Does lomotil make you sleepy


Lomotil Addiction

· Are you using Lomotil along with other drugs?
· Are you lying to doctors in order to obtain Lomotil?
· Does your drug abuse interfere with your functioning at work or school?
· Do your family members and friends criticize you for using drugs?
· Have you tried to quit using drugs but failed?
· Do you find it hard to go more than a day or two without drugs?
· Do you feel guilty or ashamed about your drug use?
· Do you have trouble with certain side effects of drugs, such as constipation?
· Do you spend too much time thinking about, obtaining and using drugs?
· Do you feel as if your life is going nowhere because of your drug use?
· Are you afraid you will be arrested or face other legal consequences because your drug use?
· Have you ever driven under the influence of drugs or otherwise endangered yourself physically, because of drugs?


“Diphenoxylate,” Medline, The United States Library of Medicine, see Rubinstein, Jonathan. (MD) “Deliberate Abuse of Diphenoxylate,” Western Journal of Medicine, 1979 August; 131(2): 148–150. “Atropine,”, Official Information from the United States Food and Drug Administration, see “Code of Federal Regulations, Schedule V, Section 1308,” The United States Drug Enforcement Agency, see “Lomotil,” The RX List, see Altman, Lawrence and Todd Purdum. “In JFK File, Hidden Illness,” The New York Times, November 17, 2002. “Travelers Diarrhea,” The New York Times Health Topics, see “Diphenoxylate,” Medline, The United States Library of Medicine, see “Lomotil Medical Facts,”, Official Information from the United States Food and Drug Administration, see see Pfizer Pharmaceuticals, Lomotil, see “Lomotil,” The RX List, see Ibid. “Lomotil Medical Facts,”, Official Information from the United States Food and Drug Administration, see see “Atropine,”, Official Information from the United States Food and Drug Administration, see “Lomotil Medical Facts,”, Official Information from the United States Food and Drug Administration, see see “Side Effects of Lomotil,” The RX List, see “Lomotil Medical Facts,”, Official Information from the United States Food and Drug Administration, see see “Lomotil: Warnings and Precautions,” The RX List, see Ibid. “Lomotil Medical Facts,”, Official Information from the United States Food and Drug Administration, see see Ibid. Lomotil Overdoses, The New York Times Health Topics, see; and “Lomotil Overdose,” The RX List, see “Opium Withdrawal,” Pub Med, The United States Library of Medicine, see Rubinstein, Jonathan. (MD) “Deliberate Abuse of Diphenoxylate,” Western Journal of Medicine, 1979 August; 131(2): 148–150. “Opium Withdrawal,” Pub Med, The United States Library of Medicine, see

Find relief in recovery. Life gets better with addiction treatment.

Call our experts today.

(855) 837-1334


Lomotil is the brand name of diphenoxylate and atropine, a combination prescription drug used to treat the symptoms of acute or chronic diarrhea.

Approved by the Food and Drug Administration (FDA) in 1960 — President Kennedy and the Apollo Space Team reportedly used it — Lomotil comes in both liquid and pill form. (Lonox is another brand name for the same drug.)

As the generic name suggests, Lomotil, which is manufactured by Pfizer, mixes two drugs: diphenoxylate, an antidiarrheal, and atropine, an anticholinergic. Diphenoxylate works by slowing down the internal movements of the bowels.

Diphenoxylate is a narcotic, and a touch of atropine (0.025 milligrams), which in large doses can bring on nausea, was added to discourage deliberate overdosing on the combo pill.

Lomotil Warnings

Lomotil needs to be used with special caution in children younger than 2 years old, as overdosage can result in severe breathing problems and coma, which could end in permanent brain damage or death.

Children are also more susceptible to atropine poisoning.

Only the liquid form should be given to children, using the plastic dropper that comes with it to measure the doses.

Doctors have also prescribed Lomotil “off label” for long-term treatment of irritable bowel syndrome (IBS), ulcerative colitis, and Crohn’s disease.

Before you begin your treatment with Lomotil, you need to tell your doctor about any allergies, and whether you’re taking barbiturates (e.g., phenobarbital or secobarbital, or tranquilizers. You also need to mention any monoamine oxidase inhibitors, or MAOIs, as these could affect your Lomotil dosage.

