Endometriosis and progesterone cream

Natural Progesterone Cream for Treating Endometriosis

There’s a huge difference between a “bad period” and endometriosis, as any woman with the condition would be able to tell you. Usually affecting women in their 30s and 40s, it turns out almost 1 in every 10 women of reproductive age lives with endometriosis. Let’s learn more about it and how progesterone creams may help.

What is endometriosis? What causes endometriosis?

As a woman, your uterus is lined with a layer of tissue called the endometrium. Your endometrium keeps the walls of your uterus from sticking together and also holds a fertilized egg so that it can eventually grow into a baby. Whenever a month goes by during which an egg has not been fertilized, your endometrium sheds. You know that as your monthly period.

Endometriosis is what happens when the endometrium grows outside the uterus. The tissue can end up covering other organs in your pelvis like your fallopian tubes, ovaries, and even your bladder and rectum.

This extreme overgrowth can cause complications with menstruation and fertility. In fact, many women discover their diagnosis when they start trying to have children.

What are signs and symptoms of endometriosis?

Pelvic pain around the time of menstruation is by far the most notable symptom of endometriosis. Other signs and symptoms include:

  • Pain during sex or urination, depending on the extent of the overgrowth
  • Heavy bleeding
  • Infertility

Since menstruation is the source of many of these symptoms, women often find that their symptoms disappear after reaching menopause. Also, some women with endometriosis never have symptoms at all.

What are treatment options for endometriosis?

Unfortunately, there’s no cure for endometriosis. Treatment options often revolve around treating the painful symptoms by using pain-relievers like ibuprofen and naproxen or altering the frequency and severity of a period through birth control like hormonal IUDs.

Compounded solutions (e.g., progesterone creams)

Progesterone is a hormone that helps slow down the growth of the endometrium. Progesterone creams are applied topically (to the skin). When progesterone is applied to the skin, it is then absorbed through the skin and enters the bloodstream to work on the endometrium.

The knowledgeable pharmacists at The Compounding Center compound bio-identical progesterone creams. In other words, they have the same chemical structure as the progesterone your body makes. We can compound your progesterone cream in the dose that is optimal for you and your body.

Nutritional alternatives

Some women have used supplements like milk thistle or curcumin to help ease endometriosis pains. You should always talk to your doctor before using herbal supplements since they may interact with other medications you are taking.

Bioidentical progesteron for Endometriosis


Purchase 4 bottles and receive one for FREE with your order

Bioidentical Progesterone for Endometriosis Treatment
Endometriosis can affect any female, from premenarche to post menopause, regardless of race or ethnicity or whether or not they have had children.
As an estrogen-dependent process, it can persist beyond menopause and persists in up to 40% of patients following hysterectomy. Since we know that estrogen and other chemical compounds that act similar to estrogen/xenohormones accelerate the occurrence of endometriosis, the aim of treatment, successful treatment, is to block this over stimulation to the aberrant endometrial islets. Weak estrogens, like estriol or phyto/(plant) estrogens do this by blocking more powerful estrogens, like estradiol and xenoestrogens. Bio identical progesterone stops further proliferation of endometrial cells and reverses the damage and growth that has occurred. Progesterone therapy is anti estrogen, anti proliferate and anti-inflammatory. Progesterone can actually heal the damage that endometriosis has caused.
Environmental toxins Several studies have investigated the strong links between exposure to dioxins a xenohormone and endometriosis.
In the early 1990s, a study found that 79% of a group of monkeys developed endometriosis within ten years after exposure to dioxin. The severity of endometriosis found in the monkeys was directly related to the amount of dioxin to which they had been exposed. Monkeys that were fed dioxin in amounts as small as five parts per trillion developed endometriosis. In addition, the dioxin-exposed monkeys showed immune abnormalities similar to those observed in women with endometriosis.
A similar follow up study in 2000 observed similar findings. Drs. Frederick Yves Bois and Brenda Eskenazi wrote in the Environmental Health Perspectives journal titled Possible Risk of Endometriosis: An Assessment of Exposure to Dioxin
Dioxins and dioxin-like compounds are by-products of various industrial processes, and continue to be used on fields that grow our food and are sprayed with pesticides. These compounds are also found in paper products like tampons and many products where they have processed paper, even your paper cup that you use for your coffee to go. Other molecules related to these are the combination of Triclosan found in topical antibacterial uses like soaps and wipes when combined with chlorinated water. The most insidious of all is the food you eat. If you’re consuming pesticide treated food your consuming ample amounts of dioxins to cause cancer; www.inchem.org/dioxin/
The average daily intake of the American people is already well above two federal guidelines for “safe” exposure. The American average daily intake is more than 200 times higher than the Environmental Protection Agency’s cancer risk guideline. www.ejnet.org/dioxin/
More information found on the links below: http://www.fda.gov/ScienceResearch/SpecialTopics/WomensHealthResearch/ucm134825.htm
World Health Organization http://www.inchem.org/documents/ehc/ehc/ehc84.htm http://www.who.int/mediacentre/factsheets/fs225/en/


-Amy G.
Dr. Eckhart,
This has worked wonders for me so far with my endo symptoms, no cramps, no swelling of my chest, and no more bloated stomach. But for the entire 2 weeks I’ve been on progestelle I have had migraines like every other day and have had to leave work early quite often. Do you have any suggestions as to why I would be getting such bad headaches like this??? I really need to stop them so that I don’t miss soooo much work.
Thank you for your quick responses on my questions.
-Amy G.
I am still using the progestelle, just finished my first bottle yesterday and my headaches have subsided since I last e-mailed, which is awesome, so I am feeling better on the progesterone oil and cut out the xenoestrogens I put on my skin.
But, do I have to stop using the progestelle oil in order to get my period??? Or do I continue using 3 dropfuls at night like I have been until my period arrives then stop the progestelle?? I’m just a little confused abt. that part of the regime.
The last time I had my period was Nov 20th, and it lasted for 12 days.
-Amy G.
Dec. 16, 2009
Honesdale, Pennslyvania
Editor’s Note: The increased headaches with the use of Progestelle is from xenoestrogens or chemical or herbal estrogens in her environment. To get rid of the headaches, get rid of the xenoestrogens. Sometimes lotions and sunscreens take about 1-3 months to wash out of the body.
Constant environmental estrogen exposure leads estrogen receptors to down regulate or become “sleepy”. Taking progesterone cream “wakes up” the estrogen receptors and estrogen now has a greater effect. This greater effect of the estrogen yields headaches. The solution is to cut out xenoestrogens.

