Chlorthalidone 25 mg tablet

Thalitone

Brand Names: Hygroton, Thalitone

Generic Name: chlorthalidone

  • What is chlorthalidone (Hygroton, Thalitone)?
  • What are the possible side effects of chlorthalidone (Hygroton, Thalitone)?
  • What is the most important information I should know about chlorthalidone (Hygroton, Thalitone)?
  • What should I discuss with my healthcare provider before taking chlorthalidone (Hygroton, Thalitone)?
  • How should I take chlorthalidone (Hygroton, Thalitone)?
  • What happens if I miss a dose (Hygroton, Thalitone)?
  • What happens if I overdose (Hygroton, Thalitone)?
  • What should I avoid while taking chlorthalidone (Hygroton, Thalitone)?
  • What other drugs will affect chlorthalidone (Hygroton, Thalitone)?
  • Where can I get more information (Hygroton, Thalitone)?

What is chlorthalidone (Hygroton, Thalitone)?

Chlorthalidone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Chlorthalidone treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or kidney disorders, or edema caused by taking steroids or estrogen. Chlorthalidone is also used to treat high blood pressure (hypertension).

Chlorthalidone may also be used for purposes not listed in this medication guide.

What are the possible side effects of chlorthalidone (Hygroton, Thalitone)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • little or no urination;
  • severe pain in your upper stomach spreading to your back;
  • pale or yellowed skin, dark colored urine, fever, easy bruising or bleeding;
  • high levels of calcium in your blood–nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, confusion, lack of energy, or tired feeling;
  • low levels of sodium in the body–headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady;
  • low potassium–leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or
  • other signs of an an electrolyte imbalance–dry mouth, thirst, nausea, vomiting, drowsiness, feeling weak or restless, muscle pain, fast heart rate, seizure (convulsions).

Common side effects may include:

  • dizziness, spinning sensation;
  • nausea, vomiting, diarrhea, constipation;
  • muscle spasm; or
  • impotence, sexual problems.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about chlorthalidone (Hygroton, Thalitone)?

You should not use chlorthalidone if you are unable to urinate, or if you are allergic to sulfa drugs.

Chlorthalidone

Identification

Are you a new drug developer? Contact us to learn more about our customized products and solutions. Stay in the know! As part of our commitment to providing the most up-to-date drug information, we will be releasing #DrugBankUpdates with our newly added curated drug pages. #DrugBankUpdates Name Chlorthalidone Accession Number DB00310 (APRD00127) Type Small Molecule Groups Approved Description

Chlorthalidone is a thiazide-like diuretic used for the treatment of hypertension and for management of edema caused by conditions such as heart failure or renal impairment. Chlorthalidone improves blood pressure and swelling by preventing water absorption from the kidneys through inhibition of the Na+/Cl− symporter in the distal convoluted tubule cells in the kidney. The exact mechanism of chlorthalidone’s anti-hypertensive effect is under debate, however, it is thought that increased diuresis results in decreased plasma and extracellular fluid volume, decreased cardiac output and therefore overall reduction in blood pressure.5

Chlorthalidone is considered first-line therapy for management of uncomplicated hypertension as there is strong evidence from meta-analyses that thiazide diuretics such as chlorthalidone reduce the risk of stroke, myocardial infarction, heart failure, and cardiovascular all-cause mortality in patients with hypertension.1 In particular, the ALLHAT trial confirmed the role of thiazide diuretics as first-line therapy and demonstrated that chlorthalidone had a statistically significant lower incidence of stroke and heart failure when compared to Lisinopril, Amlodipine, or Doxazosin.2,3 Further studies have indicated that low-dose thiazides are as good as, and in some secondary endpoints, better than β-blockers, ACE inhibitors, Calcium Channel Blockers or ARBs.

Chlorthalidone has been shown to have a number of pleiotropic effects that differentiate it from other diuretics such as Hydrochlorothiazide. In addition to its antihypertensive effects, chlorthalidone has also been shown to decrease platelet aggregation and vascular permeability, as well as promote angiogenesis in vitro, which is thought to be partly the result of reductions in carbonic anhydrase–dependent pathways. These pathways may play a role in chlorthalidone’s cardiovascular risk reduction effects.7

Structure 3D Download Similar Structures

Structure for Chlorthalidone (DB00310)

× Close Synonyms Product Images Prescription Products

Name Dosage Strength Route Labeller Marketing Start Marketing End
Unlock Additional Data
Chlorthalidone Tablet 50 mg Oral Aa Pharma Inc 1976-12-31 Not applicable Canada
Chlorthalidone 100mg Tablets Tablet Oral Laboratoires Confab Inc Not applicable Not applicable Canada
Chlorthalidone 50mg Tablets Tablet Oral Laboratoires Confab Inc Not applicable Not applicable Canada
Chlorthalidone Tab 100mg Tablet Oral Duchesnay Inc. 1978-12-31 2003-07-18 Canada
Chlorthalidone Tab 100mg Tablet Oral Pro Doc Limitee 1978-12-31 1999-08-12 Canada
Chlorthalidone Tab 50mg Tablet Oral Duchesnay Inc. 1978-12-31 2003-07-18 Canada
Chlorthalidone Tab 50mg Tablet Oral Pro Doc Limitee 1978-12-31 1999-08-12 Canada
Hygroton 50mg Tablet Oral Novartis 1968-12-31 1999-08-04 Canada
Thalitone Tablet 15 mg/1 Oral Monarch Pharmaceuticals, Inc. 1988-12-20 Not applicable US
Uridon Tab 100mg Tablet Oral Icn Pharmaceuticals 1970-12-31 2005-04-26 Canada

