinant)) U-100 and Humulin R (insulin (human recombinant)) U-500. Make sure that you have the formulation prescribed by your doctor.

Always check the appearance of your bottle of Humulin R (insulin (human recombinant)) before withdrawing each dose. Humulin R (insulin (human recombinant)) is a clear and colorless liquid with a water-like appearance and consistency. Do not use Humulin R (insulin (human recombinant)) :

  • if it appears cloudy, thickened, or slightly colored, or
  • if solid particles are visible.

If you see anything unusual in the appearance of Humulin R (insulin (human recombinant)) solution in your bottle or notice your insulin requirements changing, talk to your doctor.

Storage

In-use (opened): The Humulin R (insulin (human recombinant)) U-100 bottle you are currently using can be kept unrefrigerated as long as it is kept as cool as possible away from heat and light. In-use bottles must be used within 31 days or be thrown out, even if they still contain Humulin R (insulin (human recombinant)) U-100.

Do not use Humulin R (insulin (human recombinant)) after the expiration date stamped on the label or if it has been frozen.

Dosage

Your doctor has told you which insulin to use, how much, and when and how often to inject it. Because each patient’s diabetes is different, this schedule has been individualized for you.

Your usual dose of Humulin R (insulin (human recombinant)) may be affected by changes in your diet, activity, or work schedule. Carefully follow your doctor’s instructions to allow for these changes. Other things that may affect your Humulin R (insulin (human recombinant)) dose are:

Illness

Illness, especially with nausea and vomiting, may cause your insulin requirements to change. Even if you are not eating, you will still require insulin. You and your doctor should establish a sick day plan for you to use in case of illness. When you are sick, test your blood glucose frequently. If instructed by your doctor, test your ketones and report the results to your doctor.

Pregnancy

Good control of diabetes is especially important for you and your unborn baby. Pregnancy may make managing your diabetes more difficult. If you are planning to have a baby, are pregnant, or are nursing a baby, talk to your doctor.

Medication

Insulin requirements may be increased if you are taking other drugs with blood-glucose-raising activity, such as oral contraceptives, corticosteroids, or thyroid replacement therapy. Insulin requirements may be reduced in the presence of drugs that lower blood glucose or affect how your body responds to insulin, such as oral antidiabetic agents, salicylates (for example, aspirin), sulfa antibiotics, alcohol, certain antidepressants and some kidney and blood pressure medicines. Your Health Care Professional may be aware of other medications that may affect your diabetes control. Therefore, always discuss any medications you are taking with your doctor.

Exercise

Exercise may lower your body’s need for insulin during and for some time after the physical activity. Exercise may also speed up the effect of an insulin dose, especially if the exercise involves the area of injection site (for example, the leg should not be used for injection just prior to running). Discuss with your doctor how you should adjust your insulin regimen to accommodate exercise.

Travel

When traveling across more than 2 time zones, you should talk to your doctor concerning adjustments in your insulin schedule.

Common Problems Of Diabetes

Hypoglycemia (Low Blood Sugar)

Hypoglycemia (too little glucose in the blood) is one of the most frequent adverse events experienced by insulin users. It can be brought about by:

  1. Missing or delaying meals.
  2. Taking too much insulin.
  3. Exercising or working more than usual.
  4. An infection or illness associated with diarrhea or vomiting.
  5. A change in the body’s need for insulin.
  6. Diseases of the adrenal, pituitary, or thyroid gland, or progression of kidney or liver disease.
  7. Interactions with certain drugs, such as oral antidiabetic agents, salicylates (for example, aspirin), sulfa antibiotics, certain antidepressants and some kidney and blood pressure medicines.
  8. Consumption of alcoholic beverages.

Symptoms of mild to moderate hypoglycemia may occur suddenly and can include:

  • sweating
  • dizziness
  • palpitation
  • tremor
  • hunger
  • restlessness
  • tingling in the hands, feet, lips, or tongue
  • lightheadedness
  • inability to concentrate
  • headache
  • drowsiness
  • sleep disturbances
  • anxiety
  • blurred vision
  • slurred speech
  • depressed mood
  • irritability
  • abnormal behavior
  • unsteady movement
  • personality changes

Signs of severe hypoglycemia can include:

  • disorientation
  • unconsciousness
  • seizures
  • death

Therefore, it is important that assistance be obtained immediately.

Early warning symptoms of hypoglycemia may be different or less pronounced under certain conditions, such as long duration of diabetes, diabetic nerve disease, use of medications such as beta-blockers, changing insulin preparations, or intensified control (3 or more insulin injections per day) of diabetes.

A few patients who have experienced hypoglycemic reactions after transfer from animal-source insulin to human insulin have reported that the early warning symptoms of hypoglycemia were less pronounced or different from those experienced with their previous insulin.

Without recognition of early warning symptoms, you may not be able to take steps to avoid more serious hypoglycemia. Be alert for all of the various types of symptoms that may indicate hypoglycemia. Patients who experience hypoglycemia without early warning symptoms should monitor their blood glucose frequently, especially prior to activities such as driving. If the blood glucose is below your normal fasting glucose, you should consider eating or drinking sugar-containing foods to treat your hypoglycemia.

Mild to moderate hypoglycemia may be treated by eating foods or drinks that contain sugar. Patients should always carry a quick source of sugar, such as hard candy or glucose tablets. More severe hypoglycemia may require the assistance of another person. Patients who are unable to take sugar orally or who are unconscious require an injection of glucagon or should be treated with intravenous administration of glucose at a medical facility.

You should learn to recognize your own symptoms of hypoglycemia. If you are uncertain about these symptoms, you should monitor your blood glucose frequently to help you learn to recognize the symptoms that you experience with hypoglycemia.

If you have frequent episodes of hypoglycemia or experience difficulty in recognizing the symptoms, you should talk to your doctor to discuss possible changes in therapy, meal plans, and/or exercise programs to help you avoid hypoglycemia.

Hyperglycemia (High Blood Sugar) and Diabetic Ketoacidosis (DKA)

Hyperglycemia (too much glucose in the blood) may develop if your body has too little insulin. Hyperglycemia can be brought about by any of the following:

  1. Omitting your insulin or taking less than your doctor has prescribed.
  2. Eating significantly more than your meal plan suggests.
  3. Developing a fever, infection, or other significant stressful situation.

