Estarylla birth control review

Estarylla is a low-dose combination contraceptive used to prevent unwanted pregnancy. The drug contains two female hormones: norgestimate and ethinyl estradiol.


  • Indications for use
  • Mechanism of action
  • Mode of application and dosage
  • Contraindications
  • Side effects
  • Interactions
  • What if I miss a dose?
  • Estarylla and pregnancy

Indications for use

  • Prevention of unwanted pregnancy.
  • Treatment of severe acne

Mechanism of action

The drug suppresses ovulation due to the inhibition of the synthesis of gonadotropic hormones, the suppression of the hypothalamic-pituitary system. The silage is able to change the implantability of the endometrium, reduces the transport function of the fallopian tubes, increases the viscosity of cervical mucus.

Mode of application and dosage

Each package of Estarylla contains 28 pills – 21 active pills with hormones and 7 pills with no medication (known as “reminders”).

The pills are taken daily for 28 days in a row, without interruption. Take the 1st pill on the first day of the menstrual period. Menstrual bleeding is expected to come after you have taken the last active pill from the package. As soon as you take the last pill from the package, start a new one.

You can start taking the drug 7 days after the childbirth or immediately after the abortion.

It is desirable to take the pills at the same time every day.


Do not take Estarylla pills if you have any of the conditions listed below:

  • thrombophlebitis (inflammation of the vein wall with occlusion);
  • thromboembolism (vascular obstruction);
  • deficiency of antithrombin 3 (one of the factors that prevent blood clotting), cerebrovascular disorders (changes in brain vessels);
  • cardiac ischemia;
  • sickle-cell anemia (hereditary hemolytic anemia);
  • carcinoma (cancer) of the breast and endometrium (inner layer of the uterus), other estrogen-dependent neoplasms;
  • bleeding from the urogenital tract (genitourinary tract) of unknown etiology;
  • pregnancy;
  • breastfeeding;
  • impaired liver function;
  • tumor of the liver

Estarylla is not recommended for smoking women over the age of 35.

Side Effects

Stop taking the birth control pills if you have any of the side effects listed below:

  • irregular spotting (especially in the first months);
  • digestive system – violations of the liver, nausea, vomiting, itching, jaundice, rarely – liver adenoma, pathology of the gallbladder;
  • central nervous system – headache, migraine, depression;
  • skin reactions – hair loss, pigment spots on the face;
  • sense organs – discomfort when wearing contact lenses;
  • sexual system – cervical erosion, vaginal candidiasis, increased secretion of uterine mucus;
  • endocrine system – spotting, menstrual-like bleeding, amenorrhea, discharge from the nipples, engorgement of the mammary glands, changes in
  • libido, increase or decrease in body weight;
  • other: allergic reactions; rarely – reduced tolerance to glucose, increased blood pressure, increased uterine fibroids.

Do not discontinue using Estarylla when menstrual bleeding occurs. If bleeding does not stop, then an additional examination should be conducted to exclude organic pathology. If the bleeding does not occur after you have finished the package, you should exclude pregnancy before taking a pill from a new package.


Drugs that cause the induction of enzymes metabolizing estrogens (eg, estrogen-2-hydroxylase-coenzyme 3A4 of the cytochrome P-450 system) may reduce the contraceptive effectiveness of Estarylla.

Plant remedies that affect the enzymes involved in the biological transformation of contraceptive steroid hormones (eg, St. John’s Wort, barbiturates, carbamazepine, phenytoin, sulfonamides, pyrazolone derivatives, rifampicin) may also weaken the contraceptive effect of the drug.

Some protease inhibitors and some antiretroviral drugs (for example, indinavir, ritonavir) may increase or reduce the concentration of norgestimate and ethinyl estradiol in the blood.

Another type of interaction is the violation of intrahepatic circulation of estrogens, as a result of which the excretion is accelerated and the concentration of ethinyl estradiol is reduced. When Estarylla is taken with certain antibiotics (eg, ampicillin or tetracycline), insufficient cleavage of conjugates of estrogens and fatty acids by intestinal bacteria is observed.

What if I miss a dose?

If you forgot to take a pill but no more than 12 hours passed, contraception remains effective. If the interval exceeds 12 hours, the effectiveness decreases and it is necessary to use additional contraception methods.

