- Can I take fexofenadine and erythromycin together?
- Can I take fexofenadine and antifungal drugs together?
- Can I take fexofenadine and St. John’s Wort together?
- Can I take fexofenadine with Quinapril together?
- Can I take fexofenadine with Cabometyx?
- Can I take fexofenadine with aluminum hydroxide?
- Fexofenadine and weight gain?
- Can I take fexofenadine with coffee?
- Can I take fexofenadine with milk?
- Can I take fexofenadine with fruit juice?
- Can I take fexofenadine with Tums?
- Can you take fexofenadine with Pepto Bismol?
- Can you take fexofenadine with Zantac?
- Can you take fexofenadine and alendronic acid together?
- Can I take fexofenadine and metoprolol together?
- Can I take the fexofenadine and ulipristal together?
- Can you use fexofenadine before skin tests?
- Proper storage and disposal information of fexofenadine
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- How to take fexofenadine
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Can I take fexofenadine and erythromycin together?
Coadministration of fexofenadine and erythromycin has been shown to increase blood concentrations of fexofenadine. The proposed mechanism is erythromycin inhibition of the fexofenadine intestinal efflux through the P-glycoprotein transporter. Furthermore, erythromycin may decrease biliary excretion of fexofenadine. However, no increases of adverse effects or QT prolongation interval were noted.
Can I take fexofenadine and antifungal drugs together?
Fexofenadine should not be taken together in combination with antifungal drugs such as: ketoconazole, itraconazole, fluconazole, clotrimazole, miconazole etc. Coadministration of fexofenadine and mentioned antifungal drugs has been shown to increase blood concentrations of fexofenadine.
The proposed mechanism is erythromycin inhibition of the fexofenadine intestinal efflux through the P-glycoprotein transporter. Furthermore, erythromycin may decrease biliary excretion of fexofenadine. However, no increases of adverse effects or QT prolongation interval were noted.
Can I take fexofenadine and St. John’s Wort together?
Fexofenadine should not be taken together with St. John’s Wort products. Acute administration of St. John’s wort may increase blood concentrations of fexofenadine, while long-term use reverses the effects and may actually reduce the fexofenadine bioavailability.
At the beginning, St. John’s wort appears to first inhibit and then subsequently induce intestinal P-glycoprotein following multiple doses, resulting in enhanced fexofenadine secretion and absorption. Otherwise, large single doses may inhibit P-glycoprotein, whereas smaller, multiple daily doses are likely to induce P-glycoprotein.
Can I take fexofenadine with Quinapril together?
No, you can’t take fexofenadine and quinapril together. If you take these medicines together then quinapril will interact with fexofenadine in the gastrointestinal tract as a result the absorption into bloodstream of fexofenadine may be ineffective which cause less fexofenadine medication effectiveness.
In such case, if you want to evade the interaction then you have to take these two medicines at least two to three hour gap. If you mark any side effects then don’t just abrupt the medication suddenly just takes the help of your physician.
Can I take fexofenadine with Cabometyx?
No, you can’t use fexofenadine with cabometyx medication together because interactions found between these two medicines. By using these two drugs together the cabometyx may boost the effect of fexofenadine and the blood levels. Sometimes you may need dose adjustment so if you mark any side effects then ask your physician and another important think you should say all the drugs you are using even if you are taking any kind of herbs.
Can I take fexofenadine with aluminum hydroxide?
No, you can’t take aluminum hydroxide with fexofenadine because if you use these two medications together then effect of fexofenadine may decrease. Remember always take fexofenadine at least two hours before the aluminum hydroxide for the best result. Never stop this medication immediately if you mark any side effects first go for a medical checkup.
Fexofenadine and weight gain?
According to the medical research, there is no such weight gain effect those who are using fexofenadine but rare people reported about weight gain. In such case, you may or may not require any medical attention. If you are gaining weight suddenly then it may be serious in such case go for the immediate medical checkup.
Can I take fexofenadine with coffee?
Fexofenadine should not be taken together with coffee. Generally the patient with gastric hyper-secretory, GERD and esophagitis should always avoid coffee as it can be very serious for you or increase the side effects.
Can I take fexofenadine with milk?
Fexofenadine should not be taken with milk as it slower the effects of the fexofenadine medication so always waits for around one to two hours after taking the fexofenadine before consuming milk for the better result.
Can I take fexofenadine with fruit juice?
Consuming large amounts of certain fruit juices, including grapefruit, apple or orange, may decrease the levels of fexofenadine in your body. Pharmacokinetics analysis showed that the bioavailability of Fexofenadine was reduced by 36%. Fexofenadine should be taken with water and refrain from drinking large amounts of grapefruit, orange, or apple juice. This will make it easier for your body to absorb the medication.
Can I take fexofenadine with Tums?
Since there are no interactions between fexofenadine and tums ingredients, the patient can combine these two medicines during a short-term period. It is especially good at the beginning of fexofenadine therapy, because fexofenadine full effects are expected at least 1 day, while Tums are working immediately in relieving heartburn, but only for a short-time.
Ideally, you would take a chewable antacid such are tums at least a half hour after taking fexofenadine because you should give your body a little time to get the fexofenadine in before taking tums that work by coating the stomach.
Can you take fexofenadine with Pepto Bismol?
There is no such drug interaction between fexofenadine with Pepto Bismol according to the medical data base that doesn’t mean that there is no interactions exists in between them so take these two medications cautiously. If you mark any side effect then go for medical attention immediately.
Can you take fexofenadine with Zantac?
Yes, you can take fexofenadine with Zantac safely. According to medical science there is no such interactions found between these two drugs.
Can you take fexofenadine and alendronic acid together?
You can’t use fexofenadine and alendronic acid together because medical interaction found in between these drugs. Alendronic acid is normally used in women for the avoidance and treatment of osteoporosis which is mostly caused by menopause and in men and women to treat osteoporosis caused by taking steroids.
Alendronic acid is also used in order to increase bone mass in men with diagnosed osteoporosis, and to treat Paget’s disease of bone in men and women. Using these two medications together can increase the side effects which can put bad effects on your body so normally these drugs are not recommended to use together.
Can I take fexofenadine and metoprolol together?
Yes, you can take fexofenadine and metoprolol together as till the date there is no such interactions found according to the medical data base.fexofenadine is an antihistamine and it has no such interaction with metoprolol so don’t worry you can take it safely.
Can I take the fexofenadine and ulipristal together?
No, you can’t take ulipristal and fexofenadine together because using these two drugs together can be serious and drug interactions happen. Ulipristal may augment the blood levels and also increase the effects of fexofenadine, in such condition you may need regular monitor of your health or dose adjustment so it’s too risky.
Can you use fexofenadine before skin tests?
No, you can’t use fexofenadine before skin tests antigens because the fexofenadine may interfere with your response to skin test antigens, multiple. If you are using fexofenadine then you need to tell it to your physician before you get tested with skin test antigens, multiple.
Proper storage and disposal information of fexofenadine
Always store fexofenadine drug in between 68 to 77 degrees F. Always keepthis medicine away from sun light, heat and moisture. Keep these medicines in the original packaging until you use these medicines. Most important thing is always keep these medicines away from the pets and children. Never keep the expired medicine and to know about the perfect disposal method you can ask your pharmacists.
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|Type of medicine||A non-drowsy antihistamine|
|Used for||Seasonal allergic rhinitis (hay fever); chronic urticaria (hives)|
|Also called (UK)||Telfast®|
|Also called (USA)||Allegra®; Aller-Ease®; Mucinex® Allergy; Wal-Fex®
Combination brand: Allegra-D® (fexofenadine with pseudoephedrine)
|Available as||Tablets, oral liquid medicine (USA)|
Exposure to pollen can cause your body to produce allergic symptoms, called hay fever. Cells in the linings of your nose and eyes release a chemical called histamine when they come into contact with pollen. Histamine causes inflammation (rhinitis), which produces symptoms such as sneezing and a runny or blocked nose. It also causes red, watery and itchy eyes (allergic conjunctivitis). Fexofenadine, an antihistamine, stops the effects of histamine and this helps to relieve these symptoms.
