Bydureon and weight loss

Bydureon is the trade name of the drug exenatide. Bydureon is a once weekly injectable medication for people with type 2 diabetes.

Bydureon was given approval to be prescribed in the UK in October 2011.

Bydureon once weekly injection

Bydureon is the same medical drug as Byetta, except Bydureon is slower released requiring one injection a week, whereas Byetta is injected twice a day.

How does Bydureon work?

Bydureon’s action takes place in response to food entering the small intestine.

Bydureon responds to presence of carbohydrate, in the form of glucose, by stimulating release of insulin, inhibiting release of glucagon and slowing down emptying of the stomach.

Each of these three mechanisms can help to keep blood glucose levels lower.

Who may take Bydureon?

NICE guidance states that Bydureon is suitable for people meeting the following conditions:

  • HbA1c of 7.5% or above
  • A BMI of 35 of higher

People with a BMI value below 35 may be considered for Bydureon if insulin therapy would have significant occupational implications or if the weight loss properties of Bydureon would provide significant medical benefit.

Which medications can Bydureon be used with?

Bydureon may be prescribed as a triple therapy regimen in combination with the following:

  • Metformin and a sulphonylurea
  • Metformin and a thiazolidinedione

Alternatively, Bydureon may be prescribed as a dual therapy with either metformin or a sulphonylurea.

Bydureon and weight loss

Bydureon has been shown in studies to be beneficial for weight loss However, because Bydureon is a relatively expensive drug to prescribe, it is only recommended in people in need of better blood glucose control.

What are the side effects of Bydureon?

Relatively common side effects of Bydureon include:

  • diarrhoea
  • feeling nauseous
  • vomiting

Hypoglycemia may result if used in combination with a sulphonylurea.

Less common side effects of Bydureon include:

  • dizziness
  • sweating
  • indigestion
  • loss of appetite
  • weight loss
  • gastro-oesophageal reflux
  • headaches
  • injection site problems such as itching or redness of the skin

Please refer to the patient information leaflet for more details about side effects.

Trulicity, Victoza, and Bydureon all belong to a newer class of non-insulin diabetes medications known as GLP-1 (glucagon-like peptide-1) receptor agonists that improve blood sugar control and may lead to weight loss. They were each approved by the FDA in the last decade, and increase how much insulin the pancreas makes in response to high glucose levels.

Which drug is the most effective?

Trulicity (dulaglutide), approved in 2014, is the newest out of these three drugs. Clinical studies show that Trulicity is just as effective at lowering Hgb-A1C as Bydureon (exenatide) and Victoza (liraglutide). It’s even equivalent to Januvia (sitagliptin) and metformin (Glucophage), other commonly prescribed diabetes drugs, in terms of lowering A1C levels.

Which drug is the easiest to use?

Trulicity is an injection under the skin given once a week at a dose of 0.75 mg. The dose may be increased to 1.5 mg once weekly if you need better control of your sugars. Trulicity is available in a ready-to-use pen device with an automatic injector.

Victoza is also an injection given under the skin. Unlike Trulicity and Bydureon, it needs to be administered once a day instead of once a week. Dosing starts at 0.6 mg per day for one week, and then it’s increased to 1.2 mg. 1.8 mg per day can be used if you need additional blood sugar control. Victoza comes in a pre-filled, multi-dose pen that delivers doses of 0.6 mg, 1.2 mg, or 1.8 mg.

Bydureon is also an injection given under the skin, and like Trulicity, it’s administered once a week. Compared to Trulicity and Victoza, Bydureon can be more complicated to use. Bydureon comes either as a pre-filled pen or as a single-dose tray with a vial, syringe, needle, and connector that you have to learn how to assemble. If you get the tray, you’ll also have to learn how to mix the medication and fill a syringe for your weekly injection.

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Which drug has the fewest side effects?

Trulicity, Victoza, and Bydureon have similar side effects because they belong to the same GLP-1 receptor agonist drug class. The most common side effects of GLP-1 receptor agonists are nausea, vomiting, and diarrhea.

