Hgh gel side effects



1. PHA-794428 is a PEGylated version of somatropin (human growth hormone). The pharmacokinetics of PHA-794428 have been studied in humans following single subcutaneous administration (dose range 10–500 µg kg−1). In the same study the pharmacokinetics of somatropin were also determined following a 3.6 mg (51 µg kg−1) subcutaneous dose. Comparison of the pharmacokinetics of both molecules indicates that PEGylation of somatropin with a 40 kD PEG results in a ten- to 20-fold increase in area under the curve and a similar increase in half-life when compared with somatropin in human (at equivalent subcutaneous doses).

2. Literature data indicate that somotropin is cleared by two mechanisms. The first processes is clearance by glomerular filtration. This is a passive, non-capacity-limited process. A second, capacity-limited, process is mediated by interaction with growth hormone receptors present in a number of tissues including the liver. It is hypothesized that PHA-794428 shares the same clearance mechanisms. However, the addition of the PEG moiety has modulated the clearance by both of these processes. Pharmacokinetic modelling of human serum concentration data obtained for these molecules strongly supports this hypothesis. The renal clearance is reduced due to the increased size of the molecule (Cl/F reduced from 9.6 to 0.1 l h−1 for somatropin and PHA-794428, respectively). In addition, the reduction in growth hormone receptor affinity has reduced the clearance mediated by interaction with this receptor (somatropin Km = 3.6 µg l−1 and Vmax = 104 µg h−1/PHA-794428 Km = 53 µg l−1 and Vmax = 84 µg h−1).

HGH Uses and Abuses

Synthetic human growth hormone was developed in 1985 and approved by the FDA for specific uses in children and adults. In children, HGH injections are approved for treating short stature of unknown cause as well as poor growth due to a number of medical causes, including:

  • Turner’s syndrome, a genetic disorder that affects a girl’s development
  • Prader-Willi syndrome, an uncommon genetic disorder causing poor muscle tone, low levels of sex hormones, and a constant feeling of hunger
  • Chronic kidney disease
  • HGH deficiency or insufficiency
  • Children born small for gestational age

In adults, approved uses of HGH include:

  • Short bowel syndrome, a condition in which nutrients are not properly absorbed due to severe intestinal disease or the surgical removal of a large portion of the small intestine
  • HGH deficiency due to rare pituitary tumors or their treatment
  • Muscle-wasting disease associated with HIV/AIDS

But the most common uses for HGH are not FDA-approved. Some people use the hormone, along with other performance-enhancing drugs such as anabolic steroids in an attempt to build muscle and improve athletic performance. Yet HGH’s effect on athletic performance is unknown.

Because the body’s HGH levels naturally decrease with age, some so-called anti-aging experts have speculated and claimed that HGH products could reverse age-related bodily deterioration. But these claims, too, are unproven. The use of HGH for anti-aging is not FDA-approved.

Nevertheless, some people obtain injectable HGH from doctors who prescribe it for off-label purposes (uses for which it was not approved by the FDA) and through Internet pharmacies, anti-aging clinics, and web sites.

Others purchase HGH products — or products that claim to increase your body’s own production of HGH — in the form of pills and sprays. Companies that market these products on TV infomercials or online claim they turn back your body’s biological clock, reducing fat, building muscle, restoring hair growth and color, strengthening the immune system, normalizing blood sugar, increasing energy and improving sex life, sleep quality, vision, and memory. However, the Federal Trade Commission has seen no reliable evidence to support the claim that these products have the same effects as prescription HGH, which is always given by injection. Taken orally, HGH is digested by the stomach before it can be absorbed into the body.

Growth hormone, athletic performance, and aging

Human growth hormone benefits, facts and fiction

Updated: June 19, 2018Published: May, 2010

Can human growth hormones really benefit aging, like the elusive fountain of youth? In 1513, the Spanish explorer Juan Ponce de Len arrived in Florida to search for the fountain of youth. If he got any benefit from his quest, it was due to the exercise involved in the search.

Few men today believe in miraculous waters, but many, it seems, believe in the syringe of youth. Instead of drinking rejuvenating waters, they inject human growth hormone to slow the tick of the clock. Some are motivated by the claims of the “anti-aging” movement, others by the examples of young athletes seeking a competitive edge. Like Ponce de Len, the athletes still get the benefit of exercise, while older men may use growth hormone shots as a substitute for working out. But will growth hormone boost performance or slow aging? And is it safe?

What is human growth hormone?

Growth hormone (GH) is a small protein that is made by the pituitary gland and secreted into the bloodstream. GH production is controlled by a complex set of hormones produced in the hypothalamus of the brain and in the intestinal tract and pancreas.

The pituitary puts out GH in bursts; levels rise following exercise, trauma, and sleep. Under normal conditions, more GH is produced at night than during the day. This physiology is complex, but at a minimum, it tells us that sporadic blood tests to measure GH levels are meaningless since high and low levels alternate throughout the day. But scientists who carefully measure overall GH production report that it rises during childhood, peaks during puberty, and declines from middle age onward.

GH acts on many tissues throughout the body. In children and adolescents, it stimulates the growth of bone and cartilage. In people of all ages, GH boosts protein production, promotes the utilization of fat, interferes with the action of insulin, and raises blood sugar levels. GH also raises levels of insulin-like growth factor-1 (IGF-1).

Human growth hormone benefits

GH is available as a prescription drug that is administered by injection. GH is indicated for children with GH deficiency and others with very short stature. It is also approved to treat adult GH deficiency — an uncommon condition that almost always develops in conjunction with major problems afflicting the hypothalamus, pituitary gland, or both. The diagnosis of adult GH deficiency depends on special tests that stimulate GH production; simple blood tests are useless at best, misleading at worst.

Adults with bona fide GH deficiencies benefit from GH injections. They enjoy protection from fractures, increased muscle mass, improved exercise capacity and energy, and a reduced risk of future heart disease. But there is a price to pay. Up to 30% of patients experience side effects that include fluid retention, joint and muscle pain, carpal tunnel syndrome (pressure on the nerve in the wrist causing hand pain and numbness), and high blood sugar levels.

HGH doping and athletic performance

Adults who are GH deficient get larger muscles, more energy, and improved exercise capacity from replacement therapy. Athletes work hard to build their muscles and enhance performance. Some also turn to GH.

It’s not an isolated problem. Despite being banned by the International Olympic Committee, Major League Baseball, the National Football League, and the World Anti-Doping Agency, GH abuse has tainted many sports, including baseball, cycling, and track and field. Competitive athletes who abuse GH risk disqualification and disgrace. What do they gain in return? And do they also risk their health?

Because GH use is banned and athletic performance depends on so many physical, psychological, and competitive factors, scientists have been unable to evaluate GH on the field. But they can conduct randomized clinical trials that administer GH or a placebo to healthy young athletes and then measure body composition, strength, and exercise capacity in the lab.

A team of researchers from California conducted a detailed review of 44 high-quality studies of growth hormone in athletes. The subjects were young (average age 27), lean (average body mass index 24), and physically fit; 85% were male. A total of 303 volunteers received GH injections, while 137 received placebo.

After receiving daily injections for an average of 20 days, the subjects who received GH increased their lean body mass (which reflects muscle mass but can also include fluid mass) by an average of 4.6 pounds. That’s a big gain — but it did not translate into improved performance. In fact, GH did not produce measurable increases in either strength or exercise capacity. And the subjects who got GH were more likely to retain fluid and experience fatigue than were the volunteers who got the placebo.

If you were a jock in high school or college, you’re likely to wince at the memory of your coach barking “no pain, no gain” to spur you on. Today, athletes who use illegal performance-enhancing drugs risk the pain of disqualification without proof of gain.

Human growth hormone and aging

To evaluate the safety and efficacy of GH in healthy older people, a team of researchers reviewed 31 high-quality studies that were completed after 1989. Each of the studies was small, but together they evaluated 220 subjects who received GH and 227 control subjects who did not get the hormone. Two-thirds of the subjects were men; their average age was 69, and the typical volunteer was overweight but not obese.