Urticaria is a condition where an itchy skin rash develops. The rash may be triggered by an allergy or it can be caused by some other factor which may not be known. If the rash lasts for longer than six weeks, it is referred to as chronic urticaria. Fexofenadine is given to ease the symptoms of rash in people with chronic urticaria.
There are three strengths of fexofenadine tablet available – 30 mg, 120 mg and 180 mg. The 30 mg strength is for treating hay fever in children aged 6-12 years; the 120 mg strength is for treating adults with hay fever; and the 180 mg strength is for chronic urticaria.
Before taking fexofenadine
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you (or your child) start taking fexofenadine it is important that your doctor knows:
- If you are pregnant, trying for a baby or breast-feeding.
- If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
- If you have ever had an allergic reaction to another antihistamine, or to any other medicine.
How to take fexofenadine
- Before you start treatment, read the manufacturer’s printed information leaflet from inside your pack. It will give you more information about fexofenadine and a full list of side-effects which you may experience from taking it.
- Recommended doses of fexofenadine are:
- For adults with seasonal allergic rhinitis (hay fever): 120 mg taken once a day.
- For children aged 6-12 years with seasonal allergic rhinitis (hay fever): 30 mg taken twice a day, in the morning and evening.
- For adults with chronic urticaria: 180 mg taken once a day.
- You should take fexofenadine before a meal where possible. Some people find it helps to swallow the tablet with a drink of water. Try to take the tablets at the same time of day each day, as this will help you to remember to take them.
- If you do forget to take a dose, don’t worry, but do remember to take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.
- Some antacids can reduce the amount of fexofenadine your body absorbs. Because of this, it is recommended that you do not take indigestion remedies during the two hours before or during the two hours after you take a fexofenadine tablet.
Getting the most from your treatment
- Many people only need to take an antihistamine when they have symptoms. Unless you are told otherwise, you should stop taking fexofenadine once your symptoms have eased.
- Although fexofenadine is classed as a non-drowsy antihistamine, it can still cause drowsiness in a few people. If this happens to you, do not drive and do not use tools or machines.
- If you drink alcohol while you are on fexofenadine, be aware of its effects on you and do not drink more than moderate amounts. Alcohol can increase the risk of side-effects from antihistamines.
- If you are having an operation, or any treatment or tests (particularly if it is to test for an allergy), make sure you say that you are taking an antihistamine.
- If you buy any medicines, check with a pharmacist that they are suitable to take with an antihistamine. This is because a number of other medicines can increase the risk of side-effects.
Can fexofenadine cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains the most common ones associated with fexofenadine. You will find a full list in the manufacturer’s information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any continue or become troublesome.
|Common fexofenadine side-effects (these affect less than 1 in 10 people)||What can I do if I experience this?|
|Headache||Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the headaches continue, let your doctor know|
|Feeling tired or dizzy||Do not drive and do not use tools or machines until you feel better. Do not drink alcohol|
|Feeling sick (nausea)||Stick to simple meals – avoid spicy foods|
If you experience any other symptoms which you think may be due to the medicine, discuss them with your doctor or pharmacist.
How to store fexofenadine
- Keep all medicines out of the reach and sight of children.
- Store in a cool, dry place, away from direct heat and light.
Important information about all medicines
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
Medical Editor: Charles Patrick Davis, MD, PhD
Last reviewed on RxList 10/24/2019
What Is Allegra?
Allegra (fexofenadine hydrochloride) is an antihistamine used to treat allergic symptoms of seasonal allergic rhinitis, including:
- runny nose,
- itchy or watery eyes, and
- urticaria (hives)
Allegra is available as a generic drug.
What Are Side Effects of Allegra?
Common side effects of Allegra include:
- upset stomach,
- muscle or back discomfort or pain,
- headache, and
- menstrual cramps.
Contact your doctor if you have serious but less common side effects of Allegra including:
- allergic reactions,
- body aches,
- cough, or
- other flu symptoms.
Dosage for Allegra
Allegra is available in several strengths and forms; as tablets in strengths of 30, 60 and 180 mg, as 30 mg fast orally disintegrating tablets (available in foil blister packs and labeled “ODT”; the drug should not be touched by skin as it may begin to dissolve and reduce the oral dose) and as an oral suspension of 30mg per 5 ml.
Allegra In Children
The dosage is dependent on the age, weight and effectiveness of the drug; special care should be taken when prescribing this drug to infants and children to make sure the recommended dosage is given.
What Drugs, Substances, or Supplements Interact with Allegra?
Allegra may interact with:
- ketoconazole, or
Allegra may also interact with other medicines that make you sleepy such as:
- cold or allergy medicine,
- narcotic pain medicine,
- sleeping pills,
- muscle relaxers, and
- medicine for seizures, depression, or anxiety
Allegra During Pregnancy and Breastfeeding
Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant while using Allegra; it is unknown if it will harm a fetus. It is unknown if Allegra passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding. Note that the Allegra ODT tablets (orally disintegrating tablets) contain 5.3 mg of phenylalanine and should not be used by individuals with phenylketonuria.
Our Allegra Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
- Abdelaziz MM, Devalia JL, Khair OA, et al. Effect of fexofenadine on eosinophil-induced changes in epithelial permeability and cytokine release from nasal epithelial cells of patients with seasonal allergic rhinitis. J Allergy Clin Immunol. 1998;101:410–20.
- Adenot M, Lahana R, Adenot M, et al. Blood-brain barrier permeation models: discriminating between potential CNS and non-CNS drugs including P-glycoprotein substrates. J Chem Inf Comput Sci. 2004;44:239–48.
- Akiyama S, Cornwell MM, Kuwano M, et al. Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog. Mol Pharmacol. 1988;33:144–7.
- Allocco FT, Votypka V, deTineo M, et al. Effects of fexofenadine on the early response to nasal allergen challenge. Ann Allergy Asthma Immunol. 2002;89:578–84.
- Asano K, Kanai K, Furuta A, et al. Suppressive activity of fexofenadine hydrochloride on nitric oxide production in-vitro and in-vivo. J Pharm Pharmacol. 2007;59:1389–95.
- Asano K, Kanai K, Suzaki H, et al. Suppressive activity of fexofenadine hydrochloride on the production of eosinophil chemoattractants from human nasal fibroblasts in vitro. Arzneimittelforschung. 2004a;54:436–43.
- Asano K, Kanai K, Suzaki H, et al. Suppressive activity of fexofenadine hydrochloride on thymus- and activation-regulated chemokine production from human peripheral blood leukocytes in response to antigenic stimulation in vitro. Int Arch Allergy Immunol. 2004b;133:267–75.
- Asano K, Kanai KI, Suzaki H, et al. Suppressive activity of fexofenadine hydrochloride on metalloproteinase production from nasal fibroblasts in vitro. Clin Exp Allergy. 2004c;34:1890–8.
- Baltes S, Gastens AM, Fedrowitz M, et al. Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein. Neuropharmacology. 2007;52:333–46.
- Banerji A, Long AA, Camargo CA., Jr Diphenhydramine versus nonsedating antihistamines for acute allergic reactions: a literature review. Allergy Asthma Proc. 2007;28:418–26.
- Banfield C, Gupta S, Marino M, et al. Grapefruit juice reduces the oral bioavailability of fexofenadine but not desloratadine. Clin Pharmacokinet. 2002;41:311–8.
- Bielory L, Leonov A. Stereoconfiguration of antiallergic and immunologic drugs. Ann Allerg Asthma Immunol. 2008;100:1–8.
- Bower EA, Moore JL, Moss M, et al. The effects of single-dose fexofenadine, diphenhydramine, and placebo on cognitive performance in flight personnel. Aviat Space Environ Med. 2003;74:145–52.
- Brannan JD, Anderson SD, Gomes K, et al. Fexofenadine decreases sensitivity to and montelukast improves recovery from inhaled mannitol. Am J Respir Crit Care Med. 2001;163:1420–5.