Estarylla and pregnancy

Estarylla is contraindicated for pregnant women. When used in the early stages of pregnancy, the drug can cause malformations in the fetus.

During breastfeeding, a small amount of norgestimate and ethinyl estradiol are excreted in breast milk. The negative impact on the child’s body is not established. However, gynecologists and pediatricians do not recommend using this hormonal contraceptive during breastfeeding. During this period, you should use non-hormonal birth control means.

Data Modified on 6-13-2018

Posted by Mary Parker

A woman who previously received Tri-Linyah from her old pharmacy was given Tri-Estarylla from her new pharmacy. Even though the new pharmacy only carried Tri-Estarylla, the amount of norgestimate and ethinyl estradiol was the same as in Tri-Linyah. The woman called the pharmacy and asked why the placebo tablets in the calendar pack were green rather than white. The pharmacist told her that Tri-Estarylla has different color tablets for weeks 1 and 4 than Tri-Linyah (Table 1). These color differences confused the woman. Thankfully, she called the pharmacy before taking the wrong tablets at the wrong time of the month. The pharmacist taught her how to take the pills correctly.

Table 1 lists the differences in the colors used for week 1 and week 4 tablets among the different brand name products. This is of concern, especially for women who are switching between various brand products. Women may inadvertently take the placebo

(no medicine) tablets when they should be taking the week 1 active tablets, especially if the labeling on the calendar pack is confusing or difficult to read. This can reduce the effectiveness of the birth control pills. It would be less confusing if all the norgestimate and ethinyl estradiol birth control pills used the same tablet colors for the same weeks of treatment.

Here’s what you can do: When picking up birth control pills at your pharmacy, talk to your pharmacist to make sure you know how to take the medicine. Also, when you pick up any medicine at your pharmacy, open the bag and look at the medicine. If you notice any change in your medicine, such as the name of the product or the color or size of the tablet, ask the pharmacist to confirm that it is the correct medicine, and then learn how to take it.

What is Tri Estarylla?

This combination hormone medication is used to prevent pregnancy. It contains 2 hormones: a progestin and an estrogen. It works mainly by preventing the release of an egg (ovulation) during your menstrual cycle. It also makes vaginal fluid thicker to help prevent sperm from reaching an egg (fertilization) and changes the lining of the uterus (womb) to prevent attachment of a fertilized egg. If a fertilized egg does not attach to the uterus, it passes out of the body. Besides preventing pregnancy, birth control pills may make your periods more regular, decrease blood loss and painful periods, decrease your risk of ovarian cysts, and also treat acne. Using this medication does not protect you or your partner against sexually transmitted diseases (such as HIV, gonorrhea, chlamydia).


  • female hypogonadism
  • polycystic ovarian syndrome
  • endometriosis
  • dysmenorrhea
  • premenstrual dysphoric disorder
  • amenorrhea
  • menorrhagia
  • abnormal uterine bleeding
  • acne vulgaris
  • Pregnancy Contraception