Taking Fibrovan for Endometriosis has Diminished the Constant Pain to Almost 0 (Zero) – Thyroid Medication Reduced
Hi there,
Just wanted to tell you how the progesterone oil has improved things for me over the last four months. I also added Fibrovan two months ago as the constant pain with endometriosis was not entirely gone, however I can say that taking Fibrovan has diminished the constant pain to almost 0. I have also been able to reduce my thyroid medication.
The problem is that I have had very heavy bleeding during my period and also my period came a week early this month. I have felt faint during the bleed and it has been quite painful with intestinal upset too. None of this is particularly a problem, its just that I am trying to work out why I am now nauseous with stomach discomfort after the bleed. I’m not sure if it is hormonal or a virus. I also have a lot of acne.
I cant seem to get rid of the nausea with slight diarrhoea and constipation alternating which I have had for six days now. I am putting on around four pipettes of oil a day and have stopped the Fibrovan for now.
Any advise would be gratefully received.
Many Thanks
Joanna S.(age 42 in July)
Apr. 11, 2010
The pain is far less, more like just a feeling now. I feel like this is very positive for me! Thyroid issue is always a bit complicated but armour thyroid dose reduced and overall am able to do more work which is important as a freelancer.
Thank you so much, I will continue with the oil and fibrovan at the level that works. I am excited at the ongoing possibilities and have hope which I havent for a long time!
Thank You
Joanna S.
May 6, 2010

Goodbye Stage IV Endometriosis!
At long last I am taking time to write – at length – my tremendously improved endometriosis and positive experience using both Progestelle Natural Progesterone Oil and my doctor/patient relationship with Dr. Peter Eckhart, M.D.
After 25+ years of being plagued with recurring, severe pelvic pain symptoms, I was finally diagnosed with Stage IV Endometriosis & “Kissing” Ovaries at the age of 39. While my surgeon went above and beyond the call of duty by performing 4.5 hours of intensive laprascopic surgery to address a myriad of issues within my pelvic region, etc., during my post-op recovery I again found myself dealing with severe pelvic/bowel spasms that the surgeon could not help me with. He wrote me one synthetic progesterone pill prescription after another, only to find that they were not helping. They were actually making me worse – which I didn’t think was possible.
While doing internet research one night, I felt a divine hand lead me to the Women’s Therapeutic Institute website and began reading about Progestelle. I also began reading the copious amount of material on the website detailing how so many other things (both environmental and dietary) were likely fueling the re-growth of my endometriosis – especially parabens!!
I placed my order for the Progestelle, immediately stopped taking all my synthetic progesterone medications and waited. It wasn’t more than 2-3 weeks before I saw dramatic improvement.
While I was awaiting my Progestelle delivery, I went through every product that I used on my skin (soap, shampoo, skincare, makeup, etc.) and if the ingredient list had ANYTHING that appeared to mimic estrogen, it went in the garbage. This wasn’t a fun thing to do – I probably trashed approximately $300.00 worth of items in the process – but it was necessary if I was going to be serious and take control over my health.
I’ve also amended my dietary behavior, removing all foods that are heavily processed, eliminating all artificial sweeteners, drinking only purified water, no fast food and trying to eat as much organic food as possible.
The next big hurdle was removing the chlorine from my showers. We bought good-quality shower filters to yank the chlorine out of the water before it was allowed to be absorbed into my pores while showering each morning. this was yet another MASSIVE step in the right direction. The only thing that caused me to have a relapse was making a trip to the beach and taking a dip in a heavily-treated swimming pool. The chlorine overload threw me back into a horrific pelvic/bowel spasm within 4 hours from exposure. Lesson learned!!
The final (to date) item that has put me over the remaining hump of painful periods was making the swap to organic tampons. I don’t know why it took me 12 months to make the connection that putting a chlorine-dyed tube of cotton inside me while bleeding (releasing dioxins all the while) was probably not a good thing but once my brain finally kicked into gear on that front, my pelvic health has been as good as it was during my early teens. That is truly remarkable.
I want to also take a moment to tell you how wonderful, kind and helpful Dr. Eckhart has been and remains in my journey to pelvic health. He always answers my e-mail questions in a VERY timely manner, listens to my concerns, questions and treats me like a person . . . not like a lab rat. Despite their best intentions, most OB-GYNS in the conventional medical universe spend very little time actually listening and most of their time making one feel like a cow running through a feedlot.
Dr. Eckhart has earned his gold stars in dealing with me and I cannot sing his praises loudly enough. He even took time to help me find safe, organic hair color to protect all the positive improvements with my endometriosis.
Can you imagine ANY other doctor doing that? I can’t . . . and believe me, I’ve seen enough traditional gynecological doctors over the years to speak from much experience.
If you have yet to take the time to try Progestelle or speak with Dr. Eckhart about your unique situation, please don’t waste any more precious time. Each of us are born with an innate sense of what our bodies need to heal and be healthy. Listen to your own voice, trust it and take back control over your health. I did . . . and thankfully I will never be the same.
Stephanie M. H., Lincoln, Alabama

Healing from Endometriosis

Life with endometriosis was not easy! I began to get sick off and on about five years ago after my second pregnancy. My OBGYN didn’t really want to listen to my complaints when pain was the only thing that was on my mind. I began to have so much pain in my pelvis I didn’t want to go to work. Then I began to have nausea to the point where it was like having the flu three weeks out of the month. Then one night after three days of not being able to eat and feeling so sick I could not get out of bed; I thought to myself, “you can’t go to sleep because you won’t wake up. When I told my husband my thoughts he said, “we are going to find some help, I don’t care what the OBGYN say’s, your sick!” So my husband did the searching on the Internet for me. He came upon the Progestelle web site. Immediately he new this was going to be my “cure”. I thought he was nuts when I heard I had to change every product in the house with certain chemicals in them and use the Progestelle oil everyday. I didn’t think that could change how ill I felt. But I had to do something, so I tried it for a few months. The first month I only was sick for about two weeks. the next month for about a week, the next about 3 days, until finally the nausea was hardly noticeable if at all. This is how good I should have felt when my OBGYN told me I should not have nausea with endometriosis. Me and my husband are so grateful to have found your web site. It changed both of our lives. I’m back to my full of energy self and the only pain I feel is when I work to hard!
Thank you
Josh and Melissa S., Vernal Utah
Editors note: Before Melissa complained of pain 9 out of 10 with endometriosis(10 being the pain of child birth). 6 months after starting Progestelle and avoiding xenoestrogens, Melissa now claims to have pain 2-3 out of 10. She says now she has “ just a twinge” now and then as opposed to constant pain before.