The dosage of GH varied considerably, and the duration of therapy ranged from two to 52 weeks. Still, the varying doses succeeded in boosting levels of IGF-1, which reflects the level of GH, by 88%.

As compared to the subjects who did not get GH, the treated individuals gained an average of 4.6 pounds of lean body mass, and they shed a similar amount of body fat. There were no significant changes in LDL (“bad”) cholesterol, HDL (“good”) cholesterol, triglycerides, aerobic capacity, bone density, or fasting blood sugar and insulin levels. But GH recipients experienced a high rate of side effects, including fluid retention, joint pain, breast enlargement, and carpal tunnel syndrome. The studies were too short to detect any change in the risk of cancer, but other research suggests an increased risk of cancer in general and prostate cancer in particular.

HGH, or simple diet and exercise?

“Every man desires to live long,” wrote Jonathan Swift, “but no man would be old.” He was right, but the fountain of youth has proved illusory. GH does not appear to be either safe or effective for young athletes or healthy older men. But that doesn’t mean you have to sit back and let Father Time peck away at you. Instead, use the time-tested combination of diet and exercise. Aim for a moderate protein intake of about .36 grams per pound of body weight; even big men don’t need more than 65 grams (about 2 ounces) a day, though athletes and men recovering from illnesses or surgery might do well with about 20% more. Plan a balanced exercise regimen; aim for at least 30 minutes of moderate exercise, such as walking, a day, and be sure to add strength training two to three times a week to build muscle mass and strength. You’ll reduce your risk of many chronic illnesses, enhance your vigor and enjoyment of life, and — it’s true — slow the tick of the clock.

Image: © porpeller | GettyImages

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Here’s what really happens when you take the ‘anti-aging’ supplement Peter Thiel swears by

Flickr/Lin Mei Human growth hormone (HGH) is heralded as a miraculous way to bulk up, get more energy, and even ward off aging.

But HGH has some pretty concerning downsides. It’s banned by nearly every major sports organization. It’s been tentatively associated with an increased risk of cancer. And if it’s not obtained with a valid prescription in the United States, it’s illegal.

The body naturally produces the hormone to help us grow as kids, but levels decline as we age.

When people take synthetic HGH, it can increase their muscle mass and decrease their body fat, according to the Mayo Clinic. But it doesn’t make people stronger or boost performance, according to experts from Harvard University.

Negative side effects include carpal tunnel, swelling, muscle pain, and joint pain; a subset of men using HGH even develop breasts.

Some people with HGH deficiencies — because they were born with one or developed one due to chemotherapy or AIDS — need to take the hormone in order to maintain their energy and fitness. But they get valid prescriptions to do so, whereas most off-label use (like for bulking up) is done illegally.

Pure HGH is administered as an injection, and if people aren’t trained in using needles, they could hurt themselves or end up with a serious infection. They could also seriously mess up the dosage, which a doctor would carefully calibrate. The risks and effects of long-term HGH supplementation in healthy people are largely unknown.

Many supplements sold online or in other countries advertise that they contain HGH. But since these are barely regulated at all, they could have no actual HGH and contain potentially dangerous ingredients instead. There’s no telling what you’re really taking.

A way to ward off age-related decline?

Peter Thiel swears by HGH. Flickr/heisenbergmedia

Some people, including billionaire Peter Thiel (who says he hopes to live to 120), take HGH to try to prevent aging. That application, however, is far from proven.

Supplementation may actually have the opposite effect, according to the National Institute on Aging (NIA), which summarized the research:

At least one epidemiological study suggests that people who have high levels of naturally produced growth hormone are more apt to die at younger ages than those with lower levels of the hormone. Researchers have also studied animals with genetic disorders that suppress growth hormone production and secretion. They found that reduced growth hormone secretion actually promotes longevity in the tested species.

While the decline in HGH as we age might be part of why older people often feel less energized and fit, that same decline “may be offering important protection from cancer and other age-associated diseases,” one study concluded.

That means there’s a chance HGH supplementation could actually increase the risk of cancer, which anti-aging pioneer Aubrey de Grey has called “the hardest aspect of aging to fix.” (When confronted with this risk, Thiel told Bloomberg News that he “hopes we’ll get cancer cured within the next decade.” That’s a claim experts have dismissed as “so wildly optimistic as to be out of touch with reality.”)

“There’s little evidence to suggest human growth hormone can help otherwise healthy adults regain youth and vitality,” Mayo Clinic staff wrote. “In fact, experts recommend against using HGH to treat aging or age-related conditions.” The only things we know can help ward off aging are a healthy diet and exercise, the researchers continued. Of course, that’s a bit more challenging than a daily pill.

The bottom line is that taking HGH recreationally could have potentially disastrous consequences, especially if you don’t have a valid prescription from a doctor. And the known benefits are basically nil.

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191AA HGH reviews



Feature: high bioactivity, high stability, high purity, 191 aaMolecular formula: C990H1528N262O300S7Formula weight: 22125DCategory: White Lyophilized PowderStorage: Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18° C. Upon reconstitution of the peptide it should be stored at 4° C between 2-21 days and for future use below -18° C.

What is HGHÂ 191AA?

Growth hormone (GH), also known as somatotropin (or as human growth hormone in its human form), is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals. It is thus important in human development. It is a type of mitogen which is specific only to certain kinds of cells. Growth hormone is a 191-amino acid, single-chain polypeptide that is synthesized, stored, and secreted by somatotropic cells within the lateral wings of the anterior pituitary gland.

There is no such thing as “the best HGH” the substance is either real growth hormone () or it is NOT! Human growth hormone is a very fragile, large molecule which is comprised of 191 amino acids, linked in very specific order and shaped to very specific form. In that regard there is no room for differences!

HGHÂ 191AAÂ usage

its shows units also. that is what GH is measured in. 2-10IU is a typical dose, id start @ 2-4iu and move up. you will need to be on this stuff for 5-8 months to see good effects.I re con peptides 1ml BAC water to 2mg peptides. slow drip the BAC down the side of the vial when re conning.

If your goal is only to build muscles faster then IGF-1 is better. If you prefer the overall body rejuvenation as well as gradual muscle building, then HGH is better.

Does your body respond to IGF-1 or are you one of the non-responders like myself? If you are a responder, then IGF-1 is better for you, otherwise HGH is the way to go.

Unfortunately there is no way of knowing if your body will respond to the IGF-1 long R3 until you give it a try. On the other hand everybody responds to HGH, but the muscle building effects are more gradual when compared with IGF-1.

Growth Hormone: What Is It And What Does It Do—An Expert’s View!

In their quest for greater muscle size and the ripped, dry look that characterizes a top-level bodybuilding physique, competitors have, since the 1950’s, as is generally thought, used a variety of supplemental substances, both naturally and pharmaceutically derived.

After experiencing unprecedented muscle growth with anabolic steroids in the early ’60s (a time when these drugs were used in larger quantities as the level of bodybuilding competition increased), bodybuilding competitors knew they had found the critical factor necessary to take them several steps higher towards physical perfection, and iron warriors the world over have not looked back since.

With the 1970’s ushering in a new era for competitive sporting success, with the emergence of lucrative contracts and entire careers based a upon athletic ability, a new compound found its way into the drug regimes of champions not adverse to pushing the boundaries: growth hormone (GH).

As a hormone critical for the health and well being of all humans, growth hormone is needed in precise amounts for the optimal functioning of a number of physiological processes and growth of body tissues, including muscle. Generally this is achieved, resulting in growth and functioning within ‘acceptable’ and ‘normal’ parameters. However, an over or under production of GH can potentially cause serious health concerns.

Excess GH, as occurs in those with Acromegaly, ultimately leads to an overgrowth of tissues and problems such insulin resistance and muscle weakness.

