Can indomethacin 25 mg get you high

Indomethacin: 6 things you should know

3. Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

  • Indigestion, heartburn, and very occasionally, stomach ulceration and bleeding. People of an older age, taking other medicines that affect the stomach, or who drink more than 3 glasses of alcohol per day may be more at risk. People of an older age, taking other medicines that affect the stomach, or who drink more than 3 glasses of alcohol per day may be more at risk. Indomethacin is considered to carry a high risk for stomach-related side effects compared with other NSAIDs.
  • A headache is also a common side effect. Other side effects include tinnitus (continuous ringing or buzzing in the ears), constipation, and difficulty concentrating.
  • Indomethacin is one of the most potent NSAIDs and is generally only used after other NSAIDs have proved ineffective.
  • NSAIDs (including indomethacin) have been associated with an increased risk of stroke or heart attack. The risk may be higher in patients with pre-existing cardiovascular conditions and with higher dosages. Indomethacin is considered to carry a high risk for cardiovascular-related side effects compared with other NSAIDs.
  • Oral and rectal preparations are not available over-the-counter (have to be prescribed).
  • May not be suitable for some people including those with kidney disease, a history of stomach ulcers or other gastrointestinal disorders, with pre-existing cardiovascular disease, or following coronary artery bypass graft surgery. Should not be used by children aged less than 14 years and during pregnancy.
  • May interact with some other medicines such as warfarin, SSRIs, ACE inhibitors, and diuretics.

Notes: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. For a complete list of all side effects, .


How does this medication work? What will it do for me?

Indomethacin belongs to the class of medications known as nonsteroidal anti-inflammatories (NSAIDs). It works by reducing pain, swelling, and inflammation. Indomethacin is used for the relief of pain accompanied by inflammation. It can be used for people with conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, degenerative hip disease, and gout. It does not prevent the progression of arthritis.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does this medication come in?

Each yellowish-to-beige, torpedo-shaped suppository with a homogeneous texture, smooth surfaced without crumbling, contains indomethacin USP 100 mg. Nonmedicinal ingredients: butylated hydroxyanisole, butylated hydroxytoluene, EDTA, glycerin, polyethylene glycol and sodium chloride.

How should I use this medication?

When used on a regular basis, the usual recommended adult starting dose of indomethacin capsules is 25 mg to 50 mg 2 or 3 times a day. Your doctor will gradually increase the dose until the best results are achieved with the least amount of side effects. The maximum recommended daily dose of indomethacin is 200 mg. To minimize the chance of developing serious side effects, use of indomethacin should be limited to the lowest effective dose for the shortest possible duration of time.

Indomethacin should always be taken with food or antacids to reduce stomach upset.

The recommended dose of indomethacin suppositories is 100 mg to 200 mg daily. Doses higher than 100 mg must be given in 2 divided doses.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take this medication?

Do not take indomethacin if you:

  • are or may be allergic to indomethacin or any ingredients of the medication
  • have a history of asthma, itchy skin rash, or allergic reactions after taking ASA (acetylsalicylic acid) or other nonsteroidal anti-inflammatory drugs (NSAIDs; e.g., ibuprofen, celecoxib, diclofenac, indomethacin, etc.)
  • currently have or recently had inflammatory diseases of the stomach and intestines such as stomach or intestinal ulcer or ulcerative colitis
  • have bleeding in the brain or other bleeding disorders
  • have severe liver or kidney disease
  • have severe uncontrolled heart failure
  • have high blood levels of potassium
  • have recently had heart bypass surgery
  • are currently taking other NSAIDs
  • are in the third trimester of pregnancy
  • are breast-feeding

Do not use indomethacin suppositories if you:

  • have any of the conditions listed above
  • have inflammation of the rectum or anus
  • have recently had rectal or anal bleeding

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • constipation
  • diarrhea
  • dizziness
  • drowsiness
  • headache
  • heartburn
  • nausea
  • sun sensitivity
  • vomiting
  • vertigo (feeling that you or your surroundings are spinning)

A common side effect of nonsteroidal anti-inflammatory drugs (NSAIDs) is stomach upset. This can be minimized by taking the medication immediately after a meal, or with food or milk.

Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • blurred vision or any change in vision
  • change in amount or colour of urine
  • confusion, forgetfulness, mental depression, or other mood or mental changes
  • headache (severe), throbbing, or with stiff neck or back
  • hearing changes
  • pain or difficulty urinating
  • swelling of face, feet, or lower legs
  • signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don’t stop bleeding)
  • signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
  • skin rash
  • vomiting or persistent nausea, stomach pain, or diarrhea

Stop taking this medication and seek immediate medical attention if any of the following occur:

  • signs of bleeding in the stomach or digestive system (e.g., bloody, black, or tarry stools, spitting up of blood, vomiting blood or material that looks like coffee grounds)
  • signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don’t stop bleeding)
  • signs of a heart attack (e.g., chest pain or pressure, pain extending through shoulder and arm, nausea and vomiting, sweating)
  • signs of stroke (e.g., sudden or severe headache; sudden loss of coordination; vision changes; sudden slurring of speech; or unexplained weakness, numbness, or pain in arm or leg)
  • symptoms of a serious allergic reaction (e.g., hives, swelling of the face or throat, or difficulty breathing)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take this medication.

Allergic reactions: If you have had a reaction to acetylsalicylic acid (ASA) or other NSAIDs (e.g., ibuprofen, ketoprofen, ketorolac) that included a runny nose, itchy skin rash, nasal polyps, or shortness of breath and wheezing, you should not take this medication. If you experience symptoms of a severe allergic reaction (e.g., hives; difficulty breathing; wheezing; swelling of the face, tongue, or throat), get immediate medical attention.

Aseptic meningitis: This medication can rarely cause symptoms of aseptic meningitis (inflammation or swelling of the membranes around the brain and spinal cord that is not caused by bacteria). If you have an autoimmune condition (e.g., systemic lupus erythematosus, mixed connective tissue disease), you are more at risk for developing this. If you experience symptoms such as stiff neck, severe headache, nausea, vomiting, fever, or changes in consciousness, stop taking this medication and get immediate medical attention.

Bladder problems: This medication may cause bladder pain, painful or difficult urination, or increased frequency of urination. If these symptoms occur without an explanation (e.g., infection), stop taking this medication and contact your doctor.

Blood clotting: This medication may reduce the ability of the blood to clot. If you are taking anticoagulants (e.g., warfarin, heparin) or have hemophilia or other blood disorders (e.g., low platelets), discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. If you have a bleeding disorder, do not take this medication.

Drowsiness and reduced alertness: Headaches, sometimes combined with dizziness or lightheadedness, may occur during treatment with indomethacin. (These headaches usually occur early in the treatment.) Avoid operating motor vehicles and doing other activities that require alertness until you determine how this medication affects you.

Heart problems and stroke: Indomethacin may increase the risk of heart attacks, strokes, and high blood pressure, and may also make existing high blood pressure worse. As well, it can cause fluid buildup, especially in the feet and legs.

If you have or have had a heart condition (such as congestive heart failure), high blood pressure, high cholesterol, stroke, kidney disease, or if you have had recent surgery, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

High blood potassium: There is a risk of high blood potassium with NSAID treatment. People most at risk are seniors, people with conditions such as diabetes or kidney failure, and people who are taking beta-adrenergic blockers, angiotensin converting enzyme (ACE) inhibitors, or some diuretics (water pills). Ask your doctor whether you need to have your potassium levels checked while you are taking this medication.

Kidney function: Long-term use of indomethacin may lead to a higher risk of reduced kidney function. This is most common for those who already have kidney disease, liver disease, or heart failure; for those who take diuretics (water pills); and for seniors. If you fit into one of these groups, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Liver function: Indomethacin may reduce liver function and can cause liver failure. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking this medication.

If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Stomach ulcers: Stomach ulcers, perforation, and bleeding from the stomach have been known to occur during therapy with indomethacin. These problems can happen even to people who have never had stomach problems before. These complications can occur at any time, and are sometimes severe enough to require immediate medical attention. The risk of ulcers and bleeding increase for people taking higher doses of NSAIDs for longer periods of time.