Additional Data Available

  • Application Number Application Number

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  • Product Code Product Code

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Generic Prescription Products

Name Dosage Strength Route Labeller Marketing Start Marketing End
Unlock Additional Data
Apo Chlorthalidone Tab 100mg Tablet Oral Apotex Corporation 1976-12-31 2019-04-05 Canada
Chlorthalidone Tablet 50 mg/1 Oral A-S Medication Solutions 1981-02-26 2013-06-18 US
Chlorthalidone Tablet 25 mg/1 Oral Mylan Pharmaceuticals Inc. 1981-02-26 Not applicable US
Chlorthalidone Tablet 25 mg/1 Oral PD-Rx Pharmaceuticals, Inc. 1981-02-26 Not applicable US
Chlorthalidone Tablet 25 mg/1 Oral Med Pharma Co., Ltd. 2011-06-15 2012-07-11 US
Chlorthalidone Tablet 25 mg/1 Oral Med Health Pharma 2011-05-19 2012-06-10 US
Chlorthalidone Tablet 25 mg/1 Oral Remedy Repack 2008-10-13 2018-10-25 US
Chlorthalidone Tablet 50 mg/1 Oral Vistapharm, Inc. 2019-07-12 Not applicable US
Chlorthalidone Tablet 25 mg/1 Oral Zydus Pharmaceuticals (USA) Inc. 2019-05-15 Not applicable US
Chlorthalidone Tablet 50 mg/1 Oral A-S Medication Solutions 2016-02-12 Not applicable US

Additional Data Available

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  • Product Code Product Code

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Mixture Products

Name Ingredients Dosage Route Labeller Marketing Start Marketing End
Apo-atenidone Chlorthalidone (25 mg) + Atenolol (100 mg) Tablet Oral Apotex Corporation 2004-08-12 Not applicable Canada
Apo-atenidone Chlorthalidone (25 mg) + Atenolol (50 mg) Tablet Oral Apotex Corporation 2004-08-12 Not applicable Canada
Atenolol and Chlorthalidone Chlorthalidone (25 mg/1) + Atenolol (50 mg/1) Tablet Oral Aidarex Pharmaceuticals LLC 1992-08-01 Not applicable US
Atenolol and Chlorthalidone Chlorthalidone (25 mg/1) + Atenolol (50 mg/1) Tablet Oral Major 1993-04-29 2014-04-30 US
Atenolol and Chlorthalidone Chlorthalidone (25 mg/1) + Atenolol (50 mg/1) Tablet Oral Rebel Distributors 1992-08-01 Not applicable US
Atenolol and Chlorthalidone Chlorthalidone (25 mg/1) + Atenolol (50 mg/1) Tablet Oral bryant ranch prepack 1992-08-01 2018-05-29 US
Atenolol and Chlorthalidone Chlorthalidone (25 mg/1) + Atenolol (50 mg/1) Tablet Oral Nucare Pharmaceuticals, Inc. 1992-08-01 Not applicable US
Atenolol and Chlorthalidone Chlorthalidone (25 mg/1) + Atenolol (50 mg/1) Tablet Oral Avera McKennan Hospital 2016-05-16 2018-07-09 US
Atenolol and Chlorthalidone Chlorthalidone (25 mg/1) + Atenolol (50 mg/1) Tablet Oral Northstar Rx Llc. 2019-03-26 Not applicable US
Atenolol and Chlorthalidone Chlorthalidone (25 mg/1) + Atenolol (100 mg/1) Tablet Oral Zydus Pharmaceuticals (USA) Inc. 2019-03-12 Not applicable US

International/Other Brands Hygroton (Novartis) / Saluretin (Balkanpharma) Categories UNII Q0MQD1073Q CAS number 77-36-1 Weight Average: 338.766
Monoisotopic: 338.012805247 Chemical Formula C14H11ClN2O4S InChI Key JIVPVXMEBJLZRO-UHFFFAOYSA-N InChI InChI=1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21) IUPAC Name 2-chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzene-1-sulfonamide SMILES NS(=O)(=O)C1=C(Cl)C=CC(=C1)C1(O)NC(=O)C2=CC=CC=C12

Pharmacology

Indication

Chlorthalidone is indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.

Chlorthalidone is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy.

Chlorthalidone has also been found useful in edema due to various forms of renal dysfunction, such as nephrotic syndrome, acute glomerulonephritis, and chronic renal failure.