- Bronsky EA, Falliers CJ, Kaiser HB, et al. Effectiveness and safety of fexofenadine, a new nonsedating H1-receptor antagonist, in the treatment of fall allergies. Allergy Asthma Proc. 1998;19:135–41.
- Casale TB, Andrade C, Qu R, et al. Safety and efficacy of once-daily fexofenadine HCl in the treatment of autumn seasonal allergic rhinitis. Allergy Asthma Proc. 1999;20:193–8.
- Cassano N, Filotico R, D’Argento V, et al. In vivo anti-inflammatory effects of fexofenadine in chronic idiopathic urticaria. J Eur Acad Dermatol Venereol. 2002;16:421–2.
- Charuk JH, Loo TW, Clarke DM, et al. Interaction of rat kidney P-glycoprotein with a urinary component and various drugs including cyclosporin A. Am J Physiol. 1994;266:F66–75.
- Chiou WL, Chung SM, Wu TC. Potential role of P-glycoprotein in affecting hepatic metabolism of drugs. Pharm Res. 2000;17:903–5.
- Choi SU, Park SH, Kim KH, et al. The bisbenzylisoquinoline alkaloids, tetrandine and fangchinoline, enhance the cytotoxicity of multidrug resistance-related drugs via modulation of P-glycoprotein. Anticancer Drugs. 1998;9:255–61.
- Ciprandi G, Cirillo I, Vizzaccaro A, et al. Mizolastine and fexofenadine modulate cytokine pattern after nasal allergen challenge. Allerg Immunol (Paris) 2004;36:146–50.
- Craig-McFeely PM, Acharya NV, Shakir SA, et al. Evaluation of the safety of fexofenadine from experience gained in general practice use in England in 1997. Eur J Clin Pharmacol. 2001;57:313–20.
- Craig-McFeely PM, Freemantle SL, Pearce GL, et al. QT lengthening and life-threatening arrhythmias associated with fexofenadine. Br J Gen Pract. 2000;50:148.
- Crowe A, Ilett KF, Karunajeewa HA, et al. Role of P glycoprotein in absorption of novel antimalarial drugs. Antimicrob Agents Chemother. 2006a;50:3504–6.
- Crowe A, Teoh YK, Crowe A, et al. Limited P-glycoprotein mediated efflux for anti-epileptic drugs. J Drug Target. 2006b;14:291–300.
- Cvetkovic M, Leake B, Fromm MF, et al. OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999;27:866–71.
- Dhar S, Hazra PK, Malakar S, et al. Fexofenadine-induced QT prolongation: a myth or fact? Br J Dermatol. 2000;142:1260–1.
- Dicpinigaitis PV, Gayle YE, Dicpinigaitis PV, et al. Effect of the second-generation antihistamine, fexofenadine, on cough reflex sensitivity and pulmonary function. Br J Clin Pharmacol. 2003;56:501–4.
- DiDiodato G, Sharom FJ. Interaction of combinations of drugs, chemosensitizers, and peptides with the P-glycoprotein multidrug transporter. Biochem Pharmacol. 1997;53:1789–97.
- Doran A, Obach RS, Smith BJ, et al. The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model. Drug Metab Dispos. 2005;33:165–74.
- Drescher S, Schaeffeler E, Hitzl M, et al. MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine. Br J Clin Pharmacol. 2002;53:526–34.
- Dresser GK, Bailey DG, Leake BF, et al. Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine. Clin Pharmacol Ther. 2002;71:11–20.
- Dresser GK, Kim RB, Bailey DG, et al. Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: possible role of organic anion transporting polypeptides. Clin Pharmacol Ther. 2005;77:170–7.
- Ejsing TB, Morling N, Linnet K, et al. A review on the relation between the brain-serum concentration ratio of drugs and the influence of P-glycoprotein. Drug Metabol Drug Interact. 2007;22:113–29.
- Elsinga PH, Hendrikse NH, Bart J, et al. PET Studies on P-glycoprotein function in the blood-brain barrier: how it affects uptake and binding of drugs within the CNS. Curr Pharm Des. 2004;10:1493–503.
- Faassen F, Vogel G, Spanings H, et al. Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003;263:113–22.
- Fardon TC, Lee DK, Hodge MR, et al. Addition of fexofenadine to inhaled corticosteroid therapy to reduce inflammatory biomarkers in atopic asthma. Ann Allergy Asthma Immunol. 2005;95:259–65.
- Feng B, Mills JB, Davidson RE, et al. In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system. Drug Metab Dispos. 2008;36:268–75.
- Fokkens WJ, Broekhuis-Fluitsma DM, Rijntjes E, et al. Langerhans cells in nasal mucosa of patients with grass pollen allergy. Immunobiology. 1991;182:135–42.
- Fromm MF. P-glycoprotein: a defense mechanism limiting oral bioavailability and CNS accumulation of drugs. Int J Clin Pharmacol Ther. 2000;38:69–74.
- Garrigues A, Nugier J, Orlowski S, et al. A high-throughput screening microplate test for the interaction of drugs with P-glycoprotein. Anal Biochem. 2002;305:106–14.
- Gelfand EW, Cui ZH, Takeda K, et al. Fexofenadine modulates T-cell function, preventing allergen-induced airway inflammation and hyperresponsiveness. J Allergy Clin Immunol. 2002;110:85–95.
- Giraud T, Giraud T. QT lengthening and arrhythmias associated with fexofenadine. Lancet. 1999;353:2072–3.
- Gouaze V, Liu YY, Prickett CS, et al. Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs. Cancer Res. 2005;65:3861–7.
- Graft DF, Bernstein DI, Goldsobel A, et al. Safety of fexofenadine in children treated for seasonal allergic rhinitis. Ann Allergy Asthma Immunol. 2001;87:22–6.
- Grewal IS, Flavell RA. A central role of CD40 ligand in the regulation of CD4+ T-cell responses. Immunol Today. 1996;17:410–4.
- Grubbe RE, Nayak A, Kittner B, et al. The pharmacokinetics (PK), safety and tolerability of fexofenadine HCL 6 mg/mL suspension in children with allergic rhinitis (AR): a multicenter, open-label, single-dose study. J Allergy Clin Immunol. 2007;119:S143.
- Hamman MA, Bruce MA, Haehner-Daniels BD, et al. The effect of rifampin administration on the disposition of fexofenadine. Clin Pharmacol Ther. 2001;69:114–21.
- Hampel FC, Kittner B, van Bavel JH, et al. Safety and tolerability of fexofenadine hydrochloride, 15 and 30 mg, twice daily in children aged 6 months to 2 years with allergic rhinitis. Ann Allergy Asthma Immunol. 2007;99:549–54.
- Handa S, Dogra S, Kumar B, et al. Comparative efficacy of cetirizine and fexofenadine in the treatment of chronic idiopathic urticaria. J Dermatolog Treat. 2004;15:55–7.
- Hanko E, Tommarello S, Watchko JF, et al. Administration of drugs known to inhibit P-glycoprotein increases brain bilirubin and alters the regional distribution of bilirubin in rat brain. Pediatr Res. 2003;54:441–5.
- Hayeshi R, Masimirembwa C, Mukanganyama S, et al. The potential inhibitory effect of antiparasitic drugs and natural products on P-glycoprotein mediated efflux. Eur J Pharm Sci. 2006;29:70–81.
- Hindmarch I, Shamsi Z, Kimber S, et al. An evaluation of the effects of high-dose fexofenadine on the central nervous system: a double-blind, placebo-controlled study in healthy volunteers. Clin Exp Allergy. 2002;32:133–9.
- Hindmarch I, Shamsi Z, Stanley N, et al. A double-blind, placebo-controlled investigation of the effects of fexofenadine, loratadine and promethazine on cognitive and psychomotor function. Br J Clin Pharmacol. 1999;48:200–6.
- Hirano H. Nippon Ika Daigaku Zasshi. 1989;56:392–9.