Pain from Endometriosis Gone.
Just for your endometriosis data collection: my first menses after started progestelle (used only about 30 mg/day from day 15-28) my pain was reduced from a 7 to a 4. The second menses (using it all month at 60 mg/day) pain reduced to about a 2. This third menses (80 mg/day) I’ve had NO pain at all. A Zero!! (Worse Pain is a pain of 10)
Melanie M., New Jersey

Pain from Endometriosis Gone!
You are more than welcome to use my testimony! I had a lap last June and had a large endometrioma cyst (tennis ball size) on my left ovary drained. The surgeon said I was covered with endometriosis everywhere and said I was already in the Third Stage of Endometriosis. He just shook his head, he felt my only options were a hysterectomy or to go on Lupron. I was only 25 and haven’t been married or had children yet so that was out of the question! I never went back and saw him again! I immediately got on the Progestelle and the U-O-Clear and stopped using any product with parabens and you know the rest of the story 🙂
I have been on Progestelle for a year now and have been taking U-O-Clear as well and all my Endometriosis symptoms are completely gone, I don’t even get menstrual cramps anymore! It’s like I don’t even have Endometriosis 🙂 It’s amazing how much everything changed for me in less than a year! It’s wonderful to have pain-free cycles 🙂
Thanks So Much,
Cynthia S.

Endometriosis Improved – Operation Avoided!
I was diagnosed with endometriosis in the summer of 2001 during laproscopy surgery. I have always had problems with my periods, especially the pain involved. I was given two choices of further treatment by the surgeon which was a hysterectomy or drugs. I was not willing to do either of these, so I never went back for my follow-up appointment. I then was on my own to search for an alternative to drugs and surgery. I read a lot and searched the internet. The information that was most beneficial to me was found on the internet at the website www.endometriosis101.com. Before that I knew there was a missing link that I had just not discovered yet. I followed all of the advice on the website including throwing away all of my personal care products and using only those with no parabens (chemical estrogens) in them. This made a tremendous difference in my bout with the severe pain of endometriosis. Since I began to follow the guidelines presented, the severe pelvic pain that I had been experiencing off and on was completely gone and hasn’t returned. I also use the progesterone product that can be purchased on the website. I was also diagnosed with low progesterone and high estrogen through a saliva test. It’s amazing how many progesterone products contain parabens. This one does not. Using progesterone is very important in the healing process of this . I am now onto the next phase of getting my thyroid in balance as this problem usually goes hand in hand with endometriosis. I am very thankful to have found this website. I also appreciate the help that Dr. Eckhart has given me over the phone and through e-mails as well. I only wish more women knew about this information so that they could make an informed choice regarding treatment for endometriosis.
Deb H.

Impressive Product!!

I was very impressed with this product for myself and my mother. I suffer from endometriosis and helps the fibroids and my mother has stage 1 of uterine cancer and stopped her bleeding and pain!! Very impressive product for the cost
March 11, 2015

Endometriosis – The Progestelle Has Been A Life Saver For Me

I have endometriosis and have been using Progestelle since March.
The pain has greatly improved since I started using the Progestelle in March. Before I began using it I missed work 3 – 4 days a month because of pain and I ended up in the ER because I had lost nearly half of my blood. Now, my periods are normal and I’m no longer missing work because of pain. I still have some bad days (although I don’t even remember when my last one was) but they are few and far between. And, on a bad day the pain isn’t bad enough to make me throw up anymore and I can usually take just Aleve and that is enough to make the pain stop.
The Progestelle has been a life saver for me. I used to be afraid to go anywhere or do anything because I was afraid the pain would start (it came on very fast, very bad, and at any time of the month) and I’d end up leaving or throwing up. Fear was taking over my life. Now I do stuff. My husband and I can go on vacation or dinner or out with friends and I don’t have to worry anymore. It has quite literally given me my quality of life back.
Thank you,
Cheri T – Marshfield, Wisconsin
Nov. 6 2006

Desperate For Relief From The Pain….I Am Now Surprised When My Period Starts

This website has been a lifesaver for me. I found it while searching for alternative treatments to endometriosis (rather than complete hysterectomy). I thought it all sounded pretty wacky, but I was desperate for relief from the pain. I followed the advice about cutting out parabens & what not, ordered my Progestelle, laundry & dish detergent, Indole-3-carbinmol. I followed all the rules & waited 2 months for the chemicals to leave my system before using the Progestelle. Wow, what a difference! Even before starting the Progestelle, my monthly pain decreased dramatically during that 2 months. I am now surprised when my period starts, whereas before I had plenty of advance pain to let me know it was coming. I was taking Hydrocodone for the pain, now I take a couple ibuprofen the first day & that is all! I don’t have to consider having surgery & going on hormone replacement therapy at 37. I’m not completely pain free, but I feel like a normal woman now. I’m no longer desperate for relief, because I have found it here. Thank you! I’m telling every woman I know about this website. Please feel free to use my name and comments on your website.
Also, I have a comment about the Bare Minerals makeup. Many of the products do not list parabens, but the Mineral Veil & the moist products like mascara & lipstick do have parabens in them. I’m still using the products that don’t have them & I’m quite happy with them. I also wanted to know if you could point me in the right direction to find a sunscreen that will not be harmful? My family is moving back to coast North Carolina, where we spend hours & hours fishing on the beach. I absolutely must use some kind of sunscreen or be burned to a crisp. Thanks for any advice you can give on this matter.
Alberta S – Amarillo, TX
March 12, 2007