Associated Conditions

  • Calcium Nephrolithiasis

Pharmacodynamics Not Available Mechanism of action

Chlorthalidone prevents reabsorption of sodium and chloride through inhibition of the Na+/Cl- symporter in the cortical diluting segment of the ascending limb of the loop of Henle.4 Reduction of sodium reabsorption subsequently reduces extracellular fluid and plasma volume via an osmotic, sodium-driven diuresis. By increasing the delivery of sodium to the distal renal tubule, Chlorthalidone indirectly increases potassium excretion via the sodium-potassium exchange mechanism. The exact mechanism of chlorthalidone’s anti-hypertensive effect is under debate, however, it is thought that increased diuresis results in decreased plasma and extracellular fluid volume which therefore requires decreased cardiac output and overall lowers blood pressure.5 Chlorthalidone has also been shown to decrease platelet aggregation and vascular permeability, as well as promote angiogenesis in vitro, which is thought to be partly the result of reductions in carbonic anhydrase–dependent pathways. These pathways may play a role in chlorthalidone’s cardiovascular risk reduction effects.7

Target Actions Organism
ASolute carrier family 12 member 1 inhibitor Humans
ACarbonic anhydrase 1 inhibitor Humans

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Learn more Absorption Not Available Volume of distribution

Chlorthalidone has been shown to rapidly concentrate within erythrocytes and subsequently equilibrate via a slow diffusion back into the serum compartment, resulting in a large volume of distribution.6

Protein binding

Approximately 75 percent of the drug is bound to plasma proteins, 58 percent of the drug being bound to albumin.Label This is caused by an increased affinity of the drug to erythrocyte carbonic anhydrase.

Metabolism

Liver

Route of elimination

Approximately 50% of the administered dose is excreted unmetabolized through the kidney, and excretion is characterized by biphasic elimination with a rapid phase followed by a slow secretory phase.6

Half life

40-50 hoursLabel,6

Clearance Not Available Toxicity Not Available Affected organisms

  • Humans and other mammals

Pathways

Pathway Category
Chlorthalidone Action Pathway Drug action

Pharmacogenomic Effects/ADRs Not Available

Interactions

Drug Interactions This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

  • All Drugs
  • Approved
  • Vet approved
  • Nutraceutical
  • Illicit
  • Withdrawn
  • Investigational
  • Experimental
Drug Interaction
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1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic Acid 1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic Acid may decrease the antihypertensive activities of Chlorthalidone.
1-benzylimidazole 1-benzylimidazole may decrease the antihypertensive activities of Chlorthalidone.
1alpha-Hydroxyvitamin D5 The risk or severity of hypokalemia can be increased when 1alpha-Hydroxyvitamin D5 is combined with Chlorthalidone.
1alpha,24S-Dihydroxyvitamin D2 The risk or severity of hypokalemia can be increased when 1alpha,24S-Dihydroxyvitamin D2 is combined with Chlorthalidone.
2,4-thiazolidinedione The therapeutic efficacy of 2,4-thiazolidinedione can be decreased when used in combination with Chlorthalidone.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Chlorthalidone.
2,5-Dimethoxy-4-ethylthioamphetamine 2,5-Dimethoxy-4-ethylthioamphetamine may decrease the antihypertensive activities of Chlorthalidone.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Chlorthalidone.
4-Methoxyamphetamine 4-Methoxyamphetamine may decrease the antihypertensive activities of Chlorthalidone.
5-methoxy-N,N-dimethyltryptamine 5-methoxy-N,N-dimethyltryptamine may decrease the antihypertensive activities of Chlorthalidone.

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Food Interactions

  • Take with food (increases availability).

Synthesis Reference

Graf, W., Schmid, E. and Stoll, W.G.; US Patent 3,055,904; September 25,1962; assigned to Geigy Chemical Corporation.

General References External Links Human Metabolome Database HMDB0014455 KEGG Drug D00272 PubChem Compound 2732 PubChem Substance 46505541 ChemSpider 2631 BindingDB 25900 ChEBI 3654 ChEMBL CHEMBL1055 Therapeutic Targets Database DAP000521 PharmGKB PA448970 RxList RxList Drug Page Drugs.com Drugs.com Drug Page Wikipedia Chlorthalidone ATC Codes G01AE10 — Combinations of sulfonamides

  • G01AE — Sulfonamides
  • G01A — ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
  • G01 — GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
  • G — GENITO URINARY SYSTEM AND SEX HORMONES

C03EA06 — Chlortalidone and potassium-sparing agents

  • C03EA — Low-ceiling diuretics and potassium-sparing agents
  • C03E — DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION
  • C03 — DIURETICS
  • C — CARDIOVASCULAR SYSTEM

C03BB04 — Chlortalidone and potassium

  • C03BB — Sulfonamides and potassium in combination
  • C03B — LOW-CEILING DIURETICS, EXCL. THIAZIDES
  • C03 — DIURETICS
  • C — CARDIOVASCULAR SYSTEM

C03BA04 — Chlortalidone

  • C03BA — Sulfonamides, plain
  • C03B — LOW-CEILING DIURETICS, EXCL. THIAZIDES
  • C03 — DIURETICS
  • C — CARDIOVASCULAR SYSTEM

AHFS Codes

  • 40:28.24 — Thiazide-like Diuretics

FDA label (631 KB)

