How does phendimetrazine work?

Phendimetrazine vs Phentermine: Main Differences and Similarities

Phendimetrazine and phentermine are two medications that can be used for obesity. They can also treat those who are overweight with high blood pressure, diabetes, or high cholesterol. Both phendimetrazine and phentermine are only recommended for a short duration with an appropriate diet and exercise regimen. As sympathomimetics, phendimetrazine and phentermine work similarly to amphetamines.

Phendimetrazine

Phendimetrazine is the generic name for Bontril PDM. It is recommended for those who are 17 years old or older with obesity. Although its mechanism of action is not entirely clear, it may help suppress appetite as a CNS stimulant.

Phendimetrazine is taken as a 35 mg oral tablet 1 hour before meals. An extended-release 105 mg oral capsule is also available. The extended-release form is taken 30 to 60 minutes before breakfast.

Phentermine

Phentermine is the generic name for Adipex P and Lomaira. Like Phendimetrazine, it is prescribed to treat obesity in combination with an appropriate diet and exercise plan. It is only recommended to be taken in those who are older than 16 years of age.

Phentermine is available as a general 37.5 mg oral tablet. It also comes in a 15 mg, 30 mg, or 37.5 mg oral capsule. The brand name, Lomaira, comes as an 8 mg tablet. Dosing ultimately depends on your doctor’s instruction. Still, it is usually taken before or after breakfast.

Phendimetrazine vs Phentermine Side by Side Comparison

Phendimetrazine and phentermine are similarly acting medications. As prescription medications for obesity, they share several similarities and differences. These features can be found below.

Phendimetrazine Phentermine
Prescribed For
  • Obesity
  • Overweight with other risk factors (hypertension, diabetes, hyperlipidemia)
  • Obesity
  • Overweight with other risk factors (hypertension, diabetes, hyperlipidemia)
Drug Classification
  • Sympathomimetic
  • Anorectic
  • Sympathomimetic
  • Anorectic
Manufacturer
  • Generic
  • Generic
Common Side Effects
  • Increased heart rate
  • Increased blood pressure
  • Heart palpitations
  • Flushing
  • Sweating
  • Constipation
  • Diarrhea
  • Dry mouth
  • Nausea
  • Dizziness
  • Headache
  • Insomnia
  • Tremors
  • Agitation
  • Nervousness
  • Restlessness
  • Irritability
  • Increased urination
  • Altered libido
  • Dry mouth
  • Insomnia
  • Increased heart rate
  • Increased blood pressure
  • Heart palpitations
  • Flushing
  • Sweating
  • Constipation
  • Diarrhea
  • Nausea
  • Dizziness
  • Headache
  • Tremors
  • Agitation
  • Nervousness
  • Restlessness
  • Irritability
  • Increased urination
  • Altered libido
Is there a generic?
  • Phendimetrazine is the generic name.
  • Phentermine is the generic name.
Is it covered by insurance?
  • Varies according to your provider
  • Varies according to your provider
Dosage Forms
  • Oral tablet
  • Oral capsule, extended release
  • Oral tablet
  • Oral capsule
Average Cash Price
  • $$32.14 per 90 tablets (35 mg)
  • $40 (per 30 tablets)
SingleCare Discount Price
  • Phendimetrazine Price
  • Phentermine Price
Drug Interactions
  • Monoamine oxidase inhibitors (selegiline, phenelzine, isocarboxazid, etc.)
  • Alcohol
  • Insulin
  • Oral hypoglycemic medications (glyburide, glimepiride, sitagliptin, pioglitazone, acarbose, etc.)
  • Adrenergic neuron blocking drugs (reserpine, guanethidine, etc.)
  • Monoamine oxidase inhibitors (selegiline, phenelzine, isocarboxazid, etc.)
  • Alcohol
  • Insulin
  • Oral hypoglycemic medications (glyburide, glimepiride, sitagliptin, pioglitazone, acarbose, etc.)
  • Adrenergic neuron blocking drugs (reserpine, guanethidine, etc.)
Can I use while planning pregnancy, pregnant, or breastfeeding?
  • Phendimetrazine is in Pregnancy Category X and may cause fetal harm when administered to pregnant women. Phendimetrazine is not recommended in pregnant women.
  • Phentermine is in Pregnancy Category X and may cause fetal harm when administered to pregnant women. Phentermine is not recommended in pregnant women.

Summary

Both phendimetrazine and phentermine are medications prescribed for obesity. The exact mechanism of action of both medications is unknown. However, they are believed to play a role in suppressing appetite.

As CNS stimulants that are similar to amphetamines, they carry similar side effects and drug interactions. Both medications can cause increased heart rate, increased blood pressure, and heart palpitations. They can even cause insomnia in some people. Therefore, they should not be taken at night before bedtime

Phendimetrazine and phentermine should also not be used during or within 14 days of using monoamine oxidase inhibitors. Otherwise, there is a higher risk of increased blood pressure.

While phendimetrazine is restricted to those age 17 years or older, phentermine is limited to those aged 16 years or older. Phendimetrazine also comes in an extended release form which may have different dosing instructions.

Phendimetrazine and phentermine should only be used under the guidance of a doctor. Because they both have similar side effects and drug interactions, it is important to discuss your options with your doctor. Both medications are also contraindicated during pregnancy because of fetal risks.

Bontril SR

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 8/15/2019

Bontril SR (phendimetrazine tartrate) is a sympathomimetic amine, which is similar to an amphetamine, used as a short-term supplement to diet and exercise in the treatment of obesity. Common side effects of Bontril SR include:

  • dizziness
  • dry mouth
  • difficulty sleeping (insomnia
  • irritability
  • nausea
  • vomiting
  • upset stomach
  • diarrhea
  • constipation
  • restlessness
  • hyperactivity
  • headache
  • tremors
  • flushing (warmth, redness, or tingly feeling)
  • increased or decreased interest in sex,
  • or impotence

The recommended dose of Bontril SR is one Slow-Release Capsule (105 mg) in the morning, taken 30-60 minutes before the morning meal. Bontril SR may interact with monoamine oxidase inhibitors (MAOIs), insulin and other diabetes drug therapies, guanethidine, or tricyclic antidepressants. Tell your doctor all medications and supplements you use. During pregnancy, Bontril SR should be used only when prescribed. It is not recommended for use near the expected delivery date because of possible harm to the fetus. Infants born to mothers who have been using this medication may have withdrawal symptoms such as irritability or extreme tiredness. Tell your doctor if you notice symptoms in your newborn. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding. Withdrawal symptoms may occur if you suddenly stop taking this medication.

Our Bontril SR (phendimetrazine tartrate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Phendimetrazine (phendimetrazine canada) – Today best deals in America for Phendimetrazine!

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