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Etodolac

People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as etodolac may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. This risk may be higher for people who take NSAIDs for a long time. Do not take an NSAID such as etodolac if you have recently had a heart attack, unless directed to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke, and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech.

If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not take etodolac right before or right after the surgery.

NSAIDs such as etodolac may cause ulcers, bleeding, or holes in the stomach or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, or drink large amounts of alcohol while you are taking etodolac. Tell your doctor if you take any of the following medications: anticoagulants (‘blood thinners’) such as warfarin (Coumadin, Jantoven); aspirin; other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). Also tell your doctor if you have or have ever had ulcers or bleeding in your stomach or intestines or other bleeding disorders. If you experience any of the following symptoms, stop taking etodolac and call your doctor: stomach pain, heartburn, vomit that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools.

Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body’s response to etodolac. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects.

Your doctor or pharmacist will give you the manufacturer’s patient information sheet (Medication Guide) when you begin treatment with etodolac and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/drugs/drugsafety/ucm085729.htm) or the manufacturer’s website to obtain the Medication Guide.

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For people with high blood pressureThis medication may cause you to develop high blood pressureIf you already have high blood pressureit may worsen your condition or increase your chances of having a heart attack or stroke.

Neurological and special sensesVisual disturbancesoptic neuritisheadachesparaethesiareports of aseptic meningitisespecially in patients with existing auto-immune disorderssuch as systemic lupus erythematousmixed connective tissue diseasewith symptoms such as stiff erythromycin fastest shipping. neckheadachenauseavomitiongfever or disorientationSee section 4.4depressionconfusionhallucinationstinnitusvertigodizzinessmalaisefatigue and drowsiness.

This medication belongs to a class of drugs called nonsteroidal anti-inflammatory drugsNSAIDsNSAIDs help reduce paininflammationand fever.

Caution is required if Lodine is administered to culturismo. patients suffering fromor with a previous history ofbronchial asthma since NSAIDs have been reported to precipitate bronchospasm in such patients.

Oedemahypertension and cardiac failurehave been reported in association with NSAID treatmentClinical trial and epidemiological data suggest that use of some NSAIDsparticularly at high doses and in long term treatmentmay be associated with an increased risk of arterial thrombotic eventsfor example myocardial infarction or strokesee section 4.4

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etodolac extended-release tablets are a nonsteroidal anti-inflammatory drug nsaid that exhibits anti-inflammatory, analgesic, and antipyretic activities in animal models.

About etodolac

Type of medicine A non-steroidal anti-inflammatory drug (NSAID)
Used for Relief of pain and inflammation in adults with arthritis
Also called Eccoxolac®; Etolyn®; Etopan®; Lodine®
Available as Capsules and modified-release tablets

Anti-inflammatory painkillers like etodolac are also called non-steroidal anti-inflammatory drugs (NSAIDs), or sometimes just ‘anti-inflammatories’. Etodolac is prescribed to ease pain and reduce inflammation for people with rheumatic conditions such as osteoarthritis and rheumatoid arthritis.

Etodolac works by blocking the effect of natural substances in your body, called cyclo-oxygenase (COX) enzymes. These enzymes help to make other chemicals in your body, called prostaglandins. Some prostaglandins are produced at sites of injury or damage, and cause pain and inflammation. By blocking the effect of COX enzymes, fewer prostaglandins are produced, which means pain and inflammation are eased.

Before taking etodolac

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking etodolac, it is important that your doctor knows:

  • If you have ever had an allergic reaction to any other NSAID (such as aspirin, naproxen, diclofenac, and indometacin), or to any other medicine.
  • If you have ever had a problem with bleeding from the stomach or intestines, such as from a peptic or duodenal ulcer.
  • If you have asthma or any other allergic disorder.
  • If you have a heart condition, or a problem with your blood vessels or circulation.
  • If you are pregnant, trying for a baby, or breast-feeding.
  • If you have ever had blood clotting problems.
  • If you have an inflammatory bowel disorder such as Crohn’s disease or ulcerative colitis.
  • If you have high blood pressure.
  • If you have a connective tissue disorder such as systemic lupus erythematosus. This is an inflammatory condition which is also called lupus or SLE.
  • If you have any problems with the way your liver works, or if you have any problems with the way your kidneys work.
  • If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.

