Does buspar lower blood pressure

Buspar

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 10/17/2018

Buspar (buspirone) is an antianxiety agent prescribed for the treatment of anxiety. Buspar is available as a generic drug. Common side effects of Buspar include:

  • dizziness,
  • nausea,
  • headache,
  • nervousness,
  • lightheadedness,
  • drowsiness,
  • feeling tired,
  • blurred vision,
  • restlessness,
  • dry mouth,
  • upset stomach,
  • stuffy nose,
  • sore throat,
  • ringing in the ears,
  • excitement, and
  • sleep problems (insomnia or strange dreams).

Buspar usual adult starting dose is 10-30mg daily in 2-3 divided doses up to a maximum of 60mg a day. Common drug interactions of Buspar include monoamine oxidase (MAO) inhibitors (for example, isocarboxazid ), trazodone (Desyrel), warfarin (Coumadin), erythromycin, itraconazole (Sporanox), nefazodone (Serzone) and rifampin. There are no adequate studies of Buspar in pregnant women and it is not known if Buspar is secreted in human breast milk. Use during pregnancy is not recommended unless the potential benefit outweighs the potential unknown risk to the fetus. It is unknown if Buspar passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

Our Buspar Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Are you currently using buspirone HCL?

Take this medication by mouth, usually 2 or 3 times a day or as directed by your doctor. You may take this medication with or without food, but it is important to choose one way and always take it the same way so that the amount of drug absorbed will always be the same.

Buspirone may come in a tablet that can be split to get the correct dose for you. Follow the manufacturer’s Patient Instruction Sheet or ask your pharmacist how to split the tablet to get your dose.

Avoid eating grapefruit or drinking grapefruit juice while taking this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details.

Dosage is based on your medical condition and response to therapy. Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same times each day. When this medication is started, symptoms of anxiety (e.g., restlessness) may sometimes get worse before they improve. It may take up to a month or more to get the full effect of this medication.

Inform your doctor if your symptoms persist or worsen.

Buspirone

Buspirone is a prescription medication used to treat anxiety.

It belongs to a group of anti-anxiety drugs called anxiolytics, but it seems to work somewhat differently than other drugs in the class.

Though researchers don’t know exactly how buspirone reduces anxiety, they believe it competes with serotonin and dopamine, which are neurotransmitters (chemical brain messengers) involved with causing anxiety symptoms.

Buspirone isn’t for treating occasional stress associated with everyday life. Rather, doctors prescribe buspirone for anxiety disorder and short-term relief of anxiety symptoms.

You may be diagnosed with anxiety disorder if you have at least one full month of anxiety symptoms such as shakiness, tension, irritability, dizziness, worry, fear, upset stomach, and trouble sleeping.

The Food and Drug Administration (FDA) approved buspirone in 1986 for the drug manufacturer Bristol-Myers Squibb, under the brand name BuSpar.

In 2001, the FDA approved a generic version of buspirone for several drug manufacturers, and Bristol-Myers Squibb discontinued the brand name BuSpar.

Recently, researchers began studying other possible uses for buspirone.

A 2013 study published in the journal International Review of Neurobiology found that buspirone may be an effective treatment for Tourette syndrome, a brain disorder that causes people to make uncontrolled and repetitive movements and sounds (tics).

An earlier study, published in 2011 in the journal Therapeutic Advances in Neurological Disorders, also found that buspirone may reduce the frequency and severity of Tourette syndrome tics.

Buspirone Warnings

You should not take buspirone if you are taking a monoamine oxidase inhibitor (MAOI), a type of drug used for treating depression.

Examples of MAOIs include phenelzine (Nardil) and tranylcypromine (Parnate).

Taking buspirone with MAOIs can cause a dangerous increase in blood pressure.

Research has shown that the safety of buspirone does not vary by age. For short-term use (no more than six weeks), it’s as safe in people 65 and older as in other adults and in children six to 17.

