Delsym side effects diarrhea

Delsym 12 Hour Cough Relief (dextromethorphan) Drug Interactions

A total of 267 drugs are known to interact with Delsym 12 Hour Cough Relief (dextromethorphan).

  • 41 major drug interactions
  • 224 moderate drug interactions
  • 2 minor drug interactions

Show all medications in the database that may interact with Delsym 12 Hour Cough Relief (dextromethorphan).

Check for interactions

Type in a drug name to check for interactions with Delsym 12 Hour Cough Relief (dextromethorphan).

Most frequently checked interactions

View interaction reports for Delsym 12 Hour Cough Relief (dextromethorphan) and the medicines listed below.

  • albuterol
  • aspirin
  • atorvastatin
  • Benadryl (diphenhydramine)
  • benzonatate
  • Claritin (loratadine)
  • gabapentin
  • ibuprofen
  • lisinopril
  • Mucinex (guaifenesin)
  • Mucinex DM (dextromethorphan / guaifenesin)
  • omeprazole
  • prednisone
  • Singulair (montelukast)
  • tramadol
  • Tylenol (acetaminophen)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)
  • Zyrtec (cetirizine)

Delsym 12 Hour Cough Relief (dextromethorphan) alcohol/food interactions

There is 1 alcohol/food interaction with Delsym 12 Hour Cough Relief (dextromethorphan)

Delsym 12 Hour Cough Relief (dextromethorphan) disease interactions

There is 1 disease interaction with Delsym 12 Hour Cough Relief (dextromethorphan):

  • psychiatric conditions

More about Delsym 12 Hour Cough Relief (dextromethorphan)

  • Side Effects
  • During Pregnancy or Breastfeeding
  • Dosage Information
  • Pricing & Coupons
  • 28 Reviews
  • Drug class: antitussives
  • FDA Alerts (1)

Related treatment guides

  • Cough

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.


Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.


Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.


Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.


No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer


Precautions & warnings

What should I know before using Delsym® (dextromethorphan)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Delsym® or other Delsym® (dextromethorphan)s.
  • You have any other illnesses, disorders, or medical conditions.

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving cough or cold medicine to a child. Death can occur from the misuse of cough or cold medicine in very young children.

Avoid drinking alcohol. It can increase some of the side effects of dextromethorphan.

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor’s advice. Taking a stimulant together with cough medicine can increase your risk of unpleasant side effects.

Ask a doctor or pharmacist before using any cold, allergy, or pain medication. Many medicines available over the counter contain dextromethorphan. Taking certain products together can cause you to get too much of this type of medication. Check the label to see if a medicine contains a cough suppressant.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Delsym® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Delsym®. Delsym® is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

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No medication comes without side effects. Some side effects may be too strong to handle, and some are mild enough to ignore as long as the reason you’re taking it is a bigger issue. However, some of the more common medications have their own crazy side effects and while not everyone will experience them it’s important to know they can happen to anyone.


5. Dark Urine – Tylenol

For some, Tylenol is the “cure-all” drug that helps everything from headaches to muscle aches. While it shouldn’t be used for successive days due to the risk of liver damage, Tylenol is one of the safer over-the-counter medications to take as long as it’s being used as directed. Dark urine may be a crazy side effect of Tylenol, but it’s also one of the more serious ones.

Dark urine is an indicator that you may have taken too much and are on the verge of overdosing. An overdose of Tylenol could be fatal, so if dark urine is what you’re experiencing, it would be best to see a doctor quickly.

4. Hallucinations – Delsym

Dextromethorphan, simply known as Delsym, is a popular over-the-counter brand for those looking for instant cough relief. An issue with Delsym is those looking for cold relief will often take this with different over-the-counter cold medications thinking there won’t be any serious drug interactions. Hallucinations are not fun and can come with any number of pharmacy-issued drugs, but one wouldn’t think you could get hallucinations from a simple cough medicine.

It may also affect your taste in music…

Taking more than the recommended dose of Delsym can induce a state of psychosis which can lead to hallucinations. Make sure that you have your phone in your hand to dial for an ambulance if it gets to that point, even if it looks like a squid during your hallucinating.

2. Anxiety – Pepto Bismol

You know how the jingle goes, “Nausea, heartburn, indigestion…” But did you know Pepto Bismol can cause anxiety? Imagine walking into a store with an upset stomach and picking up a little pink bottle of anxiety juice. For some, Pepto Bismol can help ease nausea from an existing anxiety-attack. For others, Pepto Bismol can cause anxiety if it wasn’t already there. If you’re at the point where you’re trembling and sweating on top of the anxiety, then you may have overdosed on the Pepto Bismol, and the next step to do would be to seek medical attention.

1. Diarrhea – Claritin

Ah, nothing says 24-hour relief of sneezing, running nose, and itchy throat like explosive diarrhea. Claritin is an antihistamine that does what the name suggests, blocks histamine, and helps alleviate some allergy symptoms. It can also cause an upset stomach and diarrhea, pretty much everything that Pepto Bismol is supposed to cure. It’s a never-ending comical cycle. At least it’s non-drowsy.

Always speak to your doctor before taking any over-the-counter medication. It’s especially important to speak to a doctor if you plan on taking different types of OTC drugs together as they may cause drug interactions.

Don’t trust Google over people with actual medical degrees.

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B Michael Logan

B Michael Logan is a certified healthcare professional secretly moonlighting as a comedy writer. He can be found around the web at @bmichaellogan

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