Does melatonin help with anxiety

Learn All About Why Melatonin Can Be Used for Anxiety

Melatonin, a hormone produced by your body, has been shown to improve symptoms of anxiety.

Supplementing with melatonin for anxiety can improve sleep quality, regulate circadian rhythm, and ease negative feelings associated with anxiousness.

Your hormone levels play a key role in your emotional state. Because of this, a hormonal imbalance can lead to anxiety.

If you suffer from anxiety and have tried several corrective protocols to no avail, a DNA health test can help you learn more about your genetic predispositions.

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Don’t know what vitamins & supplements are right for you? Take GNC’s quick & easy quiz to receive personalized recommendations to better achieve your health goals!

Melatonin is important because it tells your body when it’s time to sleep and when it’s time to wake up.

Your body produces higher levels of melatonin at night. Levels begin to rise once the sun sets, and drop in the morning as the sun rises.

The light you are exposed to each day, plus your own internal body clock, determine how much melatonin your body will produce.

Melatonin is also sold as a health supplement. It comes in pill, liquid, and chewable forms. You can typically find it at your local drugstore, supermarket, or vitamin shop.

As with most things, you can buy it online, as well. Melatonin is available in both natural and synthetic forms. The natural form is created from animal pineal glands.

The search for specific genes related to anxiety disorders is in the preliminary phase.

What Supplements can you Use for Anxiety?

There is a wide variety of supplements that can be used to help alleviate the symptoms of anxiety. Supplements are not intended to take the place of prescription medication or other medical treatments—but they can be useful additions to your healthcare plan.

Don’t know what vitamins & supplements are right for you? Take GNC’s quick & easy quiz to receive personalized recommendations to better achieve your health goals!

Also Read: Why Magnesium for Anxiety Might Be Your Supplement!

If appropriate for your individual needs, these supplements can be used to relieve anxiety symptoms:

  • Vitamin A: Those who struggle with anxiety may be lacking in Vitamin A levels. Vitamin A has antioxidant properties that have been shown to help manage the symptoms of anxiety. The average dose is about 10,000 IU taken once per day (IU stands for international units).
  • B-complex: B-complex supplements contain all of the B vitamins that your body requires. B vitamins are vital for maintaining a healthy, functioning nervous system. They can potentially improve the symptoms associated with depression and anxiety. Doses for B-complexes vary, ranging from 300 to 500 milligrams taken once per day.
  • Vitamin C: Antioxidants like Vitamin C work to stop oxidative damage to your nervous system. Anxiety can be increased by this type of damage. The average dose ranges from 500 to 1,000 mg taken once or twice per day.
  • Vitamin D: This important nutrient assists your body in absorbing other vitamins. Vitamin D deficiency can cause other vitamin deficiencies, which makes anxiety worse. The average dose is between 1,000 and 2,000 IU taken once or twice daily.
  • Vitamin E: Another vitamin with antioxidant properties, Vitamin E is quickly burned up in times of anxiety and high stress. Taking Vitamin E supplements can help restore balance in your body and reduce stress-related symptoms. The dose is typically 400 IU taken once daily.

  • Fish oil: Fish oil is loaded with omega-3 acids, which act as antioxidants. EPA and DHA are two omega-3 supplements that have been shown to help calm anxiousness. The average dose may contain 2,000 mg of EPA, DHA, and ALA. Each dose can be split up across multiple servings or taken at once.
  • GABA: When there’s not enough GABA (gamma-aminobutyric acid) present in the brain, anxiety can deepen. Supplements containing GABA may help replace missing GABA in the brain, though research is ongoing. The dose is about 500 to 700 mg taken once or twice per day.
  • L-theanine: This amino acid, often found in green tea, has been proven to reduce anxiety in both animal and human trials. The average dose is 200 mg once daily.
  • Magnesium: Magnesium is a necessary mineral for the human body. You don’t need a lot of it, but not having enough can cause anxiety symptoms. The supplement dose is 100 to 500 milligrams once per day.
  • 5-HTP: 5-HTP is a neurotransmitter and precursor to serotonin, the “happy brain chemical.” When used with certain therapies, 5-HTP supplements can help with anxiousness. The dose is typically 50 to 200 mg per day.
  • Melatonin: Though your body produces melatonin on its own, you might not make enough. That can cause sleeplessness, trouble relaxing, and general anxiety. Supplementing with melatonin for anxiety can improve sleep quality, regulate circadian rhythm, and ease negative feelings associated with anxiousness. Doses are different based on the reason you’re taking the melatonin. For anxiety, a typical dose might be 3 to 10 mg.