Clinical Trials

Clinical Trials

Phase Status Purpose Conditions Count
1 Completed Not Available High Blood Pressure (Hypertension) 1
1 Completed Basic Science High Blood Pressure (Hypertension) 2
1 Completed Treatment High Blood Pressure (Hypertension) 2
2 Completed Treatment Cardiovascular Heart Disease / Heart Diseases / High Blood Pressure (Hypertension) / Vascular Diseases 2
2 Completed Treatment High Blood Pressure (Hypertension) 1
2 Recruiting Treatment High Blood Pressure (Hypertension) / Renal Insufficiency,Chronic 1
2 Recruiting Treatment Hypercalciuria / Type 1 Diabetes Mellitus 1
3 Completed Not Available Cardiovascular Heart Disease / Death, Sudden,Cardiac / Heart Arrest / Heart Diseases / High Blood Pressure (Hypertension) 1
3 Completed Prevention Atherosclerosis / Cardiovascular Heart Disease / Coronary Heart Disease (CHD) / Diabetes Mellitus / High Blood Pressure (Hypertension) / High Cholesterol / Type 2 Diabetes Mellitus 1
3 Completed Prevention Cardiovascular Heart Disease / Cerebrovascular Diseases / Heart Diseases / High Blood Pressure (Hypertension) 1
3 Completed Prevention Cardiovascular Heart Disease / Coronary Heart Disease (CHD) / Diabetes Mellitus / Heart Diseases / Heart Failure / High Blood Pressure (Hypertension) / High Cholesterol / Myocardial Infarction / Myocardial Ischemia 1
3 Completed Prevention Cardiovascular Heart Disease / High Blood Pressure (Hypertension) / Pre-Hypertension 1
3 Completed Treatment Cardiovascular Heart Disease / Heart Diseases / High Blood Pressure (Hypertension) 1
3 Completed Treatment Cardiovascular Heart Disease / Heart Diseases / High Blood Pressure (Hypertension) / Vascular Diseases 1
3 Completed Treatment Cardiovascular Heart Disease / High Blood Pressure (Hypertension) 1
3 Completed Treatment High Blood Pressure (Hypertension) 5
3 Completed Treatment High Blood Pressure (Hypertension) / OSAS (Obstructive Sleep Apneas Syndrome) 1
3 Completed Treatment High Blood Pressure (Hypertension) / Sleep Apnea 1
3 Completed Treatment High Blood Pressure (Hypertension) / Transplantation, Kidney 1
3 Completed Treatment Hypertension,Essential 5
3 Completed Treatment Safety 1
3 Not Yet Recruiting Treatment Arterial Hypertension 1
3 Not Yet Recruiting Treatment Essential Arterial Hypertension 1
3 Recruiting Treatment High Blood Pressure (Hypertension) 2
3 Unknown Status Treatment Arterial Hypertension 1
3 Withdrawn Treatment Essential Arterial Hypertension 2
4 Active Not Recruiting Treatment Cardio-Renal Syndrome / Renal Insufficiency,Chronic 1
4 Completed Treatment Chronic Kidney Disease (CKD) / Poorly-Controlled Hypertension 1
4 Completed Treatment High Blood Pressure (Hypertension) 2
4 Completed Treatment Renal Insufficiency,Chronic 1
4 Recruiting Treatment Aortic Valve Insufficiency / Aortic Valve Stenosis / High Blood Pressure (Hypertension) / Left Ventricular Hypertrophy / LVM 1
4 Recruiting Treatment High Blood Pressure (Hypertension) 2
4 Recruiting Treatment Hypertension,Essential 1
4 Terminated Treatment Diabetes / High Blood Pressure (Hypertension) / Stage 2 Hypertension 1
4 Withdrawn Treatment High Blood Pressure (Hypertension) 2
4 Withdrawn Treatment Resistant Hypertension in Kidney Transplant Patients 1
Not Available Active Not Recruiting Treatment High Blood Pressure (Hypertension) 1
Not Available Completed Not Available Cardiovascular Heart Disease / Coronary Heart Disease (CHD) / Heart Diseases / High Blood Pressure (Hypertension) / Myocardial Infarction 1
Not Available Completed Not Available High Blood Pressure (Hypertension) 1
Not Available Completed Not Available High Blood Pressure (Hypertension) / Hypertension,Essential / Resistant Hypertension 1
Not Available Completed Diagnostic High Blood Pressure (Hypertension) 1
Not Available Completed Treatment Ambulatory Blood Pressure Monitoring / Arterial Stiffness 1
Not Available Recruiting Prevention High Blood Pressure (Hypertension) 1
Not Available Recruiting Prevention Kidney Stones 1

Pharmacoeconomics

Manufacturers

  • Abbott laboratories pharmaceutical products div
  • Ascot hosp pharmaceuticals inc div travenol laboratories inc
  • Clonmel healthcare ltd
  • Ivax pharmaceuticals inc
  • Kv pharmaceutical co
  • Mutual pharmaceutical co inc
  • Mylan pharmaceuticals inc
  • Pioneer pharmaceuticals inc
  • Pliva inc
  • Purepac pharmaceutical co
  • Sandoz inc
  • Superpharm corp
  • Teva pharmaceuticals usa inc
  • Usl pharma inc
  • Vangard laboratories inc div midway medical co
  • Warner chilcott div warner lambert co
  • Watson laboratories inc
  • Sanofi aventis us llc
  • Monarch pharmaceuticals inc

Packagers

  • Advanced Pharmaceutical Services Inc.
  • Amerisource Health Services Corp.
  • Apothecon
  • A-S Medication Solutions LLC
  • AstraZeneca Inc.
  • Bryant Ranch Prepack
  • Comprehensive Consultant Services Inc.
  • Dispensing Solutions
  • Diversified Healthcare Services Inc.
  • H and H Laboratories
  • Hl Moore Drug Exchange
  • IPR Pharmaceuticals Inc.
  • Ivax Pharmaceuticals
  • Kaiser Foundation Hospital
  • King Pharmaceuticals Inc.
  • Lake Erie Medical and Surgical Supply
  • Major Pharmaceuticals
  • Medvantx Inc.
  • Merckle GmbH
  • Monarch Pharmacy
  • Murfreesboro Pharmaceutical Nursing Supply
  • Mutual Pharmaceutical Co.
  • Mylan
  • Nucare Pharmaceuticals Inc.
  • Palmetto Pharmaceuticals Inc.
  • PD-Rx Pharmaceuticals Inc.
  • Pharmaceutical Utilization Management Program VA Inc.
  • Physicians Total Care Inc.
  • Pliva Inc.
  • Preferred Pharmaceuticals Inc.
  • Prepak Systems Inc.
  • Qualitest
  • Rebel Distributors Corp.
  • Remedy Repack
  • Sandhills Packaging Inc.
  • Southwood Pharmaceuticals
  • Stat Scripts LLC
  • UDL Laboratories
  • Watson Pharmaceuticals