In patients with type 1 or insulin-dependent diabetes, prolonged hyperglycemia can result in DKA (a life-threatening emergency). The first symptoms of DKA usually come on gradually, over a period of hours or days, and include a drowsy feeling, flushed face, thirst, loss of appetite, and fruity odor on the breath. With DKA, blood and urine tests show large amounts of glucose and ketones. Heavy breathing and a rapid pulse are more severe symptoms. If uncorrected, prolonged hyperglycemia or DKA can lead to nausea, vomiting, stomach pain, dehydration, loss of consciousness, or death. Therefore, it is important that you obtain medical assistance immediately.

Rarely, administration of insulin subcutaneously can result in lipoatrophy (seen as an apparent depression of the skin) or lipohypertrophy (seen as a raised area of the skin). If you notice either of these conditions, talk to your doctor. A change in your injection technique may help alleviate the problem.

Allergy

Local Allergy — Patients occasionally experience redness, swelling, and itching at the site of injection. This condition, called local allergy, usually clears up in a few days to a few weeks. In some instances, this condition may be related to factors other than insulin, such as irritants in the skin cleansing agent or poor injection technique. If you have local reactions, talk to your doctor.

Systemic Allergy — Less common, but potentially more serious, is generalized allergy to insulin, which may cause rash over the whole body, shortness of breath, wheezing, reduction in blood pressure, fast pulse, or sweating. Severe cases of generalized allergy may be life threatening. If you think you are having a generalized allergic reaction to insulin, call your doctor immediately.

Additional Information

Information about diabetes may be obtained from your diabetes educator.

Additional information about diabetes and Humulin can be obtained by calling The Lilly Answers Center at 1-800-LillyRx (1-800-545-5979) or by visiting www.LillyDiabetes.com.

Instructions For Insulin Vial Use

NEVER SHARE NEEDLES AND SYRINGES.

Correct Syringe Type

Doses of insulin are measured in units. U-100 insulin contains 100 units/mL (1 mL=1 cc). With Humulin R (insulin (human recombinant)) , it is important to use a syringe that is marked for U-100 insulin preparations. Failure to use the proper syringe can lead to a mistake in dosage, causing serious problems for you, such as a blood glucose level that is too low or too high.

Syringe Use

To help avoid contamination and possible infection, follow these instructions exactly.

Disposable syringes and needles should be used only once and then discarded by placing the used needle in a puncture-resistant disposable container. Properly dispose of the puncture-resistant container as directed by your Health Care Professional.

Preparing the Dose

  1. Wash your hands.
  2. Inspect the insulin. Humulin R (insulin (human recombinant)) solution should look clear and colorless. Do not use Humulin R (insulin (human recombinant)) if it appears cloudy, thickened, or slightly colored, or if you see particles in the solution. Do not use Humulin R (insulin (human recombinant)) if you notice anything unusual in its appearance.
  3. If using a new Humulin R (insulin (human recombinant)) bottle, flip off the plastic protective cap, but do not remove the stopper. Wipe the top of the bottle with an alcohol swab.
  4. If you are mixing insulins, refer to the “Mixing Humulin R (insulin (human recombinant)) with Longer-Acting Human Insulins” section below.
  5. Draw an amount of air into the syringe that is equal to the Humulin R (insulin (human recombinant)) dose. Put the needle through rubber top of the Humulin R (insulin (human recombinant)) bottle and inject the air into the bottle.
  6. Turn the Humulin R (insulin (human recombinant)) bottle and syringe upside down. Hold the bottle and syringe firmly in one hand.
  7. Making sure the tip of the needle is in the Humulin R (insulin (human recombinant)) solution, withdraw the correct dose of Humulin R (insulin (human recombinant)) into the syringe.
  8. Before removing the needle from the Humulin R (insulin (human recombinant)) bottle, check the syringe for air bubbles. If bubbles are present, hold the syringe straight up and tap its side until the bubbles float to the top. Push the bubbles out with the plunger and then withdraw the correct dose.
  9. Remove the needle from the bottle and lay the syringe down so that the needle does not touch anything.
  10. If you do not need to mix your Humulin R (insulin (human recombinant)) with a longer-acting insulin, go to the “Injection Instructions” section below and follow the directions.

Mixing Humulin R (insulin (human recombinant)) with Longer-Acting Human Insulins

  1. Humulin R (insulin (human recombinant)) should be mixed with longer-acting human insulins only on the advice of your doctor.
  2. Draw an amount of air into the syringe that is equal to the amount of longer-acting insulin you are taking. Insert the needle into the longer-acting insulin bottle and inject the air. Withdraw the needle.
  3. Draw an amount of air into the syringe that is equal to the amount of Humulin R you are taking. Insert the needle into the Humulin R (insulin (human recombinant)) bottle and inject the air, but do not withdraw the needle.
  4. Turn the Humulin R (insulin (human recombinant)) bottle and syringe upside down.
  5. Making sure the tip of the needle is in the Humulin R (insulin (human recombinant)) solution, withdraw the correct dose of Humulin R (insulin (human recombinant)) into the syringe.
  6. Before removing the needle from the Humulin R (insulin (human recombinant)) bottle, check the syringe for air bubbles. If bubbles are present, hold the syringe straight up and tap its side until the bubbles float to the top. Push the bubbles out with the plunger and then withdraw the correct dose.
  7. Remove the syringe with the needle from the Humulin R (insulin (human recombinant)) bottle and insert it into the longer-acting insulin bottle. Turn the longer-acting insulin bottle and syringe upside down. Hold the bottle and syringe firmly in one hand and shake gently. Making sure the tip of the needle is in the longer-acting insulin, withdraw the correct dose of longer-acting insulin.
  8. Remove the needle from the bottle and lay the syringe down so that the needle does not touch anything.
  9. Follow the directions under “Injection Instructions” section below

Follow your doctor’s instructions on whether to mix your insulins ahead of time or just before giving your injection. It is important to be consistent in your method.

Syringes from different manufacturers may vary in the amount of space between the bottomline and the needle. Because of this, do not change:

  • the sequence of mixing, or
  • the model and brand of syringe or needle that your doctor has prescribed.

Injection Instructions

  1. To avoid tissue damage, choose a site for each injection that is at least ½ inch from the previous injection site. The usual sites of injection are abdomen, thighs, and arms.
  2. Cleanse the skin with alcohol where the injection is to be made.
  3. With one hand, stabilize the skin by spreading it or pinching up a large area.
  4. Insert the needle as instructed by your doctor.
  5. Push the plunger in as far as it will go.
  6. Pull the needle out and apply gentle pressure over the injection site for several seconds. Do not rub the area.
  7. Place the used needle in a puncture-resistant disposable container and properly dispose of the puncture-resistant container as directed by your Health Care Professional.