Within One Month I Had NO PAIN

This is my testimony. This is more than you want probably but chop out anything you don’t need. I had the scraping surgery for endometriosis April 16, 2002. In 3 months the pain was back, actually worse than before. They put me on birth control pills for 3 years. I didn’t realize that the birth control pills allowed the endometriosis to grow unchecked. They basically just reduced the pain somehow and gave me a false sense that I was getting better. By the time I realized I wasn’t getting better, but worse, it was everywhere. My gallbladder was removed in 9/2004 and the surgeon took pics of the endometriosis for me. My gyno took one look at the pics and said something had to be done but she wouldn’t touch me. I foolishly waited until May 2005 but found a wonderful doctor who did a surgery not considered conventional. He had 20 or 30 years experience in treating endometriosis and someone that had the surgery told me about him. By now:
The pain was intense,
I couldn’t hold my urine,
I urinated constantly,
I had a constant headache – nothing made it go away,
My skin hurt to touch it,
I had diarrhea a lot and it would hit with no warning
Depression had started
My joints ached and I was convinced I had lupus or arthritis or cancer.
I couldn’t sleep due to the pain and only had 1 week a month that I did NOT have intense pain.
The surgery worked. I was hospitalized for 5 days and wore a catheter for 3 weeks. But over a couple of months – most immediately, the pain went away. I had a life again. There is a 90% success rate with this surgery. But I was the worst he’d ever seen. They cut out part of my small intestine and bladder because the endometriosis had pierced them. They burned off the peritoneum (however you spell it) from all my internal organs. It grows back in 7 days.
Well, about 1 1/2 years later, the pain came back in my bladder area. To urinate was getting painful for about 3 days. Then over 3 months the pain got to the point where walking was painful at times. The pain was probably about a 7. I would be walking and just stop and take a deep breath. I was crying and terrified because surgery wasn’t going to help. That was obvious and I almost lost my bladder the first time Dr. Kelly said.
On November 6, 2006 I stopped all xenoestrogens – I went full force – detergent, hair products, food, no makeup. On November 13, 2006 I ordered the Indole 3 Carbinole and started taking it when I received it along with all the other vitamin recommendations. I ordered the Progesterone oil but I am not sure of the date. I started with 1/2 dropperful and now use 1 dropperful a day. Within one month I had NO PAIN. The next month I cheated in small ways – chocolate mainly and some spices. Unfortunately I cooked with a lot of oregano and thyme. I had minor pain (2). My last period was great so I am cheating with a little hairspray right now (this week). My ovarian cysts seem to be better also. They had left for 1 1/2 years as well and started coming back in May 2006. Combined with the endometriosis, the cysts are extremely painful.
I hope you can use some of this. If it’s way off base, please let me know and I can do something else. Basically, I was a case that had no hope and your methods seem to have worked with no knives to boot. My gyno is completely for it. Marcy L., Tampa, FL and feel free to use my full name and city. I don’t mind at all. I talk to a lot of women about endometriosis because no one cares to research it or treat it and it’s a horrible that can rob your life. It almost took mine. I will always be grateful to Dr. Kelly for cutting it out and you for keeping it from growing back.
Marcy L – Tampa, FL
Jan 17, 2007
Marcy L. has graciously agreed to email anyone that wants to know more.
luthmarlaura @ yahoo.com


Thank you so much for your wonderful product. For the past several years I have suffered from severe endometriosis, ovarian cysts, MONTHLY BLOATING AND MOOD SWINGS, debilitating cramps, and infertility. I have had multiple surgeries to remove the endometriosis and spent nearly six months enduring the hot flashes associated with receiving Lupron injections. When my doctor wrote me a prescription for the birth control pill in October to try to control the endometriosis, it was the last straw. I couldn’t bear the thought of putting more chemicals into my body, and I knew there had to be a more natural way of dealing with the endometriosis. So, after searching the Internet, I found your product and decided to try it.
After eliminating a majority of the phyto- and xenoestrogens mentioned in your information packet and trying the progestelle for 2 months, I was amazed at the results. My cysts are gone, I had no MONTHLY BLOATING AND MOOD SWINGS, and—for the first time in my life–I had absolutely no cramps with my period. I was ecstatic—this is the best I have felt in years. I have shared my story with my friends, family, doctors, and colleagues, and everyone has been amazed. In fact, my physical therapist was so amazed that she tried it for one month with the hope that it would help shrink her grapefruit-sized fibroids. It did. Recently she had an ultrasound, and her doctor was shocked to see that the fibroids had totally disappeared. As a result of me “spreading the news” to everyone who will listen, I have had numerous requests to try my Progestelle and to borrow the information packet that you sent with my initial order. Unfortunately, one of these requests resulted in my information packet getting lost. If possible, would you please send me another information packet? (Or several more—they are awesome marketing tools for the Progestelle and I would love to be able to give them to friends who are interested so that they might purchase the Progestelle and enjoy the same success that I have found.)
Thank you so much for your help. You are making the world a healthier and happier place—one woman at a time.
Jennifer C – Pittsburgh, PA
Jan 8, 2007

If your medications aren’t doing the trick, or you simply prefer natural treatments and therapies, here are a few that have been said to improve health and help ease endometriosis pain. However, remember there isn’t much scientific support in regards to alternative medicine and its ability to treat endometriosis safely and effectively.

MORE: Six complementary therapies to ease endometriosis symptoms

1. Reduce your intake of chemicals.
There’s more and more evidence that exposure to environmental chemicals dioxins and polychlorinated biphenyls (PCBs) is linked to an increase in the prevalence of endometriosis and the severity of its symptoms.

The only way to cut down on exposure to these chemicals is to reduce the amount of animal fat in your diet, as it’s our main source of exposure to those harmful substances. Try to increase your intake of celery, parsley, broccoli, cauliflower, cabbage, kale, Brussels sprouts, and bok choy, as they’ve been shown to improve women’s estrogen metabolism. There have also been studies that suggest eating flaxseeds can improve estrogen-related conditions.