However, long-term safety of buspirone in children is unknown.

Let your doctor know if you’re taking other medications for anxiety.

Many anxiety medications can be dangerous if you stop taking them suddenly. They can cause a dangerous withdrawal reaction that could include anxiety, insomnia, abdominal pain, and seizure.

Switching from one of these drugs to buspirone will not prevent a withdrawal reaction because buspirone does not act like these other medications. Instead, you have to taper down the dose of the drugs gradually.

Your doctor should know if you have certain conditions so he or she can decide if buspirone is the right drug for you. They include:

  • Kidney disease
  • Liver disease
  • Drug or alcohol abuse
  • Pheochromocytoma (a rare tumor that causes high blood pressure)

Buspirone ‘High’ and Addiction

Numerous online and anecdotal reports have suggested that some people abuse buspirone for a narcotic-like “high.”

Buspirone abuse can result in:

  • Hallucinations
  • Nausea or vomiting
  • Euphoria
  • Memory loss
  • Lack of coordination
  • Fatigue

Take buspirone only as directed by your doctor, and keep this and all other drugs away from children, teenagers, and anyone for whom the drug has not been prescribed.

Buspirone and Pregnancy

Buspirone has not been tested enough to know whether it’s safe to take during pregnancy.

Women should let their doctor know if they are or may become pregnant before taking buspirone.

Also, the drug may pass through breast milk, but it’s not known whether it’s safe to take buspirone while breastfeeding.

Buspirone Drug Interactions

A total of 416 drugs are known to interact with buspirone.

  • 86 major drug interactions
  • 328 moderate drug interactions
  • 2 minor drug interactions

Show all medications in the database that may interact with buspirone.

Check for interactions

Type in a drug name to check for interactions with buspirone.

Most frequently checked interactions

View interaction reports for buspirone and the medicines listed below.

  • 5-HTP (5-hydroxytryptophan)
  • Abilify (aripiprazole)
  • Adderall (amphetamine / dextroamphetamine)
  • Aspirin Low Strength (aspirin)
  • Benadryl (diphenhydramine)
  • Celexa (citalopram)
  • clonazepam
  • Cymbalta (duloxetine)
  • Effexor (venlafaxine)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • Flexeril (cyclobenzaprine)
  • grapefruit
  • hydrocodone
  • hydroxyzine
  • ibuprofen
  • Lamictal (lamotrigine)
  • Lexapro (escitalopram)
  • Lyrica (pregabalin)
  • Norco (acetaminophen / hydrocodone)
  • Paxil (paroxetine)
  • ProAir HFA (albuterol)
  • Prozac (fluoxetine)
  • Seroquel (quetiapine)
  • sertraline
  • Synthroid (levothyroxine)
  • tramadol
  • trazodone
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)
  • Wellbutrin (bupropion)
  • Xanax (alprazolam)
  • Zoloft (sertraline)
  • Zyrtec (cetirizine)

Buspirone alcohol/food interactions

There is 1 alcohol/food interaction with buspirone

Buspirone disease interactions

There are 5 disease interactions with buspirone which include:

  • depression
  • renal/liver disease
  • glaucoma
  • liver disease
  • drug dependence

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.

Major

Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.

Moderate

Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.

Minor

Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Unknown

No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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  • Dosage forms

    Form Route Strength
    Tablet Oral
    Tablet Oral 10 mg/1
    Tablet Oral 15 mg/1
    Tablet Oral 30 mg/1
    Tablet Oral 5 mg/1
    Tablet Oral 10 mg
    Powder Not applicable 1 g/1g
    Tablet Oral 10 1/1
    Tablet Oral 15 1/1
    Tablet Oral 5 1/1
    Tablet Oral 7.5 mg/1