Short-Acting Insulin

Short-acting insulins or regular insulins are recombinant human insulins that were developed to mimic normal after-meal insulin release. They are intended to be used as a bolus mealtime insulin to quickly lower the increase in blood glucose (sugar) after eating. Even though they are regular human insulins, they do not end up controlling the after-meal blood glucose like the insulin produced in the body. This is because after regular human insulin is injected it has a delay before it is absorbed into the body. This delays the onset (usually 30 minutes) and prolongs the effect (usually 3-6 hours) of the injected regular insulin. This limits short-acting insulins effectiveness in providing good glucose control and increases the risk of hypoglycemia.

Some of the short-acting insulins available in the US include:

  • Humulin R
  • Novolin R
  • Myxredlin

What is Humulin R (regular human insulin)?

Humulin R (regular human insulin) is used with diet and exercise to improve blood glucose control after meals in the treatment of type 2 diabetes. Humulin R is given as a subcutaneous (under the skin) injection 30 minutes before meals. It can be injected in the abdomen, thigh, or upper arm or buttocks. Injection sites should be rotated each time to prevent the risk of lipodystrophy, an accumulation of fatty tissue under the skin at the site where  insulin  is injected. Consult with your healthcare provider on proper use and to determine the specific dose needed.

Humulin R is available in a vial containing 100 units/ml (Humulin R U-100), a highly concentrated vial containing 500 units/ml (Humulin R U-500), and a highly concentrated pen containing 500 units/ml (Humulin R U-500 Kwikpen). Humulin R U-500 vials must be injected with a U-500 insulin syringe, otherwise life-threatening hypoglycemia may result. Unopened vials and pens should be kept in the refrigerator. Opened Humulin R U-100 vials should be discarded 31 days after opening. Opened Humulin R U-500 vials can be stored at room temperature for up to 40 days. Opened Humulin R U-500 KwikPens should be stored at room temperature after opening and discarded after 28 days.

Some of the most common side effects from Humulin R include:

  • Hypoglycemia
  • Injection site reactions
  • Weight gain

Some side effects, like anaphylaxis, hypoglycemia, edema, heart failure or diabetic ketoacidosis can be severe and even life threatening. Consult your healthcare provider on how to recognize the signs and symptoms of these side effects and let them know if you experience any side effects after using Humulin-R or any other medication. People who are allergic to any of the ingredients in Humulin R should not use it. Always check with your healthcare professional about any potential drug interactions before starting treatment.

What is Novolin R (regular human insulin)?

Novolin R (regular human insulin) is used with diet and exercise to improve blood glucose control after meals in the treatment of type 2 diabetes. Novolin R is given as a subcutaneous (under the skin) injection 30 minutes before meals. It can be injected in the abdomen, thigh, or upper arm or buttocks. Injection sites should be rotated each time to prevent the risk of lipodystrophy, an accumulation of fatty tissue under the skin at the site where  insulin  is injected. Consult with your healthcare provider on proper use and to determine the specific dose needed.

Novolin R is available in a vial containing 100 units/ml. Store unopened vials in the refrigerator. Opened vials should be stored at room temperature for up to 42 days.

Some of the most common side effects from Novolin R include:

  • Hypoglycemia
  • Injection site reactions
  • Weight gain

Some side effects, like anaphylaxis, hypoglycemia, edema, heart failure or diabetic ketoacidosis can be severe and even life threatening. Consult your healthcare provider on how to recognize the signs and symptoms of these side effects and let them know if you experience any side effects after using Novolin R or any other medication. People who are allergic to any of the ingredients in Novolin R should not use it. Always check with your healthcare professional about any potential drug interactions before starting treatment.

What is Myxredlin?

Myxredlin (human insulin) is the first and only ready-to-use insulin for IV infusion in the hospital and other acute care settings. It is indicated to improve glycemic control in adults and pediatric patients with diabetes mellitus. Myxredlin is intended for use only in acute care settings. It is given intravenously only under medical supervision with close monitoring of blood glucose and potassium levels.

Myxredlin is provided in a standardized concentration of 100 units/100 mL in a flexible plastic container.

Some of the most common side effects from Myxredlin include:

  • Hypoglycemia
  • Swelling
  • Weight gain

Some side effects, like anaphylaxis, hypoglycemia, low potassium levels, and heart failure can be severe and even life threatening. People who are allergic to any of the ingredients in Myxredlin should not use it. Always check with your healthcare professional about any potential drug interactions before starting treatment.

Humulin N

HUMULIN®
(HU-mu-lin) N (human insulin isophane) Suspension

What is HUMULIN N?

  • HUMULIN N is a man-made insulin that is used to control high blood sugar in adults and children with diabetes mellitus.

Who should not use HUMULIN N?

Do not use HUMULIN N if you:

  • are having an episode of low blood sugar (hypoglycemia).
  • have an allergy to HUMULIN N or any of the ingredients in HUMULIN N.

Before using HUMULIN N, tell your healthcare provider about all your medical conditions including, if you:

  • have liver or kidney problems.
  • take any other medicines, especially ones commonly called TZDs (thiazolidinediones).
  • have heart failure or other heart problems. If you have heart failure, it may get worse while you take TZDs with HUMULIN N.
  • are pregnant, planning to become pregnant, or are breastfeeding.
  • are taking new prescription or over-the-counter medicines, vitamins, or herbal supplements.

Before you start using HUMULIN N, talk to your healthcare provider about low blood sugar and how to manage it.

How should I use HUMULIN N?

  • Read the Instructions for Use that come with your HUMULIN N.
  • Use HUMULIN N exactly as your healthcare provider tells you to.
  • Know the type and strength of insulin you use. Do not change the type of insulin you use unless your healthcare provider tells you to. The amount of insulin and the best time for you to take your insulin may need to change if you use different types of insulin.
  • Check your blood sugar levels. Ask your healthcare provider what your blood sugars should be and when you should check your blood sugar levels.

Your HUMULIN N dose may need to change because of:

  • change in level of physical activity or exercise, weight gain or loss, increased stress, illness, change in diet.

What should I avoid while using HUMULIN N?

While using HUMULIN N do not:

  • Drive or operate heavy machinery, until you know how HUMULIN N affects you.
  • Drink alcohol or use prescription or over-the-counter medicines that contain alcohol.

What are the possible side effects of HUMULIN N?