2. Use progesterone cream.
Endometriosis patients often recommend progesterone cream to relieve pain symptoms. It’s also believed that progesterone may slow the growth of abnormal endometrial tissue. However, there haven’t been any conclusive studies on it in regards to its effectiveness or its safety.

The application of this cream must be supervised by a professional and you must abide by the schedule you are given as side effects can include severe mood changes, weight changes, and menstrual bleeding issues.

3. Increase your intake of omega-3 fatty acids.
There have been several studies advising omega-3 fatty acids are good for women with endometriosis. It can reduce levels of an inflammatory chemical and slow the growth of endometrial tissue.

The most common source of these acids is fish, including salmon and sardines. However, the most recommended source would be fish oil capsules as reputable brands have just a small amount of the harmful chemicals mentioned earlier.

4. Reduce your stress levels.
Stress is directly linked to hormonal imbalance. Hormones such as cortisol have been known, in some studies, to show up with more frequency in women with an advanced type of endometriosis compared to those not affected by any form of the disease. There are several natural ways to reduce stress, from supplements like vitamins B and C, zinc and magnesium to a different approach like meditation or breathing exercises.

5. Try homemade remedies.
Simple homemade recipes, including ginger tea mixed with raw honey and a contrast sitz bath (alternating between hot and cold water basins), are both believed to relieve nausea and endometriosis-related pain.

MORE: How essential oils can benefit chronic illness sufferers

Endometriosis News is strictly a news and information website about the disease. It does not provide medical advice, diagnosis or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or another qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.

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Margarida graduated with a BS in Health Sciences from the University of Lisbon and a MSc in Biotechnology from Instituto Superior Técnico (IST-UL). She worked as a molecular biologist research associate at a Cambridge UK-based biotech company that discovers and develops therapeutic, fully human monoclonal antibodies. × Margarida graduated with a BS in Health Sciences from the University of Lisbon and a MSc in Biotechnology from Instituto Superior Técnico (IST-UL). She worked as a molecular biologist research associate at a Cambridge UK-based biotech company that discovers and develops therapeutic, fully human monoclonal antibodies. Latest Posts

I have been researching this one for a while now and will be bringing out a series of articles on the topic because it is really quite an in-depth topic.

One of the key reasons we want to use progesterone cream is to really just give ourselves a chance to heal from existing Endometriosis. It can often feel like an uphill battle trying to beat this thing. We are constantly forming new cells in the wrong places and with excess estrogens being a common symptom of Endometriosis, these cells are simply encouraged to grow more.

Let me explain this one a little more. Essentially, estrogens and progesterones oppose each other in our bodies. They need to have a yin yang effect, neither hormone should be higher than the other and they should level each other out. If we are lacking in progesterone, our estrogen will go up. If we are lacking in estrogen, our progesterone will go up. We don’t want either to be too high or too low. They need to both exist in perfect harmony with each other. Many women with Endometriosis suffer from estrogen dominance, IOW they don’t have enough progesterone to balance out the estrogen and therefore have too much estrogen. Estrogen creates growth. That is its main function. It will draw with it a series of symptoms which are all in line with wanting to create growth, many of which we are familiar with.

Here is a comprehensive list of symptoms you may experience with estrogen dominance:

  • Acceleration of aging,
  • Increased body fat and weight gain,
  • Salt and fluid retention,
  • Breast tenderness,
  • Foggy thinking,
  • Depression, anxiety and headaches,
  • Cyclical migraines,
  • Impaired blood sugar levels,
  • Impaired thyroid function, particularly hypothyroidism,
  • Little or low libido,
  • Increased risk of blood clots and growth,
  • Cell proliferation in “womanly bits” (breast growths, fibroids, endometrial cells, cancers),
  • Dilated blood vessels,
  • Auto-immune diseases and responses like allergies and skin sensitivity,
  • Bladder infections and bladder issues, possibly even interstitial cystitis,
  • Loss of zinc and retention of copper,
  • Increased risk of gallbladder disease,
  • Miscarriages, and
  • PMS

It is likely that you don’t have all of these symptoms or even a great extent of them. We are all different and it is important to test your hormone levels before using any specific progesterone cream for levelling out your hormones, mainly so you know where you are at and can measure if they are working for you. There are a number of other imbalances in the body which can actually illustrate very similar symptoms and you may be barking up the wrong tree. Hypothyroidism often displays many similar symptoms to estrogen dominance and the approach would be quite different in treating that.

However, there is also no inherent danger in using progesterone cream, according to Dr. John Lee. He expresses that the only way progesterone creams can be harmful is if they are not real progesterone creams and if too high a dosage is used. You can read his book to gain a full comprehensive understanding of progesterone cream. I have been researching this one for a while now and will be bringing out a series of articles on the topic because it is really quite an in-depth topic.

Real progesterone will actually be listed as an ingredient in the cream. It will not say wild yam or progestin. Progestin is a pharmaceutically created product and your body will not be able to synthesize this correctly or expel it correctly. It needs to actually list progesterone as an ingredient.

How to use Progesterone Cream

Progesterone will stay in your body for up to 12 hrs. The levels will be at their highest at 3 or 4 hrs after use. It is best to take progesterone in the morning and at night.
• Use no more than 20 mg per day; just measure your body and see how it feels. If you start to get any adverse symptoms, simply lower the dose. It is okay to experiment and work out what your body needs, according to Dr. John Lee.
• Rotate where you apply it; don’t put it on the same place every day;
• Put it on the thin areas of skin; the face, neck, chest, inside arm;
• Spread it wide. Spread over a larger area of skin to get the best absorption; and
• Apply after showering or bathing.

My personal opinion on Progesterone Cream and how they fit in with healing Endo

I think progesterone creams can certainly help us feel better. They will lower the proliferation of cells forming and growing in the wrong places! What they can do is give us a chance to rectify the problem—the cells are at their smallest and we can then flush them out and reduce the inflammatory response in the area by flushing out more toxins.