How to take etodolac

  • Before you start the treatment, read the manufacturer’s printed information leaflet from inside the pack. It will give you more information about the tablets/capsules, and it will also provide you with a full list of the side-effects which you could experience from taking them.
  • There are two forms of etodolac available: modified-release tablets (which release etodolac slowly throughout the day) and capsules (which release etodolac more quickly). If you are prescribed tablets, you will be asked to take one 600 mg tablet daily. If you are prescribed capsules, you could be asked to take either one or two 300 mg capsules a day. Your doctor will tell you which dose is right for you. You should take etodolac exactly as your doctor tells you to.
  • Try to take your doses at the same time(s) each day as this will help you to remember to take etodolac regularly.
  • Swallow the tablet or capsule whole; do not chew or break the tablets, and do not open the capsules. Most people find it helps to swallow the tablet/capsule with a drink of water.
  • It is best to take your doses with food, such as with a snack or at a mealtime. This is because the food in your stomach will help to protect from side-effects such as indigestion and stomach irritation.
  • If you forget to take a dose, take it as soon as you remember unless your next dose is due. If when you remember, your next dose is due then take the dose that is due and leave out the forgotten one. Do not take two doses together to make up for a missed dose.

Getting the most from your treatment

  • Your doctor will try to prescribe you the lowest dose for the shortest time in order to reduce the risk of side-effects. If you need to take etodolac over a long period of time, your doctor may want to prescribe another medicine along with it to protect your stomach from irritation.
  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
  • If you have asthma, symptoms such as wheeze or breathlessness can be made worse by anti-inflammatories such as etodolac. If this happens to you, you should stop taking the tablets/capsules and see your doctor as soon as possible.
  • There is known to be a small increased risk of heart and blood vessel problems in people taking some anti-inflammatory painkillers long-term. Your doctor will explain this to you and will prescribe the lowest suitable dose in order to reduce the risk. Do not take more than the recommended dose.
  • If you buy any medicines, check with a pharmacist that they are safe to take with an anti-inflammatory like etodolac. This is because you should not take etodolac with any other anti-inflammatory painkiller, some of which are available in cold and flu remedies which can be bought ‘over the counter’.
  • If you are due to have an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.

Can etodolac cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with etodolac. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer’s printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer’s information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following continue or become troublesome.

Common etodolac side-effects What can I do if I experience this?
Indigestion, heartburn, stomach pain Remember to take your doses with a meal or with a glass of milk. If the discomfort continues, speak with your doctor
Feeling sick or being sick (vomiting) Stick to simple meals – avoid fatty or spicy foods
Diarrhoea or constipation Drink plenty of water
Feeling dizzy or tired Do not drive and do not use tools or machines while affected

Important: if you experience any of the following less common but possibly serious symptoms, stop taking etodolac and contact your doctor for advice straightaway:

  • If you have any breathing difficulties such as wheeze or breathlessness.
  • If you have any signs of an allergic reaction such as swelling around your mouth or face, or a severe itchy skin rash.
  • If you pass blood or black stools, bring up blood, or have severe tummy (abdominal) pains.

If you experience any other symptoms which you think may be due to etodolac, speak with your doctor or pharmacist for further advice.

How to store etodolac

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

Important information about all medicines

Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.

This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.

Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

If you have any questions about this medicine ask your pharmacist.

Lodine

Generic Name: etodolac (ee toe DOE lak)
Brand Names: Lodine, Lodine XL

Medically reviewed by Drugs.com. Last updated on Aug 29, 2019.

  • Overview
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  • Dosage
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The Lodine brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.

What is Lodine?

Lodine (etodolac) is a nonsteroidal anti-inflammatory drug (NSAID). Etodolac works by reducing hormones that cause inflammation and pain in the body.

Lodine is used to treat mild to moderate pain, osteoarthritis, or rheumatoid arthritis.

Lodine may also be used for purposes not listed in this medication guide.

Important information

Lodine can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Lodine may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using Lodine, especially in older adults.

Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or other medicines similar to etodolac (such as ibuprofen, ketoprofen, or naproxen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen. Do not drink alcohol while taking Lodine. Alcohol can increase the risk of stomach bleeding caused by etodolac. Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Lodine can make your skin more sensitive to sunlight and sunburn may result.

Before taking this medicine

Lodine can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Even people without heart disease or risk factors could have a stroke or heart attack while taking this medicine.

Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Lodine may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using Lodine, especially in older adults.

