- How does this medication work? What will it do for me?
- What form(s) does this medication come in?
- How should I use this medication?
- Who should NOT take this medication?
- What side effects are possible with this medication?
- Are there any other precautions or warnings for this medication?
- What other drugs could interact with this medication?
- How Long Does Vyvanse Stay in Your System?
- How Long Does Vyvanse Last in the System?
- Drug Screenings for Vyvanse
- Should I take Straterra at Night or Morning?
- Does Strattera interact with other medications or foods?
- Generic Name: Atomoxetine (AT-oh-mox-e-teen)
How does this medication work? What will it do for me?
Lisdexamfetamine belongs to the class of medications known as central nervous system stimulants. It is used to treat attention deficit hyperactivity disorder (ADHD). It works by affecting the balance of natural chemicals in the brain. It helps to increase attention and decrease hyperactivity and impulsiveness in children with ADHD. Lisdexamfetamine should be part of a treatment plan that includes other treatments (e.g., counselling, education).
Lisdexamfetamine is also used to treat moderate-to-severe binge eating disorder (BED) in adults.
Your child’s doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your child’s doctor, or are not sure why your child is taking this medication, speak to their doctor. Your child should not stop taking this medication without consulting their doctor.
Do not give this medication to anyone else, even if they have the same symptoms as your child. It can be harmful for people to take this medication if their doctor has not prescribed it.
What form(s) does this medication come in?
Each capsule with pink body and pink cap imprinted with “S489 10 mg” contains 10 mg of lisdexamfetamine dimesylate. Nonmedicinal ingredients: microcrystalline cellulose, croscarmellose sodium, and magnesium stearate; capsule shell: gelatin, titanium dioxide, and one or more of the following: FD&C Yellow No. 6, FD&C Blue No. 1, FD&C Red No. 3, FDA/E172 black iron oxide, FDA/E172 yellow iron oxide.
Each capsule with ivory body and ivory cap imprinted with “S489 20 mg” contains 20 mg of lisdexamfetamine dimesylate. Nonmedicinal ingredients: microcrystalline cellulose, croscarmellose sodium, and magnesium stearate; capsule shell: gelatin, titanium dioxide, and one or more of the following: FD&C Yellow No. 6, FD&C Blue No. 1, FD&C Red No. 3, FDA/E172 black iron oxide, FDA/E172 yellow iron oxide.
Each capsule with white body and orange cap imprinted with “S489 30 mg” contains 30 mg of lisdexamfetamine dimesylate. Nonmedicinal ingredients: microcrystalline cellulose, croscarmellose sodium, and magnesium stearate; capsule shell: gelatin, titanium dioxide, and one or more of the following: FD&C Yellow No. 6, FD&C Blue No. 1, FD&C Red No. 3, FDA/E172 black iron oxide, FDA/E172 yellow iron oxide No. 40.
Each capsule with white body and blue-green cap imprinted with “S489 40 mg” contains 40 mg of lisdexamfetamine dimesylate. Nonmedicinal ingredients: microcrystalline cellulose, croscarmellose sodium, and magnesium stearate; capsule shell: gelatin, titanium dioxide, and one or more of the following: FD&C Yellow No. 6, FD&C Blue No. 1, FD&C Red No. 3, FDA/E172 black iron oxide, FDA/E172 yellow iron oxide.
Each capsule with white body and blue cap imprinted with “S489 50 mg” contains 50 mg of lisdexamfetamine dimesylate. Nonmedicinal ingredients: microcrystalline cellulose, croscarmellose sodium, and magnesium stearate; capsule shell: gelatin, titanium dioxide, and one or more of the following: FD&C Yellow No. 6, FD&C Blue No. 1, FD&C Red No. 3, FDA/E172 black iron oxide, FDA/E172 yellow iron oxide.
Each capsule with aqua blue body and aqua blue cap imprinted with “S489 60 mg” contains 60 mg of lisdexamfetamine dimesylate. Nonmedicinal ingredients: microcrystalline cellulose, croscarmellose sodium, and magnesium stearate; capsule shell: gelatin, titanium dioxide, and one or more of the following: FD&C Yellow No. 6, FD&C Blue No. 1, FD&C Red No. 3, FDA/E172 black iron oxide, FDA/E172 yellow iron oxide.