If you have ever had a stomach ulcer, bloody stools, diverticulosis or other conditions affecting the stomach or intestines (such as ulcerative colitis or Crohn’s disease), discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Pregnancy: Do not use this medication if you are in the third trimester of pregnancy. For the first and second trimesters, this medication should not be used unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

This medication may reduce fertility. If you are trying to get pregnant or are having difficulty getting pregnant, you should not use this medication.

Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking indomethacin, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children. Seniors: Seniors appear to have a higher risk of side effects. They should use the lowest effective dosage under close medical supervision.

What other drugs could interact with this medication?

There may be an interaction between indomethacin and any of the following:

  • ASA (acetylsalicylic acid)
  • alcohol
  • aliskiren
  • alpha agonists (e.g., clonidine, methyldopa)
  • aminoglycoside antibiotics (e.g., amikacin, gentamicin, tobramycin)
  • angiotensin converting enzyme inhibitors (ACEIs; e.g., captopril, enalapril, ramipril)
  • angiotensin receptor blockers (ARBs; e.g., candasartan, irbesartan, losartan)
  • apixaban
  • beta-adrenergic blockers (e.g., metoprolol, atenolol)
  • bisphosphonates (e.g., alendronate, etidronate)
  • calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
  • celecoxib
  • cholestyramine
  • cilostazol
  • clopidogrel
  • colestipol
  • corticosteroids (e.g., dexamethasone, hydrocortisone, prednisone)
  • cyclosporine
  • dabigatran
  • dasatinib
  • deferasirox
  • desmopressin
  • digoxin
  • dipyridamole
  • diuretics (water pills; e.g., furosemide, hydrochlorothiazide, triamterene)
  • drospirenone
  • eplerenone
  • 5-ASA medications (e.g., mesalamine, sulfasalazine)
  • glucosamine
  • haloperidol
  • heparin
  • hydralazine
  • lithium
  • low molecular weight heparins (e.g., dalteparin, enoxaparin, tinzaparin)
  • methotrexate
  • multivitamins
  • other non-steroidal anti-inflammatory medications (NSAIDs; e.g., diclofenac, ibuprofen, ketorolac, naproxen)
  • Omega-3 fatty acids
  • pentoxifylline
  • porfimer
  • potassium supplements
  • probenecid
  • prostaglandin eye drops (e.g., bimatoprost, latanoprost, travoprost)
  • quinolone antibiotics (e.g., ciprofloxacin, norfloxacin, ofloxacin)
  • rivaroxaban
  • selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, duloxetine, fluoxetine, paroxetine, sertraline)
  • serotonin/norepinephrine reuptake inhibitors (SNRIs; e.g., desvenlafaxine, duloxetine, venlafaxine)
  • sodium phosphates
  • tacrolimus
  • tenofovir
  • ticagrelor
  • ticlopidine
  • tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, trimipramine)
  • vancomycin
  • warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. In many cases, interactions are intended or are managed by close monitoring. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material copyright MediResource Inc. 1996 – 2020. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source:


Indomethacin (Indocin) is a prescription drug used to treat moderate to severe pain, swelling, and stiffness from arthritis.

Indomethacin belongs to a class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs).

These drugs treat swelling, pain, and fever by blocking the production of substances in the body called prostaglandins, which regulate inflammation and other bodily processes.

Indomethacin is approved to treat:

  • Moderate to severe osteoarthritis (wear-and-tear arthritis)
  • Rheumatoid arthritis (inflammatory arthritis)
  • Ankylosing spondylitis (inflammatory arthritis of the spine)

Doctors may also use indomethacin to treat bursitis (shoulder joint inflammation), gout, or gouty arthritis, (a form of arthritis caused by crystals of uric acid building up inside joints), and inflammation of tendons (tissue that attaches muscles to bones).

The Food and Drug administration (FDA) approved indomethacin in 1965 for the drug company Iceutica Operations under the brand name Indocin.

Today, several drug manufacturers make generic versions of the drug. It’s also sold under other brand names, including Indo-Lemmon and Tivorbex.

Indomethacin Warnings

Indomethacin and other NSAIDs can cause heart attack and stroke.