Different Ways to Take Melatonin

Melatonin supplements can be taken several different ways, depending on the individual and the symptoms being treated.

The most common method is the oral consumption of melatonin capsules or tablets. To treat anxiety, this is generally a quick and easy method. Melatonin has a myriad of uses, though, and can be administered in all of the following ways:

  • Orally: Melatonin can be taken orally in capsule or tablet form. Be sure to take an appropriate dose for your age and symptoms.
  • Sublingually: Melatonin can be dissolved under the tongue. This is a common method of administration for patients attempting to reduce anxiety before surgery.
  • Topically: Melatonin has many uses, including topical skin care. Sunburn can be treated by rubbing melatonin-containing gel into the skin fifteen minutes prior to sun exposure, or four hours after sun exposure.
  • Intravenously: Though not a common or DIY-friendly method of consumption melatonin can be administered intravenously. This might be done as part of various therapies to treat tumors. As you can see, melatonin is a very versatile supplement.

Also Read: Does Fish Oil Work for Anxiety? Find Out How it Can Help

What are the Benefits of Checking Melatonin Levels?

There are many benefits to making yourself aware of your melatonin levels. Melatonin is a super clever and versatile hormone that can help with anxiety and depression, relieve pain from chronic disease, prevent cancer cell growth, and decrease the effects of estrogen on tumor growth. With so many amazing benefits, it’s in your best interest to check your melatonin level—and supplement if necessary.

Your melatonin levels can be checked with a blood, saliva, or urine test. A common method of testing involves collecting a saliva sample at around ten o’clock in the evening. That’s the time when your melatonin level should be at its highest.

This test isn’t always readily available at a standard medical clinic or doctor’s office. You may need to find a naturopathic or functional medicine doctor. They will interpret the results of your test and help you create a supplemental melatonin plan.

Normal levels of melatonin vary throughout the twenty-four hour in a day. There is still some argument over whether it’s best to measure melatonin levels using blood, urine, or saliva.

What Causes Melatonin Levels to be Low?

There are a number of factors that can cause your body’s melatonin production to decrease, including:

  • Stress
  • Lack of natural light exposure
  • Exposure to light at nighttime (televisions, cell phones, computers)
  • Working night shifts at your job
  • Traveling and changing time zones (jet lag)
  • Lack of sleep or poor sleep quality (parents with an infant child)
  • Nutritional deficiencies

When your melatonin levels are too low, you may experience difficulty sleeping or forgetfulness. You may notice that it’s hard to get to sleep and that you feel awake, rather than sleepy, after ten o’clock in the evening.

When your melatonin levels are low, your immunity is also lower.

You’re more susceptible to catching a cold or getting the flu. If you experience any of these symptoms, your melatonin levels could be low and you should consider getting tested by a functional medicine practitioner or other qualified professional.

Don’t know what vitamins & supplements are right for you? Take GNC’s quick & easy quiz to receive personalized recommendations to better achieve your health goals!

Other Benefits of Supplemental Melatonin

Using supplemental melatonin for anxiety symptoms and sleep quality is a fairly well-known practice. Its applications, however, go much further.

Here are a few other things melatonin supplements can do:

  • Boost your immune system
  • Prevent you from gaining fat
  • Delay age-related vision loss
  • Reduce ringing in your ears
  • Lessen the negative side effects of smoking cessation
  • Prevent premature aging
  • Improve Mood
  • Reduce occurrences of cluster headaches

Also Read: What Are The Best Probiotics for Allergies?

There are even more potential benefits of supplemental melatonin still being examined. They include the treatment of dementia, endometriosis, restless leg syndrome, and non-alcoholic liver disease.

Seasonal Affective Disorder

Seasonal affective disorder, or SAD for short, is important to mention when discussing melatonin levels and anxiety. The amount of melatonin your body produces changes due to light exposure levels. When sunlight exposure is infrequent, such as during the shortened daylight hours of winter, a temporary depression may set in.

SAD is especially prominent in areas of higher latitude. Due to the reduction in light exposure, your melatonin levels will start fluctuating at abnormal times. Serotonin, a chemical tied to feelings of happiness, is also produced at reduced levels.