Dosage forms

Form Route Strength
Tablet Oral
Tablet Oral 25 1/1
Tablet Oral 25 mg/1
Tablet Oral 50 mg
Tablet Oral 50 1/1
Tablet Oral 50 mg/1
Tablet Oral
Tablet Oral 15 mg/1

Prices

Unit description Cost Unit
Tenoretic 100 100-25 mg tablet 2.91USD tablet
Tenoretic 100 tablet 2.91USD tablet
Tenoretic 50 50-25 mg tablet 2.18USD tablet
Tenoretic 50 tablet 2.07USD tablet
Thalitone 15 mg tablet 1.55USD tablet
Chlorthalidone 100 mg tablet 1.07USD tablet
Chlorthalidone 50 mg tablet 0.46USD tablet
Chlorthalidone 25 mg tablet 0.28USD tablet
Apo-Chlorthalidone 50 mg Tablet 0.13USD tablet

DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only. Patents Additional Data Available

  • Filed On Filed On

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Properties

State Solid Experimental Properties Predicted Properties

Property Value Source
Water Solubility 0.0528 mg/mL ALOGPS
logP 1.27 ALOGPS
logP 1.6 ChemAxon
logS -3.8 ALOGPS
pKa (Strongest Acidic) 8.76 ChemAxon
pKa (Strongest Basic) -2.6 ChemAxon
Physiological Charge 0 ChemAxon
Hydrogen Acceptor Count 4 ChemAxon
Hydrogen Donor Count 3 ChemAxon
Polar Surface Area 109.49 Å2 ChemAxon
Rotatable Bond Count 2 ChemAxon
Refractivity 81.3 m3·mol-1 ChemAxon
Polarizability 31.29 Å3 ChemAxon
Number of Rings 3 ChemAxon
Bioavailability 1 ChemAxon
Rule of Five Yes ChemAxon
Ghose Filter Yes ChemAxon
Veber’s Rule No ChemAxon
MDDR-like Rule No ChemAxon

Predicted ADMET features

Property Value Probability
Human Intestinal Absorption + 1.0
Blood Brain Barrier + 0.5447
Caco-2 permeable 0.6272
P-glycoprotein substrate Non-substrate 0.767
P-glycoprotein inhibitor I Non-inhibitor 0.9603
P-glycoprotein inhibitor II Non-inhibitor 0.9573
Renal organic cation transporter Non-inhibitor 0.891
CYP450 2C9 substrate Non-substrate 0.6403
CYP450 2D6 substrate Non-substrate 0.822
CYP450 3A4 substrate Non-substrate 0.6369
CYP450 1A2 substrate Non-inhibitor 0.9046
CYP450 2C9 inhibitor Non-inhibitor 0.9071
CYP450 2D6 inhibitor Non-inhibitor 0.9231
CYP450 2C19 inhibitor Non-inhibitor 0.9025
CYP450 3A4 inhibitor Non-inhibitor 0.9299
CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.8193
Ames test Non AMES toxic 0.7277
Carcinogenicity Non-carcinogens 0.5752
Biodegradation Not ready biodegradable 1.0
Rat acute toxicity 1.8623 LD50, mol/kg Not applicable
hERG inhibition (predictor I) Weak inhibitor 0.9968
hERG inhibition (predictor II) Non-inhibitor 0.8914

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST) Not Available Spectra

Taxonomy

Description This compound belongs to the class of organic compounds known as isoindolones. These are aromatic polycyclic compounds that an isoindole bearing a ketone. Kingdom Organic compounds Super Class Organoheterocyclic compounds Class Isoindoles and derivatives Sub Class Isoindolines Direct Parent Isoindolones Alternative Parents Benzenesulfonamides / Benzenesulfonyl compounds / Isoindoles / Chlorobenzenes / Aryl chlorides / Organosulfonamides / Aminosulfonyl compounds / Lactams / Secondary carboxylic acid amides / AlkanolaminesAzacyclic compounds / Organooxygen compounds / Organochlorides / Organic oxides / Hydrocarbon derivatives / Organopnictogen compounds show 6 more Substituents Benzenesulfonamide / Isoindolone / Isoindole / Benzenesulfonyl group / Chlorobenzene / Halobenzene / Aryl chloride / Aryl halide / Monocyclic benzene moiety / Organosulfonic acid amideBenzenoid / Organosulfonic acid or derivatives / Organic sulfonic acid or derivatives / Aminosulfonyl compound / Sulfonyl / Secondary carboxylic acid amide / Carboxamide group / Lactam / Azacycle / Alkanolamine / Carboxylic acid derivative / Organosulfur compound / Organic oxide / Organopnictogen compound / Organic oxygen compound / Hydrocarbon derivative / Organohalogen compound / Organic nitrogen compound / Organochloride / Organonitrogen compound / Organooxygen compound / Aromatic heteropolycyclic compound show 22 more Molecular Framework Aromatic heteropolycyclic compounds External Descriptors sulfonamide, monochlorobenzenes, isoindoles (CHEBI:3654)