- Ibrahim S, Peggins J, Knapton A, et al. Influence of antipsychotic, antiemetic, and Ca(2+) channel blocker drugs on the cellular accumulation of the anticancer drug daunorubicin: P-glycoprotein modulation. J Pharmacol Exp Ther. 2000;295:1276–83.
- Ishizaka T, Ishizaka K. Immunological events at the surface of basophil granulocytes and mast cells which induce degranulation. Scand J Respir Dis Suppl. 1977;98:13–22.
- Ito T, Yano I, Tanaka K, et al. Transport of quinolone antibacterial drugs by human P-glycoprotein expressed in a kidney epithelial cell line, LLC-PK1. J Pharmacol Exp Ther. 1997;282:955–60.
- Jette L, Murphy GF, Leclerc JM, et al. Interaction of drugs with P-glycoprotein in brain capillaries. Biochem Pharmacol. 1995;50:1701–9.
- Johnson WW. P-glycoprotein-mediated efflux as a major factor in the variance of absorption and distribution of drugs: modulation of chemotherapy resistance. Methods Find Exp Clin Pharmacol. 2002;24:501–14.
- Juergens UR, Darlath W, Stober M, et al. Differential effects of fexofenadine on arachidonic acid metabolism in cultured human monocytes. Pharmacology. 2006a;76:40–5.
- Juergens UR, Gillissen A, Uen S, et al. New evidence of H1-receptor independent COX-2 inhibition by fexofenadine HCl in vitro. Pharmacology. 2006b;78:129–35.
- Kamath AV, Yao M, Zhang Y, et al. Effect of fruit juices on the oral bioavailability of fexofenadine in rats. J Pharm Sci. 2005;94:233–9.
- Kamei H, Noda Y, Ishikawa K, et al. Comparative study of acute effects of single doses of fexofenadine, olopatadine, d-chlorpheniramine and placebo on psychomotor function in healthy volunteers. Hum Psychopharmacol. 2003;18:611–8.
- Kawashima M, Harada S, Tango T, et al. Review of fexofenadine in the treatment of chronic idiopathic urticaria. Int J Dermatol. 2002;41:701–6.
- Kawashima M, Tango T, Noguchi T, et al. Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study. Br J Dermatol. 2003;148:1212–21.
- Ketabi-Kiyanvash N, Weiss J, Haefeli WE, et al. P-glycoprotein modulation by the designer drugs methylenedioxymethamphetamine, methylenedioxyethylamphetamine and paramethoxyamphetamine. Addict Biol. 2003;8:413–8.
- Kharasch ED, Walker A, Hoffer C, et al. Evaluation of first-pass cytochrome P4503A (CYP3A) and P-glycoprotein activities using alfentanil and fexofenadine in combination. J Clin Pharmacol. 2005;45:79–88.
- Kim RB, Kim RB. Drugs as P-glycoprotein substrates, inhibitors, and inducers. Drug Metab Rev. 2002;34:47–54.
- King M, Su W, Chang A, Zuckerman A, et al. Transport of opioids from the brain to the periphery by P-glycoprotein: peripheral actions of central drugs. Nat Neurosci. 2001;4:268–74.
- Kulthanan K, Gritiyarangsan P, Sitakalin C, et al. Multicenter study of the efficacy and safety of fexofenadine 60 mg. twice daily in 108 Thai patients with chronic idiopathic urticaria. J Med Assoc Thai. 2001;84:153–9.
- Lee CH, Lee CH. Differential regulation of P-glycoprotein genes in primary rat hepatocytes by collagen sandwich and drugs. J Cell Biochem. 2002;86:12–20.
- Leung DY. Molecular basis of allergic diseases. Mol Genet Metab. 1998;63:157–67.
- Leung S, Bendayan R. Role of P-glycoprotein in the renal transport of dideoxynucleoside analog drugs. Can J Physiol Pharmacol. 1999;77:625–30.
- Ling V. Charles F. Kettering Prize. P-glycoprotein and resistance to anticancer drugs. Cancer. 1992;69:2603–9.
- Litman T, Skovsgaard T, Stein WD, et al. Pumping of drugs by P-glycoprotein: a two-step process? J Pharmacol Exp Ther. 2003;307:846–53.
- Loo TW, Bartlett MC, Clarke DM, et al. Simultaneous binding of two different drugs in the binding pocket of the human multidrug resistance P-glycoprotein. J Biol Chem. 2003;278:39706–10.
- Makowski P, Pikula S. Participation of the multispecific organic anion transporter in hepatobiliary excretion of glutathione S-conjugates, drugs and other xenobiotics. Pol J Pharmacol. 1997;49:387–94.
- Mansfield L, Mendoza C, Flores J, et al. Effects of fexofenadine, diphenhydramine, and placebo on performance of the test of variables of attention (TOVA). Ann Allergy Asthma Immunol. 2003;90:554–9.
- Meltzer EO, Scheinmann P, Rosado Pinto JE, et al. Safety and efficacy of oral fexofenadine in children with seasonal allergic rhinitis – a pooled analysis of three studies. Pediatr Allergy Immunol. 2004;15:253–60.
- Milgrom H, Kittner B, Lanier R, et al. Safety and tolerability of fexofenadine for the treatment of allergic rhinitis in children 2 to 5 years old. Ann Allergy Asthma Immunol. 2007;99:358–63.
- Milne RW, Larsen LA, Jorgensen KL, et al. Hepatic disposition of fexofenadine: influence of the transport inhibitors erythromycin and dibromosulphothalein. Pharm Res. 2000;17:1511–5.
- Miura M, Uno T, Tateishi T, et al. Pharmacokinetics of fexofenadine enantiomers in healthy subjects. Chirality. 2007;19:223–7.
- Miyabe S, Koizuka I, Ochi K, et al. Effect of fexofenadine hydrochloride on cedar pollinosis. Auris Nasus Larynx. 2003;30(Suppl):S61–8.
- Mollgard L, Hellberg E, Smolowicz A, et al. Interactions between P-glycoprotein and drugs used in the supportive care of acute myeloid leukemia patients. Leuk Lymphoma. 2001;42:177–85.
- Morrison D, Sahasranaman S. The 30 mg dose of fexofenadine HCL 6 mg/mL suspension is bioequivalent to the marketed 30 mg tablet in healthy adult subjects under fasted conditions: a randomized crossover, open-label study. J Allergy Clin Immunol. 2007;119:S143.
- Nelson HS, Reynolds R, Mason J, et al. Fexofenadine HCl is safe and effective for treatment of chronic idiopathic urticaria. Ann Allergy Asthma Immunol. 2000;84:517–22.
- Neuhoff S, Langguth P, Dressler C, et al. Affinities at the verapamil binding site of MDR1-encoded P-glycoprotein: drugs and analogs, stereoisomers and metabolites. Int J Clin Pharmacol Ther. 2000;38:168–79.
- Ngamphaiboon J, Direkwattanachai C, Visitsunthorn N, et al. The efficacy and safety of 30 mg fexofenadine HCl bid in pediatric patients with allergic rhinitis. Asian Pac J Allergy Immunol. 2005;23:169–74.
- Nicholson AN, Stone BM, Turner C, et al. Antihistamines and aircrew: usefulness of fexofenadine. Aviat Space Environ Med. 2000;71:2–6.
- Okubo K, Gotoh M, Shimada K, et al. Fexofenadine improves the quality of life and work productivity in Japanese patients with seasonal allergic rhinitis during the peak cedar pollinosis season. Int Arch Allergy Immunol. 2005;136:148–54.
- Orlowski S, Garrigos M. Multiple recognition of various amphiphilic molecules by the multidrug resistance P-glycoprotein: molecular mechanisms and pharmacological consequences coming from functional interactions between various drugs. Anticancer Res. 1999;19:3109–23.
- Pascaud C, Garrigos M, Orlowski S. Multidrug resistance transporter P-glycoprotein has distinct but interacting binding sites for cytotoxic drugs and reversing agents. Biochem J. 1998;333:351–8.