How should I use this medication?
The usual starting dose of lisdexamfetamine is 30 mg once a day in the morning. Afternoon doses should be avoided as this medication may cause difficulty sleeping.
Although doses larger than 30 mg have not been shown to be more effective, and often cause more side effects, your child’s doctor may choose to increase the dose gradually, if the lower dose is not fully effective. The maximum daily dose is 60 mg per day.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your child’s doctor has recommended a dose different from the ones listed here, do not change the way that your child is taking the medication without consulting your doctor.
Lisdexamfetamine may be taken with or without food. The capsules may be taken whole, or the contents of the capsule can be dissolved in yogurt or a glass of water or orange juice. Any compacted powder from inside the capsule can be broken apart with a spoon. The mixture should be taken immediately.
It is important for your child to take this medication exactly as prescribed by their doctor. If your child misses a dose in the morning, skip the missed dose and wait until the next day to continue with their regular dosing schedule. Do not give your child a double dose to make up for a missed one. If you are not sure what to do after your child misses a dose, contact your doctor or pharmacist for advice.
Store this medication at room temperature, protect it from light, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Who should NOT take this medication?
Do not use this medication if you:
- are allergic to lisdexamfetamine or any ingredients of the medication
- are allergic to amphetamines or related medications (e.g., epinephrine)
- are in an agitated state
- have a history of drug misuse
- have an overactive thyroid
- have glaucoma
- have hardened arteries (arteriosclerosis)
- have heart disease with symptoms (e.g., chest pain, shortness of breath)
- have moderate to severe high blood pressure
- have taken a monoamine oxidase inhibitor (MAOI; e.g., phenelzine, tranylcypromine, moclobemide) within the last 14 days
What side effects are possible with this medication?
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
- decreased or loss of appetite
- difficulty sleeping
- dry mouth
- increased sweating
- upper belly pain
- weight loss
Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- behaviour changes (agitation, aggression, paranoia)
- blurred vision
- hallucinations (seeing, hearing, or feeling things that are not there)
- increased blood pressure
- mania (racing thoughts, rapid talking, impulsiveness, extremely elevated mood, extremely high energy)
- mood swings
- pounding or fast heartbeat
- Raynaud’s phenomenon (e.g., bluish, white or purple discolouration of fingers and toes, sensation of cold and/or numbness, pain)
- signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
- signs of heart problems (e.g., fast or irregular heartbeat or pulse, chest pain, sudden weight gain, difficulty breathing, leg swelling)
- signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
- slowed growth
- new tics (involuntary movements or vocalizations)
- vision changes
You should stop taking the medication and seek immediate medical attention if any of the following occur:
- signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort
- suicidal thoughts or behaviour
- symptoms of a severe allergic reaction (hives; difficulty breathing; swelling of the face, mouth, tongue, or throat)
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.
Are there any other precautions or warnings for this medication?
Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, and any other significant facts about your health. These factors may affect how you should take this medication.
HEALTH CANADA ADVISORY
March 30, 2015
Health Canada has issued new restrictions concerning drugs used in the management of Attention Deficit Hyperactivity Disorder (ADHD). To read the full Health Canada Advisory, visit Health Canada’s web site at www.hc-sc.gc.ca.
Behaviour changes: This medication can cause behaviour changes such as increased aggression and agitation. If you seem more aggressive or have other behaviour changes while taking this medication, contact your doctor.
Blood pressure: Lisdexamfetamine and other stimulant medications can cause an increase in blood pressure and heart rate. Your doctor will monitor your blood pressure and heart rate while you are taking this medication.
If you have high blood pressure, heart failure, or an abnormal heart rhythm, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. People with moderate-to-high blood pressure should not use this medication.
Dependence: This medication has the potential to be misused. People with a history of past or current substance-use problems may be at greater risk of developing abuse or addiction while taking this medication. Abuse of medications such as lisdexamfetamine can result in serious heart problems and death.