Certain antihistamines, anti-seizure drugs, drugs for sleep or anxiety, painkillers (such as codeine), or muscle relaxants also need to be discussed with your doctor, along with any medical conditions, such as liver disease (jaundice, cirrhosis), or diarrhea brought on by such bacterial infections as E. coli, Salmonella, or Shigella (an intestinal disease), as there’s a danger Lomotil can make these infections worse, and it certainly won’t cure you of them.

You also need to tell your doctor if you have ever had ulcerative colitis, emphysema, asthma, bronchitis, or other chronic lung infections.

Pregnancy and Lomotil

Lomotil is in Pregnancy Category C, according to the FDA, which means that harm to a woman’s fetus cannot be ruled out. Nonetheless, the drug’s benefits to the mother may outweigh the potential risks to her developing fetus.

Since there are no well-controlled studies of the effect of Lomotil on pregnant women, it’s important that your doctor know if you are pregnant or are breastfeeding, as the drug may be excreted in breast milk.

What is Lomotil used for?

  • Relieving acute diarrhoea.
  • Relieving diarrhoea and pain associated with mild or long-term ulcerative colitis.
  • Regulating stool formation in people who have had a colostomy or ileostomy, to reduce the number of stools produced and make them less watery.

How does Lomotil work?

Lomotil tablets contain two ingredients, diphenoxylate hydrochloride and atropine sulfate. This combination of medicines is known as co-phenotrope.

Co-phenotrope works by slowing down the muscular contractions of the intestine. It reduces the speed at which the gut contents are pushed through the intestines, allowing more time for water and electrolytes to be reabsorbed from the gut contents back into the body. This results in firmer stools that are passed less frequently and so controls diarrhoea.

Slowing down the muscles in the intestines also relieves painful spasms.

How do I take Lomotil?

  • Always follow the instructions given by your doctor or pharmacist and do not take more than the recommended dose. The usual doses are as follows:
    • Adults and teenagers aged 16 years and over should take four tablets initially, followed by two tablets after six hours and then a further two tablets every six hours.
    • Children aged 13 to 16 years should take two tablets three times a day.
    • Children aged 9 to 12 years should take one tablet four times a day.
    • Children aged 4 to 8 years should take one tablet three times a day.
  • Most people only need to take Lomotil for a few days to control diarrhoea. If you’re taking it because you have a colostomy or ileostomy you may need to take it on a more long-term basis. Always follow the instructions given by your doctor or pharmacist.
  • Lomotil tablets should be swallowed with a drink of water. They can be taken either with or without food.
  • If you forget to take a dose, just leave out that dose and wait to take your next dose as usual when it’s due. Do not take a double dose to make up for a missed dose.

What should I know before taking Lomotil?

  • Don’t take this medicine and consult a doctor instead if any of the following apply to you: you have diarrhoea that started either during or after taking a course of antibiotics, if the diarrhoea contains yellow or greenish mucus or blood, or if you also have a fever.
  • Acute diarrhoea makes you lose more fluids and salt than you usually would and can make you dehydrated. This medicine only treats the symptoms of diarrhoea and so will not rehydrate you. You should make sure that you drink plenty of fluids, and you may also want to take an oral rehydration therapy, which is a soluble powder containing sugars and salts, to help rehydrate you. This is particularly important for frail and elderly people. Rehydration salts can be bought from pharmacies or may be prescribed by your doctor.
  • If you get any swelling of your stomach or constipation after taking Lomotil, don’t take any further doses and consult your doctor.
  • Lomotil may make you feel sleepy or dizzy. If affected do not drive or operate machinery. Avoid drinking alcohol as it may make these problems worse.

Who shouldn’t take Lomotil?

  • Children under four years of age. Co-phenotrope should not be given to children under 16 years of age unless prescribed by a doctor.
  • People with severe constipation, or a lack of movement or blockage in the gut.
  • People with pyloric stenosis, a condition where the opening from the stomach into the small intestine is narrowed.
  • People with severe acute ulcerative colitis.
  • People with diarrhoea caused by inflammation of the gut following antibiotic treatment (antibiotic-associated pseudomembranous colitis).
  • People with a head injury or raised pressure inside the skull.
  • People with jaundice.
  • People with a condition called myasthenia gravis, in which there is abnormal muscle weakness.
  • Men with an enlarged prostate gland.