    Prices

    Unit description Cost Unit
    Wellbutrin xl 300 mg tablet 8.68USD tablet
    Wellbutrin xl 150 mg tablet 6.58USD tablet
    Buspar 30 mg tablet 5.52USD tablet
    Buspirone hcl powder 4.74USD g
    Buspirone hcl 30 mg tablet 3.71USD tablet
    Buspar 15 mg tablet 3.07USD tablet
    Buspirone hcl 15 mg tablet 2.16USD tablet
    Buspar 10 mg tablet 2.05USD tablet
    Buspirone hcl 7.5 mg tablet 1.62USD tablet
    Buspirone hcl 10 mg tablet 1.42USD tablet
    Buspar 5 mg tablet 1.18USD tablet
    Vanspar 7.5 mg tablet 1.18USD tablet
    Buspar 10 mg Tablet 1.12USD tablet
    Buspirone hcl 5 mg tablet 0.79USD tablet
    Apo-Buspirone 10 mg Tablet 0.62USD tablet
    Novo-Buspirone 10 mg Tablet 0.62USD tablet
    Nu-Buspirone 10 mg Tablet 0.62USD tablet
    Pms-Buspirone 10 mg Tablet 0.62USD tablet
    Ratio-Buspirone 10 mg Tablet 0.62USD tablet

    DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only. Patents Not Available

    Properties

    State Solid Experimental Properties

    Property Value Source
    melting point (°C) 201.5-202.5 Buspirone hydrochloride (B7148) – Sigma Aldrich Product Information Sheet
    logP 2.63 TAKACS-NOVAK,K 1995 (IN PRESS)

    Predicted Properties

    Property Value Source
    Water Solubility 0.588 mg/mL ALOGPS
    logP 1.95 ALOGPS
    logP 1.78 ChemAxon
    logS -2.8 ALOGPS
    pKa (Strongest Basic) 7.62 ChemAxon
    Physiological Charge 1 ChemAxon
    Hydrogen Acceptor Count 6 ChemAxon
    Hydrogen Donor Count 0 ChemAxon
    Polar Surface Area 69.64 Å2 ChemAxon
    Rotatable Bond Count 6 ChemAxon
    Refractivity 108.89 m3·mol-1 ChemAxon
    Polarizability 44.12 Å3 ChemAxon
    Number of Rings 4 ChemAxon
    Bioavailability 1 ChemAxon
    Rule of Five Yes ChemAxon
    Ghose Filter Yes ChemAxon
    Veber’s Rule No ChemAxon
    MDDR-like Rule Yes ChemAxon

    Predicted ADMET features

    Property Value Probability
    Human Intestinal Absorption + 0.9935
    Blood Brain Barrier + 0.9839
    Caco-2 permeable 0.538
    P-glycoprotein substrate Substrate 0.5726
    P-glycoprotein inhibitor I Inhibitor 0.8563
    P-glycoprotein inhibitor II Non-inhibitor 0.8282
    Renal organic cation transporter Inhibitor 0.598
    CYP450 2C9 substrate Non-substrate 0.8703
    CYP450 2D6 substrate Substrate 0.8918
    CYP450 3A4 substrate Substrate 0.6728
    CYP450 1A2 substrate Non-inhibitor 0.9046
    CYP450 2C9 inhibitor Inhibitor 0.8948
    CYP450 2D6 inhibitor Inhibitor 0.7186
    CYP450 2C19 inhibitor Non-inhibitor 0.9026
    CYP450 3A4 inhibitor Non-inhibitor 0.8309
    CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.8681
    Ames test Non AMES toxic 0.6277
    Carcinogenicity Non-carcinogens 0.8959
    Biodegradation Not ready biodegradable 0.987
    Rat acute toxicity 2.8167 LD50, mol/kg Not applicable
    hERG inhibition (predictor I) Weak inhibitor 0.7042
    hERG inhibition (predictor II) Inhibitor 0.6914

    ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

    Spectra

    Mass Spec (NIST) Not Available Spectra

    Taxonomy

    Description This compound belongs to the class of organic compounds known as n-arylpiperazines. These are organic compounds containing a piperazine ring where the nitrogen ring atom carries an aryl group. Kingdom Organic compounds Super Class Organoheterocyclic compounds Class Diazinanes Sub Class Piperazines Direct Parent N-arylpiperazines Alternative Parents Azaspirodecane derivatives / Piperidinediones / Dialkylarylamines / Aminopyrimidines and derivatives / N-alkylpiperazines / Delta lactams / N-substituted carboxylic acid imides / Heteroaromatic compounds / Dicarboximides / TrialkylaminesAmino acids and derivatives / Azacyclic compounds / Carbonyl compounds / Hydrocarbon derivatives / Organic oxides / Organopnictogen compounds show 6 more Substituents Azaspirodecanedione / N-arylpiperazine / Azaspirodecane / Piperidinedione / Dialkylarylamine / Aminopyrimidine / N-alkylpiperazine / Piperidinone / Delta-lactam / PyrimidinePiperidine / Carboxylic acid imide, n-substituted / Heteroaromatic compound / Carboxylic acid imide / Dicarboximide / Amino acid or derivatives / Tertiary aliphatic amine / Tertiary amine / Lactam / Azacycle / Carboxylic acid derivative / Organic oxide / Organonitrogen compound / Organooxygen compound / Amine / Carbonyl group / Organic oxygen compound / Organic nitrogen compound / Organopnictogen compound / Hydrocarbon derivative / Aromatic heteropolycyclic compound show 21 more Molecular Framework Aromatic heteropolycyclic compounds External Descriptors N-arylpiperazine, pyrimidines, N-alkylpiperazine, piperidones, azaspiro compound (CHEBI:3223)

    Targets

    Binding Properties

    × Details Binding Properties1. 5-hydroxytryptamine receptor 1A Kind Protein Organism Humans Pharmacological action Yes Actions Partial agonist General Function Serotonin receptor activity Specific Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers… Gene Name HTR1A Uniprot ID P08908 Uniprot Name 5-hydroxytryptamine receptor 1A Molecular Weight 46106.335 Da

    1. de Boer SF, Lesourd M, Mocaer E, Koolhaas JM: Selective antiaggressive effects of alnespirone in resident-intruder test are mediated via 5-hydroxytryptamine1A receptors: A comparative pharmacological study with 8-hydroxy-2-dipropylaminotetralin, ipsapirone, buspirone, eltoprazine, and WAY-100635. J Pharmacol Exp Ther. 1999 Mar;288(3):1125-33.
    2. Rehman J, Kaynan A, Christ G, Valcic M, Maayani S, Melman A: Modification of sexual behavior of Long-Evans male rats by drugs acting on the 5-HT1A receptor. Brain Res. 1999 Mar 13;821(2):414-25.
    3. Liang KC: Pre- or post-training injection of buspirone impaired retention in the inhibitory avoidance task: involvement of amygdala 5-HT1A receptors. Eur J Neurosci. 1999 May;11(5):1491-500.
    4. Becker C, Hamon M, Benoliel JJ: Prevention by 5-HT1A receptor agonists of restraint stress- and yohimbine-induced release of cholecystokinin in the frontal cortex of the freely moving rat. Neuropharmacology. 1999 Apr;38(4):525-32.
    5. Dupuis DS, Tardif S, Wurch T, Colpaert FC, Pauwels PJ: Modulation of 5-HT1A receptor signalling by point-mutation of cysteine351 in the rat Galpha(o) protein. Neuropharmacology. 1999 Jul;38(7):1035-41.
    6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.
    7. Osei-Owusu P, Scrogin KE: Buspirone raises blood pressure through activation of sympathetic nervous system and by direct activation of alpha1-adrenergic receptors after severe hemorrhage. J Pharmacol Exp Ther. 2004 Jun;309(3):1132-40. Epub 2004 Feb 9.