GH-secreting tumors, occurring in childhood, can also cause excessive GH production and resultant Pituitary Giantism, as witnessed with Andre the Giant, for example, who at 12 years old stood 6’3″ and at his full height was 7’4″. He ultimately died from this condition.

As there can be problems with an over production of GH there can also be so with too little. Genetic conditions and congenital malformations manifested through GH deficiency can cause a lack of growth in children. Though rare, Growth Hormone Deficiency (GHD) in adults can cause decreased muscle mass, quality of life and energy.

In both of these groups, carefully monitored GH supplementation restores the functions affected by GH deficiency. Benefits, in this context, generally include reduced fat mass, increased lean muscle tissue, increased bone density, improved lipid (fat) profile, reduced cardiovascular risk factors and improved mental health.

Bodybuilders being bodybuilders soon realized that if GH were introduced into their drug repertoire big muscles and shredded conditioning would result. And this is exactly what was experienced in those who began using this, until then, largely unknown anabolic agent.

Competitors of the ’70s, and especially the ’80s began to present a more refined look with chiseled muscle development reminiscent of Classical Sculpture and resembling deeply etched rock. Those guys, one could reasonably postulate, were not adding additional cardio to their programs and eating more lean proteins.

Since GH had become a mainstay for serious bodybuilders worldwide, it has attracted its fair share of criticism: some feel it is extremely dangerous while others contend it simply does not very well at all.

Those who use it, however, know just how effective it can be. Indeed, since its inception, and first application as a bodybuilding super-substance GH has remained an anabolic that has attracted many conflicting opinions and has been shrouded in mystery. I sought some answers.

One man who has, for many years, observed GH being used, and who is the first to say how effectively it builds muscle and reduces fat, but is also realistic as far as its application and efficacy in all who use it, is Ali Amini.

“GH”, says Ali, “is a single-chain protein made of 191 amino acids with a molecular weight of approximately 22 kDa (Kilo Daltons). It is released into the blood-stream by the somatotrope cells of the anterior pituitary gland. Initially it was taken from human pituitary glands, however, in 1985, biosynthetic GH replaced this earlier version.”

What of Growth Hormone’s widespread use and its application amongst the sporting elite? “GH is used in sport for its ability to burn fat, increase lean body mass, shorten recovery time and strengthen joints and ligaments while healing damaged tissue,” says Ali.

“And as far as pro bodybuilders go, all of them use GH, especially these days as it is much easier to get than in the early ’90s. But it is not as essential a part of contest prep or of an off-season cycle as most think.

It helps a lot if taken in the right amount and at the right time according to the type of program/cycle one is on, but it is not a crucial aspect of the whole program.”

Bodybuilding Benefits Of GH And Effective Administration

“A lot of people think that GH is a magic potion,” says Ali. “But most of these people are not taking GH at its maximum potential. GH doesn’t add 50% to your gains, not even close to that. By adding GH to a cycle you will be lucky and considered genetically gifted and blessed (that your body responds well to GH) if you get a 15% benefit/gain.”

In light of Ali’s observations GH does not appear to be the magic bullet that many feel will give them bodybuilding success. However, if a bodybuilder were to solely use GH while excluding anabolic steroids from their program, what kind of effect would this have on their physique?

“Very little in the way of muscle gains and a barely noticeable decrease in body fat,” says Ali, perhaps controversially. “GH alone isn’t that strong of an anabolic, and even though it has the property of holding protein synthesis, like testosterone, it doesn’t provide a constant durability of its effect, like testosterone, nor does it noticeably increase strength like other anabolic drugs.”

But, though not a miracle drug, GH can work well for bodybuilders as shown in those who use it at optimal dosages. Surely if it is used by all professional bodybuilders it must have much merit.

“I know smart bodybuilders never do over 8 IU (International Units) a day, but, in some cases, I have heard of others doing 24 IU a day and even some non-pros, less then 150 lbs, who use 24 IU a day. This results in bloating because of all the water retention caused by that dose.”

So what is the optimal dose of GH one should take to attain its benefits? Ali: “To get the full effect of GH, timing and amount are crucial. Needless to say, period taken and consistency is more important than the total amount, as taking a 200 IU kit of GH over 50 days (at 4 IU a day) is more efficient than taking the same 200 IU over a period of 25 days (at 8 IU a day).”

As is clear from what Ali has said, GH used in conjunction with anabolic steroids is the most effective form of administration. It is known to work, but how? What exactly does GH do and what are its positive effects?

“GH diverts calories in food towards protein synthesis and away from fat synthesis as demonstrated in animal tests. It is as powerful as testosterone in stimulating protein synthesis properties.”

Those who are GH deficient are often cited as proof positive that GH is an important building agent; that we all need it to function properly. Ali’s take on GH deficiency?

“GH-deficient (GHD) adults have reduced lean body mass and increased fat mass, particularly central abdominal fat mass, thus proving that the higher the GH level, the more muscle mass and less fat is synthesized.”

And how long does GH have to exert its anabolic effects? “GH”, Says Ali, “has a half-life of 15 to 20 minutes after sub-q (subcutaneous) or intravenous injection. After that, blood concentrations of GH reach their peak between one and three hours after injection.”

So once the optimal dosage of GH and the potential benefits have been decided, how can it be administrated timing-wise?

“A lot of theories and speculation have made about the best way to administrate GH,” says Ali. “The most reasonable way would be decided after one gained an understanding of how GH is produced in the body, how it interacts with other hormones and under which circumstances it converts best to IGF-1.

IGF-1 production is regulated by factors other than GH, most notably nutritional and thyroid status. But when GH is released it goes to the liver to stimulate a set of Growth Factors, and IGF-1 happens to be the best known of these.

“IGF-1 is a 70 amino acid single chain hormone that has been shown to be the most potent derivative (caused by GH release or administration) of GH,” continues Ali. “GH is a hormone that works back to back with insulin so the lower the insulin, the more GH the pituitary gland produces, and thus there will be a better environment for GH to work.

Some speculations recommend taking GH at any time because they say what I just mentioned is applicable for the GH produced by the pituitary and not that externally administrated. However, the body produces GH in those conditions because it is the best time for it, sequentially leading it to function at its maximum potential.

Therefore, using GH at a time when insulin is low (using blood sugar as an indicator), post workout would be the best time to use it. However, if administrated in conjunction with insulin, GH should be taken immediately post workout with the insulin administered within a 30-40 minute window after that.”

Since within bodybuilding circles it is common knowledge that elite competitors take GH twice a day, and that timing is of the essence, if post workout is one of these optimal periods, when is the other?

“A second dose,” says Ali, “can be taken before going to bed, again at a time when ones blood sugar is very low as when a bodybuilder is getting ready for a show and is on low a carbohydrate diet; this is the optimal period – night – especially if a low carbohydrate meal was the last meal or two.

However, it would be even better to take it (the second GH dose) during the sleeping period, when, for example, waking up in middle of the night to go to the bathroom.”

Optimal Dosage And Timing

And what, typically, would each of the two dosages be?

“The main benefit of GH is its action on the liver to produce IGF-1,” says Ali. “So, for this matter, it is important to know the capability of the liver in terms of how much GH it can use to get the maximum result/benefit. The liver can work with three to four IU of GH at a time and can do that twice a day with a reasonable gap of five to seven hours.

Therefore, the best dose would be a total six to eight IU a day divided into two doses and having those five to seven hours apart. For example, a dose (either three or four IU) can be taken post training with another three to four IU dose before bed or during the night sleeping period.”

Clearly, as with any anabolic agent, there is an optimal dosage, but it has not been clearly documented as to what would occur if one took too little or too much GH. If one took below the recommended IU of six to eight per day of GH, as Ali recommends, what effects, if any, could they experience? If a bodybuilder took, for example, 2 IU, what effect would this have?

A Dose (Either Three Or Four IU) Can Be Taken Post Training.