Targets

Kind Protein Organism Humans Pharmacological action Yes Actions Inhibitor General Function Sodium:potassium:chloride symporter activity Specific Function Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. Gene Name SLC12A1 Uniprot ID Q13621 Uniprot Name Solute carrier family 12 member 1 Molecular Weight 121449.13 Da Kind Protein Organism Humans Pharmacological action Yes Actions Inhibitor General Function Zinc ion binding Specific Function Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea. Gene Name CA1 Uniprot ID P00915 Uniprot Name Carbonic anhydrase 1 Molecular Weight 28870.0 Da

Carriers

Details1. Serum albumin Kind Protein Organism Humans Pharmacological action No General Function Toxic substance binding Specific Function Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid… Gene Name ALB Uniprot ID P02768 Uniprot Name Serum albumin Molecular Weight 69365.94 Da ×Unlock Data

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Drug created on June 13, 2005 07:24 / Updated on February 02, 2020 00:12

Generic Name: chlorthalidone (klor THAL i done)
Brand Name: Hygroton, Thalitone

Medically reviewed by Drugs.com on Oct 11, 2019 – Written by Cerner Multum

  • Overview
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What is chlorthalidone?

Chlorthalidone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Chlorthalidone treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or kidney disorders, or edema caused by taking steroids or estrogen.

Chlorthalidone is also used to treat high blood pressure (hypertension).

Chlorthalidone may also be used for purposes not listed in this medication guide.

Important Information

You should not use chlorthalidone if you are unable to urinate, or if you are allergic to sulfa drugs.

Before taking this medicine

You should not use chlorthalidone if you are allergic to it, or if:

  • you are unable to urinate; or

  • you are allergic to sulfa drugs.

Tell your doctor if you have ever had:

  • kidney disease;

  • heart failure;

  • gout;

  • high cholesterol or triglycerides;

  • diabetes; or

  • if you are on a low-salt diet.

Tell your doctor if you are pregnant or plan to become pregnant. Taking chlorthalidone during pregnancy may cause side effects in the newborn baby, such as jaundice (yellowing of the skin or eyes), bruising or bleeding, low blood sugar, or an electrolyte imbalance.

Do not start or stop taking chlorthalidone during pregnancy without your doctor’s advice. Although chlorthalidone may cause side effects in a newborn, having high blood pressure during pregnancy can cause complications such as diabetes or eclampsia (dangerously high blood pressure that can lead to medical problems in both mother and baby). The benefit of treating hypertension may outweigh any risks to the baby.

You should not breastfeed while using chlorthalidone.

How should I take chlorthalidone?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking chlorthalidone. This can lead to very low blood pressure, a serious electrolyte imbalance, or kidney failure.

Your blood pressure will need to be checked often. Your blood and urine may both be tested if you have been vomiting or are dehydrated.

chlorthalidone can affect the results of certain medical tests. Tell any doctor who treats you that you are using chlorthalidone.

If you need surgery, tell your surgeon you currently use this medicine.

If you have high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.

Store this medicine at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, weakness, dizziness, drowsiness, extreme thirst, muscle pain, or rapid heartbeats.

What should I avoid while taking chlorthalidone?

Drinking alcohol with chlorthalidone can cause side effects.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor’s instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Chlorthalidone side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;

  • low sodium–headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady;

  • low potassium–leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling;

  • low magnesium–dizziness, irregular heartbeats, feeling jittery, muscle cramps, muscle spasms, cough or choking feeling; or

  • kidney problems–little or no urination, swelling in your feet or ankles, feeling tired or short of breath.

Common side effects may include:

  • low blood pressure (feeling light-headed);

  • kidney problems;

  • dizziness; or

  • an electrolyte imbalance (such as low levels of potassium, sodium, or magnesium in your blood).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Chlorthalidone dosing information

Usual Adult Dose for Hypertension:

-Initial dose: 25 mg orally once a day
-Titration: Increase to 50 mg orally once a day if response is inadequate; if response is still inadequate, increase to 100 mg orally once a day, or a second antihypertensive drug (step 2 therapy) may be added
-Maintenance dose: 25 to 100 mg orally once a day
-Maximum dose: 100 mg orally once a day

-Doses should be taken in the morning with food.
-Maintenance doses may be lower than initial doses and should be adjusted according to individual patient response.
-Effectiveness is well sustained during continued use.
Use: Hypertension (alone or with another antihypertensive drug)

Usual Adult Dose for Edema:

-Initial dose: 50 to 100 mg orally once a day, or 100 mg orally every other day; some patients may require 150 to 200 mg orally at these intervals
-Maximum dose: 200 mg orally once a day

-Doses should be taken in the morning with food.
-Maintenance doses may be lower than initial doses and should be adjusted according to individual patient response.
-Effectiveness is well sustained during continued use.
Use: For edema due to various forms of renal dysfunction, such as nephrotic syndrome, acute glomerulonephritis, and chronic renal failure

What other drugs will affect chlorthalidone?

