Cefpodoxime proxetil side effects

Contents

Cepodem 200 MG Tablet: Uses, Side Effects, Composition, Dosages & Price

Cepodem 200 MG Tablet is an antibiotic that is often used in the short-term treatment of bacterial infections. It is used to prevent post-surgery wound infection, bacterial infections of the genitourinary tract, skin, and soft tissue, blood and others. It is manufactured by Ranbaxy Laboratories Ltd.

Nature Antibiotic
Composition Cefpodoxime
Uses Sinusitis, Gonococcal infection, Acute exacerbations of chronic bronchitis, Pneumonia, and Tonsilitis/ Pharyngitis.
Side effects Diarrhea, Headache, Nausea, Stomach Pain, Loss of appetite, Fungal skin rash, Blurred vision, Excessive gas in the stomach, Change in taste, Change in color/ odor of vaginal discharge, Joint Pain, Acid or sour stomach, and Dark or Clay-colored stools.
Precautions Dizziness and Allergic reactions

Uses and Benefits of Cepodem 200 MG Tablet:

Cepodem 200 MG Tablet can be used in the treatment of the following conditions:

  • Pneumonia
  • Sinusitis
  • Cystitis
  • Gonococcal Infection
  • Pharyngitis/Tonsilitis
  • Acute exacerbations of chronic bronchitis

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Side Effects of Cepodem 200 MG Tablet:

Cepodem 200 MG Tablet may also interact with some substances or medical conditions and exhibit certain side effects. Some of the side effects of Cepodem 200 MG Tablet:

  • Diarrhea
  • Abdominal pain
  • Dark or Clay-colored stools
  • Dizziness
  • Excessive air or gas in the stomach
  • Heartburn
  • Indigestion
  • Redness of skin
  • Acid or sour stomach
  • Swelling of face, eyelids, lips, tongue, hands, and feet

Some side effects are very rare in occurrence. However, do not hesitate to consult your gynecologist in case the patients feel any of the above-mentioned symptoms while taking the drug or any other unusual symptoms that are not listed above. Women consuming this medicine for longer duration are more susceptible to experience side effects.

Read More: HCQS 200 Side Effects | Rablet 20 Side Effects

Common Dosage of Cepodem 200 MG Tablet:

The dosage of Cepodem 200 MG Tablet is based on the following factors:

  • Reaction to the first dose
  • History of drug reaction/ allergy
  • Severity of disease
  • A medical condition of the patient/ health history

In case if the symptoms get worst, it is advised to seek immediate medical attention.

Cepodem 200 MG Tablet should be taken at a fixed time and for the duration prescribed by the doctor. The tablet has to be swallowed whole, and should not be broken, crushed or chewed. It is advised to continue the prescribed course of the medicine and not to stop it once the patient feels better.

It is advisable that the tablet should be consumed after meals. It is likely to be consumed in intervals of 12 hours.

  • Missed Dose : If the patient missed the dose of Cepodem 200 MG Tablet, it is advisable to take it as soon as the patient remembers. But if it’s already time to take the next dose, skip the missed dose and take the medicine as per scheduled dosage.
  • Overdose : In case the patient overdosed the medicine, it is advised to seek immediate medical attention.

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Composition and Nature of Cepodem 200 MG Tablet:

The active ingredient in Cepodem (200 mg) tablet is Cefpodoxime (200mg).

Warnings and Precautions – When to Avoid Cepodem 200 MG Tablet?

Patients who are using Cepodem 200 MG Tablet should take care to note the following precautions before use:

  • If the patient is allergic to any ingredients of Cepodem 200 MG Tablet, then it is important to inform the doctor immediately.
  • Patients should refrain from consuming alcohol while taking Cepodem 200 MG Tablet.
  • Cepodem 200 MG Tablet is safe to consume for women who are pregnant, planning to get pregnant, or breastfeeding.
  • Driving after taking Cepodem 200 MG Tablet is not advice, as it could reduce alertness and cause dizziness. As an extension, the use of heavy machinery should also be avoided for the same reasons.
  • People with kidney problems and liver-related ailments must exercise caution while administering Cepodem 200 MG Tablet. It is advisable to consult a doctor before administering the medicine for an appropriate alternative or dose adjustment if needed.
  • Patients who develop bloody or watery diarrhea should contact the doctor immediately.
  • Patients co-administering antacids and Cepodem 200 MG Tablet are generally advised to keep a gap of at least 2 hours between the doses of the two medicines for maximum efficacy.