There are special boxes, called SAD light boxes, that can be used to treat Seasonal Affective Disorder. The box emits a light that is twenty-five times brighter than normal daylight. Using a SAD light box for thirty minutes per day can help regulate melatonin production, relieving heightened symptoms of anxiety and restlessness.

Types of Anxiety That can be Treated With Melatonin

Anxiety can be broken down into different categories, based on causal factors and symptoms. Melatonin can be used to help treat the following types of anxiety:

  • Generalized Anxiety: Those who struggle with generalized anxiety may “overreact” to daily troubles and obstacles in life. They undergo huge psychological stress in reaction to relatively minor problems. This excessive, often irrational worrying can prevent normal functioning. Supplemental melatonin can be used to decrease anxiety scores—measures of anxiety symptoms—in generalized anxiety sufferers.
  • Age-Related Anxiety: Recent research has shown that the elderly population experience more anxiety than previously thought. A decline in physical health reduced social contact, and change in mental status could all be anxiety-inducing factors for the elderly. Melatonin, taken nightly, could alleviate anxiety and depression in older adults.
  • Surgical Anxiety: Hospital and surgical anxiety is an extremely common occurrence in those requiring medical procedures. Sedatives can relieve this anxiety but often have some unwanted side effects. Melatonin has enabled some patients to get through surgeries with less anxiety and less pain.

Hormone Balance is Vital for Reducing Anxiety Levels

An imbalance in the body’s endocrine system will cause instability in hormone levels. This imbalance can lead to anxiety. Your hormone levels play a key role in your emotional state.

The endocrine system controls your energy level and determines how well we deal with stress and remain calm. When hormones are out of balance, the result can be anxiety, depression, mood swings, agitation, and disturbed sleep.

Women, especially, are prone to anxiety. That’s partly because women’s hormones can go awry during pregnancy and menstruation. The decrease in estrogen and serotonin experienced during menstruation and menopause can have a major impact on mood and cognitive function.

Anxiety is a serious and debilitating condition. People with anxiety resulting from hormonal imbalance may think that they have a disorder or mental illness, but that is not necessarily the case. Your body may simply be sending you a message that something is not right internally.

If you suffer from anxiety and have tried several corrective protocols to no avail, you should get tested to determine your levels of melatonin and other hormones.

It’s important to understand that hormones are responsible for almost every process that occurs in your body. Your body is used to a very specific number of hormones, and any fluctuation can have very noticeable effects. Puberty and improper nutrition are other factors that can affect hormone levels—in men or women.

Anxiety is so complex that it can cause hormonal imbalances that actually lead to more stress and anxiety! Hormone imbalances affect both men and women and produce anxiety even if you’ve never had anxiety before. If you do already have anxiety, hormonal imbalances can definitely pile on more stress.

In addition to using supplemental melatonin for anxiety, there are other things you should do to help restore balance to your hormones. Proper nutrition, exercise, and sleep, for instance, should become a regular part of your routine. The good news is that anxiety induced by hormonal imbalance can be treated and corrected.

By testing your melatonin and other hormone levels, you can begin taking steps to reduce your anxiety and alleviate your stress symptoms. Restoring balance to your hormones will restore balance to your life!

Review Article
Advancing role of melatonin in the treatment of neuropsychiatric disorders

Melatonin is a pineal neurohormone whose secretion is influenced by circadian changes of 24 hour night and day cycle. Over the recent past, several studies have highlighted the ubiquitous influence of the circadian timing in almost all the physiologic functions. An altered/deficient sleep–wake cycle has been correlated with physiological imbalances which are linked to the development of various disorders, viz depression, anxiety, psychosis, attention deficits, sleep deprivation and others. Melatonin and its oxidation products, viz cyclic 3-hydroxymelatonin, N1-acetyl-N2-formyl-5-methoxykinuramine and N1-acetyl-5-methoxykinuramine possess excellent antioxidant properties. Melatonin’s beneficial neuroprotective properties are mostly attributed to excellent free radical scavenging properties. A gathering body of evidence has shown that besides strong antioxidant activities, melatonin is a pleiotropic regulator molecule which orchestrates multiple functions through all the three melatonin receptors, i.e. MT1, MT2, and MT3. For example, MT2 receptor agonistic activity is attributed to neuroprotective, hypnotic and anxiolytic properties while MT1 and MT2 agonistic activity is associated with the clinical efficacy of agomelatine. The third melatonin receptor has been identified as quinone reductase (QR) 2, an enzyme involved in detoxification. MT3 agonist has been linked to strong hypotensive effects in preclinical study.