Who might need a lower dose or extra monitoring?

  • People with kidney or liver problems.
  • People with Down’s syndrome.

Can I take Lomotil while pregnant or breastfeeding?

  • Only if it’s prescribed by your doctor. If you’re pregnant or breastfeeding you should get advice from your doctor before taking this medicine. Since it’s safety for use during pregnancy and breastfeeding has not been fully established, it should only be used with caution, and only if the expected benefit to the mother outweighs any potential risk to the baby. Co-phenotrope may pass into breast milk.

What are the possible side effects of Lomotil?

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with co-phenotrope. Just because a side effect is stated here doesn’t mean that all people using Lomotil will experience that or any side effect.

  • Nausea and vomiting.
  • Abdominal pain.
  • Constipation.
  • Loss of appetite.
  • Feeling tired or sleepy.
  • Dizziness.
  • Feeling generally unwell.
  • Confusion.
  • Restlessness.
  • Headache.
  • Difficulty passing urine.
  • Dry mouth or skin.
  • Fever or flushing.
  • Changes in heart rate.
  • A condition called paralytic ileus, where the bowels become paralysed and stop working.
  • Hallucinations.
  • Changes in mood.
  • Raised pressure in the eyeball.
  • Dilated pupils and blurred vision.

Read the leaflet that comes with your medicine or talk to your doctor or pharmacist if you want any more information about the possible side effects of Lomotil. If you think you have experienced a side effect, did you know you can report this using the yellow card website?

Can I take Lomotil with other medicines?

It’s important to tell your doctor or pharmacist if you’re already taking any medicines, including those bought without a prescription and herbal medicines, before starting treatment with Lomotil. Similarly, check with your doctor or pharmacist before taking any new medicines with this one, to make sure that the combination is safe.

These are the main things to be aware of:

If you feel sleepy while taking Lomotil this may be made worse if you take any of the following medicines as well:

  • antihistamines that cause drowsiness, eg chlorphenamine, promethazine
  • baclofen
  • benzodiazepines, eg diazepam, temazepam
  • sleeping tablets, eg zopiclone
  • strong opioid painkillers such as morphine or codeine
  • tricyclic antidepressants, eg amitriptyline.

You’re more likely to get side effects such as constipation, dry mouth, blurred vision or difficulty passing urine, if you take Lomotil with other medicines that can have antimuscarinic effects, such as the following:

  • amantadine
  • antihistamines that cause drowsiness
  • antimuscarinic medicines for Parkinson’s symptoms, eg procyclidine, orphenadrine, trihexiphenidyl
  • antimuscarinic medicines for urinary incontinence, eg oxybutynin, flavoxate, tolterodine, propiverine, trospium
  • antispasmodics, eg atropine, hyoscine
  • disopyramide
  • MAOI antidepressants, eg phenelzine
  • some antisickness medicines
  • some antipsychotic medicines
  • tricyclic antidepressants, eg amitriptyline.

Lomotil may oppose the effect of the following medicines:

  • domperidone
  • galantamine
  • metoclopramide
  • neostigmine
  • pilocarpine
  • pyridostigmine.

Lomotil may decrease the blood level of the Parkinson’s medicine levodopa, which could make it less effective.

If you get a dry mouth while taking Lomotil you may find that medicines that are designed to dissolve and be absorbed from under the tongue, eg sublingual glyceryl trinitrate (GTN) tablets, become less effective. This is because the tablets do not dissolve properly in a dry mouth. To resolve this, drink a mouthful of water before taking sublingual tablets.

What other medicines containing the same active ingredient?

Co-phenotrope tablets are also available without a brand name, ie as the generic medicine.

Last updated 14.06.2017

About co-phenotrope

Type of medicine An antimotility medicine
Used for Diarrhoea
Also called Diphenoxylate hydrochloride with atropine sulfate
Available as Tablets

Co-phenotrope is used in acute diarrhoea (this is diarrhoea which starts suddenly and lasts less than two weeks). It contains two ingredients: diphenoxylate hydrochloride and atropine sulfate. It is the diphenoxylate hydrochloride which is the main ingredient.