I personally don’t believe it is a long-term fix for Endo. I think Endo is not just about regulating hormones and cell growth. The Endo got there due to a different imbalance and progesterone cream doesn’t get to the source of that imbalance.

I would personally only recommend taking progesterone cream for about four months and see if it has helped. Use that time to focus on healing the rest of your body, like your liver and your colon etc.

I am going to be doing heaps more research on the subject, so I might feel differently about it in a few months but for now these are my thoughts. If you have used progesterone cream please feel free to share, positive or negative. It is worth sharing so others can learn more.

Keep yourself updated through the RSS Feed on the blog or subscribe to the newsletter and you can see all the articles that are coming up in the next few months.

Health Costs Impact American Women

In August 2016, I discovered that my endometriomas were shrinking, without surgery or traditional Western medications. I had previously had surgery a year and half before for my endometriosis, and after only 10 months, other endo lesions and cysts developed in various areas, including the bowel. I learned that endo is a chronic condition, and I couldn’t picture my life having many surgeries again.

It was pretty shocking. I was always told I was healthy, or just “aging”, until I was diagnosed with a chronic illness for which medicine can only try to suppress symptoms. The options for traditional treatment of endometriosis are medications, which all have side effects in some form or other, or surgery, which can potentially compromise organ functions and create complications through formation of scar tissue. Both methods do not address the causes of the illness and do not work to rebuild the body’s ideal health and balance.

I did my research. Bowel endo can be risky and difficult to treat. The surgery may either cause perforation of the bowel or may need to remove part of the bowel, decreasing quality of life. I looked for alternatives, and I found out I could improve my symptoms naturally, but only through some serious changes. I become hopeful, trusted in myself, and motivated more than ever.

Many say relief from endometriosis symptoms is out of our hands, but having these symptoms shows that my body is not functioning properly, otherwise my health wouldn’t be compromised. I needed to do everything necessary to help my body heal and work as it should. For instance, for years I suffered with sinus issues and only got corticosteroid spray and many rounds of antibiotics. I now know that my sinus issues were caused by inflammation, and medications deplete the gastrointestinal system, opening the way for candida and leaky gut.

So I approached my disease with many paths: diet, holistic medicine, exercise, toxin reduction and mental support.

Diet and Supplements

With the help of my naturopath, I addressed my diet. We focused on an anti-inflammatory diet overall, adding Brassicae family vegetables, fibre and flax oil to help with estrogen metabolism and clearance. We also did food sensitivity testing in order to help reduce overall inflammation. This also helped with the chronic sinus problems.

I added some supplements in a program individualized for me by my naturopath. I used probiotics to help improve my digestive health. I used a supplement called Estresense to improve estrogen metabolism through cleansing the liver, and to reduce total estrogen in order to balance this with progesterone (helping improve symptoms such as heavy and painful periods). I also used a progesterone cream: to help counter balance the effect of excess estrogen and prevent the progression of endometriosis, and to improve PMS symptoms associated with low progesterone, and excess estrogen (low moods, cramping, acne, insomnia, breast tenderness). I took B-vitamins and magnesium to help with liver metabolism, to improve PMS symptoms associated with low progesterone and excess estrogen. I used fish oils as an anti-inflammatory.

Adapting to the diet and supplements was very difficult. It took several months to understand how important it was for me, through tons of reading and personal experience, and stop grieving the food of my past life. I now do a diet similar to paleo (with only hormone free sources of proteins and mostly organic and unprocessed food ), as most of my food intolerances are important sources of protein in a vegan diet, like beans, nuts and seeds. Indeed, I felt even sicker when once trying the China Study diet, a vegan diet.

A doctor suggested sexyfoodtherapy.com, a great website, where a nutritionist has very yummy recipes and offers a motivational support network to stick to the plan, which includes exercises and meditation.

Other Natural Approaches

I made a point of doing 90 minutes of exercise every day, which included walking, biking and yoga. I discovered that doing the hardest activity in the morning would address my fatigue issues.

Regarding the toxin reductions, I threw away every care product that had toxic components and replaced them with natural ones, or made my own, and I did the same for the house cleaning products. I also substituted plastic containers for glass ones, did skin brushing and castor oil packs.

For mental health and general physical balance, I had acupuncture weekly or biweekly at a community acupuncture studio, which also helped to balance my hormones. I joined a local support group which helped me to understand more of my symptoms, to be able to talk about it to other people, and to inform my family and friends. I also did meditation, Reiki, body talk and Shiatsu. I started to say no to people when they were asking too much for what I could comfortably do. I put myself and my health first, and stayed away from any abusive kind of relationship or situation.

I’m looking forward to the day I’ll be completely cleared of the endometriomas, but I can tell I am feeling much better. Seeing these improvements, my surgeon supports my holistic path. He’s impressed that I can avoid gluten and sugar, but I think it’s necessary. When people feel sorry for me about my lifestyle changes, I tell them, “Why? I am not sorry to feel well!”

It is challenging to maintain this lifestyle, in terms of time management and social activities, but my job allows for flexible hours and most friends are understanding. My very supportive partner is also helping in some of the home chores and sharing these changes in our lives.

Functioning properly is the most important thing for me and I’m very determined to keep this as my number one priority. If I am not functioning well, I am of no use for anybody else.

Highlighted Readings

“Endometriosis: You can Heal Yourself” by Cristiana Zenoni

Endometriosis Resolved

“Never be sick again” by Raymond Francis

“The Hormone Cure” by Sara Gottfried MD

“Taking Charge of your Fertility” by Toni Weschler MPH

“Pandora’s Lunch Box” by Melanie Warner

Endometriosis and Natural Progesterone


My daughter has endometriosis about as badly as you can get. She just had surgery, it was removed, and now they want to stop the periods with synthetic drugs. She wants to use natural progesterone; can natural progesterone be used and, if so, how much and how?


Yes, natural progesterone can be used to suppress endometriosis. Estrogen stimulates endometriosis and progesterone inhibits it. Approximately 20 years ago it was common to treat severe endometriosis with medroxyprogesterone, a cousin of natural progesterone.