Substitutes for Cepodem 200 MG Tablet:

Listed below are the variously available substitutes of Cepodem 200 MG Tablet:

  • Mahapod Tablet manufactured by Mankind Pharmaceuticals Ltd
  • Nupod Tablet manufactured by Abbott Healthcare Pvt. Ltd
  • Podocip Tablet manufactured by Cipla Ltd
  • Finecef 200mg Tablet manufactured by 10s Abbott India
  • Nupod-200mg Tab 10s manufactured by Abbott India
  • Cefective 200 MG Tablet manufactured by Merck Consumer Healthcare Ltd.
  • Cefpotas 200 MG Tablet manufactured by Intas Pharmaceuticals Ltd.
  • Cepotil 200 MG Tablet manufactured by Orchid Chemicals & Pharmaceuticals Ltd.
  • Metoxim 200mg Tablet 10s manufactured by Novartis India
  • Alpoxime 200 MG Tablet manufactured by Alembic Ltd.
  • Zipod 200 MG Tablet manufactured by Fdc Ltd

Cepodem 200 MG Tablet Interactions with Other Drugs:

Interaction with Alcohol

It is not recommended to consume alcohol while administering Cepodem 200 MG Tablet as it may cause adverse effects.

Interactions with Diseases

  • Colitis : Patients who have been prescribed to administer Cepodem 200 MG Tablet are advised to inform the doctor in case they are suffering from any pre-existing gastrointestinal ailments. Regular monitoring of certain body functions may be advised by the doctor.
  • Renal Diseases: Patients suffering from pre-existing kidney related ailments or having a family history of kidney diseases are advised to use the medicine with extreme caution. The doctor may prescribe regular monitoring of the kidney function during the course of the drug. It is advisable to consult a doctor before starting a dose of the medicine.

Interactions with Lab Test

  • Urine ketones test: The patient should inform the doctor if they are advised to undergo a Urine ketones test while administering Cepodem 200 MG Tablet as it may result in getting falsified test results.

Interaction with Medicines

  • Ethinyl Estradiol : Ethinyl Estradiol is a contraceptive pill that may not be effective if consumed alongside Cepodem 200 MG Tablet. It is advisable to consult a doctor for case-specific recommendations.
  • Amikacin and Furosemide : The patient may experience nausea, vomiting, edema, sudden weight gain, increased or decreased urination, and weakness when administering along with Cepodem 200 MG Tablet. The doctor may prescribe regular monitoring of the kidney function in such a case.
  • Chloramphenicol : Concurrent use of Cepodem 200 MG Tablet with Chloramphenicol may lead to reduced efficacy of both the drugs.
  • Nifedipine : Nifedipine increases the absorption of Cepodem 200 MG Tablet in the body, which exposes the patient to a number of side-effects. A doctor should be consulted for appropriate dosage instructions.

Cepodem 200 MG Tablet Price in India:

Quantity of medicine Price (INR)
10 Tablets in a strip 152.25

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How does Cepodem 200 MG Tablet work?

The active ingredient in Cepodem 200 MG Tablet is Cefpodoxime is an antibacterial that works by preventing the growth of bacteria by forming a bacterial protective wall.

How to Use Cepodem 200 MG Tablet?

It is advisable to take Cepodem 200 MG Tablet after having a meal. Don’t chew, break or crush the tablet. It is suggested to take the medicine as per the dosage and timing prescribed by the doctor.

When Cepodem 200 MG Tablet is prescribed?