The most common cause of acute diarrhoea is infection. Other causes include drinking lots of beer, as a side-effect from other medicines, and anxiety. In most cases the diarrhoea settles within a few days, although it may take longer in some people. The main treatment is to have lots to drink to prevent lack of fluid in the body (dehydration). Antidiarrhoeal medicines like co-phenotrope may not be necessary; however, if you wish to reduce the number of trips that you need to make to the toilet, it can be useful. Most people only need to take it for a few days.

Diphenoxylate works by slowing down the activity of your bowel. This reduces the speed at which the contents pass through, and so food remains in your intestines for longer. This allows more water to be absorbed back into your body and results in firmer stools that are passed less often.

You can buy co-phenotrope tablets from your local pharmacy, or get them on prescription from your doctor. They are not suitable for children under the age of 16 years unless they have been prescribed by a doctor.

Because co-phenotrope regulates the passage of food through the digestive system, the tablets are also prescribed to help people regulate their bowel activity following surgery on the intestines.

Before taking co-phenotrope

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking co-phenotrope it is important that your doctor or pharmacist knows:

  • If you are pregnant or breast-feeding.
  • If you have any problems with the way your liver works, or the way your kidneys work.
  • If you have any breathing problems, such as asthma or chronic obstructive pulmonary disease (COPD).
  • If you have prostate problems or any difficulties passing urine.
  • If you have been told you have low blood pressure.
  • If you have any problems with your thyroid or adrenal glands.
  • If you have epilepsy.
  • If you have a problem in your bile duct.
  • If you have a bowel obstruction or an inflammatory bowel problem.
  • If you have a condition causing muscle weakness, called myasthenia gravis.
  • If you have ever had a drug addiction.
  • If you have ever had an allergic reaction to a medicine.
  • If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.

How to take co-phenotrope

  • Before you start this treatment, read the manufacturer’s printed information leaflet from inside your pack. The manufacturer’s leaflet will give you more information about the tablets and a full list of the side-effects which you may experience from taking them.
  • Start by taking four tablets, and then take a further two tablets every six hours until the diarrhoea is controlled. Do not take more than 10 tablets in 24 hours.
  • Co-phenotrope should not be taken by a child under 16 years of age unless it is on the advice of a doctor. If your child has been prescribed co-phenotrope, check the label carefully to make sure you know what dose to give, as the dose will depend upon your child’s age.
  • If you forget to take a dose, do not worry, just take a dose after the next time you pass some diarrhoea. Do not take two doses together to make up for a missed dose.

Getting the most from your treatment

  • It is important that you have lots to drink to prevent you from becoming lacking in fluid in the body (dehydrated). Drinking plain water is ideal, but juice and/or soup are also suitable. Try to avoid drinks that contain a lot of sugar, such as cola or pop, as they can sometimes make diarrhoea worse.
  • Oral rehydration salts can be taken to help prevent dehydration and replace lost salts. These are especially recommended for children and for people who are frail or who have underlying health problems. You can buy these from a pharmacy.
  • Eat small, light meals as soon as you are able. Plain foods such as wholemeal bread and rice are good foods to try eating first.
  • If your symptoms continue for more than 48 hours, speak with a doctor or pharmacist for advice if you have not already done so.
  • If your symptoms get worse, or if you develop a high temperature, or if you pass blood in the diarrhoea, you should ask your doctor or pharmacist for advice as soon as possible.
  • If you buy any medicines check with a pharmacist that they are suitable to take with co-phenotrope. This is because the risk of side-effects can be increased when co-phenotrope tablets are taken with some other medicines.
  • Do not take more than the prescribed dose. If you suspect that someone has taken an overdose of this medicine, or that a child has taken it by accident, go to the accident and emergency department of your local hospital straightaway. Take the container with you, even if it is empty.