Importantly, GLP-1 receptor agonists are not recommended for people with a history of thyroid cancer because they can increase the risk for thyroid tumors, including cancer. These drugs can also increase the risk for inflammation of the pancreas and kidney failure, so they’re not recommended in people who have had pancreatitis or have kidney problems. In few cases, they can also lead to gallstones, allergic reactions, and injection-site reactions like itching, pain, and swelling.

GLP-1 receptor agonists will not work if sugars are low. Therefore, unlike with insulin, there is almost no risk of low sugar levels, or hypoglycemia with these medication. The risk for hypoglycemia is higher is you’re taking another medication like insulin that is known to lower blood sugar.

Which drug causes the most weight loss?

The American Diabetes Association recommends weight loss as an important goal for overweight people with type 2 diabetes. Trulicity, Bydureon, and Victoza are not weight loss drugs, but some patients have lost weight while taking them. (Some patients have also gained weight while taking these medicines.)

Trulicity may cause a modest weight loss of about six pounds over 26 weeks. In two studies, patients on Bydureon lost an average of three pounds after 28 weeks. And clinical studies of Victoza ranging from 26 to 52 weeks long showed that Victoza could help with weight loss. When Victoza was taken with metformin, patients lost an average of about six pounds.

Dr O.

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  • Exenatide Promotes Weight Loss When Added To Diet And Exercise

    Previous studies show that exenatide, an injectable medication marketed as Byetta (Amylin Pharmaceuticals and Eli Lilly and Company), not only lowers blood sugar but also can result in weight loss in some people with diabetes. This study, financed by both pharmaceutical companies, is “the first to assess the effect of exenatide on body weight in nondiabetic obese individuals,” said the principal investigator, Michael Trautmann, MD, a researcher with Eli Lilly in Indianapolis.

    “Drug therapy is considered important adjunctive treatment to diet and exercise in the successful management of obesity,” Trautmann said. “To date, however, there are few effective drugs that help obese people lose weight.”

    Trautmann and colleagues studied 152 patients in the United States—27 men and 125 women—who were obese (body mass index, or BMI, greater than 30). The study subjects had an average weight of about 241 pounds (108.6 kilograms) and an average BMI of 39.6. Of the 152 subjects, 38 (25%) had impaired glucose tolerance. None of the subjects took another weight loss medication during the study or in the several months preceding the study.

    Subjects were randomly assigned to receive an injection of either exenatide, 10 micrograms twice a day (73 subjects), or placebo (79 subjects), along with a structured lifestyle modification program involving diet and exercise, for 24 weeks. Neither the subjects nor the staff giving the treatments knew which individuals received the study medication. There was no statistically significant difference in beginning weight between the exenatide-treated subjects and the control subjects, who got the placebo injection.

    Individuals who received exenatide lost more weight in 24 weeks than controls did, the authors reported. Those who received the medication lost an average of more than 11 pounds (5.06 kg), whereas the controls lost just 3.5 pounds (1.61 kg). This difference was statistically significant and noted as early as week 8. Only exenatide-treated subjects lost more than 10 percent of their body weight (seven of 73 subjects, or 9.6%).

    The most common side effects of exenatide were mild or moderate nausea and diarrhea, but weight loss was independent of nausea, the authors reported. Although exenatide lowers blood glucose, or sugar, levels in people with diabetes, it is known to only act in the presence of high blood glucose so that no subjects reported low blood sugar.

    Possible reasons why exenatide may cause weight loss include decreased food intake and increased feelings of fullness, he explained.

    Bydureon

    Generic Name: exenatide (ex EN a tide)
    Brand Names: Bydureon

    Medically reviewed by Sophia Entringer, PharmD Last updated on Jun 13, 2019.

    • Overview
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    What is Bydureon?

    Bydureon is an extended release injectable diabetes medicine that helps control blood sugar levels. This medication helps your pancreas produce insulin more efficiently. Bydureon is a long-acting form of exenatide.

    Bydureon is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. This medicine is not for treating type 1 diabetes.

    This medication guide provides information about the Bydureon brand of exenatide. Byetta is another brand of exenatide that is not covered in this medication guide.