You should not use Lodine if you are allergic to etodolac, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

To make sure Lodine is safe for you, tell your doctor if you have:

  • heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke;

  • a history of heart attack, stroke, or blood clot;

  • a history of stomach ulcers or bleeding;

  • asthma;

  • liver or kidney disease; or

  • fluid retention.

Taking Lodine during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using Lodine.

Etodolac can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

The Lodine regular tablet is not approved for use by anyone younger than 18 years old. The extended-release form is not approved for use by anyone younger than 6 years old.

How should I take Lodine?

Take Lodine exactly as it was prescribed for you. Follow all directions on your prescription label. Do not take this medicine in larger amounts or for longer than recommended. Use the lowest dose that is effective in treating your condition.

Do not crush, chew, or break an extended-release tablet. Swallow it whole.

It may take up to 2 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

If you use Lodine long-term, you may need frequent medical tests.

This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using Lodine.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Lodine?

Avoid drinking alcohol. It may increase your risk of stomach bleeding.

Avoid taking aspirin or other NSAIDs while you are taking Lodine.

Ask a doctor or pharmacist before using any cold, allergy, or pain medication. Many medicines available over the counter contain aspirin or other medicines similar to Lodine. Taking certain products together can cause you to get too much of this type of medication. Check the label to see if a medicine contains aspirin, ibuprofen, ketoprofen, or naproxen.

Lodine side effects

Get emergency medical help if you have signs of an allergic reaction to Lodine: sneezing, runny or stuffy nose; wheezing or trouble breathing; hives; swelling of your face, lips, tongue, or throat.

Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.

Stop using Lodine and call your doctor at once if you have:

  • changes in your vision;

  • the first sign of any skin rash, no matter how mild;

  • shortness of breath (even with mild exertion);

  • swelling or rapid weight gain;

  • signs of stomach bleeding – bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

  • liver problems – nausea, upper stomach pain, itching, tired feeling, flu-like symptoms, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  • kidney problems – little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath;

  • low red blood cells (anemia) – pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or

  • severe skin reaction – fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common Lodine side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Lodine dosing information

Usual Adult Dose of Lodine for Osteoarthritis:

Capsules or tablets: 300 mg orally 2 to 3 times a day or 400 mg orally twice a day or 500 mg orally twice a day. Total daily dose should not exceed 1200 mg.
Extended-release tablets: 400 to 1200 mg orally, given once daily.

Usual Adult Dose of Lodine for Rheumatoid Arthritis:

Capsules or tablets: 300 mg orally 2 to 3 times a day or 400 mg orally twice a day or 500 mg orally twice a day. Total daily dose should not exceed 1200 mg.
Extended-release tablets: 400 to 1200 mg orally, given once daily.

Usual Adult Dose for Pain:

Capsules or tablets: 200 to 400 mg orally every 6 to 8 hours. Total daily dose should not exceed 1200 mg.

Usual Pediatric Dose for Juvenile Rheumatoid Arthritis:

Extended-release tablets:
6 to 16 years: dose based on weight, given orally once daily
For 20 to 30 kg, dose is 400 mg
For 31 to 45 kg, dose is 600 mg
For 46 to 60 kg, dose is 800 mg
For greater than 60 kg, dose is 1000 mg

What other drugs will affect Lodine?

Ask your doctor before using Lodine if you take an antidepressant such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone. Taking any of these medicines with an NSAID may cause you to bruise or bleed easily.

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • cyclosporine;

  • lithium;

  • methotrexate;

  • a blood thinner (warfarin, Coumadin, Jantoven);

  • heart or blood pressure medication, including a diuretic or “water pill”; or

  • steroid medicine (prednisone and others).

This list is not complete. Other drugs may interact with etodolac, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Lodine only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2020 Cerner Multum, Inc. Version: 10.01.

Medical Disclaimer

More about Lodine (etodolac)

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  • 14 Reviews
  • Drug class: Nonsteroidal anti-inflammatory drugs
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Consumer resources

  • Lodine (Advanced Reading)

Other brands: Lodine XL

Professional resources

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  • … +1 more

Related treatment guides

  • Juvenile Rheumatoid Arthritis
  • Osteoarthritis
  • Pain
  • Rheumatoid Arthritis

SIDE EFFECTS

In patients taking etodolac or other NSAIDs, the most frequently reported adverse experiences occurring in approximately 1 to 10% of patients are:

Gastrointestinal experiences including: abdominal pain, constipation, diarrhea, dyspepsia, flatulence, gross bleeding/perforation, heartburn, nausea, GI ulcers (gastric/duodenal), vomiting.