Cepodem 200 MG Tablet is generally prescribed to treat, control and prevent the following conditions:

  • Urinary tract infection: Cepodem 200 MG Tablet is known to be very effective in treating urinary tract infections caused by E.coli, Enterococci, and Klebsiella pneumonia or Pseudomonas aeruginosa. It is advisable to consult a doctor for appropriate dose and duration instructions.
  • Bronchitis: Bronchitis is caused by bacterial infections such as Haemophilus influenza, Streptococcus pneumonia, or Mycoplasma pneumoniae. Cepodem 200 MG Tablet effectively treats the symptoms associated with this condition.
  • Gonococcal Infection: Gonococcal infection caused by Neisseria gonorrhea can be treated effectively by administering Cepodem 200 MG Tablet.
  • Tonsilitis/Pharyngitis: The medicine is used for the treatment of Tonsilitis/Pharyngitis caused due to Haemophilus influenza, Streptococcus pneumoniae, or some fungal infections.
  • Ear Infection (Otitis Media): Otitis media is generally caused by Pseudomonas aeruginosa, Streptococcus pneumoniae, E.coli, and Klebsiella pneumonia. Cepodem 200 MG Tablet is used for the treatment of symptoms associated with this condition. It is advisable to consult a doctor for case-specific dose and duration instructions.

Cepodem 200 MG Tablet Suspension form:

Cepodem 200 MG Tablet is also available in the form of oral suspension. It is a board spectrum antibiotic used to treat a variety of infections. The active ingredient of the oral suspension is Cefpodoxime.

Medicine that should not be taken with Cepodem 200 MG Tablet:

Listed below medicines are not recommended to be taken with Cepodem 200 MG Tablet:

  • Amikacin and Furosemide : The patient may experience nausea, vomiting, edema, sudden weight gain, increased or decreased urination, and weakness when administering along with Cepodem 200 MG Tablet. The doctor may prescribe regular monitoring of the kidney function in such a case.
  • Ethinyl Estradiol : Ethinyl Estradiol is a contraceptive pill that may not be effective if consumed alongside Cepodem 200 MG Tablet. It is advisable to consult a doctor for case-specific recommendations.
  • Nifedipine : Nifedipine increases the absorption of Cepodem 200 MG Tablet in the body, which exposes the patient to a number of side-effects. A doctor should be consulted for appropriate dosage instructions.
  • Chloramphenicol : Concurrent use of Cepodem 200 MG Tablet with Chloramphenicol may lead to reduced efficacy of both the drugs.

How to Store Cepodem 200 MG Tablet?

  • Cepodem 200 MG Tablet is advised to store the medicine in a cool and dry place.
  • Cepodem 200 MG Tablet is not recommended to freeze or refrigerate the tablet.
  • Cepodem 200 MG Tablet should be kept away from the reach of the children and pets.

FAQ’s

1) What is Cepodem 200 used to treat?

Ans: Cepodem 200 Tablet is mainly used to treat, control, prevent and improve symptoms associated with bacterial infections such as ear infection, urinary tract infection, throat infection, Tonsilitis etc.

2) Is Cepodem 200 mg Tablet safe for consumption?

Ans: Cepodem 200 MG Tablet is a broad spectrum antibiotic that is safe to use if taken in the exact dosage and duration as prescribed by a medical practitioner.

3) Is Cepodem 200 MG Tablet available as an over- the counter medicine?

Ans: Cepodem 200 MG Tablet is a prescription- only medicine that can only be purchased post getting a prescription from a doctor. It is not available for purchase over- the- counter.

4) What is Cepodem 200 mg Tablet used for?

Ans: This medicine is mainly used for relieving symptoms associated with bacterial infections such as urinary tract infections, ear and throat infections, Tonsilitis etc.

5) What are the side effects associated with administering Cepodem 200 mg Tablet?

Ans: A few of the most commonly occurring side effects associated with the consumption of Cepodem 200 mg Tablet are nausea, dizziness, abdominal pain, dry mouth, skin allergy, nervousness, and blurred vision. Different patients may experience different side effects depending on their medical condition.

6) Is it safe to drive or operate heavy machinery post administering Cepodem 200?