Usage Instructions

Read the Patient Information Leaflet provided by your pharmacist before you start using this product and each time you get a refill. The leaflet contains very important information on when to take your pills and what to do if you miss a dose. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth as directed by your doctor, usually once daily. Pick a time of day that is easy for you to remember, and take your pill at the same time each day. It is very important to continue taking this medication exactly as prescribed by your doctor. With certain brands of birth control pills, the amount of estrogen and progestin in each active tablet will vary at different times in the cycle. Therefore, it is very important that you follow the package instructions to find the first tablet, start with the first tablet in the pack, and take them in the correct order. Do not skip any doses. Pregnancy is more likely if you miss pills, start a new pack late, or take your pill at a different time of the day than usual. Vomiting or diarrhea can prevent your birth control pills from working well. If you have vomiting or diarrhea, you may need to use a back-up birth control method (such as condoms, spermicide). Follow the directions in the Patient Information Leaflet and check with your doctor or pharmacist for more details. Taking this medication after your evening meal or at bedtime may help if you have stomach upset or nausea with the medication. You may choose to take this medication at another time of day that is easier for you to remember. No matter what dosing schedule you use, it is very important that you take this medication at the same time each day, 24 hours apart. Ask your doctor or pharmacist if you have any questions. Your pill pack contains 21 pills with active medication. It may also contain 7 reminder pills with no medication. Take one active pill (with hormones) once daily for 21 days in a row. If you are using a product with 28 tablets, take an inactive pill once daily for 7 days in a row after you have taken the last active pill unless otherwise directed by your doctor. If you are using a product with 21 tablets, do not take any tablets for 7 days unless otherwise directed by your doctor. You should have your period during the fourth week of the cycle. After you have taken the last inactive tablet in the pack or gone 7 days without taking an active tablet, start a new pack the next day whether or not you have your period. If you do not get your period, consult your doctor. If this is the first time you are using this medication and you are not switching from another form of hormonal birth control (such as patch, other birth control pills), take the first tablet in the pack on the first Sunday following the beginning of your menstrual period or on the first day of your period. If your period begins on a Sunday, begin taking this medication on that day. For the first cycle of use only, use an additional form of non-hormonal birth control (such as condoms, spermicide) for the first 7 days to prevent pregnancy until the medication has enough time to work. If you start on the first day of your period, you do not need to use back-up birth control the first week. Ask your doctor or pharmacist about how to switch from other forms of hormonal birth control (such as patch, other birth control pills) to this product. If any information is unclear, consult the Patient Information Leaflet or your doctor or pharmacist.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Estarylla is a combination hormone medication, which contains progestin (norgestimate) and estrogen (ethinyl estradiol). It is used to prevent pregnancy by inhibiting ovulation (release of an egg during a woman’s menstrual period). It also prevents the sperm to reach the egg by making the vaginal fluid thicker along with changing the uterine lining to prevent the fertilized egg to attach to the uterus (womb). If the fertilized egg is not implanted in the uterus, the body sheds the uterine lining, and the female’s menstrual period starts.

Birth control pills can also correct menstrual periods and make them more regular, make periods less painful, decrease blood loss, treat acne, and help reduce the risk of developing ovarian cysts. However, this medication does not protect women from contracting sexually transmitted diseases (STDs), such as chlamydia, HIV, or gonorrhea.

Have a question aboutBirth Control Pills?Ask a doctor now

Proper Usage

Before using this medication, read the Patient Information Leaflet provided by the pharmacist. You may ask your doctor or pharmacist for more information or if you have any questions about the product.

The product is available in a blister pack. One packet has 28 tablets with different colors. After the initial treatment to prevent pregnancy, the body needs to adjust to the medication for seven days. For this reason, you may also use another form of contraception for the first seven days. If the next dose is taken within 24 hours, then optimal effects will be achieved.

If you miss a dose, there are chances of pregnancy. During the first few months of starting the treatment, you may feel sick or nauseated. However, if these symptoms persist, consult your doctor. The dosage usually depends on the patient’s medical problem.

  • To prevent pregnancy in adults and teenagers – One blue tablet should be taken daily for 21 days. For Day 22 to Day 28, take one green tablet daily for seven days.
  • For the treatment of adult and teen acne (15 years old and above) – One white, blue, or light blue tablet should be taken daily for 21 days followed by taking one green tablet daily for seven days for each menstrual cycle. The dosage for teens and children who are below 15 years old is usually determined by the doctor.

Inform your doctor if you missed your period for two months straight since it could indicate a pregnancy. If you miss more than one pill or have changed your usual schedule, you may not have a menstrual period for that month. Moreover, if you do not take your pills on time, you may experience spotting or light bleeding. Remember that the more pills you miss, the more prone you are to experience bleeding.


To monitor whether the drug is working effectively, regular visits should be made to the doctor. You can visit the doctor every six or 12 months. Since this drug has a teratogenic potential, if you feel or suspect that you are pregnant, it is very important to inform your doctor.