In conclusion, the gathering body of evidence both from preclinical and clinical literatures suggests strong antioxidant activities and diverse pleiotropic mechanisms of melatonin for potential neuroprotective role in diverse neuropsychiatric disorders. However, there is still a lack of melatonergic ligands with high selectivity and specificity to precisely target any particular neuropsychiatric disorders for which limited therapeutic options are currently available clinically.

Insomnia is such a prevalent medical condition in this day and age of our fast-paced world. Juggling the hustle and bustle of everyday life, whether it is school, work, parenting, or family, can really do a number on our stress levels. Add a tinge of anxiety and depression, and this can be a recipe for some major sleepless nights.

Medications should never be our first choice when tackling insomnia, however. Most insomnia can be treated well with some behavioral changes, albeit not always easy to accomplish but quite worth the effort. The goal should primarily be to allow your body and mind to learn to fall asleep on its own, chemical free. And then to seek medication if all else fails.

But I know that the reality is that many seek over-the-counter sleep aids as a first step. Aside from antihistamines, melatonin seems to be a popular first choice amongst many.

But does it work? Is it safe? And what is the proper way to take it?

What Is Melatonin?

Melatonin is a hormone released by the pineal gland, a structure that sits tucked well inside the brain. This hormone regulates sleep patterns, referred to as our “circadian rhythm.” When night falls, melatonin levels rise almost ten-fold, commanding our bodies and mind to wind and eventually shut down in order to rejuvenate. In the daytime, when exposed to sunlight, melatonin levels are then suppressed. Hence, we then feel awake and most alert.

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How Melatonin for Sleep may help your Anxiety Symptoms

We think that you will agree: Everyone has felt stressed or even anxious at some point in his or her life! For some people, anxiety is brief and temporary. But for others, anxiety can be a chronic health condition that interferes with their ability to function daily. The “sleep hormone” melatonin has shown the potential to RELIEVE many anxiety symptoms. In this article, we’ll be going over the close relationship between melatonin, sleep, and anxiety.

But first:

Melatonin has alternatively been called both the “sleep hormone” and “darkness hormone.” It is a naturally occurring hormone synthesized by the pineal gland, a small endocrine gland deep in the center of the brain. The pineal gland normally remains inactive during the daytime and becomes active during the nighttime. The production of melatonin is triggered by the body being in a dark environment. The “sleep hormone” is steadily released into the bloodstream, which helps you fall asleep.

Many studies have shown that melatonin benefits sleep in numerous ways:

  • Induces feelings of drowsiness to help prepare you to sleep
  • Makes it easier for you to fall asleep quicker
  • Extends your total sleep duration
  • Improves your overall sleep quality
  • Boosts your daytime alertness
  • Helps treat sleep issues related to jet lag or insomnia

During a normal night of sleep, blood levels of melatonin will remain heightened between the hours of 9 PM – 9 AM, for about 12 hours. As the morning and daylight come, the pineal gland becomes inactive and stops producing melatonin, reducing the levels of melatonin in the bloodstream. During the daytime, those levels are almost immeasurable in testing. Now that we know what melatonin is:

What Is Anxiety?

The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, or DSM-5, contains a comprehensive list of diagnostic criteria for generalized anxiety disorder, or GAD:

  1. Excessive anxiety and worry, which is defined as feeling anxious about the possibility of, and expecting something bad to happen in the future, which:
    1.1 You experience more often than not for a period of at least 6 months, about a number of events or activities, such as your academic/work performance.
  2. You find it difficult to control your worry.
  3. Your anxiety and worry are connected to at least 3 of the following 6 symptoms, with at least some of these symptoms have been present more often than not for the past 6 months:
    3.1 Restlessness, feeling very nervous or excited before an important event, or being on edge
    3.2 Being easily fatigued
    3.3 You have difficulty with concentrating, or your mind going blank
    3.4 Irritability or agitation
    3.5 Muscle tension
    3.6 Sleep disturbances, including difficulties with falling or staying asleep, or having restless, unsatisfying sleep
  4. Your anxiety, worry, or physical symptoms cause clinically significant distress or impairment in your social, occupational, and psychological functioning.
  5. Your anxiety and worry are not a result of the physiological effects of a substance, such as a drug that you may be abusing, or medication, or because of another medical condition.
  6. Your anxiety and worry are not better explained through another medical disorder including, but not limited to:
    6.1 Anxiety or worry about getting panic attacks due to panic disorder
    6.2 Negative evaluation in social anxiety disorder
    6.3 Contamination or other obsessions related to obsessive-compulsive disorder
    6.4 Separation from attachment figures in separation anxiety disorder
    6.5 Reminders of traumatic events in posttraumatic stress disorder