Ans: Cepodem 200 is an antibacterial medicine and may cause drowsiness and sleepiness in some patients. Thus, it is advised to avoid driving or operating heavy machinery while administering the drug if such side effects are being experienced.

7) Can Cepodem 200 mg Tablet be used to treat diarrhea?

Ans: Cepodem 200 mg Tablet is generally prescribed to illnesses caused due to bacterial infections. Diarrhea caused due to bacterial infections can be treated by the use of this medicine.

8) Does Cepodem 200 mg Tablet help in relieving menstrual cramps?

Ans: No. Cepodem 200 MG Tablet is an antibacterial drug that does not help in getting relief from menstrual cramps.

9) Does Cepodem 200 mg Tablet help in getting relief from symptoms associated with flu?

Ans: Cepodem 200 MG Tablet is only used for relieving infections caused due to bacteria. Flu is a condition caused due to viral infection and thus cannot be treated by using this drug.

10) Can I consume over- the- counter Esomeprazole along with Cepodem 200 mg Tablet?

Ans: It is not recommended to administer over- the- counter Esomeprazole along with Cepodem 200 MG Tablet. This is because Esomeprazole makes Cepodem 200 MG Tablet less effective by reducing the amount of the drug being absorbed by the body. Unless prescribed by a doctor, the interaction of these two drugs must be avoided.

11) Can Cepodem 200 mg Tablet be administered by pregnant females?

Ans: Cepodem 200 MG Tablet is a prescription- only medicine that must only be used post consultation from a doctor. It is generally advised for pregnant females to avoid administering this drug. If it is absolutely necessary for the pregnant female to administer this medicine, doctor consultation is very important.

12) Can lactating mothers administer Cepodem 200 mg Tablet?

Ans: No. Cepodem 200 MG Tablet is not commonly advised to lactating mothers as it has the tendency to pass through the breast milk in large amounts. This can lead to adverse side effects on the health of the infant. A doctor must be consulted before administering this medicine.

13) Can I consume alcohol while administering Cepodem 200 mg Tablet?

Ans: It is not recommended to consume alcohol while taking a dosage of Cepodem 200 mg Tablet. This is because alcohol has the tendency to cause excessive drowsiness in the patient if being taken alongside Cepodem 200 which itself has a tendency of causing lethargy and sleepiness in some cases.

14) How much time does a dose of Cepodem 200 mg Tablet take to show effect?

Ans: Cepodem 200 MG Tablet generally shows its effect within 2-3 hours of oral administration.

15) Should I take Cepodem 200 mg Tablet before or after a meal?

Ans: It is generally advised to administer Cepodem 200 mg Tablet after having a meal for maximum efficacy and increased absorption.

16) Can I stop taking the medicine promptly or should I slowly ween off its consumption?

Ans: It is advised to consult a doctor for dosage suggestions as per health history and condition, as stopping or starting the medicine promptly can cause adverse side effects.

17) What is the normally prescribed dosage for Cepodem 200 mg Tablet?

Ans: The generally prescribed dosage for Cepodem 200 Tablet is 1-2 tablets per day. The dosage may be altered depending on the severity of the patient’s condition.

18) Is Cepodem 200 mg Tablet addictive in nature?

Ans: No, the medicine is not known to be addictive in nature. All addictive drugs in India are classified as schedule X or H. It is advised to read the packaging label of the drug carefully for all the related information.

19) What will happen if I accidentally have an expired dose of Cepodem 200 mg Tablet?

Ans: Although there are no reported side effects of consuming an expired dose of Cepodem 200 mg Tablet, the efficacy of the drug may be hampered.

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Generic Name: cefpodoxime (SEF poe DOX eem)
Brand Name: Vantin

Medically reviewed by Drugs.com on Oct 30, 2019 – Written by Cerner Multum

  • Overview
  • Side Effects
  • Dosage
  • Professional
  • Interactions
  • More

What is cefpodoxime?

Cefpodoxime is a cephalosporin (SEF a low spor in) antibiotic. It works by fighting bacteria in your body.