    Important information

    You should not use Bydureon if you have severe kidney disease (or you are on dialysis), slowed digestion, diabetic ketoacidosis, a personal or family history of thyroid cancer, or if you have a type of cancer called multiple endocrine neoplasia type 2 (MEN 2).

    Stop using Bydureon and call your doctor at once if you have severe pain in your upper stomach spreading to your back, with nausea, vomiting, and a fast heart rate. These could be symptoms of pancreatitis.

    Do not use Bydureon to treat type 1 diabetes, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

    Bydureon is an extended-release form of exenatide administered as an injection once every seven days. The dose can be administered at any time of day, with or without meals. Follow your doctor’s instructions.

    Before taking this medicine

    You should not use Bydureon if you are allergic to exenatide, or if you have:

    • severe kidney disease (or if you are on dialysis);

    • a severe stomach disorder that causes slow digestion;

    • diabetic ketoacidosis (call your doctor for treatment with insulin);

    • a personal or family history of thyroid cancer; or

    • multiple endocrine neoplasia type 2 (MEN 2, a cancer that can affect the thyroid, parathyroid, and adrenal glands).

    To make sure this medicine is safe for you, tell your doctor if you have ever had:

    • kidney disease, or a kidney transplant;

    • problems with digestion;

    • pancreatitis or gall stones;

    • alcoholism; or

    • high triglycerides (a type of fat in blood).

    In animal studies, Bydureon caused thyroid tumors. However, very high doses are used in animal studies. It is not known whether these effects would occur in people using doses recommended for human use. Ask your doctor about your personal risk.

    It is not known whether Bydureon will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

    It is not known whether exenatide passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

    Bydureon is not FDA-approved for use by anyone younger than 18 years old.

    How should I use Bydureon?

    Use Bydureon exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

    Bydureon is injected under the skin. You may be shown how to use injections at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of used needles and syringes.

    Read and carefully follow any Instructions for Use provided with your medicine. Do not use Bydureon if you don’t understand all instructions for proper use. Ask your doctor or pharmacist if you have questions.

    Prepare your injection only when you are ready to give it. You must give the injection right away after mixing.

    Bydureon is usually injected once every 7 days. Bydureon can be used with or without food and given at any time of the day. Follow your doctor’s instructions. You may change your weekly dosing day, but do not inject on your new dosing day if it has been less than 3 days since your last dose.

    Bydureon is a powder medicine that must be mixed with a liquid (diluent) before using it. You must give the injection right away after mixing. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.

    Your care provider will show you the best places on your body to inject Bydureon. Use a different place each time you give an injection. Do not inject into the same place two times in a row.

    Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, irritability, dizziness, nausea, fast heart rate, and feeling anxious or shaky. To quickly treat low blood sugar, always keep a fast-acting source of sugar with you such as fruit juice, hard candy, crackers, raisins, or non-diet soda.

    Your doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drink. Be sure your family and close friends know how to give you this injection in an emergency.

    Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst or urination, blurred vision, headache, and tiredness.

    Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.

    Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof “sharps” disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

    Bydureon is only part of a complete treatment program that may also include diet, exercise, weight control, regular blood sugar testing, and special medical care. Follow your doctor’s instructions very closely.

    Store this medicine in the original container. Refrigerate and use until expiration date. Protect from light.

    Do not freeze Bydureon, and throw away the medicine if it has been frozen.

    You may also store Bydureon at room temperature for up to 4 weeks.

    Bydureon dosing information

    Usual Adult Dose for Diabetes Type 2:

    Bydureon extended-release:
    -Dose: 2 mg subcutaneously once every seven days; administer at any time of day, with or without meals
    -Patients may switch from immediate-release exenatide to extended-release exenatide, although prior treatment with immediate-release exenatide is not necessary.
    -For patients who do switch, discontinue immediate-release exenatide on initiation of extended-release; transient elevations in blood glucose may occur and generally improve within the first 2 weeks of initiation.

    -For patients concomitantly receiving a sulfonylurea, a lower dose of the sulfonylurea may be required to reduce the risk of hypoglycemia.
    Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus

    What happens if I miss a dose?

    Use the missed dose as soon as you remember. Skip the missed dose if your next dose is less than 3 days away. Do not use extra medicine to make up the missed dose.