HUMULIN N may cause serious side effects that can lead to death, including:

  • low blood sugar (hypoglycemia). Signs and symptoms that may indicate low blood sugar include:
    • dizziness or light-headedness, sweating, confusion, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, or mood changes, hunger.
  • serious allergic reaction (whole body reaction). Get medical help right away, if you have any of these symptoms of an allergic reaction:
    • a rash over your whole body, trouble breathing, a fast heartbeat, or sweating.
  • low potassium in your blood (hypokalemia).
  • heart failure. Taking certain diabetes pills called thiazolidinediones or “TZDs” with HUMULIN N may cause heart failure in some people. This can happen even if you have never had heart failure or heart problems before. If you already have heart failure it may get worse while you take TZDs with HUMULIN N. Your healthcare provider should monitor you closely while you are taking TZDs with HUMULIN N. Tell your healthcare provider if you have any new or worse symptoms of heart failure including:
    • shortness of breath, swelling of your ankles or feet, sudden weight gain Treatment with TZDs and HUMULIN N may need to be adjusted or stopped by your healthcare provider if you have new or worse heart failure.

Get emergency medical help if you have:

  • trouble breathing, shortness of breath, fast heartbeat, swelling of your face, tongue, or throat, sweating, extreme drowsiness, dizziness, confusion.

The most common side effects of HUMULIN N include:

  • low blood sugar (hypoglycemia), allergic reactions including reactions at the injection site, skin thickening or pits at the injection site (lipodystrophy), itching, rash, weight gain, and swelling of your hands and feet.

These are not all the possible side effects of HUMULIN N. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

General information about the safe and effective use of HUMULIN N:

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. You can ask your pharmacist or healthcare provider for information about HUMULIN N that is written for health professionals. Do not use HUMULIN N for a condition for which it was not prescribed. Do not give HUMULIN N to other people, even if they have the same symptoms that you have. It may harm them.

What are the ingredients in HUMULIN N?

Active Ingredient: insulin human (rDNA origin)

Inactive Ingredients: protamine sulfate, glycerin, dibasic sodium phosphate, metacresol, phenol, zinc oxide, water for injection, hydrochloric acid or sodium hydroxide For more information, call 1-800-545-5979 or go to www.humulin.com.

This Patient Information has been approved by the U.S. Food and Drug Administration. Revised: Month DD, YYYY

Instructions for Use

HUMULIN®
(HU-mu-lin) N (human insulin isophane suspension) vial (100 Units/mL, U-100)

Read the Instructions for Use before you start taking HUMULIN N and each time you get a new HUMULIN N vial. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or your treatment.

Do not share your syringes or needles with anyone else. You may give an infection to them or get an infection from them.

Supplies needed to give your injection:

  • a HUMULIN N vial
  • a U-100 insulin syringe and needle
  • 2 alcohol swabs
  • 1 sharps container for throwing away used needles and syringes. See “Disposing of used needles and syringes” at the end of these instructions.

Preparing your HUMULIN N dose:

  • Wash your hands with soap and water.
  • Check the HUMULIN N label to make sure you are taking the right type of insulin. This is especially important if you use more than 1 type of insulin.
  • Do not use HUMULIN N past the expiration date printed on the label or 31 days after you first use it.
  • Always use a new needle for each injection to help ensure sterility and prevent blocked needles.

Step 1: Gently roll the vial between the palms of your hands at least 10 times.

Step 2: Invert the vial at least 10 times.

Do not shake.

Mixing is important to make sure you get the right dose. Humulin N should look white and cloudy after mixing. Do not use it if it looks clear or contains any lumps or particles.

Step 3: If you are using a new vial, pull off the plastic Protective Cap, but do not remove the Rubber Stopper.

Step 4: Wipe the Rubber Stopper with an alcohol swab.

Step 5: Hold the syringe with the needle pointing up. Pull down on the Plunger until the tip of the Plunger reaches the line for the number of units for your prescribed dose. (Example Dose: 20 units shown)

Step 6: Push the needle through the Rubber Stopper of the vial.

Step 7: Push the plunger all the way in. This puts air into the vial.

Step 8: Turn the vial and syringe upside down and slowly pull the Plunger down until the tip is a few units past the line for your prescribed dose. (Example Dose: 20 units Plunger is shown at 24 units)

If there are air bubbles, tap the syringe gently a few times to let any air bubbles rise to the top.

Step 9: Slowly push the Plunger up until the tip reaches the line for your prescribed dose.

Check the syringe to make sure that you have the right dose. (Example Dose: 20 units shown)

Step 10: Pull the syringe out of the vial’s Rubber Stopper.

Giving your HUMULIN N injection:

  • Inject your insulin exactly as your healthcare provider has shown you.
  • Change (rotate) your injection site for each injection.

Step 11: Choose your injection site.

HUMULIN N is injected under the skin (subcutaneously) of your stomach area (abdomen), buttocks, upper legs or upper arms.

Wipe the skin with an alcohol swab. Let the injection site dry before you inject your dose.

Step 12: Insert the needle into your skin.

Step 13: Push down on the Plunger to inject your dose.

The needle should stay in your skin for at least 5 seconds to make sure you have injected all of your insulin dose.

Step 14: Pull the needle out of your skin.

  • If you see blood after you take the needle out of your skin, press the injection site with a piece of gauze or an alcohol swab. Do not rub the area.
  • Do not recap the needle. Recapping the needle can lead to a needle stick injury.

Disposing of used needles and syringes:

  • Put your used needles and syringes in a FDA-cleared sharps disposal container right away after use. Do not throw away (dispose of) loose needles and syringes in your household trash.
  • If you do not have a FDA-cleared sharps disposal container, you may use a household container that is:
    • made of a heavy-duty plastic,
    • can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out,
    • upright and stable during use,
    • leak-resistant, and
    • properly labeled to warn of hazardous waste inside the container.
  • When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used needles and syringes. For more information about safe sharps disposal, and for specific information about sharps disposal in the state that you live in, go to the FDA’s website at: http://www.fda.gov/safesharpsdisposal
  • Do not recycle the container.

How should I store HUMULIN N?

All unopened HUMULIN N vials:

  • Store all unopened vials in the refrigerator.
  • Do not freeze. Do not use if it has been frozen.
  • Keep away from heat and out of direct light.
  • Unopened vials can be used until the expiration date on the carton and label, if they have been stored in the refrigerator.
  • Unopened vials should be thrown away after 31 days, if they are stored at room temperature.

After HUMULIN N vials have been opened:

  • Store opened vials in the refrigerator or at room temperature below 86°F (30°C) for up to 31 days.
  • Keep away from heat and out of direct light.
  • Throw away all opened vials after 31 days of use, even if there is still insulin left in the vial.