You may be wondering: How common is anxiety?

There are 6.8 million adults in the U.S. who are affected by a generalized anxiety disorder, which amounts to 3.1% of the U.S. population. Only 43.2% of those affected are receiving treatment. Women have double the risk of being affected by generalized anxiety disorder as men do. It is important to note that there are other types of anxiety disorders besides generalized anxiety disorder, including:

  1. Panic Disorder
    a. Affects 6 million adults, which amounts to 2.7% of the U.S. population
    b. Women have double the risk of being affected by the panic disorder as men do
  2. Social Anxiety Disorder (SAD)
    a. Affects 15 million adults, which amounts to 6.8% of the U.S. population
    b. It usually starts around the age of 13 years old
    c. In a survey done by the Anxiety and Depression Association of America in 2007, it was found that 36% of people affected by social anxiety disorder suffered from their symptoms for at least 10 years before they looked for treatment.
  3. Obsessive-Compulsive Disorder (OCD)
    a. Affects 2.2 million adults, which amounts to 1.0% of the U.S. population
    b. The average age at which the symptoms first appear is 19 years old; 25% of cases occurred by age 14
    c. One out of three affected adults first experienced the symptoms during their childhood
  4. Posttraumatic Stress Disorder (PTSD)
    a. Affects 7.7 million adults, which amounts to 3.5% of the U.S. population
    b. Women are more likely to develop PTSD than men
  5. Major Depressive Disorder (MDD)
    a. Affects more than 16.1 million adults, which amounts to 6.7% of the U.S. population aged 18 or older in a given year
    b. Women are more likely to develop MDD than men.
    c. Although it may develop at any age, the median age at which the symptoms first appear is 32.5 years old
  6. Persistent Depressive Disorder (PDD)
    a. It affects about 3.3 million adults, which amounts to about 1.5% of the U.S. population aged 18 and older in a given year
    b. The average age at which the symptoms first appear is 31 years old
  7. Specific Phobias
    a. Affect 19 million adults, which amounts to 8.7% of the U.S. population
    b. Women have double the risk of being affected by specific phobias as men do
    c. Symptoms usually first appear in childhood, with the average age being about 7 years old

Did you know that people can be affected by both anxiety and depression at the same time? Nearly half of those who have been diagnosed with depression are also diagnosed with an anxiety disorder. For example, people who have been diagnosed with major depressive disorder have also been diagnosed with a generalized anxiety disorder. Obsessive-compulsive disorder and posttraumatic stress disorder are closely related to anxiety disorders. Some people may have both disorders at the same time, as well as depression.

Astonishing, isn’t it? Generally, according to the World Health Organization, 1 in every 13 people globally suffers from anxiety. The World Health Organization also reported that anxiety disorders are the most common mental disorders globally. Specific phobias, social anxiety disorder, and major depressive disorder are the most common anxiety disorders.

Now that we’ve dived deep into anxiety, let’s look at:

The Connection Between Melatonin, Sleep, and Anxiety

It is interesting to note that sleep disturbances are one of the symptoms of generalized anxiety disorder. Melatonin has been shown to be effective in treating these sleep disturbances. Indirectly, in this way, melatonin helps relieve your anxiety symptoms. Sleep deprivation has been demonstrated to induce anxiety-like behaviors in rats. One study published in the American Journal of Translational Research in 2017 examined the effects of melatonin on sleep deprivation-induced anxiety-like behaviors and tried to determine the possible mechanisms involved.