Cefpodoxime is used to treat infections caused by bacteria, including upper respiratory infections, ear infections, skin infections, and urinary tract infections.

Cefpodoxime may also be used for purposes not listed in this medication guide.

Important Information

You should not use cefpodoxime if you are allergic to cefpodoxime or to similar antibiotics, such as Ceftin, Cefzil, Omnicef, and others. Tell your doctor if you are allergic to any drugs, especially penicillins or other antibiotics.

Before taking this medicine

You should not use this medicine if you are allergic to cefpodoxime or to other cephalosporin antibiotics, such as:

To make sure cefpodoxime is safe for you, tell your doctor if you have ever had:

  • kidney disease; or

  • an allergy to any drugs (especially penicillins).

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

Cefpodoxime can pass into breast milk and may affect the nursing baby. Tell your doctor if you are breast-feeding.

Cefpodoxime should not be given to a child younger than 2 months old.

How should I take cefpodoxime?

Follow all directions on your prescription label. Do not take cefpodoxime in larger or smaller amounts or for longer than recommended.

The cefpodoxime tablet should be taken with food.

Cefpodoxime oral suspension (liquid) can be taken with or without food.

Shake the liquid well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Cefpodoxime can cause you to have false results with certain medical tests, including urine glucose (sugar) tests. Tell any doctor who treats you that you are using cefpodoxime.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Cefpodoxime will not treat a viral infection such as the flu or a common cold.

Store the tablets at room temperature away from moisture, heat, and light.

Store the liquid medicine in a tightly-closed bottle in the refrigerator. Do not freeze. Throw away any unused liquid after 14 days.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, stomach pain, and diarrhea.

What should I avoid while taking cefpodoxime?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Ask your doctor before using an antacid, and use only the type your doctor recommends. Some antacids can make it harder for your body to absorb cefpodoxime.

Cefpodoxime side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;

  • fever, swollen glands, rash or itching, joint pain, or general ill feeling;

  • pounding heartbeats or fluttering in your chest;

  • shortness of breath; or

  • a seizure.

Common side effects may include:

  • vaginal itching or discharge;

  • diaper rash in an infant using cefpodoxime;

  • nausea, vomiting, diarrhea;

  • stomach pain; or

  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect cefpodoxime?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • probenecid;

  • antiviral medicine or other antibiotics;

  • chemotherapy, or medicine to prevent organ transplant rejection;

  • a diuretic or “water pill”;

  • medicine for bowel disorders;

  • injectable osteoporosis medication;

  • a stomach acid reducer (Pepcid, Zantac, Tagamet, and others); or

  • pain or arthritis medicines (including aspirin, Tylenol, Advil, and Aleve).

This list is not complete. Other drugs may interact with cefpodoxime, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2018 Cerner Multum, Inc. Version: 6.01.

Medical Disclaimer

More about cefpodoxime

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  • Drug class: third generation cephalosporins

Consumer resources

  • Cefpodoxime Tablets
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  • Cefpodoxime (Advanced Reading)

Other brands: Vantin

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Vantin

SIDE EFFECTS

Clinical Trials

Film-coated Tablets (Multiple dose)

In clinical trials using multiple doses of cefpodoxime proxetil film-coated tablets, 4696 patients were treated with the recommended dosages of cefpodoxime (100 to 400 mg Q 12 hours). There were no deaths or permanent disabilities thought related to drug toxicity. One-hundred twenty-nine (2.7%) patients discontinued medication due to adverse events thought possibly or probably related to drug toxicity. Ninety-three (52%) of the 178 patients who discontinued therapy (whether thought related to drug therapy or not) did so because of gastrointestinal disturbances, nausea, vomiting, or diarrhea. The percentage of cefpodoxime proxetil-treated patients who discontinued study drug because of adverse events was significantly greater at a dose of 800 mg daily than at a dose of 400 mg daily or at a dose of 200 mg daily. Adverse events thought possibly or probably related to cefpodoxime in multiple-dose clinical trials (N=4696 cefpodoxime-treated patients) were:

Incidence Greater Than 1%

Diarrhea 7.0%

Diarrhea or loose stools were dose-related: decreasing from 10.4% of patients receiving 800 mg per day to 5.7% for those receiving 200 mg per day. Of patients with diarrhea, 10% had C. difficile organism or toxin in the stool. (See WARNINGS.)