General information about the safe and effective use of HUMULIN N.

Keep HUMULIN N vials, syringes, needles, and all medicines out of the reach of children.

If you have any questions or problems with your HUMULIN, contact Lilly at 1-800Lilly-Rx (1-800-545-5979) or call your healthcare provider for help. For more information on HUMULIN and insulin, go to www.humulin.com.

Scan this code to launch the humulin.com website

This Instructions for Use has been approved by the U.S. Food and Drug Administration.

Instructions for Use

HUMULIN® N KwikPen™
(human insulin isophane suspension)

Read the Instructions for Use before you start taking HUMULIN N and each time you get another HUMULIN® N KwikPen™. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or your treatment.

HUMULIN N KwikPen (“Pen”) is a disposable pen containing 3 mL (300 units) of U100 HUMULIN® N (human insulin isophane suspension ) insulin. You can inject from 1 to 60 units in a single injection.

HUMULIN N KwikPen has a blue and light green Label with a matching light green Dose Knob (See the KwikPen Parts diagram below).

Do not share your HUMULIN N KwikPen or needles with another person. You may give an infection to them or get an infection from them.

This Pen is not recommended for use by the blind or visually impaired without the assistance of a person trained in the proper use of the product.

KwikPen Parts

Supplies you will need to give your HUMULIN N injection:

  • HUMULIN N KwikPen
  • KwikPen compatible Needle (Becton, Dickinson and Company Pen Needles recommended)
  • alcohol swab

Preparing HUMULIN N KwikPen:

  • Wash your hands with soap and water.
  • Check the HUMULIN N KwikPen Label to make sure you are taking the right type of insulin. This is especially important if you use more than 1 type of insulin.
  • Do not use HUMULIN N past the expiration date printed on the Label or 14 days after you start using the Pen.
  • Always use a new needle for each injection to help ensure sterility and prevent blocked needles.

Step 1:

  • Pull the Pen Cap straight off.
  • Wipe the Rubber Seal with an alcohol swab.
    • Do not twist the cap.
    • Do not remove the HUMULIN N KwikPen Label.
    • Do not attach the Needle before mixing.

Step 2:

  • Gently roll the Pen between your hands 10 times.

Step 3:

  • Move the Pen up and down (invert) the Pen 10 times.

Mixing by rolling and inverting the Pen is important to make sure you get the right dose.

Step 4:

  • Check the liquid in the Pen. HUMULIN N should look white and cloudy after mixing. Do not use if it looks clear or has any lumps or particles in it.

Step 5:

  • Select a new Needle.
  • Pull off the Paper Tab from the Outer Needle Shield.

Step 6:

  • Push the capped Needle straight onto the Pen and twist the Needle on until it is tight.

Step 7:

  • Pull off the Outer Needle Shield. Do not throw it away.
  • Pull off the Inner Needle Shield and throw it away.

Priming the HUMULIN N KwikPen:

Prime the HUMULIN N KwikPen before each injection. Priming ensures the Pen is ready to dose and removes air that may collect in the cartridge during normal use. If you do not prime before each injection, you may get too much or too little insulin.

Step 8:

  • Turn the Dose Knob to select 2 units.

Step 9:

  • Hold the Pen with the Needle pointing up. Tap the Cartridge Holder gently to collect air bubbles at the top.

Step 10:

  • Hold the Pen with Needle pointing up. Push the Dose Knob in until it stops, and “0” is seen in the Dose Window.
  • Hold the Dose Knob in and count to 5 slowly.
    A stream of insulin should be seen from the needle.
    • If you do not see a stream of insulin, repeat steps 8 to 10, no more than 4 times.
    • If you still do not see a stream of insulin, change the needle and repeat steps 8 to 10.

Selecting your dose:

Step 11:

  • Turn the Dose Knob to select the number of units you need to inject. The Dose Indicator should line up with your dose.
    The dose can be corrected by turning the Dose Knob in either direction until the correct dose lines up with the Dose Indicator.
    • The even numbers are printed on the dial. (Example: 10 units shown)

    • The odd numbers, after the number 1, are shown as full lines. (Example: 15 units shown)

  • The HUMULIN N KwikPen will not let you dial more than the number of units left in the Pen.
  • If your dose is more than the number of units left in the Pen, you may either:
    • inject the amount left in your Pen and then use a new Pen to give the rest of your dose, or
    • get a new Pen and inject the full dose.
  • The Pen is designed to deliver a total of 300 units of insulin. The cartridge contains an additional small amount of insulin that cannot be delivered.

Giving your HUMULIN N injection:

  • Inject your HUMULIN N exactly as your healthcare provider has shown you.
  • Change (rotate) your injection site for each injection.
  • Do not try to change your dose while injecting HUMULIN N.

Step 12:

  • Choose your injection site.
    HUMULIN N is injected under the skin (subcutaneously) of your stomach area, buttocks, upper legs or upper arms.
  • Wipe the skin with an alcohol swab, and let the injection site dry before you inject your dose.

Step 13:

  • Insert the Needle into your skin.

Step 14:

  • Put your thumb on the Dose Knob and push the Dose Knob in until it stops.

  • Hold the Dose Knob in and slowly count to 5.

Step 15:

  • Pull the Needle out of your skin.
    You should see “0” in the Dose Window. If you do not see “0” in the Dose Window, you did not receive your full dose.
    • If you see blood after you take the Needle out of your skin, press the injection site lightly with a piece of gauze or an alcohol swab. Do not rub the area.
    • A drop of insulin at the needle tip is normal. It will not affect your dose.
    • If you do not think you received your full dose, do not take another dose. Call Lilly at 1-800-LillyRx (1-800-545-5979) or your healthcare provider for help.

Step 16:

  • Carefully replace the Outer Needle Shield.

Step 17:

  • Unscrew the capped Needle and throw it away.
  • Do not store the Pen with the Needle attached to prevent leaking, blocking of the Needle, and air from entering the Pen.

Step 18:

  • Replace the Pen Cap by lining up the Cap Clip with the Dose Indicator and pushing straight on.

After your injection:

  • Put your used needles and pens in a FDA-cleared sharps disposal container right away after use. Do not throw away (dispose of) loose needles and pens in your household trash.
  • If you do not have a FDA-cleared sharps disposal container, you may use a household container that is:
    • made of a heavy-duty plastic,
    • can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out,
    • upright and stable during use,
    • leak-resistant, and
    • properly labeled to warn of hazardous waste inside the container.
  • When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used needles and syringes. For more information about safe sharps disposal, and for specific information about sharps disposal in the state that you live in, go to the FDA’s website at: http://www.fda.gov/safesharpsdisposal

How should I store my HUMULIN N KwikPen?