- Petri N, Tannergren C, Rungstad D, et al. Transport characteristics of fexofenadine in the Caco-2 cell model. Pharm Res. 2004;21:1398–404.
- Pinto YM, van Gelder IC, Heeringa M, et al. QT lengthening and life-threatening arrhythmias associated with fexofenadine. Lancet. 1999;353:980.
- Potter PC, Schepers JM, Van Niekerk CH, et al. The effects of fexofenadine on reaction time, decision-making, and driver behavior. Ann Allergy Asthma Immunol. 2003;91:177–81.
- Pratt C, Brown AM, Rampe D, et al. Cardiovascular safety of fexofenadine HCl. Clin Exp Allergy. 1999;29(Suppl 3):212–6.
- Rebbeor JF, Senior AE. Effects of cardiovascular drugs on ATPase activity of P-glycoprotein in plasma membranes and in purified reconstituted form. Biochim Biophys Acta. 1998;1369:85–93.
- Ridout F, Hindmarch I, Ridout F, et al. The effects of acute doses of fexofenadine, promethazine, and placebo on cognitive and psychomotor function in healthy Japanese volunteers. Ann Allergy Asthma Immunol. 2003a;90:404–10.
- Ridout F, Shamsi Z, Meadows R, et al. A single-center, randomized, double-blind, placebo-controlled, crossover investigation of the effects of fexofenadine hydrochloride 180 mg alone and with alcohol, with hydroxyzine hydrochloride 50 mg as a positive internal control, on aspects of cognitive and psychomotor function related to driving a car. Clin Ther. 2003b;25:1518–38.
- Robbins DK, Castles MA, Pack DJ, et al. Dose proportionality and comparison of single and multiple dose pharmacokinetics of fexofenadine (MDL 16455) and its enantiomers in healthy male volunteers. Biopharm Drug Dispos. 1998;19:455–63.
- Russell T, Stoltz M, Weir S, et al. Pharmacokinetics, pharmacodynamics, and tolerance of single- and multiple-dose fexofenadine hydrochloride in healthy male volunteers. Clin Pharmacol Ther. 1998;64:612–21.
- Safa AR, Safa AR. Identification and characterization of the binding sites of P-glycoprotein for multidrug resistance-related drugs and modulators. Curr Med Chem Anti-Canc Agents. 2004;4:1–17.
- Sakairi T, Suzuki K, Makita S, et al. Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis. Pharmacology. 2005;75:76–86.
- Saraswat A, Saraswat M, Saraswat A, et al. Pustular exacerbation of psoriasis due to fexofenadine. Clin Exp Dermatol. 2006;31:477–8.
- Savolainen J, Edwards JE, Morgan ME, et al. Effects of a P-glycoprotein inhibitor on brain and plasma concentrations of anti-human immunodeficiency virus drugs administered in combination in rats. Drug Metab Dispos. 2002;30:479–82.
- Schinkel AH, Wagenaar E, Mol CA, et al. P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J Clin Invest. 1996;97:2517–24.
- Sharom FJ. The P-glycoprotein efflux pump: how does it transport drugs? J Membr Biol. 1997;160:161–75.
- Shimizu M, Fuse K, Okudaira K, et al. Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans. Drug Metab Dispos. 2005;33:1477–81.
- Shirasaka Y, Onishi Y, Sakurai A, et al. Evaluation of human P-glycoprotein (MDR1/ABCB1) ATPase activity assay method by comparing with in vitro transport measurements: Michaelis-Menten kinetic analysis to estimate the affinity of P-glycoprotein to drugs. Biol Pharm Bull. 2006;29:2465–71.
- Shon JH, Yoon YR, Hong WS, et al. Effect of itraconazole on the pharmacokinetics and pharmacodynamics of fexofenadine in relation to the MDR1 genetic polymorphism. Clin Pharmacol Ther. 2005;78:191–201.
- Shukla S, Sauna ZE, Ambudkar SV. Evidence for the interaction of imatinib at the transport-substrate site(s) of the multidrug-resistance-linked ABC drug transporters ABCB1 (P-glycoprotein) and ABCG2. Leukemia. 2008;22:445–7.
- Simons FE, Bergman JN, Watson WT, et al. The clinical pharmacology of fexofenadine in children. J Allergy Clin Immunol. 1996;98:1062–4.
- Simons F, Estelle R, Semus M, et al. H1-antihistaminic activity of cetirizine and fexofenadine in allergic children. Pediatr Allergy Immunol. 2003;14:207–11.
- Smit JW, Duin E, Steen H, et al. Interactions between P-glycoprotein substrates and other cationic drugs at the hepatic excretory level. Br J Pharmacol. 1998;123:361–70.
- Stoltz M, Arumugham T, Lippert C, et al. Effect of food on the bioavailability of fexofenadine hydrochloride (MDL 16455A) Biopharm Drug Dispos. 1997;18:645–8.
- Stone BM, Turner C, Mills SL, et al. Studies into the possible central effects of the H-1 receptor antagonist, fexofenadine. Int Arch Allergy Immunol. 1999;118:338.
- Storch CH, Theile D, Lindenmaier H, et al. Comparison of the inhibitory activity of anti-HIV drugs on P-glycoprotein. Biochem Pharmacol. 2007;73:1573–81.
- Tahara H, Kusuhara H, Fuse E, et al. P-glycoprotein plays a major role in the efflux of fexofenadine in the small intestine and blood-brain barrier, but only a limited role in its biliary excretion. Drug Metab Dispos. 2005;33:963–8.
- Tahara H, Kusuhara H, Maeda K, et al. Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid. Drug Metab Dispos. 2006;34:743–7.
- Takahata T, Yasui-Furukori N, Yoshiya G, et al. Fexofenadine does not affect omeprazole pharmacokinetics: both are putative P-glycoprotein substrates. Basic Clin Pharmacol Toxicol. 2004;94:252–6.
- Tannergren C, Knutson T, Knutson L, et al. The effect of ketoconazole on the in vivo intestinal permeability of fexofenadine using a regional perfusion technique. Br J Clin Pharmacol. 2003;55:182–90.
- Tashiro M, Horikawa E, Mochizuki H, et al. Effects of fexofenadine and hydroxyzine on brake reaction time during car-driving with cellular phone use. Hum Psychopharmacol. 2005;20:501–9.
- Terao T, Hisanaga E, Sai Y, et al. Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier. J Pharm Pharmacol. 1996;48:1083–9.
- Theunissen EL, Jonkman LM, Kuypers KP, et al. A combined neurophysiological and behavioural study into the stimulating effects of fexofenadine on performance. J Psychopharmacol. 2006a;20:496–505.
- Theunissen EL, van Kroonenburgh MJ, van Deursen JA, et al. Stimulating effects of the antihistamine fexofenadine: testing the dopamine transporter hypothesis. Psychopharmacology (Berl) 2006b;187:95–102.
- Uno T, Shimizu M, Sugawara K, et al. Lack of dose-dependent effects of itraconazole on the pharmacokinetic interaction with fexofenadine. Drug Metab Dispos. 2006;34:1875–9.
- van Heeswijk RP, Bourbeau M, Campbell P, et al. Time-dependent interaction between lopinavir/ritonavir and fexofenadine. J Clin Pharmacol. 2006;46:758–67.
- Vercelli D, Jabara HH, Arai K, et al. Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens. J Exp Med. 1989;169:1295–307.
- Wang JS, Zhu HJ, Markowitz JS, et al. Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein. Psychopharmacology (Berl) 2006;187:415–23.
- Wang Z, Hamman MA, Huang SM, et al. Effect of St John’s wort on the pharmacokinetics of fexofenadine. Clin Pharmacol Ther. 2002;71:414–20.
- Watanabe N, Matsuda E, Masuda A, et al. The effects of fexofenadine on eosinophilia and systemic anaphylaxis in mice infected with Trichinella spiralis. Int Immunopharmacol. 2004;4:367–75.