People who have taken too much of this medication may experience difficulty sleeping, irritability, hyperactivity, and personality changes. If you notice any of these symptoms, contact your doctor immediately.
Dizziness and vision changes: This medication may cause side effects including blurred vision, trouble focusing, and dizziness. These side effects may affect your ability to perform dangerous activities or drive. Ensure you are not experiencing these side effects before performing such activities.
Growth and weight gain: This medication can cause children to lose weight and can slow their growth rate. The doctor will monitor them for slowed growth while they are taking this medication. Children who are not growing or gaining weight as expected may need to stop their treatment with this medication, as recommended by their doctor.
Heart effects: When given at usual doses, lisdexamfetamine and other stimulant medications can cause sudden death in children with heart defects and other serious heart problems. This medication should generally not be given to people with heart defects and other heart problems (e.g., enlarged heart, serious abnormal heart rhythms).
If you have a heart problem, exercises strenuously, or have a family history of sudden death, talk with your doctor about how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Children with heart disease or hardening of the arteries should not use this medication.
If you experience chest pain, shortness of breath, or fainting while taking this medication, contact your doctor immediately.
Lisdexamfetamine can cause increased blood pressure and heart rate in adults. There have been reports of sudden death, stroke, and heart attack among adults taking other stimulant medications. Generally, adults with heart defects and other heart problems should not take this medication.
Kidney function: Kidney disease or reduced kidney function may cause this medication to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Mental health issues: This medication can worsen mental health issues such as psychosis or bipolar disorder. Before starting this medication, people with depression (feelings of sadness, hopelessness, or worthlessness) should be properly screened to ensure they do not have or are not at risk for bipolar disorder.
If you experience hallucinations (seeing, hearing, or feeling things that are not there), distorted thoughts, or mania (racing thoughts, rapid talking, impulsiveness, extremely elevated mood, extremely high energy), contact your doctor immediately.
Seizures: This medication may increase the risk of seizures, especially for people with seizure disorders. If you have a history of epilepsy or medical conditions that increase your risk of seizures, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
If you have a seizure while taking this medication, get immediate medical attention. This medication should be stopped if seizures occur.
Self-harm: There have been rare reports of people who are taking this medication feeling that they want to hurt themselves or commit suicide. These symptoms may occur within several weeks after starting this medication. If you experience these side effects or notice them in a family member who is taking this medication, contact your doctor immediately. You should be closely monitored by your doctor for emotional and behavioural changes while taking this medication.
Suicidal or agitated behaviour: People taking this medication may feel agitated (restless, anxious, aggressive, emotional, and feeling not like themselves), or they may want to hurt themselves or others. Suicidal thoughts or behaviours may occur at any time during treatment. If you experience these side effects or notice them in a family member who is taking this medication, contact your doctor immediately. You should be closely monitored by your doctor for emotional and behaviour changes while taking this medication.
Tics: This medication may worsen motion and verbal tics, or Tourette’s syndrome. If you have tics or Tourette’s syndrome, discuss with your doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Pregnancy: Although this medication is intended to for children and adolescents 6 to 17 years of age, it may be used by older individuals with ADHD and adults with binge eating disorder. It is still important to note that this medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking lisdexamfetamine, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children less than 6 years of age.
Seniors: Older adults are more likely to have conditions such as high blood pressure that can make taking lisdexamfetamine dangerous. This medication is not recommended for people over 55 years old.
What other drugs could interact with this medication?
There may be an interaction between lisdexamfetamine and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
All material copyright MediResource Inc. 1996 – 2020. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Vyvanse
How Long Does Vyvanse Stay in Your System?
Vyvanse (lisdexamfetamine dimesylate) is a stimulant medication that is approved by the Food and Drug Administration (FDA) for the treatment of the disorder attention deficit hyperactivity disorder (ADHD) and moderate to severe binge eating disorder (BED). The drug is approved for use in individuals over 6 years old for ADHD and over 18 years old for BED. Vyvanse is not approved for weight control, to assist with weight loss, or for the treatment of obesity, like many central nervous system stimulants are, although some individuals may use it in this capacity.