Other events including: abnormal renal function, anemia, dizziness, edema, elevated liver enzymes, headaches, increased bleeding time, pruritis, rashes, tinnitus.

Adverse-reaction information for etodolac was derived from 2,629 arthritic patients treated with etodolac capsules and tablets in double-blind and open-label clinical trials of 4 to 320 weeks in duration and worldwide postmarketing surveillance studies. In clinical trials, most adverse reactions were mild and transient. The discontinuation rate in controlled clinical trials, because of adverse events, was up to 10% for patients treated with etodolac.

New patient complaints (with an incidence greater than or equal to 1%) are listed below by body system. The incidences were determined from clinical trials involving 465 patients with osteoarthritis treated with 300 to 500 mg of etodolac b.i.d. (i.e., 600 to 1000 mg/day). Incidence Greater That or Equal to 1% – Probably Causally Related

Body as a whole – Chills and fever.

Nervous system – Asthenia/malaise*5, dizziness*5, depression, nervousness.

Skin and appendages – Pruritus, rash.

Special senses – Blurred vision, tinnitus.

Urogenital system – Dysuria, urinary frequency.

Drug-related patient complaints occurring in fewer than 3%, but more than 1%, are unmarked. 5*Drug-related patient complaints occurring in 3 to 9% of patients treated with etodolac. Incidence Less Than 1% – Probably Causally Related

(Adverse reactions reported only in worldwide postmarketing experience, not seen in clinical trials, are considered rarer and are italicized)

Body as a whole – Allergic reaction, anaphylactic/anaphylactoid reactions (including shock).

Cardiovascular system – Hypertension, congestive heart failure, flushing, palpitations, syncope, vasculitis (including necrotizing and allergic).

Digestive system – Thirst, dry mouth, ulcerative stomatitis, anorexia, eructation, elevated liver enzymes, cholestatic hepatitis, hepatitis, cholestatic jaundice, duodenitis, jaundice, hepatic failure, liver necrosis, peptic ulcer with or without bleeding and/or perforation, intestinal ulceration, pancreatitis.

Hemic and lymphatic system – Ecchymosis, anemia, thrombocytopenia, bleeding time increased, agranulocytosis, hemolytic anemia, leukopenia, neutropenia, pancytopenia.

Metabolic and nutritional – Edema, serum creatinine increase, hyperglycemia in previously controlled diabetic patients.

Nervous system – Insomnia, somnolence.

Respiratory system – Asthma, pulmonary infiltration with eosinophilia.

Skin and appendages – Angioedema, sweating, urticaria, vesiculobullous rash, cutaneous vasculitis with purpura, Stevens-Johnson Syndrome, toxic epidermal necrolysis, hyperpigmentation, erythema multiforme.

Special senses – Photophobia, transient visual disturbances.

Urogenital system – Elevated BUN, renal failure, renal insufficiency, renal papillary necrosis.

Incidence Less Than 1% – Causal Relationship Unknown

(Medical events occurring under circumstances where causal relationship to etodolac is uncertain. These reactions are listed as alerting information for physicians)

Body as a whole – Infection, headache.

Cardiovascular system – Arrhythmias, myocardial infarction, cerebrovascular accident.

Digestive system – Esophagitis with or without stricture or cardiospasm, colitis.

Metabolic and nutritional – Change in weight.

Nervous system – Paresthesia, confusion.

Respiratory system – Bronchitis, dyspnea, pharyngitis, rhinitis, sinusitis.

Skin and appendages – Alopecia, maculopapular rash, photosensitivity, skin peeling.

Special senses – Conjunctivitis, deafness, taste perversion.

Urogenital system – Cystitis, hematuria, leukorrhea, renal calculus, interstitial nephritis, uterine bleeding irregularities.

Additional Adverse Reactions Reported with NSAIDs

Body as a whole – Sepsis, death.

Cardiovascular system – Tachycardia.

Digestive system – Gastric ulcers, gastritis, gastrointestinal bleeding, glossitis, hematemesis.

Hemic and lymphatic system – Lymphadenopathy.

Nervous system – Anxiety, dream abnormalities, convulsions, coma, hallucinations, meningitis, tremors, vertigo.

Respiratory system – Respiratory depression, pneumonia.

Urogenital system – Oliguria/polyuria, proteinuria.

Read the entire FDA prescribing information for Lodine (Etodolac)

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