“What I recommend,” says Ali, “is aligned with the capability of the body to use GH at maximum doses to produce maximum effect. However, taking less will definitely work and the gains will be noticed, just not at full potential (the body’s full capability of occupying GH and employing it).”

Conversely, what would be likely to happen if that same person took well over the recommended amount? If they took, for example, 20 to 25 IU what could happen?

“Nothing dramatic,” says Ali. “Just some water retention side effects, in a case where the subject abusing GH is not suffering from any kind of disease. But if you understand how GH works in the body and how the body utilizes it, it will become pretty obvious how, when and how much you should take.

Needless to say, trying to make GH use more constant for a longer period of time will result in more gains and make it much more cost efficient, as the legitimate form of it is still not cheap.”

That being said, GH does, like any other drug, hold dangers if used irresponsibly. So exactly how does GH compare to other anabolic drugs in terms of health problems if used excessively?

“Anabolic steroids can cause serious problems if overused,” says Ali. “With some, the side effects are harsher than others. 17aa (one of the most potent steroids ever synthesized) is the least of your problems when you talk about overdosing, as insulin, Trenbolone and diuretics respectively are the most dangerous when overdosed.

With GH, by comparison, you don’t need any special form of detoxification post cycle, as the body doesn’t become toxic from legitimate GH.”

GH And Insulin: Negative Interaction

As Ali says, insulin, a transport hormone, secreted from the pancreas to store nutrients in various body tissues, can be extremely dangerous if taken synthetically for bodybuilding purposes. It is also understood that insulin and GH do not interact positively with one another to produce lean muscle gains. What is the deal here?

Ali: “By introducing insulin to your body, GH and thyroid hormone levels drop dramatically. That is just how the human body works. Therefore you need to supplement your body with the two hormones mentioned to compensate the shortage, edge out the gains and minimize the side effect of insulin.

Naturally, GH is produced best when insulin levels are low, and biologically that is the best time for GH to be produced and to begin working.” How is this dilemma solved among bodybuilders who use GH?

“I do, however,” says Ali, “recommend taking insulin and GH together, but not at the same time. Depending on your insulin protocol, which we won’t get into here because this is a discussion about GH, GH should be taken when insulin is low. And I advocate this protocol because this is the way the body works and all we can do is learn more about this and act accordingly.

You can say that the body is doing this in absence of an external source of GH and insulin and choose to take them both at the same time. But why risk the benefits and gains when there is no study to prove this?

And what I am recommending is what is recommended by the body in the first place. As I said, GH can be taken post workout in an intramuscular manner to reach the system ASAP and then insulin can be introduced 30-40 minutes after that.”

Best Form Of Administration

GH can be taken in a variety of ways, but what is the most effective method? What do the pros do? Ali: “The most common has been sub-q (subcutaneously) for years, and a lot are still doing so. However, this was the medical method used when it was first introduced for GH-deficient people or infants born with a very low birth weight and/or lack of height.

But in the case of “GH in sports” it is different. The administrator is not a deficient patient; he is a person who wants GH to work in his body as soon as possible to get the most benefit from it, making the intramuscular (IM) method the best choice for administration in athletes as, in this fashion, it reaches the system much faster and starts its actions sooner than a sub-q injection.”

Side Effects

It is often thought that the larger the competitor, the more GH they will need to realize any kind of benefit. It seems this is yet another myth.

“The size and weight of the athlete is not a big factor here as it all depends on the liver’s capability to utilize GH and produce IGF-1,” says Ali. “Even though some athletes take up to 24 IU of GH a day, the body/liver can’t utilize this amount, hence the abuse of GH and the undesirable side effects that can be seen.”

As is known, all drugs have their share of side effects. What can be expected as far as the deleterious effects of taking GH? Can death result, as some think?

“There has been nothing recorded or reported on the matter of dying from GH,” says Ali. “However, GH has the tendency to worsen any cancer due to its cell volumizing and anabolic effect on a cell’s size. These are the serious potential effects. Jaw and nose growth are the main, and most noticeable, signs of using GH over a longer period.

No study has yet proved that GH causes cancer, even though a lot of speculation is made. The truth is: the cause of cancer is still not clear today. So no GH or, for that matter, any anabolic steroid is cancerous (theoretically to date) unless the person has been suffering from cancer before using any kind of anabolic; which, in some forms of cancer, the usage of anabolic drugs might worsen the case.”

GH Detection

As Ali suggested before, the intramuscular method of GH administration is the most popular, as this causes a faster cascade of Insulin-like growth factor 1 (IGF-1) and faster growth as a result. Why is this method best exactly? Why can’t it be taken orally like some anabolic steroids?

According to Ali this is “because it is a protein hormone and, as a result, has to be administered by injection as it is completely digested to its basic amino acids (the amino acids it was made of) when administered by mouth, which means it can’t be differentiated from an oral amino acid supplement. Thus, only injectable administration can allow GH to function at its full potential.”

This being the case, can GH be detected in a drug test?

Ali: “Due to the liver and kidney internalizing the GH-receptor complex and completely degrading it to its basic amino acids, only minimal quantities of GH appear in the urine and the pattern of urinary excretion has been shown, in those using, to be too low, leading its metabolites in a urine sample to look identical to the metabolites of orally administrated amino acids, making GH an undetectable drug in a doping test.”

Growth Hormone: Good Or Bad?

With their eternal search for a bodybuilding edge, bodybuilders have turned to synthetic growth hormone to boost what nature provides for them naturally. But is it as effective as many are led to believe?

The fact bodybuilders at the cutting edge use it to obtain rock hard definition and additional muscle size is testimony to its powerful nature, but according to Ali it is not a miracle substance and will not work as effectively as steroids for adding pure muscle mass.

However, in today’s ultra competitive bodybuilding climate any edge appears to be worth pursuing and chemicals seem to be a firmly entrenched way in which to gain it. So is GH use good or bad?

From an effectiveness standpoint there is much divergence of opinion, with those considering it to be essential and those, like Ali, who feel it might add the finishing touches to a base of rock hard muscle that hard training and good nutrition has first established.

From a health standpoint there has been not one documented death directly attributable to GH administration, nor does it seem this hormone is as dangerous as some of the more powerful steroids along with insulin and diuretics, the latter of which has taken lives.

With its high cost and, in some quarters, questionable effectiveness, is GH worth the time and expense? As the pro bodybuilding scene continues to grow, along with it athletes, themselves ably assisted by various chemicals, a definitive answer will likely be given sometime soon.

Disclaimer: Conclusions and opinions given in this article are for educational and entertainment purposes only. They do not necessarily represent those of this site and David Robson.


Somatropin is a form of human growth hormone important for the growth of bones and muscles.

Somatropin is used to treat growth failure in children and adults who lack natural growth hormone. This includes people with short stature due to Noonan syndrome, Turner syndrome, Prader-Willi syndrome, short stature at birth with no catch-up growth, and other causes.

Somatropin is also used in adults to treat short bowel syndrome, or to prevent severe weight loss related to AIDS.

Somatropin may also be used for purposes not listed in this medication guide.

You should not use somatropin if you have cancer, diabetic retinopathy, or if you are being treated for Prader-Willi syndrome and you are overweight or have severe breathing problems. You should not use somatropin if you have a serious illness due to lung failure or complications from recent surgery, injury, or medical trauma.

You should not use this medicine if you are allergic to somatropin or benzyl alcohol, or if you have:

  • a serious illness due to lung failure, or complications from recent surgery, injury, or medical trauma;
  • active cancer;
  • eye problems caused by diabetes (diabetic retinopathy); or
  • you are being treated for Prader-Willi syndrome and you are overweight or have severe breathing problems (including sleep apnea).

Tell your doctor if you have ever had:

  • cancer (especially during childhood);
  • diabetes;
  • a pituitary gland disorder;
  • abnormal curvature of the spine (scoliosis);
  • underactive thyroid;
  • a head injury or brain tumor; or
  • childhood brain cancer and radiation treatment.