    What happens if I overdose?

    Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

    Overdose can cause severe nausea and vomiting, or signs of low blood sugar (headache, hunger, irritability, dizziness, feeling shaky).

    What should I avoid while taking Bydureon?

    Do not use Bydureon together with Byetta.

    Avoid drinking alcohol. It can lower your blood sugar.

    Bydureon side effects

    Get emergency medical help if you have signs of an allergic reaction to Bydureon: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

    Stop using this medicine and call your doctor at once if you have:

    • pain, itching, warmth, swelling, skin sores, blisters, skin changes, or a hard lump where the injection was given;

    • swelling in your neck or throat (enlarged thyroid), hoarse voice, trouble swallowing or breathing;

    • pancreatitis – severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;

    • low blood sugar – headache, hunger, sweating, irritability, dizziness, fast heart rate, and feeling anxious or shaky; or

    • kidney problems – little or no urination, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath.

    Common Bydureon side effects may include:

    • indigestion, nausea, vomiting, diarrhea, constipation;

    • headache; or

    • itching or a small bump where an injection was given.

    This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    What other drugs will affect Bydureon?

    Bydureon can make it harder for your body to absorb other medicines you take by mouth. Tell your doctor about all medicines you use, and those you start or stop using. Other drugs may interact with exenatide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

    Further information

    Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Bydureon only for the indication prescribed.

    Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

    Copyright 1996-2020 Cerner Multum, Inc. Version: 3.03.

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    More about Bydureon (exenatide)

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    • Diabetes, Type 2

    Bydureon is the brand name of exenatide, which is an injectable medication used to treat people with type 2 diabetes.

    Type 2 diabetes occurs when the body doesn’t produce or use the hormone insulin properly.

    Bydureon is used along with diet and exercise to help control blood sugar levels and aid in weight loss. It’s a long-acting form of the medication contained in another brand name drug known as Byetta.

    The medicine is in a class of drugs known as incretin mimetics, which work by prompting the pancreas to release insulin when blood sugar levels are high and slowing the emptying of the stomach.

    The Food and Drug Administration (FDA) approved Bydureon in 2012. It’s manufactured by AstraZeneca.

    Bydureon Warnings

    Bydureon shouldn’t be used to treat people with type 1 diabetes, a disease that occurs when the body doesn’t produce any insulin.

    The drug also shouldn’t be used by someone who is in a state of diabetic ketoacidosis (a condition that causes dangerously high blood sugar levels).

    Don’t use Bydureon in place of insulin. It’s not known whether this medicine is safe to use along with insulin.

    Bydureon caused thyroid tumors in animal studies. However, it’s not known whether the drug has the same effect in humans.

    Don’t take this medicine if you have any of the following:

    • Thyroid cancer
    • A family history of thyroid cancer
    • Multiple endocrine neoplasia type 2 (a type of cancer that can affect the thyroid, adrenal glands, and parathyroid)

    Stop taking Bydureon immediately if you experience any signs of pancreatitis (inflammation of the pancreas), which may include severe pain in your upper stomach that spreads to your back along with nausea, vomiting, and a fast heart rate.

    Bydureon and the drug Byetta both contain the active ingredient exenatide and shouldn’t be used together.

    Before taking Bydureon, tell your doctor if you have or have ever had any of the following conditions:

    • Kidney disease
    • A kidney transplant
    • A stomach disorder that causes slow digestion
    • Pancreatitis or gallstones
    • Dehydration
    • High triglyceride levels
    • High blood pressure

    You should also tell your health care provider if you’ve ever consumed large amounts of alcohol or suffered from alcoholism before taking Bydureon.

    This medicine may cause changes in your blood sugar. You should know the symptoms of a high and low blood sugar episode and what to do if you experience them.

    Illnesses, injuries, or unusual stress can impact your blood sugar levels. They may also affect how much Bydureon you need.

    Talk to your physician if you experience any of these conditions while taking this medicine.

    Your doctor will likely want to check your blood sugar levels often while you are taking Bydureon. Keep all appointments with your health care provider and laboratory.