Using chlorthalidone with other drugs that make you light-headed can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your other medicines, especially:

  • other blood pressure medications;

  • lithium;

  • digoxin, digitalis;

  • insulin or oral diabetes medicine; or

  • steroid medicine.

This list is not complete. Other drugs may affect chlorthalidone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2018 Cerner Multum, Inc. Version: 7.01.

Medical Disclaimer

More about chlorthalidone

  • Side Effects
  • During Pregnancy or Breastfeeding
  • Dosage Information
  • Drug Images
  • Drug Interactions
  • Pricing & Coupons
  • En Español
  • 20 Reviews
  • Drug class: thiazide diuretics

Consumer resources

  • Chlorthalidone
  • Chlorthalidone (Advanced Reading)

Other brands: Thalitone

Professional resources

  • Chlorthalidone (AHFS Monograph)
  • … +2 more

Related treatment guides

  • High Blood Pressure
  • Edema
What is this medication?

Diuretics are also called “water pills.” They are usually taken with other medications.

Diuretics include:

  • Chlorthalidone
  • Ethacrynic acid (Edecrin®)
  • Furosemide (Lasix®)
  • Hydrochlorothiazide
  • Indapamide (Lozide®)
  • Metolazone (Zaroxolyn®)

Be aware:

  • Generic names are listed first.
  • Canadian brand names are in brackets.
  • This list doesn’t include every brand name.
  • If your prescription isn’t listed, your pharmacist is the best source for more information.
What does it do?

These drugs treat high blood pressure and heart failure. They do it by helping your kidneys produce more urine.

  • The more you pee, the more excess salt and water you flush out of your body.
  • Without the extra fluid, it’s easier for your heart to pump.

Key facts about diuretics:

  • Lower your blood pressure.
  • Can relieve shortness of breath.
  • Reduce swelling and bloating.
  • Make you pee more often.
  • Reduce the time you spend in hospital.
  • Help you to live longer with heart failure.
How do I take it?

Take your diuretic exactly as prescribed.

  • Take it at least six hours before bedtime to help avoid getting up in the night.
Are there any interactions?

Some medications can stop your heart medicine from working properly. They may even cause other health problems.

Water pills can affect your routine. If you take a diuretic:

  • Your kidneys will make more urine (pee). You will need to use the bathroom more often.
    • To avoid getting up at night, take your medication at least six hours before bedtime.
  • Limit your salt.
  • Do not use salt substitutes without first talking to your healthcare provider or pharmacist.
    • Ask if you should restrict your fluids.
  • Some diuretics can cause you to lose potassium.
    • Ask your pharmacist if you should eat foods rich in potassium or take a potassium supplement.
    • If you are on other medications that retain potassium, you may not need extra potassium.
  • You may be asked to weigh yourself every day or two.
    • Rapid weight gain can be a sign of water retention.

Be aware: Furosemide may cause your skin to be more sensitive to sunlight. Protect yourself from sunburn.

Always tell your healthcare provider or pharmacist about any other medications you are taking. These include:

  • Prescriptions
  • Non-prescription drugs
  • Inhalers
  • Creams or ointments
  • Over-the-counter or natural health products
  • Alternative therapies
  • Vitamins, minerals or supplements
  • Herbal remedies
  • Homeopathic medicines
  • Traditional remedies, such as Chinese medicines
  • Probiotics
  • Amino acids or essential fatty acids
Are there any side effects?

Most people have no problem with diuretics.

Call your healthcare provider or pharmacist if you experience:

  • Dehydration
    • Not enough pee
    • Dry mouth
    • Decreased skin “springiness”
    • Muscle cramps
    • Weakness
    • Fever, sore throat or skin rash
  • Dizziness
    • If you feel dizzy or faint, limit how much alcohol you drink.
  • Upset stomach

If you have side effects, talk to your pharmacist or healthcare provider.

Lifestyle changes that can also help

There are two ways to control and manage your heart health: medication and lifestyle.

Medication can help you control heart disease and high blood pressure, but it cannot cure it.

A healthy lifestyle can help you keep medication to a minimum.

Visit heartandstroke.ca/get-healthy. Learn how to keep your heart healthy with current information and advice from Heart and Stroke Foundation experts.

Talk to your healthcare provider about the most beneficial lifestyle goals for you.

Related information

Your healthcare provider or pharmacist are your best sources of information. You can also learn more about medications at any of these trusted sites.

Health Canada – Drugs and Health Products
Provides health and medical information for Canadians to maintain and improve their health.

Learn more about:

  • Safe Use of Medicines
  • Safety and Effectiveness of Generic Drugs
  • Buying drugs over the Internet
  • Drug Product Database
  • MedEffect Canada
    Provides safety alerts, public health advisories, warnings and recalls.

Your ministry of health also offers health resources in your province or territory. For example, Ontario’s MedsCheck program provides free pharmacist consultations. And British Columbia’s Senior Healthcare web page provides information about important health programs.

Drug coverage

Chlorthalidone Prescription Online

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Chlorthalidone (Thalitone) – Overview

Chlorthalidone is a long-acting oral diuretic medication. People in need of a chlorthalidone prescription can connect with a medical provider through Push Health who can prescribe chlorthalidone when appropriate to do so.