In some cases, somatropin should not be used in a child. Certain brands of somatropin contain an ingredient that can cause serious side effects or death in very young infants or premature babies. Do not give this medicine to a child without medical advice.

Some brands of somatropin are not expected to harm an unborn baby, including Genotropin, Omnitrope, Saizen, and Serostim.

It is not known whether certain other brands of somatropin will harm an unborn baby, including Humatrope, Norditropin, Nutropin, Zomacton, and Zorbtive.

Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breast-feed a baby while you are using this medicine. Ask your doctor about any risks.

Somatropin may contain an ingredient that can cause serious side effects or death in very young or premature babies. Do not give this medicine to a child without medical advice.

Hormone Gel Cannot Make Health Benefit Claims; Somaderm Agrees to Modify, Discontinue Certain Claims After ERSP Review of Its Advertising

New York, NY – Jan. 23, 2019 – New U Life, Inc., the makers of Somaderm Gel, have agreed to modify or discontinue certain health benefit claims in its online advertising of the product, following recommendations from the Electronic Retailing Self-Regulation Program.

ERSP is an investigative unit of the advertising industry’s system of self-regulation and is administered by the Council of Better Business Bureaus. The marketer’s advertising came to the attention of ERSP pursuant to an anonymous challenge.

According to the marketer, Somaderm Gel is a transdermal human growth hormone (HGH) product which purports to have a variety of health benefits. ERSP reviewed online advertising claims for Somaderm Gel and identified several claims for review, including:

  • “The benefits listed below are based on clinical studies where individuals growth hormone levels were brought to a healthy level under the care and direction of a licensed medical professional. 1. *May support better mood 2.*May support healthier hair, skin & nails 3.*May promote hair growth 4.*May increase joint mobility 5. *May enhance libido 6. *May increase fat loss (especially around the mid-section 7. *May support greater muscle tone 8.* May increase strength 9.* May improve memory.”
  • “… Many experts say that elevating growth hormone when you are older can bring back your levels to when you were in your 20’s. Most people experience these anti-aging benefits in as little as two weeks.”
  • “SOMADERM gel is the only FDA registered transdermal human growth hormone product available without a prescription.”
  • “I am shrinking and feeling great contrary to other products I have tried”

During the course of the inquiry, the marketer participated in the self-regulatory process and made several changes to the advertising reviewed. This included removing all consumer testimonials and expert endorsements from a “scientific advisory board.”

ERSP determined that the marketer did not adequately support claims that Somaderm Gel will confer health benefits. Specifically, the marketer failed to submit any competent and reliable evidence to demonstrate that the Somaderm Gel formula and/or transdermal administration would provide the purported health benefits of HGH. Based upon the information provided, ERSP recommended that the marketer discontinue all performance and establishment claims.

ERSP also noted that the marketer did not submit any information regarding the characterization of its product and ingredients as “homeopathic” in the advertising at issue. ERSP further advised the marketer that claims regarding whether the product or its ingredients are homeopathic should comply with applicable FDA guidelines.

As to claims that Somaderm Gel is FDA registered, ERSP determined that the marketer could make limited claims that were truthful and accurate. Specifically, the marketer could state that the marketer’s facilities are FDA registered and that Somaderm Gel has been assigned a National Drug Code (NDC) number. In its decision, ERSP noted that the advertising reviewed included detailed explanations regarding the NDC and registration of the facilities. However, ERSP also stated that the marketer should not include any claims that state or imply that the Somaderm Gel product is FDA approved.

The company, in its marketer’s statement, said, “We at New U Life take our position and standing with ERSP very seriously… would like to personally acknowledge the importance of the ERSP decision and will continue to work with them and provide them with updated information to make all description accurate and fair to the consumer.”

Somaderm Gel Reviews – Regain Your Youth?

By HighYa Research Team Published on: Sep 20, 2018

Somaderm Gel is a homeopathic, transdermal, over-the-counter product that promises to slowly elevate human growth hormone (HGH) levels in the body. As a result, the manufacturer advertises it works at the cellular level to help you obtain optimal health and regain your youth.

They indicate that since hormones are stored in the fatty tissue layer, you should apply the gel to thin areas of the skin. Specifically, “wherever veins are visible,” such as your underarms, forearms, wrists, and behind the knees.

This way, it will “ensure that Somaderm Gel will be transported directly to the bloodstream.”

Is this really the only homeopathic, transdermal, over-the-counter HGH product available without a prescription? Even then, is it the cutting-edge scientific breakthrough advertised by New U Life? Let’s start by taking a look at the role this hormone plays in the human body.


The Science Behind Human Growth Hormone (HGH)

Created by the pea-sized pituitary gland located at the base of the brain, the Mayo Clinic explains growth hormone “fuels childhood growth and helps maintain tissues and organs throughout life.”

However, this gland “slowly reduces the amount of growth hormone it produces” beginning in middle age. And it’s this recognition, they tell us, that has triggered an interest in using synthetic human growth hormone (HGH) to potentially help reduce common downsides related to the natural aging process, including “decreased muscle and bone mass.”

The problem? “There’s little evidence to suggest human growth hormone can help otherwise healthy adults regain youth and vitality,” they report. In fact, “experts recommend against using HGH to treat aging or age-related conditions.”

Granted, all of this relates to the injection of artificial HGH. What about the ingredients found in Somaderm Gel and their HGH-boosting ability via the skin?

What Ingredients Will You Find in Somaderm Gel?

The New U Life lists the following ingredients for Somaderm Gel:

Active ingredients: Glandula suprarenalis suis 6X, Thyroidinum 8X, Somatropin 30X

Inactive ingredients: Purified Water, Phenoxyethanol, Caprylyl Glycol, Sorbic Acid, Aloe Barbadensis Leaf, Camellia sinensis (Green Tea) Leaf, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Glycyrrhiza glabra (Licorice) Root, Vitex agnuscastus (Chaste Tree) Fruit, Epimedium sagittatum (Epimedium) Aerial Parts, Ginkgo Biloba Leaf, Mucuna pruriens (Velvet Bean) Seed, Dioscorea villosa (Wild Yam) Root, Sodium Hydroxide, Ascorbic Acid, PEG-33/PEG-8/PEG-14/Dimethicone, Aloe barbadensis Leaf Juice, Tocopherols (Soy), Edetate Disodium, Natural Plant Extract, Potassium Sorbate Extract

Sites like Truth in Aging, Paula’s Choice, and EWG.org indicate that most of Somaderm’s inactive ingredients work as conditioning agents (caprylyl glycol, aloe, licorice, PEG-33/PEG-8/PEG-14/dimethicone), consistency agents (acrylates/C10-30 alkyl acrylate crosspolymer), and cleansing agents (sodium hydroxide).

Additional functions include preservatives (phenoxyethanol, sorbic acid, potassium sorbate), antioxidants components (Camellia sinensis, ascorbic acid), and penetration enhancers (edetate disodium). In other words, ingredients you’re likely to find in many other skincare formulations.

Taking a Closer Look at Somaderm Gel’s Homeopathic Ingredients

What about Somaderm Gel’s active ingredients? The National Library of Medicine’s DailyMed (last updated 4/20/18) lists this specific formulation’s marketing status as “unapproved homeopathic.” They also include the following disclaimer:

“This homeopathic product has not been evaluated by the Food and Drug Administration for safety or efficacy. FDA is not aware of scientific evidence to support homeopathy as effective.”

Why is this? Homeopathic formulations are based on two central principles: like cures like, and dilutions/the law of minimum dose.

First, an ingredient that produces similar symptoms to the disease being addressed is added to a solution, such as water or alcohol. Then, this water/ingredient mix is subjected to a series of successive dilutions (also referred to as dynamizations or potentizations).

An X next to a number indicates that a “substance has been diluted by a factor of 10 at each stage.” So, in the instance of Somaderm Gel’s Glandula suprarenalis suis (as the first example), it’s been diluted to one part in ten, eight times.