- Weiler JM, Bloomfield JR, Woodworth GG, et al. Effects of fexofenadine, diphenhydramine, and alcohol on driving performance. A randomized, placebo-controlled trial in the Iowa driving simulator. Ann Intern Med. 2000;132:354–63.
- Weiss J, Kerpen CJ, Lindenmaier H, et al. Interaction of antiepileptic drugs with human P-glycoprotein in vitro. J Pharmacol Exp Ther. 2003;307:262–7.
- Yi SY, Hong KS, Lim HS, et al. A variant 2677A allele of the MDR1 gene affects fexofenadine disposition. Clin Pharmacol Ther. 2004;76:418–27.
Allegra Allergy Review
Does Allegra (Fexofenadine HCl) Work for Allergies? My OTC Allegra Review:
A lot of you are really suffering from the effects of every season, including summer and winter. Perhaps your allergy symptoms are severe and disrupting the productivity of your day, making you sneeze constantly and struggle to blow your congested nose. I’ve been there and tried almost every allergy treatment available, both prescription and over-the-counter, so here is my honest and personal review of Allegra Fexofenadine HCl allergy medication.
Product: Allegra Allergy (Fexofenadine HCl)
Best Price: 40% off for $24.99 on Amazon
Treats: Seasonal allergy symptoms, minor food allergy symptoms, excessive sneezing, watery eyes, nasal congestion, inflammation of the sinuses, pollen allergies, itchy nose, sinus pressure, sinus headaches, indoor allergies, chemical sensitivities, other environmental allergies
Click here for the lowest price I could find! It’s on sale right now for 50% off. Forget about buying it in the store!
Benefits Compared to Others: Strong allergy effectiveness, lasts longer for allergy symptoms, less drowsiness
Allergens Treated: Pollen, Dust, Dander, Dust Mites, Mold, Food allergies, Environmental allergies, chemical allergies
Rating: 4.5 out of 5
My Allergy Symptoms were Horrible too!
When I was in school, I was known as the boy that had severe allergies and I think that everybody felt bad for me. Every day, I would try to blow my nose in class but nothing came out despite how hard I blew because my nasal congestion was so bad. I couldn’t hide my severe sinus congestion, excessive and constant sneezing, nasal drip, and sinus headaches and they were unbearable.
This was a point in my life where I was ignorant about allergy treatment options, whether it be from natural or medical sources. I am not sure why I didn’t try to solve my annoying problem, but I guess that I was just a lazy teenager. But finally, I started getting the motivation to seek allergy treatment because my family members, doctor, and the media had suggested that I pop pills and snort liquids to deal with my problems.
Throughout my life now, I have probably tried almost every OTC allergy drug, as well as a few prescriptions, from Benadryl, Claritin, Zyrtec, Allegra, to Xyzal. I could probably go on a list all the stuff that didn’t genuinely work for me or treat my allergy problem effectively, but Allegra was one of the more efficient drug treatments that really helped my allergy symptoms for the short term.
I am not taking Allegra anymore because I have learned that our unique individual health is complex and takes time to understand and take advantage of. The best allergy treatment for me was a change in lifestyle and tweaking my diet to supplement my unique nutritional needs, as well as using gentle, natural alternatives to harsh drugs that can affect your body in adverse ways.
If you started taking Allegra or another Fexofenadine generic brand or are considering trying it, let me share some useful information that I’ve learned about it from a seasoned allergy sufferer (me) to help you out.
How Does Allegra Work for Allergies?
Fexofenadine is a compound that works as an antihistamine in our bodies. It basically reacts with histamine, a pro-inflammation chemical produced in response to the exposure of our bodies to allergens, and eliminates it from the body. This effectively soothes the direct cause of inflammation in our bodies for the short term.
Histamine is produced by our body’s immune system as a way to promote inflammation. You hear about inflammation all the time as being a bad thing to have, but this mechanism has a biological purpose.
When there is a deadly disease in your body, your immune system tries to kill it and eliminate it so you can survive. Therefore, it produces inflammation around the disease to try to squeeze it and kill it. However, your body puts deadly diseases on the same level as harmless pollen that you are allergic to for some reason.
Your body treats allergens like it’s a pathogen going to kill you. Basically, Fexofenadine and other antihistamines like it, simply stop your own body from producing unnecessary inflammation that could have adverse effects on other aspects of your health.
Allegra is a more recently researched and developed drug that is much newer than the first-generation antihistamines like Benadryl or Diphenhydramine. Fexofenadine boasts that it is a third-generation antihistamine that focuses on increased allergy relief efficiency for a longer duration with less harmful side effects like drowsiness. However, Allegra still gives you the potential for uncomfortable side effects that may make it not worth taking it for some individuals.
This study proves that real Allegra is twice as effective than a placebo. It does something for allergies.
Proper Fexofenadine Dose by Weight and Age
This unique compound has many different uses in the body that have been backed by scientific studies and research. Along with being able to soothe allergy symptoms from hay fever, it is also used for treatment of allergic rash or “chronic idiopathic urticaria.” But we are talking about using it for allergies here, obviously.
For children ages 11 and younger, medical professionals recommend that you supplement a child with a 30 milligram dose of Allegra without the consumption of fruit juice.
For everyone ages 12 and older, the recommended dosage starts at 60 milligrams and ends at 180 milligrams depending on what your unique allergy problem is and what your doctor says. I would say that 60 milligrams was more than enough for me anyway.
Check out my source on that.
I should add that it is highly recommended that you don’t consume fruit juice, especially grapefruit or other citrus while taking your allergy supplement with Fexofenadine because it can interact with the effectiveness of the drug. It can pretty much make it useless and do nothing if you drink fruit juice with it. Strange.
Is Fexofenadine Addictive and Will it Cause Withdrawal Symptoms?
The simple answer is: Yes, Allegra can cause a physical dependency that will make your body rely on its supplementation every day. With chronic long-term use, it is very likely that you will experience withdrawal symptoms after you stop taking it cold turkey.
Antihistamines like these have such a big impact on your health in many different ways that we do not recognize or consider. There’s evidence that suggests that your body starts to work around the supplementation of Allegra and once it is gone, your immune system will not know how to react.
When you are supplementing with Fexofenadine, you are completely masking the symptoms of histamine. Since the root cause of the problem still exists (you still being allergic to whatever it is you were reacting to) your body will slowly start to increase its levels of histamine to make up for its inefficiency.
Your body still sees a harmless allergen as a deadly invader and your immune system is like “What the hell? Why isn’t the histamine working? Let’s make more to get rid of this invader,” so higher levels of histamine and other allergy chemicals will be released. However, you won’t notice because you are in a constant Allegra haze and the histamine doesn’t have a chance to work because it is quickly eliminated. One the drug is gone, you will feel the full effects of your body’s confusion until it adapts over time and stabilizes itself like it always tries to do.
This is what causes withdrawal symptoms, just like what would happen if you were addicted to a stimulant drug that gives us feelings of pleasure. Your body just gets used to something constantly supplementing its natural chemicals so it stops adapting properly itself. Once the drug is gone, your body will start to realize that it needs to adapt so that you can have a harmonious state of health.
Check out more that I wrote about the long-term effects of antihistamines on our health in a more in-depth post.
But the Internet Says that Allegra isn’t Addictive!
Don’t let the internet fool you if you search the question “Can Allegra allergy treatment cause a physical dependence or addiction?” because you will likely get biased results that are trying to get you to buy something. In fact, when you search that, the literal Allegra website comes up. Are they going to tell you the truth that their chemical drug has implications? No, they want you to buy more of their shit and for you to not be afraid of it. A negative connotation to a product or skepticism about it makes you lose customers and they know this.
Of course they are going to tell you that “Allegra is not habit-forming and can safely be used on a daily basis” because they want your money and don’t really care about your health or funding research about the long-term effects of taking it. The truth will always set us free no matter what and that is my opinion. We need to be more skeptical about what is told to us because money will always be a possible ulterior motive that we should consider before making decisions, especially regarding our and our children’s health.