    Bydureon will help control type 2 diabetes, but it won’t cure the condition. Continue to take this medicine even if you feel well.

    Don’t stop taking this drug without first talking to your physician.

    Pregnancy and Bydureon

    It’s not known whether Bydureon will harm an unborn baby.

    Tell your doctor if you’re pregnant or plan to become pregnant before using this medicine.

    It’s also not known whether Bydureon passes into breast milk or could harm a breastfeeding baby. Tell your doctor if you’re breastfeeding before taking this drug.

    How does this medication work? What will it do for me?

    Exenatide extended-release belongs to a group of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists. It is used alone or with other medications (e.g., metformin, glyburide, gliclazide, or insulin glargine) to improve blood glucose (sugar) levels for people with type 2 diabetes. It works by helping your body release more insulin and control blood glucose levels.

    This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

    Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are using this medication, speak to your doctor. Do not stop using this medication without consulting your doctor.

    Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use this medication if their doctor has not prescribed it.

    What form(s) does this medication come in?

    Each pen injector contains a dual chamber glass cartridge injector with a bypass channel and injection needle.

    • The front chamber of the glass cartridge contains a white-to-off-white powder containing 2 mg of exenatide. Nonmedicinal ingredients: poly (D,L-lactide-co-glycolide) and sucrose.
    • The rear chamber of the glass cartridge injector pen contains sufficient diluent to deliver 0.65 mL after reconstitution. Nonmedicinal ingredients: carboxymethylcellulose sodium, dibasic sodium phosphate heptahydrate, monobasic sodium phosphate monohydrate, polysorbate 20, sodium chloride, and water for injection.

    How should I use this medication?

    The usual adult dose of this medication is 2 mg of extended release suspension, injected subcutaneously (under the skin) in the thigh, abdomen, or upper arm once a week.

    Exenatide extended-release is used with the guidance and supervision of a doctor. Your doctor or nurse will assist you in the preparation and injection of your first dose (or first few doses). Do not attempt to inject this medication on your own until you completely understand how to inject a dose.

    This medication is provided in a pen injector that contains a glass cartridge with 2 compartments. One compartment contains the medication in a powder form, while the other compartment contains the diluent that, when mixed with the medication powder, creates a suspension that is injected. Read the user manual for instructions on how to properly use this medication. If you have questions about how to use this medication, contact your doctor or pharmacist.

    Rotate the injection sites (arms, thighs, upper buttocks, or stomach) to minimize injection site skin irritation.

    The diluent is clear and colourless and should not contain particles. After it has been mixed with the medication powder, the mixture will be white to off-white and cloudy. Inject the medication immediately after mixing the solution and powder.

    Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

    It is important that this medication be used exactly as prescribed by your doctor. If you miss a dose, and it is less than 3 days since the missed dose, inject it as soon as possible. If it is more than 3 days since the missed dose, skip the missed dose and continue with your regular dosing schedule. Do not use a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

    Store this medication in the refrigerator, protect it from light, and keep it out of the reach of children. Do not allow it to freeze. If necessary, your pen may be stored at room temperature for up to 4 weeks.

    Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

    Who should NOT take this medication?

    Do not use this medication if you:

    • are allergic to exenatide or any ingredients of the medication
    • have or have had a family member with medullary thyroid cancer
    • have multiple endocrine neoplasia syndrome type 2 (a disease where people have tumours in more than one gland in their body)
    • have severe or end-stage kidney disease

    What side effects are possible with this medication?

    Many medications can cause side effects. A side effect is an unwanted response to a medication when it is used in normal doses. Side effects can be mild or severe, temporary or permanent.

    The side effects listed below are not experienced by everyone who uses this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

    The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

    Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

    • abdominal pain
    • cold symptoms
    • constipation
    • cough
    • decreased appetite
    • diarrhea
    • dizziness
    • headache
    • joint pain
    • muscle pain
    • nausea
    • pain, swelling, burning, or bruising at the place of injection
    • rash
    • vomiting
    • weight loss

    Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.