  • Store unused HUMULIN N KwikPens in the refrigerator at 36°F to 46°F (2°C to 8°C). The Pen you are currently using should be stored at room temperature, below 86°F (30°C).
  • Do not freeze HUMULIN N. Do not use HUMULIN N if it has been frozen.
  • Unused Pens may be used until the expiration date printed on the Label, if kept in the refrigerator.
  • The HUMULIN N Pen you are using should be thrown away after 14 days, even if it still has insulin left in it.
  • Keep HUMULIN N away from heat and out of the light.

General information about the safe and effective use of HUMULIN N KwikPen.

  • Keep HUMULIN N KwikPen and needles out of the reach of children.
  • Do not use the Pen if any part looks broken or damaged.
  • Always carry an extra Pen in case yours is lost or damaged.
  • If you cannot remove the Pen Cap, gently twist the Pen Cap back and forth, and then pull the Pen Cap straight off.
  • If it is hard to push the Dose Knob or the Pen is not working the right way:
    • Your Needle may be blocked. Put on a new Needle and prime the Pen.
    • You may have dust, food, or liquid inside the Pen. Throw the Pen away and get a new one.
    • It may help to push the Dose Knob more slowly during your injection.
  • Use the space below to keep track of how long you should use each HUMULIN N KwikPen.
    • Write down the date you start using your HUMULIN N KwikPen. Count forward 14 days.
    • Write down the date you should throw it away.

Example:

First used on _______ + 14 days = Throw out on ______

__________________Date_____________________ Date

Pen 1 -First used on _______ Throw out on _______

__________________Date_____________________ Date

Pen 2 -First used on _______ Throw out on _______

__________________Date_____________________ Date

Pen 3 -First used on _______ Throw out on _______

__________________Date_____________________ Date

Pen 4 -First used on _______ Throw out on _______

__________________Date_____________________ Date

Pen 5 -First used on _______ Throw out on _______

__________________Date_____________________ Date

If you have any questions or problems with your HUMULIN N KwikPen, contact Lilly at 1-800-LillyRx (1-800-545-5979) or call your healthcare provider for help. For more information on HUMULIN N KwikPen and insulin, go to www.lilly.com.

This Instructions for Use has been approved by the U.S. Food and Drug Administration.

SIDE EFFECTS

Hypoglycemia

Hypoglycemia is one of the most frequent adverse events experienced by insulin users.

Symptoms of mild to moderate hypoglycemia may occur suddenly and can include:

  • sweating
  • dizziness
  • palpitation
  • tremor
  • hunger
  • restlessness
  • tingling in the hands, feet, lips, or tongue
  • lightheadedness
  • inability to concentrate
  • headache
  • drowsiness
  • sleep disturbances
  • anxiety
  • blurred vision
  • slurred speech
  • depressed mood
  • irritability
  • abnormal behavior
  • unsteady movement
  • personality changes

Signs of severe hypoglycemia can include:

  • disorientation
  • unconsciousness
  • death
  • seizures
  • coma

Early warning symptoms of hypoglycemia may be different or less pronounced under certain conditions, such as long duration of diabetes, autonomic diabetic neuropathy, use of medications such as beta-adrenergic blockers, changing insulin preparations, or intensified control (3 or more insulin injections per day) of diabetes.

Without recognition of early warning symptoms, the patient may not be able to take steps to avoid more serious hypoglycemia. Patients who experience hypoglycemia without early warning symptoms should monitor their blood glucose more frequently, especially prior to activities such as driving. Mild to moderate hypoglycemia may be treated by eating foods or taking drinks that contain sugar. Patients should always carry a quick source of sugar, such as hard candy, non-diet carbohydrate-containing drinks or glucose tablets.

Hypokalemia

See PRECAUTIONS

Lipodystrophy

Administration of insulin subcutaneously can result in lipoatrophy (depression in the skin) or lipohypertrophy (enlargement or thickening of tissue).

Allergy

Local Allergy – Patients occasionally experience erythema, local edema, and pruritus at the site of injection. This condition usually is self-limiting. In some instances, this condition may be related to factors other than insulin, such as irritants in the skin cleansing agent or poor injection technique.

Systemic Allergy – Less common, but potentially more serious, is generalized allergy to insulin, which may cause rash over the whole body, shortness of breath, wheezing, reduction in blood pressure, fast pulse, or sweating. Severe cases of generalized allergy (anaphylaxis) may be life threatening.

Weight Gain

Weight gain can occur with some insulin therapies and has been attributed to the anabolic effects of insulin and the decrease in glycosuria.

Peripheral Edema

Insulin may cause sodium retention and edema, particularly if previously poor metabolic control is improved by intensified insulin therapy.

Read the entire FDA prescribing information for Humulin R (Insulin (Human Recombinant))

Humulin R is the brand name of a medicine that contains insulin regular (a short-acting form of insulin).

Insulin is a hormone that’s produced by the body in the pancreas. It works to lower levels of sugar in the blood.

This prescription medicine is injected to improve blood sugar control in adults with diabetes.

The U.S. Food and Drug Administration (FDA) first approved human insulin in 1982. Humulin R is marketed by Ely Lilly and Company.

Humulin R Warnings

Humulin R shouldn’t be used during an episode of hypoglycemia (low blood sugar).

Low blood sugar is a common side effect of insulin. Symptoms may include:

  • Hunger
  • Headache
  • Weakness
  • Sweating
  • Irritability
  • Tremors
  • Trouble concentrating
  • Fast heartbeat
  • Fainting
  • Seizures

Look out for signs of low blood sugar, and carry candy or glucose tablets in case you have an episode.

You may also experience signs of hyperglycemia (high blood sugar), which often include:

  • Hunger
  • Increased thirst
  • Dry mouth
  • Fruity breath odor
  • Dry skin
  • Blurred vision
  • Weight loss
  • Increased urination
  • Drowsiness

You’ll need to monitor your blood sugar levels often while taking this medicine.

It’s important that you keep Humulin R with you at all times. Be sure to get your prescription refilled before you run out of this medicine.

Don’t change the brand of insulin or type of syringe you’re using without first talking to your healthcare provider. They may not be interchangeable.