This study has shown strong evidence that melatonin supplementation is able to reduce sleep deprivation-induced anxiety-like behaviors. This is due to a combination of factors:

  1. The antioxidant and free radical scavenger properties of melatonin
  2. Melatonin’s role in regulating GABAergic and glutamatergic transmission in the amygdala

Melatonin as an Antioxidant

Melatonin may reverse the activation of the HPA axis due to stress. The HPA axis drives the body’s stress response to chronic stress and stimulates the production of cortisol, the “stress hormone.” Additionally, melatonin inhibits both spontaneous and stimulated HPA axis activity. As an antioxidant and free radical scavenger, melatonin helps prevent oxidative stress and damage in the central nervous system, which is particularly sensitive to this type of damage.

Oxidative stress also plays an important role in the HPA axis and the anxiety-like behaviors induced by sleep deprivation. In that way, the antioxidant and free radical scavenger properties of melatonin may produce an anxiolytic effect.

Melatonin’s Role in Regulating Amygdalar Neurotransmission

Anxiety-like behaviors may be caused by hyperexcitation, which could be due to increased excitatory transmission or reduced inhibitory transmission. Pathological anxiety is when the intensity, duration, and/or frequency of anxiety become so distressful and chronic that it interferes with a person’s ability to function. This type of anxiety is a result of an imbalance of excitation and inhibition of the neural circuits of the amygdala.

For reference: The cluster of neurons known as the amygdala is responsible for the processing of emotions including fear, which is closely connected to anxiety. Numerous studies have shown that melatonin interacts with GABA to induce a tranquilizing action, which means that the combination of the two reduces feelings of anxiety, fear, tension, and agitation.

For those of you who don’t know: GABA is an inhibitory neurotransmitter that is often used as a natural anxiety treatment. It counteracts and balances glutamate, which is an excitatory neurotransmitter.

Let’s take a closer look: Melatonin supplementation has been shown to increase the levels of GABA in some brain regions. Additionally, chronic melatonin treatment has been demonstrated to increase GABA binding to inhibit neuronal activity. Melatonin affects GABA in many more ways, such as increasing GABA production and promoting the sleep-inducing effects of GABA. N-acetyl-5-metoxikynuramine, which is a product of the metabolism of melatonin, has been found to stimulate GABA-benzodiazepine receptors.

These receptors have been established in numerous clinical trials to be connected to the functional changes in the body that cause anxiety. This helps justify the anxiolytic and sedative effects of melatonin. It is important to promote the production and effects of GABA because research has suggested that there may be a trait-like abnormality in GABA neuronal function that contributes to the development of the panic disorder. More generally, disruptions to the metabolism of GABA may contribute to the functional changes in the human body that cause anxiety disorders.

Melatonin Supplementation in Stressful Situations

Most human research related to melatonin administration has to do with surgery. People usually feel stressed and anxious before they undergo surgery. They are usually given benzodiazepines and other such medications to reduce their anxiety symptoms, as well as induce sedation and amnesia. However, the use of such medications has the side effects of impairing cognitive and psychomotor functioning.

Liposomal Melatonin Supplements

If you are looking for ways to increase your melatonin blood levels, you should consider a melatonin supplement.

More specifically, you may want to do some research on Liposomal Melatonin Technology. Liposomal Technology uses micro-sized fluid-filled liposomes to protect and deliver nutrients directly into the cells and tissues of the body. These liposomes are very similar to human cells, which makes it easier for them to be transported within the body. As a result, nutrient absorption is greatly increased, and there is less intestinal discomfort than with using standard oral supplements.

Liposomal Melatonin Technology provides several different advantages, including:

  1. Micro-sized encapsulation that protects against the harsh acidity of the gastrointestinal tract
  2. Increased delivery to cells, tissues, and organs
  3. Higher absorption rates and bioavailability than other standard oral supplements
  4. Noninvasive compared to intravenous supplementation
  5. Lower doses provide the same effects as high-dose standard oral supplements
  6. Helps put nutrients to use by the body faster
  7. Prevents gastrointestinal distress usually experienced with standard oral supplements

Clearly, liposomal melatonin supplement deserves serious consideration as a potential sleep aid.

Melatonin May Help Relieve Many Anxiety Symptoms

Many trials and studies have shown that melatonin is equally as effective, if not more effective in treating preoperative anxiety than common anti-anxiety premeditates. The antioxidant and free radical scavenger properties of melatonin produce anxiolytic effects. Melatonin also increases GABA concentrations in certain brain regions, promotes the sleep-inducing effects of GABA, and increases GABA binding. This is important because GABA is used as a natural anti-anxiety treatment.

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