Nausea 3.3%
Vaginal Fungal Infections 1.0%
Vulvovaginal Infections 1.3%
Abdominal Pain 1.2%
Headache 1.0%

Incidence Less Than 1%

By body system in decreasing order

Clinical Studies

Adverse Events Thought Possibly Or Probably Related To Cefpodoxime Proxetil That Occurred In Less Than 1% Of Patients (N=4696)

Body – fungal infections, abdominal distention, malaise, fatigue, asthenia, fever, chest pain, back pain, chills, generalized pain, abnormal microbiological tests, moniliasis, abscess, allergic reaction, facial edema, bacterial infections, parasitic infections, localized edema, localized pain.

Cardiovascular – congestive heart failure, migraine, palpitations, vasodilation, hematoma, hypertension, hypotension.

Digestive – vomiting, dyspepsia, dry mouth, flatulence, decreased appetite, constipation, oral moniliasis, anorexia, eructation, gastritis, mouth ulcers, gastrointestinal disorders, rectal disorders, tongue disorders, tooth disorders, increased thirst, oral lesions, tenesmus, dry throat, toothache.

Hemic and Lymphatic – anemia.

Metabolic and Nutritional – dehydration, gout, peripheral edema, weight increase.

Musculo-skeletal – myalgia.

Nervous – dizziness, insomnia, somnolence, anxiety, shakiness, nervousness, cerebral infarction, change in dreams, impaired concentration, confusion, nightmares, paresthesia, vertigo.

Respiratory – asthma, cough, epistaxis, rhinitis, wheezing, bronchitis, dyspnea, pleural effusion, pneumonia, sinusitis.

Skin – urticaria, rash, pruritus non-application site, diaphoresis, maculopapular rash, fungal dermatitis, desquamation, dry skin non-application site, hair loss, vesiculobullous rash, sunburn.

Special Senses – taste alterations, eye irritation, taste loss, tinnitus.

Urogenital – hematuria, urinary tract infections, metrorrhagia, dysuria, urinary frequency, nocturia, penile infection, proteinuria, vaginal pain.

Granules For Oral Suspension (Multiple dose)

In clinical trials using multiple doses of cefpodoxime proxetil granules for oral suspension, 2128 pediatric patients (93% of whom were less than 12 years of age) were treated with the recommended dosages of cefpodoxime (10 mg/kg/day Q 24 hours or divided Q 12 hours to a maximum equivalent adult dose). There were no deaths or permanent disabilities in any of the patients in these studies. Twenty-four patients (1.1%) discontinued medication due to adverse events thought possibly or probably related to study drug. Primarily, these discontinuations were for gastrointestinal disturbances, usually diarrhea, vomiting, or rashes.

Adverse events thought possibly or probably related, or of unknown relationship to cefpodoxime proxetil for oral suspension in multiple-dose clinical trials (N=2128 patients treated with cefpodoxime) were:

Diarrhea 6.0%
The incidence of diarrhea in infants and toddlers (age 1 month to 2 years) was 12.8%.
Diaper rash/Fungal skin rash 2.0% (includes moniliasis)
The incidence of diaper rash in infants and toddlers was 8.5%.
Other skin rashes 1.8%
Vomiting 2.3%

Body: Localized abdominal pain, abdominal cramp, headache, monilia, generalized abdominal pain, asthenia, fever, fungal infection.

Digestive: Nausea, monilia, anorexia, dry mouth, stomatitis, pseudomembranous colitis.

Hemic & Lymphatic: Thrombocythemia, positive direct Coombs’ test, eosinophilia, leukocytosis, leukopenia, prolonged partial thromboplastin time, thrombocytopenic purpura.

Metabolic & Nutritional: Increased SGPT.

Musculo-Skeletal: Myalgia.