Taking this medicine may also increase one’s risk of developing blood clotting problems. See your doctor immediately if you have any of the following symptoms while taking this medication:

  • Chest pain
  • Pain in the legs, calves, or groin
  • Breathing difficulties (sudden shortness of breath)
  • A sudden and severe headache
  • Slurred speech
  • Vision problems
  • A sudden loss of coordination

Side Effects

This medicine may also cause some side effects. See your doctor right away if you experience any of the following side effects:

  • Abdominal pain
  • Bloating
  • Nausea and vomiting
  • Hematemesis (vomiting blood)
  • Amenorrhea (no menstrual period)
  • Missed or irregular periods
  • Anxiety
  • Irritable
  • Vision changes
  • Skin color changes
  • Chest pain
  • Fever
  • Chills
  • Sudden severe headache
  • Pale stool
  • Constipation or diarrhea
  • Coughing
  • Dark-colored urine
  • Lightheadedness
  • Dizziness
  • Syncope (fainting)
  • Itchy skin,
  • Hives or welts
  • Swelling of the face, lips, tongue, throat, eyelids, hands, feet, legs, and genital organs
  • Appetite loss
  • Irregular vaginal bleeding (medium to heavy) between monthly periods
  • Pain in the neck, jaw, arms, and back
  • Swelling of the leg or foot
  • Pain in the groin and legs, particularly the calves
  • Thumping ear noise
  • Skin rash
  • Skin redness
  • Unusual fatigue or weakness
  • Breathing problems
  • Slurred speech
  • Irregular heartbeat
  • Sweating
  • Sudden lack of coordination

Even though not all of the above side effects may occur, it is still important to seek immediate medical attention if any of them do occur.

Estarylla Reviews

On the website, users were asked on a scale of 1 to 10 about the effectiveness and ease of use of Estarylla, along with its positive and adverse side effects.

1 (not effective) to 10 (most effective)

  • Average rating for ovarian cysts is 6.
  • Average rating for acne is 4.9.
  • Average rating for abnormal uterine bleeding is 3.7.
  • Average rating for birth control is 3.5.
  • Overall rating for Estarylla is 4.5.


Drug interactions can change how a certain medication works as well as increase a person’s risk for dangerous side effects. For this reason, it is very important to inform your doctor or pharmacist about the medications you are using including both prescription or nonprescription drugs, supplements, and herbal products. Moreover, do not self-medicate as well as change, stop, or start any medications without your doctor’s advice.

The following are medications that may interact with Estarylla:

  • Aromatase inhibitors (anastrozole, exemestane)
  • Tamoxifen
  • Tizanidine
  • Ospemifene
  • Tranexamic acid
  • Ombitasvir/paritaprevir/ritonavir with or without dasabuvir (combination products for the treatment of chronic hepatitis C)

Other drugs may also decrease the amount of birth control hormones in a woman’s body, leading to a decreased effectiveness of birth control medications. Such drug interaction may result in pregnancy. Some examples of these drugs are:

  • Anti-seizure drugs (barbiturates, carbamazepine, felbamate, phenytoin, primidone, topiramate)
  • Drugs for HIV (nelfinavir, nevirapine, ritonavir)
  • Griseofulvin
  • Modafinil
  • Rifamycins (rifampin, rifabutin)
  • St. John’s wort

When you need to take a new drug, inform your doctor and discuss whether you need to use another birth control pill. Moreover, inform your doctor if experience any breakthrough bleeding or spotting between regular menstrual periods. It may be a sign that your medication is not working as it should be.

Estarylla may also interfere with certain lab tests, such as thyroid tests and blood clotting factors. To avoid getting false test results, inform the doctor or laboratory personnel that you are currently taking this medication.


I was switched to Estarylla due to insurance coverage and the name changed. I have taken Sprintec/previfem before this medication. The side effects of this medication have been the worst. My review is similar to others I have read, and luckily I’m going to my doctor tomorrow to get switched back to the brand! First off, I never really had acne growing up. The most I would normally get is a pimple or two once and while but would go away within a week. Since starting this medication, I have had large areas of pimples that do not go away even with prescription medications for it. I never had large patches of acne especially on my cheeks and chin then did not go away on their own. Another side effect I’ve been having is terrible mood swings/depression. Sometimes (usually the week before my period) I find myself crying for no reason, anxiety and over thinking everything, and just not feeling myself. I also have had headaches more. All of these symptoms seemed to have started after the brand of my birth control was switched to Estarylla. I’m going to try to switch back to what I had before!

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