    × Details Binding Properties2. Dopamine D2 receptor Kind Protein Organism Humans Pharmacological action Yes Actions Antagonist General Function Potassium channel regulator activity Specific Function Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Gene Name DRD2 Uniprot ID P14416 Uniprot Name D(2) dopamine receptor Molecular Weight 50618.91 Da

    1. Malt EA, Olafsson S, Aakvaag A, Lund A, Ursin H: Altered dopamine D2 receptor function in fibromyalgia patients: a neuroendocrine study with buspirone in women with fibromyalgia compared to female population based controls. J Affect Disord. 2003 Jun;75(1):77-82.
    2. Boido A, Boido CC, Sparatore F: Synthesis and pharmacological evaluation of aryl/heteroaryl piperazinyl alkyl benzotriazoles as ligands for some serotonin and dopamine receptor subtypes. Farmaco. 2001 Apr;56(4):263-75.
    3. Nader MA, Hannemann M: Interactions of buspirone or gepirone with nicotine on schedule-controlled behavior of pigeons. Behav Pharmacol. 1993 Jun;4(3):263-268.
    4. Pache DM, Fernandez-Perez S, Sewell RD: Buspirone differentially modifies short-term memory function in a combined delayed matching/non-matching to position task. Eur J Pharmacol. 2003 Sep 23;477(3):205-11.
    5. Fernandez-Perez S, Pache DM, Sewell RD: Co-administration of fluoxetine and WAY100635 improves short-term memory function. Eur J Pharmacol. 2005 Oct 17;522(1-3):78-83. Epub 2005 Oct 7.

    Kind Protein Organism Humans Pharmacological action Unknown Actions Antagonist General Function G-protein coupled amine receptor activity Specific Function Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. Gene Name DRD3 Uniprot ID P35462 Uniprot Name D(3) dopamine receptor Molecular Weight 44224.335 Da Kind Protein Organism Humans Pharmacological action Unknown Actions Antagonist General Function Sh3 domain binding Specific Function Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins … Gene Name DRD4 Uniprot ID P21917 Uniprot Name D(4) dopamine receptor Molecular Weight 48359.86 Da Kind Protein group Organism Humans Pharmacological action Unknown Actions Partial agonist General Function Protein heterodimerization activity Specific Function This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) prot…

    Components:

    Enzymes

    Kind Protein Organism Humans Pharmacological action Unknown Actions Substrate General Function Vitamin d3 25-hydroxylase activity Specific Function Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react… Gene Name CYP3A4 Uniprot ID P08684 Uniprot Name Cytochrome P450 3A4 Molecular Weight 57342.67 Da Kind Protein Organism Humans Pharmacological action Unknown Actions Substrate General Function Oxygen binding Specific Function Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un… Gene Name CYP3A5 Uniprot ID P20815 Uniprot Name Cytochrome P450 3A5 Molecular Weight 57108.065 Da Kind Protein Organism Humans Pharmacological action Unknown Actions Substrate General Function Oxygen binding Specific Function Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un… Gene Name CYP3A7 Uniprot ID P24462 Uniprot Name Cytochrome P450 3A7 Molecular Weight 57525.03 Da

    1. Flockhart Table of Drug Interactions

    Kind Protein Organism Humans Pharmacological action Unknown Actions Substrate General Function Steroid hydroxylase activity Specific Function Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic… Gene Name CYP2D6 Uniprot ID P10635 Uniprot Name Cytochrome P450 2D6 Molecular Weight 55768.94 Da

    Carriers

    Details1. Serum albumin Kind Protein Organism Humans Pharmacological action Unknown Actions Binder General Function Toxic substance binding Specific Function Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid… Gene Name ALB Uniprot ID P02768 Uniprot Name Serum albumin Molecular Weight 69365.94 Da