Using progesterone for suppression requires high doses—such as oral micronized progesterone, Prometrium®, 300 mg by mouth at bedtime and 300 mg vaginally (held in with a tampon) daily in the mornings. Because anything suppressing estrogen levels will cause bone loss, high doses of calcium and vitamin D, healthy exercise and stable weight are needed to prevent bone loss (See The ABCs of Osteoporosis Prevention for Premenopausal Women). Suppression should continue for six months before gradually decreasing to once a day and then changing to cyclic progesterone therapy.

A high dose of progesterone is needed for ovarian and endometriomal suppression. It must suppress hypothalamic gonadotrophin releasing hormone (GnRH) production and therefore cause the ovaries to make less estrogen. Progesterone treatment also decreases the activity of estrogen receptors (and therefore slows estrogen action in tissues such as the endometrium).

I recommend a daily dose of 300 mg of Prometrium® at bedtime and 300 mg vaginally in the morning. (Progesterone by mouth causes too much drowsiness to be taken during the day.) If this dose is not sufficient to stop flow, control cramps and endometriosis-related abdominal pain, the dose must be increased. The idea is to suppress flow for about six months. Keeping a record using the daily Menstrual Cycle Diary® is a good idea.

After six months without flow and pain, I would recommend decreasing the Prometrium dose to 300 mg at bedtime daily and see if she continues without symptoms. If she remains pain free, she could then stop the treatment for two weeks and begin again in two weeks, always taking Prometrium® 300 mg at bedtime for two weeks at a time. Once flow starts, progesterone should be taken cyclically days 14 through 27 of her own cycle for at least a further six months.

If Prometrium® is too expensive to afford for both morning and night, its cousin, medroxyprogesterone 10 mg/d could be taken in the morning instead. Medroxyprogesterone is less costly than Prometrium®. If medroxyprogesterone were taken instead of Prometrium® the dose is 10 mg in the morning and evening. As with progesterone, this suppressive dose should be continued for six months, then once a day for another month or two and finally cyclically for a further six months.

Note that any medicine that suppresses periods and estrogen levels will cause bone loss (much like DepoProvera® does). For this reason it is very important to do the following things to prevent bone loss.

  1. Take elemental calcium in a total daily dose of 2000 mg/d. Calcium is not stored so it is best absorbed when spread across the day with meals and at bedtime. Calcium can be obtained from foods (a glass of milk of milk or a fortified beverage provides 300 mg of calcium) and supplements taking a maximum dose of 500 mg at a time.
  2. I would recommend 800-1200 IU of vitamin D a day to assist in the absorption of calcium. It can be taken all at once.
  3. Continue to be physically active with at least a half an hour a day of walking.
  4. Don’t lose weight.

I think that using natural progesterone to suppress endometrial growth is safer than other therapies. Why? First, natural progesterone stimulates new bone formation. If bone loss can be controlled by higher doses of calcium and vitamin D, progesterone will be less negative for bones than other suppressive therapies. Second, natural progesterone suppresses the ovaries without causing hot flushes like GnRH agonist therapy does. Third, progesterone has no side effects such as hair growth or acne like danazol does. Fourth, this treatment is flexible and can be adjusted based on a women’s experiences. It is under her control and is not an injection that is temporarily irreversible.

Thank you for your question. I hope this is helpful for you.

Topic: Heavy flow, Cramps and painful periods, Ovulation and menstrual cycles Life Phase: Adolescence, Premenopause Updated Date: Wednesday, November 20, 2013 – 14:15

Medical Treatments for Endometriosis

Similar to the lining of the uterus, endometriosis usually responds to estrogen and progesterone, the hormones that control your menstrual cycle. The natural fluctuations (or rise and fall of the amounts) of these hormones can increase the activity of endometriosis and aggravate symptoms, whereas steady medical doses of estrogens, progestins, and other medications that decrease natural hormone production can lessen endometriosis “flare ups.”

As a general rule, women are less likely to have problems with endometriosis before their first menstrual period or after menopause. On the other hand, women with endometriosis tend to experience more symptoms around their period. It is also believed that endometriosis may form when menstrual tissue flows backwards through the fallopian tubes and implants in the abdominal cavity and pelvis. Thus, suppressing (stopping) your period with the following hormonal medications can help relieve endometriosis-related pain and prevent endometriosis from developing or becoming worse over time.

Continuous Estrogen/Progestin Hormonal Therapy

Medications containing a combination of an estrogen and a progestin can be used to control your periods and suppress the activity of endometriosis. The most common combination of estrogen and progesterone is in the form of the birth control pill, but hormones can also be delivered by a vaginal contraceptive ring (Nuvaring®) that lasts 3-4 weeks or a patch (Ortho Evra®) that you wear on your skin and change weekly. All hormonal medications appear to be most effective against endometriosis when used in a continuous fashion. This means that you use an active pill, ring, or patch daily, and skip the hormone-free week when you would normally have your period.

Instructions on How to take Continuous Combined Hormonal Therapy

  • Birth Control Pills – Take one active pill every day at the same time
  • Vaginal Ring – Insert a new vaginal ring every 3-4 weeks
  • Patch – Change your patch weekly

Continuous use is as easy as skipping the inactive pills in your pill pack or replacing your ring/patch as soon as it would normally be time to remove the old one. In doing so, you will decrease the number of bleeding days that you have and prevent pain associated with your period.

Continuous combined estrogen and progestin therapy is safe and well-tolerated by most women. The estrogen/progestin therapies also provide reliable contraception but do not protect from sexually transmitted diseases (STDs). The most frequently encountered problem is unscheduled “breakthrough” bleeding or spotting, which usually becomes less frequent the longer you are on the hormone treatment. Taking the pill at the same time every day and avoiding missed pills helps to prevent break-through bleeding. Some women who are at higher risk for blood clots or stroke should not take hormonal therapies with estrogen. Talk to your gynecologist to see whether or not continuous combined estrogen/progestin treatment is right for you.

Continuous Progestin Hormonal Therapy

Progestins, or “progesterone-like” hormones, are one of the components found in combined estrogen/progestin treatments, like the birth control pill (see medical treatments: continuous estrogen/progestin). Progestins alone are also effective in treating endometriosis. When taken in a long-term continuous fashion, progestins tend to thin the lining of the uterus which stops regular periods and lessens the chance for break-through bleeding or spotting and has similar activity against endometriosis lesions themselves.