Or, to put it into raw numbers, this means the formula contains one part Glandula to 100 million parts solution (10 x 10 x 10 x 10 x 10 x 10 x 10 x 10).

The problem, according to the International Journal of Pharmacotherapy, is that when it comes to homeopathic solutions, “the largest dilution possible that still contains at least one molecule of the original substance is 12C.” This could present a logistical problem based on the 30X dilution of Somatropin in Somaderm Gel.

And “even among smaller dilutions that do contain some molecules of the original substance, there almost certainly aren’t enough to have a meaningful effect on the human body.”

Could Somaderm Gel’s Homeopathic Ingredients Cause Side Effects

With so little of each active ingredient in Somaderm Gel, side effects could be rare. And like any skincare formulation, its inactive ingredients could cause irritation and redness at the application site, especially for those with sensitivities.

This is why it’s essential to have an in-depth consultation with your dermatologist before beginning any new skincare, supplement, or homeopathic regimen, who can help you avoid potential side effects based on your diagnosis. This is especially the case for any product that promises to have a hormonal effect on the body.

With these details in mind, the Somaderm website emphasizes that application location “should be rotated so that no area of the skin gets overused.”

How Much Does Somaderm Gel Cost?

Somaderm Gel is only available from New U Life, at the following prices:

  • One-time purchase: $169.99, plus applicable S&H
  • Membership: $149.99, plus free S&H

All orders come with a 30-day refund policy, less S&H. Per the site’s cancellation policy, “If your Somaderm Bottle has been open or the plastic wrap has been broken, you must Contact Us before returning the product.” Otherwise, you can “simply mail it back with your packing slip or the return order form.”

You can call support at 844-510-6398 or send an email to [email protected]

How to Choose Between Somaderm Gel & Other Homeopathic Solutions

We encountered many other homeopathic formulations aimed at boosting HGH levels during our research, including popular options on marketplaces such as Amazon and Google Shopping, like High-Tech Somatomax ($45), Liddell Homeopathic Vital High Immune ($32), HPTP Pituitary Drops ($21), Vital II Hormone Free Spray ($28), and Clinical Strength Secretagogue Gold – Orange ($45), to name just a few.

As advertised on the New U Life website, though, Somaderm Gel was the only topical/transdermal offering available. Does this mean it’s worth the meaningfully higher price, though?

Returning to our Evidence-Based Medicine article cited earlier, regardless of the formula or the sales price, the fact of the matter is there’s little-to-no double-blind, placebo-controlled, peer-reviewed clinical evidence that homeopathy works. In fact, the FTC is considering requiring that all homeopathic products sold in the US come with a disclaimer on their packaging that they don’t work.

For this reason alone, we’ll reiterate that if you’re considering a homeopathic product—Somaderm Gel or otherwise—to address a real-world problem, make sure that you discuss the situation with your doctor before proceeding.

They can a) deliver a scientifically sound diagnosis after questioning and testing, and b) recommend options based on this diagnosis, including whether or not your options include homeopathy.

Bottom Line

In addition to the lack of reported clinical evidence for homeopathy in general, explicitly referencing Pleasant Hill, CA-based New U Life, the company held an F rating with the Better Business Bureau, calculated according to seven customer reviews and nine closed complaints, as of 9/20/18.

Most seemed to reference problems receiving orders and no response from support. All were listed as ‘unanswered.’

Another critical factoid to keep in mind is that, although New U Life promotes Somaderm Gel as ‘FDA registered,’ the reality is that the supplements industry is almost wholly responsible for self-regulation. In other words, supplements aren’t reviewed by the FDA prior to public release, and the FDA doesn’t keep a database of ‘registered’ supplements.

Considering all of this, in addition to the product’s ultra-high price, we think the best option for achieving the most value for your money is talking with your primary care physician before placing an order for Somaderm Gel.


HGH Gel Side Effects

If you are a skeptical like me, you may be wondering what are the hgh gel side effects? I don’t blame you, human growth hormone, in any other form is illegal and only administered by a medical doctor in the USA. So how do I know my skin is not going to get irritated, or worse, that something else inside of me is not going to go haywire!?

Answer: 14 years of usage and thousands of testimonies* with ZERO recorded toxicity or negative side effects recorded.

*Ask me to add you to a private group of 75K individuals reporting their amazing results and any HGH Gel Side Effects on Facebook.

HGH gel is a topical microdose, which contributes to hgh gel side effects being unknown. The fact that is in very small doses and applied topical is what removes the chance of toxicity. The gel is absorbed by your body and then released from your body within a few hours.

The molecular breakdown of HGH found in the Gel is a synthetic USP human growth hormone (somatropin). This HGH Gel is a homeopathic form of growth hormone and is 100% safe and effective for men and women over the age of 18.

In order for HGH Gel to be an FDA registered product, Somatropin needed to be diluted to a 30X dose. Any less of a dilution would make HGH Gel a “prescription only” product. Glandula Suprarenalis Suis 6X is added to support proper adrenal function and Thyroidinum 8X is added to support a healthy thyroid.

Since this HGH Gel is applied topically, within 5-10 minutes the gel is quickly absorbed in the bloodstream. Taking human growth hormone orally is shown to be ineffective as it is easily destroyed by the enzymes in our saliva and our gut, rendering these products ineffective. This makes this HGH Gel superior to any other growth hormone supplement on the market.


If there is a BUZZ word in the health and fitness world it is HGH. There are a lot of well known benefits in using Human Grown Hormone (HGH) such as increased anti- aging, strength, energy, stamina, muscle growth and youthfulness. Previously HGH was only available by prescription and administered through injection at a medical facility. Due to the exorbitant cost and regularity of maintenance needed to maintain HGH treatment it has not been available for the mainstream of consumers.


Recently a Health/ Fitness trainer and dear friend recommended I look into Somaderm a trans-dermal Homeopathic HGH Gel. I have people approach me regularly to try new products and endorse or evaluate a line or brand they are excited about. I LOVE to research and will often try new things. The following are my personal findings/changes and research.

Somaderm is an enriched Homeopathic dilution of HGH 30 x and is absorbed transdermally (through the skin), making it accessible to a much wider variety of people. In this homeopathic diluted form trace amounts of the compound are introduced to the body and illicit a healing response. Because it is transdermal and absorbed through the skin, an inefficient digestive tract will not disrupt the absorption of the compound. It’s used 5 days on and two days off for the first month or two. After that reduced regulatory doses are used to maintain levels in the body.

Research is showing new and captivating evidence that in Small homeopathic doses HGH can have very powerful results. Researches Leon Cass Terry, M.D. and Edmund Chein, M.D. led a study in which participants were injected with small amounts of a high-frequency HGH for six months. The participants showed notable enhancements in strength, healing, flexibility, energy and vitality.., In “Feeling Younger with Homeopathic HGH,” Dr. H. A. Davis states “When growth hormone is combined with homeopathic preparation, the results are truly on the leading edge of anti-aging benefits. People taking the homeopathic growth hormone have noticed the same effects as the molecular (injectable) GH.”


This is a bit more technical but the scientist in me is fascinated by our body’s system so bear with me. HGH is a polypeptide compound created/stored/released by the cell walls in the Pituitary “Master” Gland. It’s comprised of 191 amino acids and in children is responsible for their bone, cartilage, muscle development and growth. The BUILDING BLOCKS or foundation of our structural system is created and repaired by this hormone.

The best example of why this is crucial to our survival is to look at the foundation of a house. The house itself is only as strong as your foundation. You can have an amazing structure, materials and décor but if you have a broken or weak foundation your house will break, wither and eventually crumble. The homeopathic dose released in the HGH gel helps your body repair damage and relays cellular messages for your body to continue to heal and basically start to “fill the cracks of your foundation.” Once all the cracks are filled YOUR house will be stronger.

Another factor of HGH is it stimulates the production of IGF-1 protein and raises concentration of glucose and free fatty acid. HGH is responsible for the regulation of body fluid, composition, muscle and bone growth as well as regulating metabolic rate and heat functions in the body. The Amino Acid composition in HGH is critical for the creation and building of stronger bones, lean muscles and reduction of body fat tissue.