Allegra (Fexofenadine) vs Xyzal (Levocetirizine) vs Zyrtec (Cetirizine) vs Claritin (Loratadine) vs Benadryl (Diphenhydramine)
Again, if you search on the internet for an accurate and honest comparison of these antihistamine tablets, then you will likely get a biased, inefficient answer that tries to make you buy something. Thankfully, I have extensive experience with all of these drugs and can give you a reasonable comparison.
Claritin or Loratadine is simply the most ineffective antihistamine I have ever tried. I remember trying this one first, taking it, and noticing no difference whatsoever. Then, I took triple the recommended dose and it made me feel very weird. This is a first-generation antihistamine so you probably shouldn’t expect anything more. I don’t recommend that you buy or take any of the first-generation antihistamines because they suck and they are potentially dangerous to your mental health.
Benadryl or Diphenhydramine is another first-generation drug that I don’t recommend even harder than Loratadine. There is extensive research that was released twenty years late that links the chronic use of Benadryl for allergies and insomnia to dementia and Alzheimer’s disease. It will get rid of your allergy symptoms for a few hours, but it will knock you out cold and make you stupid. I remember the cool kids in high school would take half a pack of Diphenhydramine to get high and I am afraid of the potential risks for their future mental health because of that.
Zyrtec or Cetirizine is a second-generation antihistamine for allergies that I also do not recommend. Although it is more effective at relieving your allergies faster and for a longer period of time, it is often criticized for its huge risk for addiction. So many adults and children are becoming physically dependent on Zyrtec due to its huge effect on the body. Many of you are struggling with this killer addiction to cetirizine and have stumbled upon this site in search of natural solutions for this problem.
Please try to not let yourself or your children become addicted to drugs like these. Some with severe allergies even check themselves into rehabilitation services after trying to stop taking Zyrtec cold turkey.
Xyzal, also known as Levocetirizine, is a third-generation antihistamine that is derived from the same chemical compound as Zyrtec. Notice how it simply has “Levo” added to “Cetirizine” because it is the racemic left enantiomer of Zyrtec. This means that the direction that the chemical compound is facing makes a huge difference in how long it will last in your system. Chemistry is complicated.
This new drug Xyzal just recently got approved for OTC purchases without the need for a prescription. After trying it, it seems extremely effective in relieving my allergy symptoms quickly. However, I am very skeptical about the long-term effects that weren’t extensively studied yet. I haven’t taken it enough to experience any addictive potential or any side effects, but it made a very strong and clear difference that kind of scared me. I felt like I was crashing at the end of the day when I took it in the morning.
I made a post all about Xyzal or Levocetirizine OTC for allergies here you can check out. Let me know in a comment if you have tried this new OTC drug!
Quercetin with bromelain does wonders for my allergies. It’s completely natural and doesn’t cause side effects or addiction. Click for the lowest price that I use myself!
Natural and Gentle Alternatives to Antihistamine Drugs
I don’t rely on antihistamines anymore because of the long-term drawbacks it had on my health. I was becoming extremely addicted to them and the side effects were very annoying and not worth taking it in the first place. The withdrawal symptoms I had experienced after stopping with these drugs for my seasonal allergies were unbearable and made me crave the drugs again to relieve the pain from my reemerged allergy symptoms.
Also, it just seems like the effectiveness of them subsides over time. At first, they are awesome and they do the job, but eventually, they just return you to the state you were at before you were taking them with mild to moderate allergy symptoms.
So what really works for allergies and excess histamine then? That is what my site is all about: figuring out what is causing your allergies in your unique health and lifestyle and then treating these factors accordingly.
Unfortunately, there’s no single answer for why you have these annoying allergies because everybody is different due to genetics, diet, exercise, and the decisions you make in your lifestyle. Everything you do affects other aspects of your health and it’s probably very ignorant to deny that without respect to your future health and well-being.
Personally, I have found that my severe allergies to all the seasons and many different foods, including food intolerances and environmental sensitivities (that have gone away now) were due to poor personal lifestyle choices that I did not realize. Some unnoticeable conditions that were affecting my allergies included organic sulfur deficiency and malnourishment from essential minerals (which is becoming very common for young people) and common intestinal parasites in humans that worsen allergies.
After supplementing with a cheap organic and bioavailable form of sulfur, which is becoming scarce in our inorganic soils due to overpopulation, and doing a natural parasite cleanse, my allergies have improved tremendously. Some of my allergies don’t even exist anymore, I would say, like my legume intolerance, gustatory rhinitis, and histamine intolerance.
From time to time, I still experience harsh allergy symptoms during peak pollen days and I will resort to taking an antihistamine like Fexofenadine for quick and effective results so that I can get through my day easily. However, I want to reject potentially addictive and harmful drugs that can affect my health adversely, like these OTC antihistamine drugs.
What genuinely works during the allergy seasons for me is a natural and gentle nasal spray for allergies and making use of a nasal irrigation tool like a neti pot to relieve the physical causes of allergy symptoms that sets your immune system off. These, among many other things, have helped me treat my allergies naturally to the point where they don’t bother me at all throughout my busy productive day and I don’t even need drugs to mask the symptoms.
Fexofenadine HCl Allegra Allergy Review Questions
Should you take Allegra in the morning or night?
Professionals recommend that you take Allegra before you go to sleep to avoid the potential side effects of drowsiness throughout the day. This makes a lot of sense to me, but I have found that the benefits of taking it slightly wear off after I wake up in the morning. I like to take antihistamines in the morning because they just work better for me that way, but becoming drowsy is always a bummer to my day. I would say that it is up to the individual to determine what works best for their body.
Does Allegra cause weight gain?
This is a tricky question and I would say that it all depends on the individual’s health. I can tell you that all antihistamines do not affect my appetite in a significant way, but some insist that the psychiatric effects of Fexofenadine increase their appetite for more unhealthy food items. Of course, that can be a problem to consider if you are affected in this way. However, this stuff does not directly cause you to gain weight because it has nothing to do with calorie or sugar intake, which is generally the root cause of weight gain and obesity.
Does Fexofenadine make you drowsy?
This antihistamine makes some people drowsy, but it does not seem to be a major problem that is frequently talked about, unlike Benadryl and Zyrtec. Perhaps I have experienced slight drowsiness when taking Allegra, but it wasn’t significant enough to be a problem. That’s why I prefer to take it in the morning. But everyone will experience things differently.
Does Allegra expire and what is its shelf life?
Yes, this drug does expire eventually. Fexofenadine has a shelf-life of about 3 years. You shouldn’t take it after this time because many people have reported severe rashes and other symptoms as a result.
Does Fexofenadine cause anxiety or depression?
This doesn’t seem to be a problem for this medication in particular. It seems that Benadryl and Zyrtec have caused significant problems for some people suffering from mental illness. Personally, I haven’t noticed a mental difference when taking Allegra allergy medicine.
Is Allegra allergy or Fexofenadine an antihistamine or steroid?
Fexofenadine is an antihistamine, not a steroid. Usually, nasal sprays contain steroids to physically relieve inflammation in your sinuses.
Does Allegra keep you awake or cause insomnia?
No, it does not seem to have any stimulating effects at all. In fact, it might even make you slightly drowsy during the night time, actually helping some people fall asleep. Perhaps something else is keeping you up at night that we can discuss in the comments below.
If you have a question or something to add about my Fexofenadine review for allergies, please leave me a comment!
Talk to you soon,
My Personal Allegra Allergy Review was last modified: November 8th, 2018 by Anthony
Here’s One Allergy Symptom You May Not Expect This Spring: Vertigo
Just as the weather has started to warm up and cold season has subsided, we’ve got yet another thing keeping us from enjoying the outdoors: seasonal allergies.
But it’s not just the sneezing, itchy eyes, and headaches we have to worry about when the trees bloom — seasonal allergies can also cause vertigo that makes you feel like the world is spinning.
Vertigo isn’t the most common symptom of seasonal allergies, says Dr. Tania Elliott, a board-certified allergist and internist in New York. But it tends to happen more often in places where pollen counts are particularly high, like Austin, Texas.