Chlorthalidone – Mechanism of Action

Chlorthalidone, marketed under the name Thalitone, is a diuretic medication used in the management of high blood pressure alone or with other medications and in the management of edema. Chlorthalidone increases the excretion of chloride and sodium from the distal convulted tubule of the nephron. Chlorthalidone can also reduce the potassium level in the serum and increase glucose and uric acid levels. Like other diuretic medications such as furosemide (Lasix), hydrochlorothiazide and spironolactone, chlorthalidone ultimately leads to an increased production of urine.

Chlorthalidone – Dosage and Cost

Thalitone (chlorthalidone) tablets are available as chlorthalidone 15 mg and chlorthalidone 25 mg tablets. Chlorthalidone does not dissolve in water. As a diuretic, chlorthalidone exhibits diuretic effects up to 3 days after oral administration. Most chlorthalidone is excreted in the urine and the half-life in the plasma is up to 60 hours with the majority of the drug bound to proteins. Chlorthalidone is moderately affordable at 50 cents per chlorthalidone 25 mg tablet and chlorthalidone coupons may be available online from the manufacturer or other sources. The cost of chlorthalidone tablets may also be covered by one’s insurance plan.

Can I Buy Chlorthalidone Online?

Chlorthalidone is a prescription medication in the US and one cannot just buy chlorthalidone online as a result. Additionally, chlorthalidone is not available over-the-counter (OTC). People in need of a chlorthalidone prescription can connect with a medical provider on Push Health who can prescribe chlorthalidone if safe and appropriate to do so.

Chlorthalidone – Side Effects

Chlorthalidone, like other medications, can cause side effects. Side effects that can occur from chlorthalidone use include nausea, vomiting, diarrhea, jaundice, and stomach pain. Chlorthalidone should generally not be used in people with kidney and liver disease. Chlorthalidone should not be used by people who have a known hypersensitivity or allergy chlorthalidone or other sulfonamide-derived drugs. Chlorthalidone should not be used by people who do not produce urine. People planning on taking chlorthalidone should discuss possible side effects with their medical provider and pharmacist.

More Chlorthalidone Information

Last updated December 2, 2019. Given the evolving nature of medicine and science, this information might not be accurate and should not be construed as medical advice or diagnosis / treatment recommendations. Please consult a licensed medical provider if you have additional questions.

If your blood pressure is too high, you could be at risk for heart disease, stroke, and kidney failure. Hydrochlorothiazide (HCTZ) is one of the most commonly prescribed generic medications to lower blood pressure and protect people from these issues, but it turns out there’s an alternative that might be more effective—chlorthalidone.

Hydrochlorothiazide (HCTZ) and chlorthalidone are both thiazide diuretics recommended as first-choice options for treating high blood pressure because of their benefits on heart health and overall death rates.

So, which one is better? Let’s look at the evidence.

  • Chlorthalidone is better at lowering blood pressure. Research shows that chlorthalidone lowers blood pressure better than HCTZ—both when the heart pumps (systolic blood pressure) and when the heart relaxes (diastolic blood pressure). In a blood pressure reading (like 120/80), systolic blood pressure is the top number (120) and diastolic blood pressure is the bottom number (80).
  • Chlorthalidone is better at lowering the risk of a cardiovascular event, such as a heart attack. Even after chlorthalidone and HCTZ achieve the same blood pressure, chlorthalidone lowers the risk of a cardiovascular event by about 20% more than HCTZ.
  • Chlorthalidone reduces the size of the left ventricle wall more than HCTZ does. In simple terms, the left ventricle is the pumping chamber of the heart, so when that chamber is working hard against high blood pressures, the muscles there can become thick and stiff (known as left ventricular hypertrophy or LVH). LVH, which occurs in about 40% of patients with high blood pressure, may lead to heart failure and increases your risk for death. Chlorthalidone appears to reduce LVH more than HCTZ does, which is a great thing.

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  • Chlorthalidone has a longer duration of action. Chlorthalidone is the preferred diuretic of the American College of Cardiology because of its long duration of action (48-72 hours) and proven ability to reduce heart disease risk. The duration of action with HCTZ is short (up to only 12 hours), which means in theory, there may be portions of the day your blood pressure isn’t covered by HCTZ, whereas it would be with chlorthalidone. Many believe this is the reason chlorthalidone produces better outcomes.
  • Both drugs have similar effects on blood sugar, cholesterol, potassium, and sodium levels. Any diuretic, including HCTZ and chlorthalidone, lowers potassium levels in your blood by making you release more potassium in your urine. This can cause side effects like fatigue, muscle spasms, and abnormal heart rhythms. Some studies show that chlorthalidone lowers potassium more than HCTZ does, but the bulk of the evidence shows that both drugs cause hypokalemia (low potassium), hyponatremia (low sodium), and any changes in blood sugar and cholesterol with the same frequency. A quick set of blood tests with your doctor is required for either drug a few weeks after you start it.
  • HCTZ is available in more combination pill options. One of the main reasons HCTZ has remained so popular—despite being second to chlorthalidone in effectiveness—is its availability in different combination pills. For convenience, diuretics are sometimes paired with another hypertension medicine (an angiotensin II receptor blocker or ARB) in the same pill. With chlorthalidone, only one type of these pills exists and it’s expensive: Edarbyclor (azilsartan medoxomil/chlorthalidone). HCTZ comes in many combinations including Atacand HCT, Benicar HCT, Diovan HCT, losartan/HCTZ, and olmesartan/HCTZ.

HCTZ and chlorthalidone are both safe and cheap first-line blood pressure medications, but the evidence is clear—chlorthalidone is better.

Dr O.

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