HGH production peaks in are adolescents and decreases as we age. HGH decreases after the age of 20 and declines approximately 15% every 10 years. By 60 years of age our HGH is usually less than half what it was accounting for the higher incidence of fatal falls due to brittle bones.

The pituitary gland produces GH (Growth Hormone) also known as SOMATOTROPHIN or HGH in humans. This peptide hormone is responsible for growth, cell regeneration, cell reproduction and stimulates growth of essentially ALL TISSUES of the body including bone, muscles, organ, hair, skin and nails.

The release of GH secretion occurs following a circadian daily rhythm. As our sleep and hours of rest are disrupted, so is the natural release and production of our own HGH production. Most adults do not get enough sleep or do not get to bed early enough to be in sync with our bodies natural circadian rhythm. When our sleep patterns or hours of sleep are disrupted so is our body’s ability to produce HGH causing a further decline in our already depleting levels of HGH.


GH (growth hormone) produced in the brain and circulates through the blood to the liver. The liver then stimulates the production of IGF-1. The current research and benefits of IGF-1 are impressive.

Benefits May Include:

  • Increased Energy

  • Decrease in Pain

  • Improves overall mood – helps level our lows and highs

  • Improved sleep quality

  • Weight loss

  • Muscle growth and combats muscle wasting disorders

  • Faster healing & antioxidant production

  • Increase mental function and alertness

  • Decrease inflammation and increase healing and overall ability to heal

  • Increase in strength and flexibility

  • Improves skin thickness/tightness

  • Evens skin tones combats acne & other skin issues

  • Improves metabolic function /speeds metabolism

  • Heals/ rebuilds -muscle/cartilage/bone density/liver/kidney/skin growth

  • Speeds healing from injury/surgery

  • Strengthens Heart Health

Research shows it increases Neurotransmission in the brain – THIS ONE IS AMAZING – Research suggests that IGF-1 promotes nerve cell survival, synaptic maturation and synaptic plasticity. Research is currently being done on HGH and its positive effects for persons suffering with Alzheimer’s, Autism Spectrum Disorder ,ADHD, Anxiety and Depressive Disorders.

Other benefits have been noted by users but the above list has re searchable and verifiable data backing its noted benefits.

These results will vary from person to person and the duration in which people will start to see benefits will depend on their overall current health.


I started to notice a difference within the first few weeks of applying the SOMODERM Homeopathic HGH Gel. I felt a transformative lift in my energy level. I work 6 days a week and also have an at home job at home outside of teaching. I drive about 3 hours a day and my teaching schedule will often include 4-5 classes per day. Most of my days starts around 5 AM and end around 11:30 pm. I try to get to bed early but find with so much on my plate that does not happen.

Due to over-training/working and lack of sleep I would feel dangerously weak around 1 -2 pm and would have to lie down for a nap. When I woke up I would still feel weak and exhausted. I would constantly dream about sleeping (NO JOKE.) I was, as a result, losing a LOT of muscle tone because I was teaching so much and OVER TRAINING. Since I was not getting enough sleep at night my body was not getting the required amount of rest to adequately heal and repair.

My findings on the Gel:

  • 2nd week- I no longer required my naps and had a notable increase in ENERGY

  • 3rd week- I noticed an increase in my muscle growth (my butt came back)

  • 4th week – I noticed a tightening of my skin – Belly and Butt – also knees

  • 5th week I saw an increase in my facial volume. My skin discoloration is improving and acne has seriously dimminished. I also noticed the fine lines around my eyes and mouth have greatly improved and started to disappear (this could save me thousands in ineffective beauty products).

  • 6th week – I notice more improvements like nail, eyebrow, hair growth and health

I am a very health conscious person. I watch everything I eat and drink but was still having major age related issues due to over doing it in my work, physical trainings and general stress. Since I lead a healthier lifestyle and the foundation of my body had less overall damage I think my results could be faster than some users but honestly feel a majority of people that use SOMADERM HGH Gel will notice a difference within 4 weeks and start to see major changes in 2-3-4 months of use.

Is HGH Safe:

HGH Injectable replacement therapy can be dangerous without regular and proper medical supervision, with incorrect dosing, and improper guidance. Injectable doses provider higher more concentrated levels of the Human Growth Hormone making its risk much greater depending on the individual and their genetic structure.

Somaderm HGH Homeopathic Gel dispenses trace amounts of the Growth Factor in its dosing allowing your body to absorb, regulate and process it more efficiently. Like any product on the market there are going to be people that should not take it or could have adverse reactions to it. Therefore, consult your doctor or primary physician before undergoing or starting a new alternative therapy.

Persons who should not take HGH Gel are those with diagnosed Insulin fasting or insulin resistance. Persons suffering with Type 2 diabetes should consult a physician before starting this product. Research shows IGF-1 is linked to increasing Insulin resistance whereas IGF1 has insulin-like effects that have also been found to reduce blood glucose levels and has been used experimentally to treat both type 1 and type 2 diabetes.


Overall I have seen amazing life changing benefits and changes in my body from using the Somaderm HGH Gel. The changes will be different for every person because we are all so different. Someone that is exercising, eating healthier and making better overall life and health choices will see faster changes than someone that is not making good choices and is not active. Note: the changes are gradual and can take a few months to see significant changes .

Do the following when starting HGH Gel:

  • Use the recommended dose

  • Take doses first thing in the morning & again at night – if sleep is disturbed then take second dose in the afternoon

  • Tract your changes (discontinue use if you have adverse reactions)

  • Start making healthier choices, exercise, yoga, breathing, meditation…..

  • Be patient – there are NO magic pills – this product is truly amazing but remember we have created decades of damage and that is not reversible overnight

For more information I have linked NewULife’s HGH Homeopathic Gel Sodaderm product information and research guide. If you have any questions/interested in trying this product/ selling this product, then please contact me.

Somatropin Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 30, 2018.

  • Overview
  • Side Effects
  • Dosage
  • Professional
  • Interactions
  • More

For the Consumer

Applies to somatropin: powder for solution

Other dosage forms:

  • powder for solution, solution

Along with its needed effects, somatropin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking somatropin:

More common

  • Abnormal or decreased touch sensation
  • bleeding after defecation
  • bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine
  • burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
  • changes in skin color
  • cold flu-like symptoms
  • cold hands and feet
  • confusion
  • constipation
  • cough or hoarseness
  • darkened urine
  • decreased urination
  • diarrhea
  • difficult urination
  • dizziness
  • dry mouth
  • fainting or loss of consciousness
  • fast heartbeat
  • fast or irregular breathing
  • feeling unusually cold
  • fever or chills
  • full or bloated feeling
  • general feeling of discomfort or illness
  • headache
  • increase in heart rate
  • itching or skin rash
  • joint pain
  • light-colored stools
  • lightheadedness
  • loss of appetite
  • lower back or side pain
  • muscle aching or cramping
  • muscle pain or stiffness
  • nausea
  • pain
  • pain, redness, or swelling in the arm or leg
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • pressure in the stomach
  • rapid, shallow breathing
  • rapid weight gain
  • rectal bleeding
  • runny nose
  • shivering
  • sneezing
  • sore mouth or tongue
  • sore throat
  • stomach bloating, burning, cramping, or pain
  • sudden decrease in the amount of urine
  • sweating
  • swelling of the abdominal or stomach area
  • swelling of the eyes or eyelids
  • swelling or puffiness of the face
  • swollen joints
  • thirst
  • tightness in the chest
  • tingling of the hands or feet
  • trouble breathing
  • trouble sleeping
  • uncomfortable swelling around the anus
  • unpleasant breath odor
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • vomiting
  • vomiting of blood
  • white patches in the mouth, tongue, or throat
  • wrinkled skin
  • yellow eyes or skin