    1. Jann MW: Buspirone: an update on a unique anxiolytic agent. Pharmacotherapy. 1988;8(2):100-16.

    Kind Protein Organism Humans Pharmacological action Unknown Actions Binder General Function Not Available Specific Function Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in… Gene Name ORM1 Uniprot ID P02763 Uniprot Name Alpha-1-acid glycoprotein 1 Molecular Weight 23511.38 Da

    1. Jann MW: Buspirone: an update on a unique anxiolytic agent. Pharmacotherapy. 1988;8(2):100-16.

    Transporters

    Kind Protein Organism Humans Pharmacological action Unknown Actions Inhibitor General Function Xenobiotic-transporting atpase activity Specific Function Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Gene Name ABCB1 Uniprot ID P08183 Uniprot Name Multidrug resistance protein 1 Molecular Weight 141477.255 Da ×Unlock Data

    There is additional data available for commercial users including Adverse Effects, Contraindications, and Blackbox Warnings. Contact us to learn more about these and other features.

    Learn more

    Drug created on June 13, 2005 07:24 / Updated on February 02, 2020 04:06

    Taking Buspar (Buspirone) With Tylenol Sinus

    There are no known interactions between buspirone and the active ingredients that are found in Tylenol Sinus Severe Daytime. It would be considered safe to treat the congestion symptoms that you are having with the Tylenol product.

    Tylenol Sinus Severe Daytime contains:

    • Acetaminophen (analgesic)
    • Phenylephrine (decongestant)
    • Guaifenesin

    Buspar Information

    Buspirone (Buspar) an anti-anxiety medication that should not be taken with MAO inhibitors, including linezolis, methylene blue injection, selegiline, rasagiline, and phenelzine

    Caution should be used when taking this drugs with other CNS active medications. Avoid taking this medication with grapefruit juice as this could affect the concentration of buspirone that is in the body. This medication commonly causes sedation and dizziness.

    Dr. Jennifer Oliver Pharm.D

    Dr. Jennifer Oliver is a licensed immunizing pharmacist in Florida. She graduated from the University of South Florida with a Doctor of Pharmacy Degree in 2015. Other than her passion for pharmacy, she loves traveling and meeting new people.

    BusPar (Buspirone)… anyone try this?

    I posted this on another thread, here’s a copy:

    Since you are taking Buspar, I would suggest taking your dose at night with the melatonin. Optimal ratio is 15mg-20mg buspar with 3mg melatonin time release. More effects are felt if you take a morning dose of buspar as well, around 15-20mg. Effects from this combo are felt within one to three days (yes, that’s days.) It is a powerful neurogenesis stimulating combination and helps with everything you just mentioned, depression, anxiety, and cognitive processes (thought processes, clear thinking) It has a slight serotonergic and dopaminergic quality to it so you will feel an uplifted mood that comes and goes throughout the day. Caffeine seems to spark this effect as well as some supplements like 5HTP. The most interesting thing about this is that you can take the combination for two-three months or more and then stop, and the effects will still be felt, almost like your brain has made permanent changes in neuron connections to unlearn negative thinking and stay away from depression. It does this by provoking neurogenesis in the regions of the brain that are responsible for mood, memory, thinking, imagination, and learning. This effect may be subdued however, if you drink alcohol on a daily basis and/or take recreational drugs. These substances reduce neurogenesis and cancel out the effect of the combination. Anything else that reduces neurogenesis will reduce the effect as well, like many prescription drugs such as Benzodizepines, Gabapentin, ADHD medicines, and so on. So, if you are careful with what you take, you have a good chance of success with feeling better and having feelings of happiness, long term. Anti-depressants are surprisingly okay to take with this combination as most of them (SSRI) do increase neurogenesis on their own (nowhere near the amount that this combination does.) I’ve been taking this combination for 4+ years, and have noticed increases in mental processes and positive effects in mood and thinking that get stronger to this day. It doesn’t hurt to just try it out, as buspar is really hit or miss with a lot of people. For me, it has been a life-changing medicine. You may or may not feel these effects, but it’s worth it to try for a couple weeks.

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