These can occur without warning and can be fatal. This risk may increase if you take indomethacin for a prolonged period of time.

You also may be at higher risk if you have a history of heart disease or high blood pressure. Taking indomethacin may trigger high blood pressure or make it worse, and high blood pressure is a risk factor for stroke and heart attack.

Indomethacin and other NSAIDs may cause ulcers, perforations, and sudden bleeding in your stomach or intestine (known as gastrointestinal, or GI, bleeding).

This can occur at any time during treatment. You may be at higher risk for GI bleeding if you are elderly, drink a lot of alcohol, smoke, are in poor health, or take any blood-thinning medication.

You may also be at higher risk if you have a history of ulcers or GI bleeding.

About 1 percent of people who take indomethacin every day for three to six months experience GI bleeding.

You should not take indomethacin if you have asthma, nasal polyps, and an allergy to aspirin.

This triple combination — known as ASA triad, aspirin triad, or Samter’s triad — can results in anaphylaxis, a potentially fatal allergic reaction.

Talk with your doctor about the warnings related to stroke, heart attack, GI bleeding, and anaphylaxis.

Tell your doctor about any history of heart disease, stroke, ulcers, or GI bleeding, including any family history of heart disease or stroke.

Ask your doctor how you will be checked for these conditions and any warning symptoms to watch for.

Use indomethacin with caution if you have high blood pressure, heart failure, or edema (fluid retention), or if you have ever had a peptic ulcer.

You should not take indomethacin for two weeks after having a type of heart bypass surgery called coronary artery bypass graft. Taking indomethacin could increase your risk for stroke or heart attack after this surgery.

Before starting indomethacin, also let your doctor know if you have any of these conditions:

  • Kidney disease
  • Liver disease
  • Anemia
  • Eye disease
  • Depression
  • Epilepsy
  • Parkinson’s disease
  • Abnormal bleeding
  • Lung disease or asthma

Indomethacin and Pregnancy

Indomethacin is not safe to take during later stages of pregnancy because it may cause heart defects and other problems to a developing fetus.

Before taking indomethacin, let your doctor know if you are pregnant or may become pregnant. And if you become pregnant while taking indomethacin, tell your doctor right away.

Indomethacin is also unsafe to take while breastfeeding because it can pass into breast milk.

Children 14 years old and younger should not take indomethacin.

Influence of indomethacin on the intrarenal uptake of gentamicin in endotoxemic rats.


Gentamicin is a commonly used antibiotic for the treatment of gram-negative-bacterial infections. Bacterial endotoxin is liberated during antibiotic therapy, and we have shown that endotoxemic animals accumulate more aminoglycosides in their renal parenchyma than normal animals. Vasoactive mediators, such as prostaglandins and thromboxanes, are released after endotoxin and are involved in inflammation. Indomethacin, a nonsteroidal anti-inflammatory drug known to inhibit the synthesis of these hormones, was infused intravenously as a bolus (3.0 mg/kg) or as a bolus followed by a continuous infusion (0.75 mg/kg per h) to rats given gentamicin. Levels of gentamicin in serum and kidney were increased 2 h post-antibiotic treatment in the endotoxemic animals. Renal function was not significantly disturbed. Indomethacin given as a bolus failed to correct the disturbed intrarenal pharmacokinetics of gentamicin induced by endotoxin. However, a bolus followed by continuous infusion of indomethacin resulted in low cortical and high papillary levels of antibiotic. These changes were correlated with the inhibition of prostaglandin synthesis from the kidney. These observations suggest an important role for prostaglandins in the interaction among endotoxin, aminoglycosides, and the kidney. Specific inhibitors of arachidonic acid metabolites should be investigated to further understand the mechanisms of this interaction.

Generic Name: indomethacin (in doe METH a sin)
Brand Name: Indocin, Indocin SR, Tivorbex

Medically reviewed by on Apr 17, 2019 – Written by Cerner Multum

  • Overview
  • Side Effects
  • Dosage
  • Professional
  • Tips
  • Interactions
  • More

What is indomethacin?

Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID).

Indomethacin is used to treat moderate to severe osteoarthritis, rheumatoid arthritis, gouty arthritis, or ankylosing spondylitis. Indomethacin is also used to treat shoulder pain caused by bursitis or tendinitis.