Less common

  • Bone or skeletal pain
  • burning, numbness, pain, or tingling in all fingers except smallest finger
  • chest pain
  • depressed mood
  • dry skin and hair
  • feeling cold
  • hair loss
  • hoarseness or husky voice
  • slowed heartbeat
  • swelling of the ankles

Get emergency help immediately if any of the following symptoms of overdose occur while taking somatropin:

Symptoms of overdose

  • Anxiety
  • blurred vision
  • changes in vision
  • cold sweats
  • coma
  • cool, pale skin
  • decrease in the amount of urine
  • depression
  • excessive sweating
  • extreme weakness
  • flushed, dry skin
  • frequent urination
  • fruit-like breath odor
  • increase in hands and feet size
  • increased hunger
  • increased thirst
  • increased urination
  • increased volume of pale, diluted urine
  • nightmares
  • noisy, rattling breathing
  • pain in the arms or legs
  • seizures
  • shakiness
  • slurred speech
  • stop in menstruation
  • swelling of the fingers or hands
  • troubled breathing at rest

Some side effects of somatropin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Body aches or pain
  • breast pain
  • change in the color, amount, or odor of vaginal discharge
  • congestion
  • discoloration of the fingernails or toenails
  • dryness or soreness of the throat
  • excess air or gas in the stomach or intestines
  • frequent urge to defecate
  • increased sweating
  • passing gas
  • sneezing
  • straining while passing stool
  • stuffy nose
  • tender, swollen glands in neck
  • trouble with swallowing
  • voice changes

Less common

  • Discouragement
  • feeling sad or empty
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • tiredness
  • trouble concentrating

For Healthcare Professionals

Applies to somatropin: injectable kit, injectable powder for injection, subcutaneous kit, subcutaneous powder for injection, subcutaneous solution


The most common adverse events were glucose intolerance, fluid retention, injection site reactions, and unmasking of latent central hypothyroidism.


Common (1% to 10%): Hematoma, fatigue, flu-like symptoms, asthenia, fatigue, generalized edema

Uncommon (0.1% to 1%): Weakness

Frequency not reported: Sudden death, pyrexia, ear infection, influenza-like illness, otitis externa,

Postmarketing reports: Increased blood alkaline phosphatase level


Very common (10% or more): IGF-1 scores above 2 standard deviations (38%), hypothyroidism (16%)

Common (1% to 10%): Hypothyroidism

Uncommon (0.1% to 1%): Central precocious puberty

Frequency not reported: Unmasking of latent central hypothyroidism

Postmarketing reports: Decrease in serum thyroxin levels


Scoliosis was reported as an adverse event in 5 out of 21 children with Noonan Syndrome who were followed for 11 years.

Very common (10% or more): Arthralgia (37.1%), myalgia (30.4%), scoliosis (23.8%), skeletal pain (11%), back pain (10.9%), arthrosis (10.7%)

Common (1% to 10%): Musculoskeletal stiffness, stiffness of extremities, joint stiffness, joint swelling, joint disorder, leg pain, hip pain, progression of preexisting scoliosis,

Uncommon (0.1% to 1%): Localized muscle pain, jaw prominence, slipped capital femoral epiphysis

Frequency not reported: fracture, joint pain, growth attenuation, interference with growth response, excessive growth of hands or feet, exacerbation of preexisting scoliosis, disproportionate growth of the lower jaw, fracture

Postmarketing reports: Legg-Calvé-Perthes disease


Very common (10% or more): Impaired fasting glucose (22%), elevated HbA1c (14%), blood glucose increased (13.8%)

Common (1% to 10%): Hyperglycemia, hyperlipidemia, glucose tolerance abnormal, fluid retention, hypertriglyceridemia, overt type II diabetes mellitus

Uncommon (0.1% to 1%): Diabetes mellitus, abnormalities of carbohydrate metabolism (glucose intolerance and high serum HbA1c)

Frequency not reported: Glucose intolerance including impaired glucose tolerance/impaired fasting glucose, increased appetite, transient episodes of fasting blood sugars between 100 and 126 mg/dL, transient episodes of fasting blood sugars exceeding 126 mg/dL, increased fasting blood glucose levels, increases in insulin levels, insulin resistance

Postmarketing reports: Exacerbation of preexisting diabetes mellitus, diabetic ketoacidosis, diabetic coma

Nervous system

Intracranial hypertension with papilledema, visual changes, headache, nausea, and/or vomiting has been reported in a small number of patients.

Very common (10% or more): Paresthesia (17.3%), hypoesthesia (15%)

Common (1% to 10%): Hypesthesia, fatigue, carpal tunnel syndrome, Tinel’s sign

Uncommon (0.1% to 1%): Benign intracranial hypertension, motor problem, seizure


Very common (10% or more): Pharyngitis (14.3%),

Common (1% to 10%): Nausea, gastroenteritis, gastritis

Frequency not reported: Abdominal pain, increased appetite

Postmarketing reports: Pancreatitis


Very common (10% or more): AST increased (12.5%)

Common (1% to 10%): ALT increased


Very common (10% or more): Eosinophilia (12%)


Very common (10% or more): Periorbital edema

Frequency not reported: Diabetic retinopathy


Very common (10% or more): Upper respiratory infection (15.9%), rhinitis (13.5%)

Common (1% to 10%): Bronchitis, cough increased, laryngitis, respiratory disorder, dyspnea, sleep apnea

Frequency not reported: Influenza, tonsillitis, nasopharyngitis, sinusitis, bronchitis


Very common (10% or more): Anti-rhGH antibodies (24%), infection (non-viral) (13%)

Frequency not reported: Antibody formation, anti-periplasmic Escherichia coli peptides (PECP) antibodies

An IgG antibody has been identified. No antibodies to the IgE class have been detected. Growth hormone antibody binding capacities less than 2 mg/L have not led to growth attenuation. Testing for antibodies should be carried out in any patient failing to respond to treatment.

Primate studies have failed to reveal evidence of histopathological changes due to immune complex formation.


Common (1% to 10%): Injection site pain

Frequency not reported: Injection site reactions/rashes, lipoatrophy, nodules, rash, inflammation, pigmentation, bleeding


Common (1% to 10%): Hypersensitivity to solvent (m-cresol/glycerol)

Rare (less than 0.1%): Generalized hypersensitivity reactions

Postmarketing reports: Hypersensitivity


Common (1% to 10%): Hypertension

Frequency not reported: Cardiac disorders


Common (1% to 10%): Increased sweating, excessive number of cutaneous nevi, acne

Uncommon (0.1% to 1%): Pruritus

Rare (less than 0.1%): Rash

Frequency not reported: Hair loss, progression of pigmented nevi, eczema


Common (1% to 10%): Gynecomastia, breast-related adverse reactions (e.g. nipple pain,

gynecomastia, breast pain/mass/tenderness/swelling/edema/hypertrophy)

Frequency not reported: Urinary tract infection


Common (1% to 10%): Insomnia

Frequency not reported: Aggressiveness, altered mood


Uncommon (0.1% to 1%): Glucosuria

Frequency not reported: Hematuria


Very rare (less than 0.01%): Leukemia

Frequency not reported: Intracranial tumors including meningiomas, melanocytic nevus

1. “Product Information. Nutropin (somatropin).” Genentech, South San Francisco, CA.

2. “Product Information. Humatrope (somatropin).” Lilly, Eli and Company, Indianapolis, IN.

3. “Product Information. Zorbtive (somatropin).” Serono Laboratories Inc, Rockland, MA.

4. “Product Information. Serostim (somatropin).” Serono Laboratories Inc, Rockland, MA.

5. “Product Information. Norditropin Cartridge (somatropin).” Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.

6. Cerner Multum, Inc. “Australian Product Information.” O 0

7. Cerner Multum, Inc. “UK Summary of Product Characteristics.” O 0

8. “Product Information. Genotropin (somatropin).” Pharmacia and Upjohn, Kalamazoo, MI.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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