Can co-phenotrope cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with co-phenotrope. You will find a full list in the manufacturer’s information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Co-phenotrope side-effects What can I do if I experience this?
Feeling tired, sleepy or dizzy If this happens, do not drive and do not use tools or machines until you feel better
Headache Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the headaches continue, let your doctor know
Tummy (abdominal) discomfort, feeling sick (nausea) Try taking the tablets after eating some food if you are not already doing so
Constipation Stop taking co-phenotrope
Feeling confused or restless, mood changes, high temperature (fever), dry mouth, difficulty passing urine, feeling flushed These should soon pass. If any become troublesome, stop taking co-phenotrope

If you experience any other symptoms which you think may be due to the medicine, speak with your doctor or pharmacist.

How to store co-phenotrope

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

Important information about all medicines

If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.

This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.

Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

If you have any questions about this medicine ask your pharmacist.

Consumer medicine information

Before you take LOMOTIL

When you must not use it

Do not take LOMOTIL if you are allergic to:

  • Diphenoxylate or atropine or any of the tablet ingredients listed at the end of this leaflet
    If you have an allergic reaction you may get a skin rash, difficulty in breathing, hayfever or faintness.
  • You have jaundice
  • You have diarrhoea caused by pseudomembranous enterocolitis (a potentially serious infection of the gut) which may occur during or up to several weeks following antibiotic treatment
  • You have an inflammatory bowel disease such as ulcerative colitis or Crohn’s disease
  • You have bacterial colitis or amoebic colitis.
  • You are breastfeeding. You should use an alternative form of infant feeding while you are taking LOMOTIL.
    LOMOTIL passes into breast milk, so if you take LOMOTIL while breastfeeding, your baby may have some effects from it.

LOMOTIL is not recommended for children less than 12 years old.

Children, especially very young children and those with Down’s syndrome, are very sensitive to the effects of LOMOTIL.

LOMOTIL must be kept out of the reach of children, since accidental overdose in children may result in serious breathing difficulties, or even death.

  • Do not use tablets after the use by date, which appears on the label after the letters “EXP”.
    They may have no effects at all, or an entirely unexpected effect if you use them after the expiry date.
  • Do not use LOMOTIL if the packaging is torn or shows signs of tampering.
  • Do not use LOMOTIL to treat any other complaints unless your doctor says to.
  • Do not give this medicine to anyone else, even if their symptoms seem similar to yours.

Before you start to use LOMOTIL

You must tell your doctor if:

  • You are allergic to any other medicines, or foods, dyes or preservatives
  • You have any other medical conditions, especially:
    – Liver disease, jaundice
    – Kidney disease
    – Colitis
    – History of drug abuse
  • You are taking any other medicines, including medicines that you buy without a prescription from a pharmacy, supermarket or health food shop.

Some of the medicines in common use that may interfere with LOMOTIL include:

  • Tranquillisers – medicines used to produce calmness, treat anxiety or help you sleep
  • Antidepressants – medicines used to treat depression, such as monoamine oxidase inhibitors (MAOI)
  • Barbiturates – medicines used to treat epilepsy and to help you sleep.

These medicines may be affected by LOMOTIL, or may affect how well it works. You may need to take different amounts of your medicine or you may need to take different medicines. Your doctor or pharmacist has a more complete list of medicines to avoid while taking LOMOTIL.

Do not drink alcohol while taking LOMOTIL.

Tell your doctor if you become pregnant while you are taking LOMOTIL.

You should not take LOMOTIL near or at the time of giving birth, because diphenoxylate is chemically related to medicines which can slow down the breathing of newborn infants.

Generic Name: atropine and diphenoxylate (A troe peen and DYE fen OX i late)
Brand Name: Lomotil

Medically reviewed by on Mar 14, 2018 – Written by Cerner Multum

  • Overview
  • Side Effects
  • Dosage
  • Professional
  • Interactions
  • More

What is Lomotil?

Atropine affects the body in many different ways, such as reducing spasms in the bladder, stomach, and intestines.

Diphenoxylate is an antidiarrheal medication.

Lomotil is a combination medicine used to treat diarrhea in adults and children who are at least 13 years old.

Lomotil may also be used for purposes not listed in this medication guide.

Important Information

Do not use Lomotil if you have diarrhea that is caused by bacteria or by taking an antibiotic. You should not use Lomotil if you have a bile duct disorder causing jaundice (yellowing of your skin or eyes).

Keep this medicine where a child cannot reach it. An overdose can be fatal to a child.