- Blood: Up to eight hours
- Urine: Up to three days and in some cases a little longer.
Vyvanse is a controlled substance, classified by the United States Drug Enforcement Administration in the Schedule II categorization of controlled substances. It requires a prescription from a physician. Stimulants like Vyvanse may often be used by physicians for off-label purposes, such as to counteract lethargy, address hypoactive delirium, or even as an aid to improve focus for individuals with neurological issues that result in cognitive problems. Because of the way that Vyvanse is metabolized in the system, it may be less likely to be used for these purposes than other stimulants.
How Long Does Vyvanse Last in the System?
According to the book Workplace Drug Testing, the length of time that a drug remains in an individual’s system is often estimated or measured by the drug’s half-life (the time it takes normal metabolic processes to reduce the concentration of the drug by half ). Lisdexamfetamine, the active ingredient in Vyvanse, is naturally metabolized into the stimulant dextroamphetamine. Lisdexamfetamine would only be detectable for a very short period of time (only a few hours in most cases). Instead, dextroamphetamine, which has a half-life of about 12 hours, would be detectable for longer. Dextroamphetamine is an amphetamine-like substance that would show up on most drug tests.
Based on a 12-hour half-life for dextroamphetamine, one would expect the drug to be eliminated from the body within 2–3 days.
For general purposes, it can be estimated that it takes about 5.5 half-lives of a particular drug for it to be eliminated from the body. However, numerous factors can affect the metabolism of any drug, including the person’s weight and gender, whether or not the drug was taken in conjunction with other drugs, and how much of the drug was taken.
Again, numerous factors could influence the detectability of the drug in the system. For instance, if an individual were to take several doses of Vyvanse several hours apart, the detectability window should be estimated from the person’s last use of the drug and not when they started taking the drug.
Drug Screenings for Vyvanse
Vyvanse was originally believed to have a lower potential for abuse compared to other prescription stimulant drugs like methylphenidate (e.g., Ritalin). However, drug abusers are often eager to try new substances and adapt them to their needs; thus, Vyvanse is a potential drug of abuse.
The detectability of any drug in a person’s system depends on numerous factors. Blood tests typically have the shortest detection window. In most cases, Vyvanse would be detectable in a person’s blood for up to eight hours after taking it. Vyvanse or its metabolites would be expected to be detectable in urine samples for up to three days and in some cases a little longer.
Hair analysis typically has the longest detection window, although it may take a few days before a hair sample would test positive for Vyvanse or its metabolites. Typically, Vyvanse would be detectable in a hair sample for about a month after the person took the drug.
How Long Are Other Drugs in the Body
- General RX Drugs
Should I take Straterra at Night or Morning?
This is all based on my experience, which is overall very positive
The reason some people say to take it night is because if you take it in the morning, you might not feel rested after a 7/8 hour sleep. Idk the drug somehow screws with your REM cycles.
I tried taking it at night and it did return the feeling of rest as well as making me more “up and at them” in the morning. However I felt that I was also sleeping through the time that the drug was most effective. The drug has a half-life of 6 hours and I got much more use out of it by taking it in the morning. I compensate for the sleep problems by taking half of a 3mg melatonin supplement and it does enough for me to not complain.
Strattera will cause heartburn and nausea if you don’t take it with a meal. However I take it with an antacid and that seems to be a loophole around this. Can’t confirm or deny the protein thing because I eat a lot of protein regardless of what drug i’m taking. Strattera also magnifies the amount of stress I feel by being hungry or thirsty.
Also, if you are a guy, Strattera will likely give you E.D. and cause premature ejaculation for the first week or two. It also makes your urinary tract feel “burny” afterwards. They all go away after a little while so don’t freak yourself out like I did.
Does Strattera interact with other medications or foods?