“Right now, the state of Texas is really getting killed with pollen,” she said. “But overall, I’d say less than 10 percent of people with allergies come to see me for vertigo or dizziness.”
Temporary dizzy spells from seasonal allergies aren’t a major health concern, but they can put you out of work for a day or two.
“The vertigo can make you feel absolutely miserable. It feels like a spinning ride at a carnival. Most people don’t even bother getting out of bed if they wake up with it,” said Elliott.
Here’s why allergies make you miserable
So, what causes your seasonal allergies to move from typical symptoms — like nasal congestion, puffy eyes, and throat irritation — to that whirling sensation that can knock you off your feet?
When you breathe in certain allergens, like pollen, your body releases inflammatory markers called histamines that cause swelling and mucus production in your nose, throat, and inner ear tubes. The response is what makes you feel like your head is filled with pressure.
“Your sinuses are supposed to be air-filled cavities, not filled with fluids. But when you get so stopped up and inflamed, fluid gets trapped and causes an imbalance in your inner ear fluids. That can contribute to headaches and feelings of dizziness — a lot of people will say that they feel like they’re stuck under water,” said Elliott.
Generally speaking, you don’t have to worry about vertigo just because of a high pollen count. The onset of dizziness tends to happen when people delay treatment for their allergies, and try to wait them out, Elliott added.
“Vertigo is directly correlated with how long patients wait to see the doctor. Once an allergic response is triggered, that begets the release of more and more chemicals in the body, creating a compounding effect. You end up with vertigo as a complication of an untreated allergic response in the nose,” said Elliott.
How to avoid vertigo during allergy season
The best way to evade springtime dizziness is to limit your exposure to allergens. Avoid spending a lot of time outdoors when pollen counts are high, and keep your windows closed.
Kick off your shoes, take a shower soon after being outside, and wash your clothes frequently to reduce the spread of pollen into your home.
Elliott also says that you might even want to change your hairstyle to avoid allergens.
“Don’t use hairspray — pollen will stick to your hair. And wear glasses instead of contact lenses, which pollen can stick to,” said Elliott.
If you start to experience allergy symptoms, make an appointment with your doctor right away. They may recommend a nasal steroid spray to bring down the swelling in your sinuses and an antihistamine to ease some of your symptoms. Allergy shots may also help people with chronic allergies to find long-term relief.
“I can’t stress enough the importance of taking your allergy symptoms seriously the first time you notice them,” said Elliott. “Most people will suffer through it and think that allergies are a lifestyle disease with no complications, but when your immune system on overdrive for a month, it increases your risk of infection, disease, and vertigo. There are downstream consequences to avoiding treatment.”
Not to mention that spring is much more enjoyable when you don’t feel like the ground is spinning under your feet.
The Best Allergy Medicine
Guide to Allergy Medicines
How to find the right allergy medicine for you
Allergy meds all work differently — and often better together.
Most experts tout corticosteroid nasal sprays, which work by reducing inflammation in the nose, as the best first-line defense for seasonal allergies. But depending on your allergy symptoms, a combination of treatments may be more effective than just one. If, like most people, your allergies take the form of nasal congestion, inflamed skin, and itchy eyes, a strategized treatment of nasal sprays, antihistamines, and eye drops may help provide the fastest, most effective relief.
In real life, many people take both nasal corticosteroids and antihistamines. It really depends on what symptoms are bothering you the most.
“When compared ‘head to head’ with standard dosed antihistamines, show more benefit for people based on subjective reporting of symptoms,” says Dr. Lichtenberger, citing a 2001 study from the University of Chicago. For best results, start taking a nasal corticosteroid several weeks prior to the start of allergy season. “While their onset of action is 30 minutes, effectiveness may take several hours to days to occur. Their maximum effectiveness occurs after two to four weeks of use,” says Dr. Cavuoto Petrizzo.
Antihistamine pills have one clear advantage over nasal steroids: more rapid relief. Have you ever walked into a house with cats and swelled right up? “Antihistamines take 30 to 60 minutes to take effect and thus can be used on an as-needed basis for quick relief,” says Dr. Cavuoto Petrizzo. That said, antihistamines don’t treat congestion like corticosteroid sprays do, so many doctors suggest combining them.
Chances are that the combo of a nasal steroid spray and an oral antihistamine (or even just one of them) will alleviate dry, itchy eyes too. However, if you’re still suffering — perhaps due to an especially high pollen count — eye drops will give immediate relief while the other medicines work in the background.
Save money buying generic.
Across the board, the doctors we consulted agree that generic allergy drugs work just as well as name brands — and cost much less. If you’re looking at a shelf full of generics and don’t know which to choose, start by comparing labels. Match the percentage of the active ingredient of the name brand, and then filter out anything with acetaminophen and decongestants. As a final check, make sure the box isn’t labelled with any scary-sounding warnings like “not safe for long-term use.” You can always flag a pharmacist for advice, too.
There hasn’t been a lot of research into natural remedies.
Natural remedies haven’t been extensively studied, meaning experts can’t be certain about their effectiveness. The lack of extensive research on natural remedies also means that there’s not a lot of conclusive knowledge about the long-term effects of natural remedies.
Keep in mind that just because it’s natural doesn’t mean it’s safe: Make sure you understand the effects and risks of main ingredients. For instance, while butterbur extract can help with nasal allergy symptoms, eating raw butterbur root is dangerous. Bitter orange (citrus aurantium), which is marketed as a decongestant, can increase the risk of heart issues, high blood pressure, and stroke. Many natural remedies contain ingredients related to ragweed — so if you suffer from ragweed allergies (and 10 to 20 percent of Americans do), be especially careful before starting any natural remedies. It’s a good idea to discuss ingredients and application methods with your doctor first, especially if you’re planning on using natural remedies long-term.
Besides pharmaceuticals and natural remedies, there are other steps you can take to alleviate your seasonal suffering: Regularly cleaning your home, especially your carpet, can help rid your home of accumulated mold, pollen, and dander. Be sure to wear goggles and a mask while cleaning your home, indoors and outdoors. If your nasal symptoms are especially bad, you can try nasal irrigation to wash out the irritants that trigger your allergies.
Consider other treatments
If shooting a spray up your nose or popping a pill every day just isn’t your style, you may want to ask your doctor about immunotherapy, which actually treats your allergies rather than simply suppressing the symptoms. If you don’t already know what you’re allergic to, your doctor may begin by conducting a skin or blood test. From there, they’ll start you on a course of shots, injecting the substance you’re allergic to into your bloodstream, be it oak pollen or animal dander.
Keep in mind this is a long-term treatment. “It starts out very dilute and then every week the concentration of the pollen increases for six or seven months,” says Dr. Cavuoto Petrizzo. “At that point we continue the injections once a month for two years. As your body keeps seeing these constant levels of an allergen, it learns to ignore it and ‘forgets’ that it’s allergic to it.”
Dr. Cavuoto Petrizzo says treatment is typically about 80 percent effective, and while it costs more up front than OTC meds, removing the need for allergy medication altogether will likely save you money in the long run. Plus, most PPO plans will cover between 60 and 100 percent of subcutaneous immunotherapy (SCIT).
Air purifiers can help with indoor allergies.
If you suffer from seasonal allergies, you’ve probably had days where it’s tempting not to leave the house. But research from the EPA suggests that air quality indoors is often worse than what’s outside: “Air within … buildings can be more seriously polluted than the outdoor air in even the largest and most industrialized cities.” An indoor air purifier can help manage your symptoms, but make sure to do your research before you buy. Some types of air purifiers can actually make your allergies worse — in particular, models that release ozone (a common allergen) or rely on negative ionic filters (which “clean” air by causing particulate matter to stick to furniture, walls, and every other exposed surface). Most experts instead recommend air purifiers that use HEPA filters, which are able to trap dander and pollen. For specific product suggestions, take a look at our review of Best Air Purifiers.