Before taking this medicine

You should not use this medicine if you are allergic to atropine or diphenoxylate, or if you have:

  • obstructive jaundice (a bile duct disorder that may cause yellowing of your skin or eyes);

  • diarrhea that is caused by bacteria; or

  • diarrhea caused by using antibiotic medication.

Lomotil is not approved for use by anyone younger than 6 years old. This medicine has not been proven safe or effective in children younger than 13 years old.

Tell your doctor if you have ever had:

  • a blockage in your intestines;

  • ulcerative colitis;

  • asthma or other breathing problems;

  • glaucoma;

  • urination problems;

  • liver or kidney disease;

  • Down’s syndrome; or

  • if you are dehydrated.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

It may not be safe to breast-feed a baby while you are using this medicine. Ask your doctor about any risks.

How should I take Lomotil?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Drink plenty of liquids to keep from getting dehydrated while you have diarrhea. Your doctor may recommend an electrolyte supplement such as Gatorade or Pedialyte. Carefully follow all care instructions.

It may take up to 48 hours before your symptoms improve. Keep using the medication as directed. Call your doctor if you still have diarrhea after 10 days, or if you have a fever.

Store at room temperature away from moisture and heat.

Keep Lomotil where a child cannot reach it. An overdose of atropine and diphenoxylate can be fatal to a child.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Lomotil can cause breathing problems and may result in death or permanent brain damage.

Early overdose symptoms include weakness, blurred vision, slurred speech, feeling hot, fast heartbeats, slowed breathing, fainting, seizure, or coma. Report any early overdose symptoms to your doctor as soon as possible.

What should I avoid while taking atropine and diphenoxylate?

Avoid driving or hazardous activity until you know how Lomotil will affect you. Your reactions could be impaired.

Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor’s instructions about the type and amount of liquids you should drink.

Drinking alcohol with this medicine can cause side effects.

Lomotil side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur up to 30 hours after you take this medicine.

Stop using this medicine and call your doctor at once if you have:

  • severe constipation, stomach pain or bloating;

  • ongoing or worsening diarrhea;

  • diarrhea that is watery or bloody;

  • severe pain in your upper stomach spreading to your back;

  • fever, flushing (warmth, redness, or tingly feeling);

  • hallucinations, seizure;

  • rapid breathing, weak or shallow breathing;

  • fast heart rate; or

  • dehydration symptoms–feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin.

Common side effects may include:

  • drowsiness, dizziness, feeling restless;

  • headache;

  • numbness in your hands or feet;

  • depression, not feeling well;

  • confusion, feelings of extreme happiness;

  • red or swollen gums;

  • dry mouth, nose, or throat;

  • nausea, vomiting, upset stomach, loss of appetite; or

  • skin rash, dryness, or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Lomotil?

Using Lomotil with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, cold or allergy medicine, or medicine for anxiety, depression, or seizures.

Tell your doctor about all your other medicines. Some may affect Lomotil, especially:

  • medicine to treat Parkinson’s disease;

  • medicine to treat excess stomach acid, stomach ulcer, motion sickness, or irritable bowel syndrome;

  • bladder or urinary medicines;

  • a bronchodilator; or

  • an MAO inhibitor–isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

This list is not complete. Other drugs may affect Lomotil, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2018 Cerner Multum, Inc. Version: 4.01.

Related questions

  • How to stop diarrhea – any medicine or remedy suggestions?

Medical Disclaimer

More about Lomotil (atropine / diphenoxylate)

  • Side Effects
  • During Pregnancy
  • Dosage Information
  • Drug Images
  • Drug Interactions
  • Compare Alternatives
  • Support Group
  • Pricing & Coupons
  • En Español
  • 35 Reviews
  • Generic Availability
  • Drug class: antidiarrheals
  • FDA Alerts (1)

Consumer resources

  • Lomotil (Diphenoxylate and Atropine Solution)
  • Lomotil (Diphenoxylate and Atropine Tablets)
  • Lomotil (Advanced Reading)

Other brands: Lonox, Lomocot, Vi-Atro

Professional resources

  • Lomotil (FDA)
  • … +1 more

Related treatment guides

  • Diarrhea

How does this medication work? What will it do for me?