Before taking Humulin R, tell your doctor if you have, or have ever had:

  • Kidney or liver disease
  • Heart failure, or other heart problems
  • Nerve, adrenal, pituitary, or thyroid problems
  • Eye problems caused by diabetes
  • Allergies to medications

Let your doctor know about all the medicines you’re taking while using Humulin R, especially certain oral diabetes drugs, such as Actos (pioglitazone hydrochloride) or Avandia (rosiglitazone maleate). These treatments may increase your risk of serious heart problems if they’re taken with insulin.

Illness, injury, or unusual stress can affect your blood sugar levels. They may also affect how much insulin you need. Talk to your doctor if you experience any of these situations while taking Humulin R.

Your doctor will probably want to perform frequent tests to monitor your diabetes while you’re using Humulin R. Keep all appointments with your healthcare provider and laboratory.

Always wear a diabetic ID bracelet to be sure you get proper treatment in case of an emergency.

Pregnancy and Humulin R

Humulin R isn’t expected to harm an unborn baby if taken during pregnancy.

Still, tell your doctor if you’re pregnant or might become pregnant while using this medicine.

It’s not known whether insulin passes into breast milk or could hurt a breastfeeding baby.

Talk to your doctor before breastfeeding while using Humulin R.

Generic Name: insulin regular (IN soo lin REG yoo lar)
Brand Name: HumuLIN R, Myxredlin, NovoLIN R

Medically reviewed by Drugs.com on Oct 29, 2019 – Written by Cerner Multum

  • Overview
  • Side Effects
  • Dosage
  • Professional
  • Interactions
  • More

What is regular insulin?

Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Regular insulin is a short-acting insulin that starts to work within 30 minutes after injection, peaks in 2 to 3 hours, and keeps working for up to 8 hours.

Regular insulin is used to improve blood sugar control in adults and children with diabetes mellitus. Humulin R may be used for type 1 or type 2 diabetes.

Regular insulin may also be used for purposes not listed in this medication guide.

Important Information

You should not use insulin if you are having an episode of hypoglycemia (low blood sugar).

Before taking this medicine

You should not use Humulin R if you are allergic to insulin, or if you are having an episode of hypoglycemia (low blood sugar).

Regular insulin is not approved for use by anyone younger than 2 years old. Regular insulin should not be used to treat type 2 diabetes in a child of any age.

Tell your doctor if you have ever had:

  • liver or kidney disease; or

  • heart failure.

Taking certain oral diabetes medicines while using insulin may increase your risk of serious heart problems. Tell your doctor if you also take medicine that contains pioglitazone or rosiglitazone.

Follow your doctor’s instructions about using insulin if you are pregnant or breastfeeding. Blood sugar control is very important during pregnancy, and your dose needs may be different during each trimester of pregnancy. Your dose needs may also be different while you are breast-feeding.

How should I use regular insulin?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Regular insulin is injected under the skin. A healthcare provider may teach you how to properly use the medication by yourself. Regular insulin must not be given with an insulin pump. Do not inject regular insulin into a vein or a muscle.

Read and carefully follow any Instructions for Use provided with your medicine. Do not use insulin if you don’t understand all instructions for proper use. Ask your doctor or pharmacist if you have questions.

Prepare your injection only when you are ready to give it. Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.

Your care provider will show you where on your body to inject insulin. Use a different place each time you give an injection. Do not inject into the same place two times in a row.

After using regular insulin, you should eat a meal within 30 minutes.

Never share a syringe with another person, even if the needle has been changed. Sharing syringes can allow infections or disease to pass from one person to another.

You may have low blood sugar (hypoglycemia) and feel very hungry, dizzy, irritable, confused, anxious, or shaky. To quickly treat hypoglycemia, eat or drink a fast-acting source of sugar (fruit juice, hard candy, crackers, raisins, or non-diet soda).

Your doctor may prescribe a glucagon injection kit in case you have severe hypoglycemia. Be sure your family or close friends know how to give you this injection in an emergency.

Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst or urination.

Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.

Insulin is only part of a complete treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor’s instructions very closely.

In case of emergency, wear or carry medical identification to let others know you have diabetes.

Keep this medicine in its original container protected from heat and light. Do not freeze insulin or store it near the cooling element in a refrigerator. Throw away any insulin that has been frozen.

Storing unopened (not in use) regular insulin:

  • Refrigerate and use until expiration date; or

  • Store at room temperature and use within the number of days shown in your Instructions for Use.

Storing opened (in use) regular insulin:

  • Store at room temperature and use within the number of days shown in your Instructions for Use.

Use a needle and syringe only once and then place them in a puncture-proof “sharps” container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

Keep insulin on hand at all times. Get your prescription refilled before you run out of medicine completely.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Insulin overdose can cause life-threatening hypoglycemia. Symptoms include drowsiness, confusion, blurred vision, numbness or tingling in your mouth, trouble speaking, muscle weakness, clumsy or jerky movements, seizure (convulsions), or loss of consciousness.

What should I avoid while using regular insulin?

Do not change the brand of insulin or syringe you are using without first talking to your doctor or pharmacist. Some brands of insulin and syringes are interchangeable, while others are not. Your doctor and/or pharmacist know which brands can be substituted for one another.

Insulin can cause low blood sugar. Avoid driving or operating machinery until you know how Humulin R will affect you.

Avoid medication errors by always checking the medicine label before injecting your insulin.

Avoid drinking alcohol. It can interfere with your diabetes treatment.

Regular insulin side effects

Get emergency medical help if you have signs of insulin allergy: redness, swelling, sweating, itchy skin rash over the entire body, trouble breathing, fast heartbeats, feeling like you might pass out, or swelling in your tongue or throat.

Call your doctor at once if you have:

  • low potassium–leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.

Common side effects may include:

  • low blood sugar;

  • swelling in your hands or feet;

  • weight gain; or

  • thickening or hollowing of the skin where you injected the medicine.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect regular insulin?

Many other medicines can affect your blood sugar, or increase/decrease the effects of insulin. Some drugs can also cause you to have fewer symptoms of hypoglycemia, making it harder to tell when your blood sugar is low. Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2018 Cerner Multum, Inc. Version: 9.03.

Medical Disclaimer

More about Humulin R (insulin regular)

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  • 1 Review
  • Drug class: insulin
  • FDA Alerts (1)

Consumer resources

  • Humulin R
  • Humulin R (Advanced Reading)

Other brands: Novolin R, Humulin R U-500 (Concentrated), Humulin R U-500 KwikPen, Myxredlin

Professional resources

  • Humulin R (FDA)

Related treatment guides

  • Diabetes, Type 2
  • Diabetes, Type 1
  • Diabetic Ketoacidosis
  • Gestational Diabetes
  • … +4 more

insulin regular (HumuLIN R, NovoLIN R, NovoLIN R Innolet)

What should I discuss with my healthcare provider before using regular insulin?