There are various forms of synthetic progesterone called, “progestins” that are used to treat endometriosis. When treating young women, we prefer to start with a daily pill, such as a progesterone “birth control pill” sometimes referred to as a “mini-pill” or norethindrone acetate (Aygestin®). These medications should be taken at the same time every day to lessen the chance of unscheduled “breakthrough” bleeding (spotting) and pain. Setting the alarm on your cell phone can be a good reminder to take your medication at the same time each day. The “mini-pill” is considered a slightly less effective contraceptive and Aygestin is not considered a contraceptive and may not protect against pregnancy. There are at least two long-acting progestin-only contraceptive methods, which may be useful in treating endometriosis: (1) injectable medroxyprogesterone (Depo-Provera®) and (2) the levonorgestrel intrauterine device (Mirena® IUD).

Progestin-only treatments

Method: Pills
Examples: Norethindrone acetate (Aygestin®), Progestin only birth control pills (Camila, Nor-QD), Medroxyprogesterone acetate (Provera®)
How Medication is Taken: Daily Pills Method: Injections Examples: Medroxyprogesterone (Depo-Provera®) How Medication is Taken: One shot every 3 months

Method: Intrauterine Device (IUD)
Examples: Levonorgestrel-releasing IUD (Mirena®)
How Medication is Taken: Small “t-shaped” device inserted into the uterus, releases medication for up to 5 years

Each of these progestin-only methods can make your periods lighter and less frequent or stop them altogether. Continuous progestins are safe, effective and well-tolerated by most women. Weight gain, bloating, and depression are sometimes reported. Irregular or unscheduled “breakthrough” bleeding can occur also but usually becomes less frequent the longer you use the medication. You should discuss the pros and cons of continuous progestin-only hormone therapy with your gynecologist to see if one of these methods is right treatment for you.


Danazol is a synthetic androgen (male hormone) which is an effective medical treatment for endometriosis.

  • It is given as a pill 2-4 times daily in doses of 400-800 mg per day
  • It works by making the active endometriosis implants “inactive” or atrophic so they do not grow
  • When endometriosis implants become inactive pelvic pain often decreases.
  • Danazol also lowers estrogen levels which is helpful in the treatment of endometriosis.
  • Danazol may be prescribed for other uses such as fibrocystic breast disease.

Side effects may include:

  • Changes in the menstrual cycle; no periods, irregular periods or spotting
  • Mild weight gain
  • Bloating
  • Some women will experience androgenic (male hormone) side effects including hair growth, acne, oily skin and/or oily hair. All of these side effects are reversible when the medication is stopped however; it may take up to 6-9 months for the effects to resolve completely.
  • Irritability and/or nervousness
  • A rare but non-reversible side effect is deepening of the voice

Rare side effects may include pressure in the brain, including stroke, liver disease and bleeding in the abdomen.

Before taking Danazol:

  • It is very important to tell your doctor if you are taking other prescription or nonprescription medicines including herbs and vitamins.
  • Be sure to tell your doctor if you suffer from migraine headaches; heart, kidney, liver disease or if you have ever had a seizure.


  • Danazol should not be taken if you are pregnant or breastfeeding
  • A non-hormonal type of birth control to prevent pregnancy must be used if you are sexually active.
  • If you become pregnant while taking Danazol, call your doctor right away.

Lupron® with Add-back

Another highly effective way to treat endometriosis is to lower the natural estrogen levels altogether by giving an injectable medication, called leuprolide acetate (Lupron®). This medication is given as a shot every 1 or 3 months depending on the dose. When given continuously, Lupron® turns off the chain of hormonal signals that tell the ovaries to make estrogen. This stops your menstrual period and lowers estrogen levels to a point where endometriosis becomes inactive.

Similar to continuous hormonal therapies, Lupron® can be associated with irregular bleeding at first but usually results in cessation of periods over time. Women should know that they may have a “flare up” of symptoms shortly after they receive their first dose of medication because estrogen levels usually increase for days to weeks before they fall, causing a temporary menopause-like condition. Later, low estrogen levels may contribute to hot flashes (episodes of feeling suddenly hot, flushed, and sweaty), mood changes, vaginal dryness, and other symptoms that are typically associated with menopause. Over time, low estrogen levels may lead to low bone mineral density and possibly fragile bones that are at greater risk for fracture.

However, there is a way to get the most benefit from Lupron® with minimal or no side effects. We always prescribe low-dose hormonal “add-back” medication such as daily Aygestin (see medical treatments: continuous progestin) or a combined estrogen/progestin add-back regimen, along with Lupron®. Add-back therapy offsets the side effects of Lupron® which results in a high degree of patient satisfaction while still suppressing endometriosis. Your doctor may monitor your bone mineral density with a DXA scan if you have been on Lupron for 6 months or longer. We do not recommend Lupron® for females less than 16 years of age. Talk to your gynecologist about whether Lupron® with add-back therapy is the right treatment for you.

Hormone treatments for endometriosis

As endometriosis responds and grows when exposed to the female hormone oestrogen, a number of hormone treatments attempt to block or reduce the production of oestrogen in the body. This means the endometriosis will be unable to continue growing and will help to relieve symptoms.

If you are offered the choice of hormone treatment, you may want to discuss with your doctor what the treatment involves, the pros and cons, along with the possible side effects of the treatment.

Hormone treatments for endometriosis either put the woman into an artificial pregnancy state or an artificial menopausal state. Both states are temporary and are reversed when the patient has stopped taking the hormones. Please note that these drugs have no effect on adhesions neither do they help to improve fertility.

Your doctor will be able to discuss different hormone treatment options that are available to you.

The following hormone treatment options are available to women with endometriosis:

Combined oral contraceptive pill (‘the Pill’)

Mirena Coil


GnRH analogues

Testosterone derivatives


Gestrinone (Dimetriose)

We are grateful to www.endometriosis.org for their help with this information.

For more information download our Information Pack

Endometriosis Treatment Information Pack

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