Diphenoxylate – atropine is used to treat diarrhea that is not caused by infection with bacteria. This medication works by slowing down the movement of the bowels.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does this medication come in?

Each round, white tablet, with “SEARLE” debossed on one side and “61” on the other side, contains diphenoxylate HCl 2.5 mg and atropine sulfate 0.025 mg. Nonmedicinal ingredients: acacia, cornstarch, magnesium stearate, mineral oil, sorbitol, sucrose, and talc.

How should I use this medication?

The usual initial adult dose of diphenoxylate – atropine is 5 mg (2 tablets) 3 or 4 times daily to a maximum of 20 mg (8 tablets) taken in 24 hours. The children’s dose is based on age and approximate body weight. This medication should not be used by children under 4 years old. As soon as symptoms are brought under control, reduce the dose or stop taking the medication as directed by your doctor.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take this medication?

Do not take diphenoxylate – atropine if you:

  • are allergic to diphenoxylate, atropine, or any ingredients of the medication
  • are being treated for diarrhea associated with pseudomembranous enterocolitis (diarrhea caused by antibiotic treatment) or for diarrhea caused by enterotoxin-producing bacteria
  • have jaundice (a liver condition causing yellowing of skin and eyes)

Do not give this medication to children under 4 years of age.

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • abdominal cramps
  • dizziness or lightheadedness
  • drowsiness
  • dry skin or mouth
  • flushing
  • general feeling of being unwell
  • headache
  • increased body temperature
  • loss of appetite
  • nausea
  • trouble sleeping
  • vomiting

Although most of these side effects listed below don’t happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • bloating (for people without ulcerative colitis)
  • blurred vision or changes in near vision
  • constipation
  • confusion
  • depression
  • difficulty urinating
  • fast heartbeat
  • numbness in the hands or feet
  • signs of dehydration (e.g., decreased urine, dry skin, dry and sticky mouth, sleepiness, dizziness, headache, thirst, confusion)
  • signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
  • skin rash or itching
  • unusual excitement, nervousness, restlessness, or irritability

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • bloating (for people with ulcerative colitis)
  • loss of consciousness/fainting
  • signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Dependence: Physical dependence, psychological dependence, and abuse are possible at high doses. Do not take more of this medication than your doctor has prescribed. People with a history of past or current substance use problems may be at greater risk of developing abuse or addiction while taking this medication.

Drowsiness/reduced alertness: This medication may cause drowsiness or dizziness. Avoid activities that require mental alertness, such as driving or operating dangerous machinery until you know how this medication affects you.

Liver function: This medication can cause complications in people with decreased liver function. If you have liver disease such as cirrhosis, hepatitis, or decreased liver function, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Ulcerative colitis: If you have active ulcerative colitis, this medication may cause a severe complication called toxic megacolon. If you experience sudden, rapid abdominal distension (bloating), or if you have any other symptoms that worry you, contact your doctor immediately. Toxic megacolon is a medical emergency and must be treated quickly.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children less than 4 years of age.

What other drugs could interact with this medication?

There may be an interaction between diphenoxylate – atropine and any of the following:

  • acetylcholinesterase inhibitors (e.g., donepezil, galantamine, rivastigmine)
  • aclidinium
  • alcohol
  • antihistamines (e.g,. cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine)
  • antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
  • atropine
  • azelastine
  • barbiturates (e.g., butalbital, pentobarbital, phenobarbital)
  • belladonna
  • benzodiazepines (e.g., alprazolam, diazepam, lorazepam)
  • benztropine
  • botulinum toxin
  • brimonidine
  • buprenorphine
  • buspirone
  • chloral hydrate
  • cisapride
  • cyclobenzaprine
  • disopyramide
  • domperidone
  • donepezil
  • droperidol
  • efavirenz
  • flavoxate
  • galantamine
  • general anesthetics (medications used to put people to sleep before surgery)
  • glucagon
  • glycopyrrolate
  • ipratropium
  • ketotifen
  • magnesium sulphate
  • metoclopramide
  • metyrosine
  • minocycline
  • mirtazapine
  • muscle relaxants (e.g., baclofen, cyclobenzaprine, methocarbamol, orphenadrine)
  • nabilone
  • narcotic pain relievers (e.g., codeine, fentanyl, morphine, oxycodone)
  • olopatadine
  • oxybutynin
  • perampanel
  • potassium chloride (solid oral forms such as tablets)
  • pramipexole
  • rivstigmine
  • ropinirole
  • rufinamide
  • scopolamine
  • secretin
  • seizure medications (e.g., carbamazepine, clobazam, felbamate, levetiracetam, phenobarbital, phenytoin, primidone, topiramate, valproic acid, zonisamide)
  • selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, duloxetine, fluoxetine, paroxetine, sertraline)
  • tapentadol
  • thiazide diuretics (water pills; e.g., hydrochlorothiazide, indapamide, metolazone)
  • tiotropium
  • tolterodine
  • tramadol
  • tranylcypromine
  • tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, imipramine)
  • umeclidinium
  • zolpidem
  • zopiclone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material copyright MediResource Inc. 1996 – 2020. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source:


Review by Christina

For three years I lived off Imodium until I built up a tolerance to it. I was desperate and asked my gastro doctor if I could survive on a liquid-only diet. That’s when he prescribed Lomotil. I actually started to believe I was a normal person again, it’s a miracle drug if you ask me. I only realize I’m not normal when I’m off work a day and attempt to go without Lomotil.

Review by Pete

I have been an IBS-D sufferer for the last six years. After struggling with my gastro doc and his conservative ways, I hit an all-time low. My condition caused me to become very depressed and also impacted my professional life since I’m in sales. I was starting to become reclusive.

Finally, by sheer luck, my PCP prescribed Lomotil during my annual physical and voila! I got my life back. At first I took two 2.5mg tablets four times a day but I began to experience gas and constipation. Now I’ve cut back to one tablet two or three times a day with meals and I’m almost like new. My wife and family have noticed how happy I am and I’m back to being me. It’s been the magic bullet I’ve been looking for and I hope my system doesn’t get immune to Lomotil’s effect.

I’ve also been watching my diet and supplementing with fennel, licorice/peppermint tea, L-Glutamine, calcium, acidophilus and other stuff I’ve read is best for IBS-D. I’m sure the combination has assisted in returning my GI system to the positive side, but the significant change became immediately noticeable the day I began taking Lomotil. I’m about to send my PCP a thank-you note and a nasty note to my GI for not prescribing it.

Review by LaVerne

I have had IBS with diarrhea for eight years. I have been on Lomotil for one week and it is great! No more running to the restroom or being worried about going out somewhere and running around to find the restroom! I drink a lot of water and I do eat less. I pray this lasts!

Review by Kean

I have had IBS-D for many years, and all the tests, but nothing found. I have been using loperamide (Imodium) for years with a good success rate, but last time my doctor switched me to Lomotil 2.5mg and it is so good. I have been on it a week now and the difference is dramatic. Long may it continue!

Review by Annette

I have had alternating IBS now for the last two years after contracting food poisoning. My only savior is Lomotil. Not only does it stop the urgency but it also stops the cramps I get and I can at least live a normal life for a while and eat and drink whatever I want, I do find though that I have to drink a lot of water and end up peeing all the time, but this is a small price to pay. I really think this drug is excellent.

Review by Crystal

I have IBS-D, and my gastroenterologist prescribed Lomotil for me to take as needed. I must say that it worked very well to control the urgency and diarrhea at first, but after about two months it seemed to stop working. Now, I can take the maximum dosage and it doesn’t even faze my diarrhea! But when it worked, it worked very well!

Review by Vanessa

I took Lomotil for several years and it worked fine for me at the beginning, but then I noticed that it just didn’t have the lasting effect it used to have. My doctor said it’s possible that it was no longer effective in my system, and she switched me to Imodium.

Review by W

I have been a sufferer of IBS-D for the last 10 years, and for the last six years I have taken two tabs of Lomotil every morning before eating anything and after going to the toilet. I promise to God it works, and until there is any concrete medication for IBS this is fine. Take plenty of water with this and eat less than what your demand is.

Do you suffer from IBS? Have you tried Lomotil? Please contact Sophie to send in your review.

About the author

Leave a Reply

Your email address will not be published. Required fields are marked *