Nervous: Hallucination, hyperkinesia, nervousness, somnolence.

Respiratory: Epistaxis, rhinitis.

Skin: Skin moniliasis, urticaria, fungal dermatitis, acne, exfoliative dermatitis, maculopapular rash.

Special Senses: Taste perversion.

Film-coated Tablets (Single dose)

In clinical trials using a single dose of cefpodoxime proxetil film-coated tablets, 509 patients were treated with the recommended dosage of cefpodoxime (200 mg). There were no deaths or permanent disabilities thought related to drug toxicity in these studies.

Adverse events thought possibly or probably related to cefpodoxime in single-dose clinical trials conducted in the United States were:

Nausea 1.4%
Diarrhea 1.2%

Central Nervous System: Dizziness, headache, syncope.
Dermatologic: Rash.
Genital: Vaginitis.
Gastrointestinal: Abdominal pain.
Psychiatric: Anxiety.

Laboratory Changes

Significant laboratory changes that have been reported in adult and pediatric patients in clinical trials of cefpodoxime proxetil, without regard to drug relationship, were:

Hepatic: Transient increases in AST (SGOT), ALT (SGPT), GGT, alkaline phosphatase, bilirubin, and LDH.

Hematologic: Eosinophilia, leukocytosis, lymphocytosis, granulocytosis, basophilia, monocytosis, thrombocytosis, decreased hemoglobin, decreased hematocrit, leukopenia, neutropenia, lymphocytopenia, thrombocytopenia, thrombocythemia, positive Coombs’ test, and prolonged PT, and PTT.

Serum Chemistry: Hyperglycemia, hypoglycemia, hypoalbuminemia, hypoproteinemia, hyperkalemia, and hyponatremia.

Renal: Increases in BUN and creatinine.

Most of these abnormalities were transient and not clinically significant.

Post Marketing Experience

The following serious adverse experiences have been reported: allergic reactions including Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme and serum sickness-like reactions, pseudomembranous colitis, bloody diarrhea with abdominal pain, ulcerative colitis, rectorrhagia with hypotension, anaphylactic shock, acute liver injury, in utero exposure with miscarriage, purpuric nephritis, pulmonary infiltrate with eosinophilia, and eyelid dermatitis.

One death was attributed to pseudomembranous colitis and disseminated intravascular coagulation.

Cephalosporin Class Labeling

In addition to the adverse reactions listed above which have been observed in patients treated with cefpodoxime proxetil, the following adverse reactions and altered laboratory tests have been reported for cephalosporin class antibiotics:

Adverse Reactions and Abnormal Laboratory Tests: Renal dysfunction, toxic nephropathy, hepatic dysfunction including cholestasis, aplastic anemia, hemolytic anemia, serum sickness-like reaction, hemorrhage, agranulocytosis, and pancytopenia.

Several cephalosporins have been implicated in triggering seizures, particularly in patients with renal impairment when the dosage was not reduced. (See DOSAGE AND ADMINISTRATION and OVERDOSAGE.) If seizures associated with drug therapy occur, the drug should be discontinued. Anticonvulsant therapy can be given if clinically indicated.

Read the entire FDA prescribing information for Vantin (Cefpodoxmine Proxetil)

About cefpodoxime

Type of medicine A cephalosporin antibiotic
Used for Infections
Available as Tablets and oral liquid medicine

Cefpodoxime is a broad-spectrum antibiotic, which means that it is active against a wide variety of bacteria. It is used to treat bacterial infections such as urinary tract infections, chest and throat infections, skin infections and sinusitis. Cefpodoxime treats an infection by killing the bacteria that are causing it.

Some people who are allergic to penicillin antibiotics may not be able to take cefpodoxime, so make sure your doctor knows if you have ever had an allergic reaction to any other antibiotic.