Extended-release indomethacin (Indocin SR) should not be used to treat gouty arthritis.

Indomethacin may also be used for purposes not listed in this medication guide.

Important Information

Indomethacin can increase your risk of fatal heart attack or stroke, even if you don’t have any risk factors. Do not use indomethacin just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Indomethacin may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using indomethacin, especially in older adults.

Before taking this medicine

Indomethacin can increase your risk of fatal heart attack or stroke, even if you don’t have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Indomethacin may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using indomethacin, especially in older adults.

You should not use indomethacin if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

Tell your doctor if you have ever had:

  • heart disease, high blood pressure;

  • a heart attack, stroke, or blood clot;

  • fluid retention;

  • bleeding problems;

  • stomach ulcers or bleeding;

  • asthma;

  • liver or kidney disease; or

  • if you smoke.

Taking indomethacin during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

This medicine may temporarily affect fertility (ability to have children) in women.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Indomethacin is not approved for use by anyone younger than 14 years old.

How should I take indomethacin?

Follow all directions on your prescription label and read all medication guides. Use the lowest dose that is effective in treating your condition.

Swallow the extended-release capsule whole and do not crush, chew, break, or open it.

Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Your dose needs may change if you switch to a different brand, strength, or form of indomethacin. Avoid medication errors by using only the form and strength your doctor prescribes.

If you use this medicine long-term, you may need frequent medical tests.

If you need surgery, tell your surgeon you currently use this medicine. You may need to stop for a short time.

Store at room temperature away from moisture and heat. Do not allow the liquid medicine to freeze.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe drowsiness, stomach pain, or vomiting.

What should I avoid while taking indomethacin?

Avoid alcohol. Heavy drinking can increase your risk of stomach bleeding.

Avoid taking aspirin while you are taking indomethacin.

Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to indomethacin (such as aspirin, ibuprofen, ketoprofen, or naproxen).

Indomethacin side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, leg swelling, feeling short of breath.

Stop using indomethacin and call your doctor at once if you have:

  • a skin rash, no matter how mild;

  • changes in your vision;

  • heart problems–swelling, rapid weight gain, feeling short of breath;

  • signs of liver or pancreas problems–loss of appetite, upper stomach pain (that may spread to your back), nausea, vomiting, diarrhea, unusual tiredness, itching, flu-like symptoms, dark urine, jaundice (yellowing of the skin or eyes);

  • signs of stomach bleeding–bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

  • kidney problems–little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or

  • low red blood cells (anemia)–pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet.

Common side effects may include:

  • indigestion, nausea;

  • headache; or

  • dizziness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect indomethacin?

Ask your doctor before using indomethacin if you take an antidepressant. Taking certain antidepressants with an NSAID may cause you to bruise or bleed easily.

Ask a doctor or pharmacist before using indomethacin with any other medications, especially:

This list is not complete. Other drugs may affect indomethacin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2018 Cerner Multum, Inc. Version: 11.01.

Related questions

  • Can I take Tylenol while taking indomethacin and can these drugs be alternated every 3 hours?

Medical Disclaimer

More about indomethacin

  • Side Effects
  • During Pregnancy or Breastfeeding
  • Dosage Information
  • Patient Tips
  • Drug Images
  • Drug Interactions
  • Compare Alternatives
  • Support Group
  • Pricing & Coupons
  • En Español
  • 178 Reviews
  • Drug class: Nonsteroidal anti-inflammatory drugs
  • FDA Alerts (5)

Consumer resources

  • Indomethacin Capsules
  • Indomethacin Extended-Release Capsules
  • Indomethacin Suppositories
  • Indomethacin Suspension
  • Indomethacin (Advanced Reading)
  • … +2 more

Other brands: Indocin, Tivorbex, Indocin SR

Professional resources

  • Indomethacin (AHFS Monograph)
  • … +5 more

Related treatment guides

  • Ankylosing Spondylitis
  • Back Pain
  • Bartter Syndrome
  • Bursitis
  • … +11 more

About the author

Leave a Reply

Your email address will not be published. Required fields are marked *