    Check with your doctor as soon as possible if any of the following side effects occur:

    • signs of dehydration (e.g., decreased urine, dry skin, dry and sticky mouth, sleepiness, dizziness, headache, thirst, confusion)
    • signs of kidney problems (e.g., increased urination at night, decreased urine production, blood in the urine, swelling of the ankles or feet)
    • symptoms of an abnormal heart rhythm (e.g., dizziness, seizures, fainting, or a fast or pounding heartbeat)
    • symptoms of low blood sugar (e.g., anxiety, blurred vision, confusion, difficulty concentrating, difficulty speaking, dizziness, drowsiness, fast heartbeat, feeling jittery, headache, hunger, irritability, nausea, weakness, nervousness, numbness or tingling lips or tongue, sweating, tiredness, trembling, weakness)
    • symptoms of thyroid cancer (e.g., a lump or swelling in the neck, trouble swallowing, hoarseness)

    Stop taking the medication and seek immediate medical attention if any of the following occur:

    • symptoms of a severe allergic reaction (e.g., hives; difficulty breathing; swelling of the mouth, face, tongue, or throat)
    • symptoms of pancreatitis (inflammation of the pancreas) such as abdominal pain and vomiting

    Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

    Are there any other precautions or warnings for this medication?

    Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

    Blood sugar control: Fever, infection, surgery, or trauma may cause a loss of blood sugar control and you may need to change to insulin temporarily, until you recover. Your doctor will recommend when this is needed.

    If you regularly experience uncontrolled blood glucose levels contact your doctor.

    Diabetes identification: It is important to either wear a bracelet (or necklace) or carry a card indicating you have diabetes and are taking medication to manage your blood glucose levels.

    Heart problems: Exenatide extended-release may increase your heart rate and may affect how electrical impulses travel through the heart muscle. If you have heart disease (e.g., recent heart attack, angina, heart failure) or an abnormal heart rhythm (e.g., heart block or fast heart rate), discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

    If you experience dizziness, palpitations (a rapid, pounding, or irregular heartbeat), fainting, or seizures, get immediate medical attention.

    Kidney problems: This medication may cause kidney problems. Your doctor will monitor your kidney function with blood tests while you are using this medication. If you have had a kidney transplant or have reduced kidney function, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. If you are on dialysis or have severely reduced kidney function, you should not use this medication.

    Low blood sugar (hypoglycemia): This medication may cause low blood sugar when it is used with sulfonylureas (e.g., glyburide, gliclazide) or insulin. If you are taking any of these types of medications, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

    If you experience symptoms of hypoglycemia such as a cold sweat, nervousness or shakiness, fast heartbeat, headache, hunger, confusion, lightheadedness, weakness, and numbness or tingling of the tongue or lips, contact your doctor. Your doctor may need to adjust the dose of your medication(s).

    Pancreatitis (inflammation of the pancreas): Exenatide extended-release may cause pancreatitis that can be serious or life threatening. If you experience symptoms of pancreatitis such as severe and persistent abdominal pain that may move to your back and may be accompanied by vomiting, stop taking this medication and contact your doctor or get immediate medical attention.

    If you have previously had pancreatitis, gallstones, or alcohol use problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

    Stomach and intestinal problems: The safety and effectiveness of using this medication have not been established for people who have inflammatory bowel disease (e.g., Crohn’s disease, ulcerative colitis) or slowed movement through the intestinal tract due to diabetes. If you have either of these conditions, you should not use this medication.

    Thyroid cancer: If you or a family member have ever had medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2 (MEN 2), you should not use this medication.

    Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you are planning to become pregnant, this medication should be stopped at least 3 months before becoming pregnant. If you become pregnant while using this medication, contact your doctor immediately.

    Breast-feeding: It is not known if exenatide extended-release passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

    Children: The safety and effectiveness of using this medication have not been established for children and adolescents less than 18 years of age.

    Seniors: If you are a senior, you may be more sensitive to the effects of this medication and be more likely to experience side effects.

    What other drugs could interact with this medication?

    There may be an interaction between exenatide extended-release and any of the following:

    If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

    • stop taking one of the medications,
    • change one of the medications to another,
    • change how you are taking one or both of the medications, or
    • leave everything as is.

    An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

    Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

    All material copyright MediResource Inc. 1996 – 2020. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Bydureon

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