Strattera (atomoxetine) should not be taken within 14 days of taking a monoamine oxidase inhibitor (MAOIs), a group of antidepressant drugs that includes: phenelzine, isocarboxazid, selegiline tranylcypromine and rasagiline. These drugs may react with Strattera to produce severe and even fatal symptoms. Other medications may also interact with Strattera, including other kinds of antidepressants, asthma medications and antihistamines.
Tell your doctor about all of the medications and supplements you take or are planning to take, including over-the-counter drugs. Some of the drugs that can interact with Strattera include: albuterol syrup or tablets, amiodarone, bupropion, antihistamines in cold medications, such as chlorpheniramine, celecoxib, cimetidine, clomipramine, dopamine, dobutamine, fluoxetine, haloperidol, metaproterenol syrup or tablets, medications for high or low blood pressure, methadone, metoclopramide, nefazodone, paroxetine, quinidine, ritonavir, ranitidine, terbinafine, sertraline and asthma medications. Your doctor may need to change the dosages of your medications or monitor you carefully for side effects.
Generic Name: Atomoxetine (AT-oh-mox-e-teen)
Drug Class: Drug Class: Antidepressant, SNRI
Table of Contents
- How to Take It
- Side Effects
- Warnings & Precautions
- Drug Interactions
- Dosage & Missing a Dose
- Pregnancy or Nursing
- More Information
Strattera (Atomoxetine) is used to treat attention deficit hyperactivity disorders (ADHD). It may also help to increase the ability to stay focused, pay attention, concentrate, and stop fidgeting. This medication is approved for use in children, adolescents, and adults.
It is available in a capsule and is taken orally.
This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your health care provider.
It works by helping change certain chemicals in the brain, which professionals refer to as “neurotransmitters.” It is not yet well-understood why changing these neurochemicals results in symptom relief for the conditions this drug is commonly prescribed for.
How to Take It
Follow the directions for using this medicine provided by your doctor. Read the patient leaflet that comes with this medicine. Ask your doctor, nurse, or pharmacist any questions that you may have about this medicine. This medicine may be taken on an empty stomach or with food. This medicine is usually taken either as a single dose in the morning or divided into two doses in the morning and late afternoon or early evening; or as directed by your doctor.
Side effects that may occur while taking this medicine include:
- decrease in sexual ability/desire
- high blood pressure
- loss of appetite
- stomach upset / nausea
- sleep problems
- FOR WOMEN: menstrual cramps or missed/irregular periods
Contact your doctor immediately if you experience:
- difficulty urinating
- irregular or unusually fast heartbeat
- liver damage, including: persistent nausea/vomiting/loss of appetite, dark urine, abdominal / stomach pain, yellowing skin or eyes.
Warnings & Precautions
- Do not increase your dose of this medicine without first talking to your doctor, even if you feel that the medicine is not working.
- This medicine may cause dizziness or lightheadedness and fainting. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to this medicine.
- Alcoholic beverages can increase the effects of this medicine and should be avoided.
- This medicine may affect growth in children. Your child’s growth should be checked regularly while using this medicine especially if they experience side effects of the drug including loss of appetite or weight loss.
- For an overdose, seek medical attention immediately. For non emergencies, contact your local or regional poison control center at 1-800-222-1222.
Before taking any new medicine, either prescription or over-the-counter, check with your doctor or pharmacist. Check the labels on all of your medicine (e.g., cough-and-cold products, diet aids) because they may ingredients that could increase your heart rate or blood pressure. Ask you pharmacist about the safe use of those products.
Dosage & Missed Dose
Strattera is a capsule taken by mouth, usually one or two times / day either with or without food. It’s important to take it at about the same time every day. Take Strattera whole.
Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses or take extra medicine to make up for the missed dose.
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (preferably not in the bathroom). Throw away any medication that is outdated or no longer needed.
If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using this medicine during pregnancy. It is NOT known if this medicine is excreted in breast milk. It is recommended that you DO NOT breast-feed while taking this medicine unless your doctor or pediatrician has told you to.
For more information, talk to your doctor, pharmacist or health care provider, or you can visit this website, https://www.nlm.nih.gov/medlineplus/druginfo/meds/a603013.html for additional information from the manufacturer of this drug.