Before taking cefpodoxime

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking cefpodoxime it is important that your doctor knows:

  • If you have ever had an allergic reaction to a medicine. It is particularly important that you tell your doctor if you have had a bad reaction to a penicillin or cephalosporin antibiotic.
  • If you have any problems with the way your kidneys work.
  • If you are pregnant, trying for a baby or breast-feeding. (Although cefpodoxime is not known to be harmful to babies, it is still important that you tell your doctor if you are expecting or breast-feeding a baby.)
  • If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.

How to take cefpodoxime

  • Before you start taking cefpodoxime, read the manufacturer’s printed information leaflet from inside your pack. The manufacturer’s leaflet will give you more information about the antibiotic and a full list of side-effects which you may experience from taking it.
  • Usual doses of cefpodoxime are as follows, but they are intended as a guide only. Your doctor will tell you what dose is right for you (or your child), and this information will be printed on the label of the pack to remind you. You should take cefpodoxime exactly as your doctor tells you to:
    • Adults: 1 or 2 tablets twice daily, morning and evening.
    • Children aged over 9 years: 1 tablet twice daily, morning and evening.
    • Children aged 3-8 years: 10 ml twice daily, morning and evening.
    • Children aged 6 months-2 years: 5 ml twice daily, morning and evening.
  • If you have been given liquid medicine for your child, read the directions carefully to make sure you measure out the correct amount of medicine. There is 40 mg of cefpodoxime in each 5 ml of medicine.
  • Take cefpodoxime with a snack or just after eating a meal, as this will help your body to absorb the medicine. Space your doses out evenly throughout the day.
  • Your doctor will tell you how long the course of treatment will last – this is commonly about five days. Keep taking the antibiotic until the course is finished unless you are told to stop by your doctor. Taking the full course is important (even if you feel your infection has cleared up) in order to prevent the infection from coming back.
  • If you forget to take a dose, take one as soon as you remember. Try to take the correct number of doses each day, but do not take two doses at the same time to make up for a missed dose.

Getting the most from your treatment

  • Some people develop thrush (redness and itching in the mouth or vagina) after taking a course of antibiotics. If you think you have thrush speak with your doctor or pharmacist for advice.
  • Antacids reduce the amount of cefpodoxime that your body absorbs. Because of this, it is recommended that you do not take indigestion remedies during the two hours before or the two hours after you take cefpodoxime.
  • If you are using oral combined hormonal contraception (the ‘pill’), additional contraceptive precautions such as condoms are recommended for a time if you have sickness (vomiting) or diarrhoea which lasts for more than 24 hours. If you need further advice about this, speak with your doctor or pharmacist.
  • If you are having an operation or any other medical treatment, tell the person carrying out the treatment that you are taking an antibiotic. This is because cefpodoxime may interfere with the results of some tests to check for sugar in urine.
  • Cefpodoxime may stop the oral typhoid vaccine from working. If you are having any vaccinations, make sure the person treating you knows that you are taking this antibiotic.

Can cefpodoxime cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with cefpodoxime. You will find a full list in the manufacturer’s information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Cefpodoxime side-effects What can I do if I experience this?
Diarrhoea Drink plenty of water to replace any lost fluids. If the diarrhoea continues for longer than 24 hours, or becomes severe or contains blood, let your doctor know straightaway
Feeling sick (nausea), tummy (abdominal) discomfort, bloating, wind (flatulence) Stick to simple foods. Make sure you remember to take your doses after meals
Skin rash, and other allergic-type reactions Let your doctor know as soon as possible, as your treatment may need to be changed

Important: if you develop an itchy rash, swollen face or mouth, or have difficulty breathing, these can be signs that you are allergic to the antibiotic. Do not take any more cefpodoxime and speak with your doctor or go to your local accident and emergency department straightaway.

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist for further advice.

How to store cefpodoxime

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.
  • If you have been given liquid medicine, store it in a refrigerator. It will have been made up by the pharmacy, so remember to check the expiry date on the bottle and do not use it after this date.

Important information about all medicines

Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.

This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.

If you buy any medicines, check with a pharmacist that they are safe to take with your other medicines.

If you are having an operation or any dental treatment, tell the person carrying out the treatment which medicines you are taking.

Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

If you have any questions about this medicine ask your pharmacist.

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