You should not use this medicine if you are allergic to insulin, or if you are having an episode of hypoglycemia (low blood sugar).

Regular insulin is not approved for use by anyone younger than 2 years old. Regular insulin should not be used to treat type 2 diabetes in a child of any age.

Tell your doctor if you have ever had:

  • liver or kidney disease; or
  • heart failure.

Taking certain oral diabetes medicines while using insulin may increase your risk of serious heart problems. Tell your doctor if you also take medicine that contains pioglitazone or rosiglitazone.

Follow your doctor’s instructions about using insulin if you are pregnant or breast-feeding. Blood sugar control is very important during pregnancy, and your dose needs may be different during each trimester of pregnancy. Your dose needs may also be different while you are breast-feeding.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Regular insulin is injected under the skin. A healthcare provider may teach you how to properly use the medication by yourself. Regular insulin must not be given with an insulin pump. Do not inject regular insulin into a vein or a muscle.

Read and carefully follow any Instructions for Use provided with your medicine. Do not use insulin if you don’t understand all instructions for proper use. Ask your doctor or pharmacist if you have questions.

Prepare your injection only when you are ready to give it. Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.

Your care provider will show you where to on your body to inject insulin. Use a different place each time you give an injection. Do not inject into the same place two times in a row.

After using regular insulin, you should eat a meal within 30 minutes.

Never share a syringe with another person, even if the needle has been changed. Sharing syringes can allow infections or disease to pass from one person to another.

Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, irritability, dizziness, nausea, and feeling shaky. To quickly treat low blood sugar, always keep a fast-acting source of sugar with you such as fruit juice, hard candy, crackers, raisins, or non-diet soda.

Your doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drink. Be sure your family and close friends know how to give you this injection in an emergency.

Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst or urination, blurred vision, headache, and tiredness.

Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.

Insulin is only part of a complete treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor’s instructions very closely.

In case of emergency, wear or carry medical identification to let others know you have diabetes.

Keep this medicine in its original container protected from heat and light. Do not freeze insulin or store it near the cooling element in a refrigerator. Throw away any insulin that has been frozen.

Storing unopened (not in use) regular insulin:

  • Refrigerate and use until expiration date; or
  • Store at room temperature and use within 42 days.

Storing opened (in use) regular insulin:

  • Store at room temperature and use within 42 days.

Use a needle and syringe only once and then place them in a puncture-proof “sharps” container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

QUESTION

Diabetes is defined best as… See Answer

insulin regular, concentrated (U-500) (HumuLIN R (Concentrated), HumuLIN R KwikPen (Concentrated))

What should I discuss with my healthcare provider before using U-500 insulin (HumuLIN R (Concentrated), HumuLIN R KwikPen (Concentrated))?

You should not use this medicine if you are allergic to insulin, or if you are having an episode of hypoglycemia (low blood sugar).

To make sure U-500 insulin is safe for you, tell your doctor if you have:

  • liver or kidney disease; or
  • low levels of potassium in your blood (hypokalemia).

Tell your doctor if you also take pioglitazone or rosiglitazone (sometimes contained in combinations with glimepiride or metformin). Taking certain oral diabetes medicines while you are using insulin may increase your risk of serious heart problems.

Follow your doctor’s instructions about using insulin if you are pregnant or breast-feeding a baby. Blood sugar control is very important during pregnancy, and your dose needs may be different during each trimester of pregnancy. Your dose needs may also be different while you are breast-feeding.

How should I use U-500 insulin (HumuLIN R (Concentrated), HumuLIN R KwikPen (Concentrated))?

U-500 insulin is concentrated and contains 500 units of insulin in each milliliter (mL). This is five times more concentrated than regular U-100 insulin, which contains 100 units per mL. Measure each dose of U-500 insulin carefully. Using too much insulin can lead to insulin shock or death. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Insulin is injected under the skin. You will be shown how to use injections at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of used needles and syringes.

U-500 insulin must not be given with an insulin pump, or mixed with other insulins. Do not inject U-500 insulin into a vein or a muscle.

Your care provider will show you the best places on your body to inject U-500 insulin. Use a different place each time you give an injection. Do not inject into the same place two times in a row.

After using U-500 insulin, you should eat a meal within 30 minutes.

If you use an injection pen, use only the injection pen that comes with U-500 insulin. Attach a new needle before each use. Do not transfer the insulin from the pen into a syringe. The injection pen has a dial on it that allows you to set your correct doses of U-500 insulin.

If you use U-500 insulin from a vial (bottle), use only a U-500 insulin syringe to inject the medicine. Do not use any other type of syringe.

Do not convert your dose when using a U-500 injection pen or U-500 insulin syringe.

Never share an injection pen, cartridge, or syringe with another person, even if the needle has been changed. Sharing these devices can allow infections or disease to pass from one person to another.

Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof “sharps” disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, irritability, dizziness, nausea, fast heart rate, and feeling anxious or shaky. To quickly treat low blood sugar, always keep a fast-acting source of sugar with you such as fruit juice, hard candy, crackers, raisins, or non-diet soda.

Your doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drink. Be sure your family and close friends know how to give you this injection in an emergency.

Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst or urination, blurred vision, headache, and tiredness.

Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your insulin dose or schedule.

U-500 insulin is only part of a complete treatment program that may also include diet, exercise, weight control, regular blood sugar testing, and special medical care. Follow your doctor’s instructions very closely.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Keep this medicine in its original container protected from heat and light. Do not draw insulin from a vial into a syringe until you are ready to give an injection. Do not freeze insulin or store it near the cooling element in a refrigerator. Throw away any insulin that has been frozen.

Storing unopened (not in use) U-500 insulin:

  • Refrigerate and use until expiration date; or
  • Store at room temperature and use within 28 days.

Storing opened (in use) U-500 insulin:

  • Store the vial in a refrigerator or at room temperature and use within 40 days. Do not shake the vial.
  • Store the injection pen at room temperature (do not refrigerate) and use within 28 days. Do not store the injection pen with a needle attached.

Do not use the medicine if it looks cloudy, has changed colors, or has any particles in it. Call your pharmacist for new medicine.

Wear a diabetes medical alert tag or carry an ID card, in case of emergency. Any medical care provider who treats you should know that you have diabetes.

Diabetes is defined best as… See Answer

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