Bacitracin neomycin polymyxin ophthalmic ointment

Dexamethasone; Neomycin; Polymyxin B ophthalmic ointment

What is this medicine?

DEXAMETHASONE; NEOMYCIN; POLYMYXIN B (dex a METH a sone; nee oh MYE sin; pol i MIX in B) is a combination of a steroid and antibiotics. It helps to reduce swelling, redness, and itching of the eye. It also is used to treat eye infections.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): AK-Trol, Maxitrol, NeoPolyDex, Ocu-Trol, Poly-Dex

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • any other active infection

  • glaucoma

  • wear contact lenses

  • an unusual or allergic reaction to dexamethasone, neomycin, polymyxin B, corticosteroids, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

This medicine is only for use in the eye. Follow the directions on the prescription label. Wash hands before and after use. Tilt your head back slightly and pull your lower eyelid down with your index finger to form a pouch. Try not to touch the tip of the tube to your eye, fingertips, or other surface. Squeeze the end of the ointment tube to apply a thin layer of the ointment to the inside of the eyelid. Close the eye gently to spread the ointment. Do not use your medicine more often than directed. Finish the full course of medicine prescribed by your doctor or health care professional even if think your condition is better. Do not stop using except on the advice of your doctor or health care professional. Do not use for longer than instructed by your doctor or health care professional.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What may interact with this medicine?

Interactions are not expected. Do not use any other eye products without asking your doctor or health care professional.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Check with your doctor or health care professional if your condition does not start to get better, or if it gets worse.

Tell your doctor or health care professional if you are exposed to anyone with measles or chickenpox, or if you develop sores or blisters that do not heal properly.

If you wear contact lenses, ask your doctor or health care professional when you can use your lenses again.

A burning or stinging reaction that does not go away may mean you are allergic to this product. Stop using and call your doctor or health care professional.

This medicine can make certain eye conditions worse. Only use it for conditions for which your doctor or health care professional has prescribed.

To prevent the spread of infection, do not share eye products, towels, and washcloths with anyone else.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • changes in vision

  • eye pain

  • severe burning, stinging or swelling of the eyelids

  • watery eyes

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • eye irritation, itching

  • mild burning, redness or stinging in the eye

  • temporary watering or blurring of vision

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

See product for storage instructions. Each product may have different instructions. Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Cortisporin Ophthalmic Ointment

PRECAUTIONS

General: The initial prescription and renewal of the medication order beyond 8 grams should be made by a physician only after examination of the patient with the aid of magnification, such as slit lamp biomicroscopy and, where appropriate, fluorescein staining. If signs and symptoms fail to improve after two days, the patient should be re-evaluated.

As fungal infections of the cornea are particularly prone to develop coincidentally with long-term corticosteroid applications, fungal invasion should be suspected in any persistent corneal ulceration where a corticosteroid has been used or is in use. Fungal cultures should be taken when appropriate.

If this product is used for 10 days or longer, intraocular pressure should be monitored (see WARNINGS).

There have been reports of bacterial keratitis associated with the use of topical ophthalmic products in multiple-dose containers which have been inadvertently contaminated by patients, most of whom had a concurrent corneal disease or a disruption of the ocular epithelial surface (see PRECAUTIONS: Information for Patients).

Allergic cross-reactions may occur which could prevent the use of any or all of the following antibiotics for the treatment of future infections: kanamycin, paromomycin, streptomycin, and possibly gentamicin.

Carcinogenesis, Mutagenesis, Impairment of Fertility: Long-term studies in animals to evaluate carcinogenic or mutagenic potential have not been conducted with polymyxin B sulfate or bacitracin. Treatment of cultured human lymphocytes in vitro with neomycin increased the frequency of chromosome aberrations at the highest concentrations (80 µg/mL) tested; however, the effects of neomycin on carcinogenesis and mutagenesis in humans are unknown.

Long-term studies in animals (rats, rabbits, mice) showed no evidence of carcinogenicity or mutagenicity attributable to oral administration of corticosteroids. Long-term animal studies have not been performed to evaluate the carcinogenic potential of topical corticosteroids. Studies to determine mutagenicity with hydrocortisone have revealed negative results.

Polymyxin B has been reported to impair the motility of equine sperm, but its effects on male or female fertility are unknown. No adverse effects on male or female fertility, litter size, or survival were observed in rabbits given bacitracin zinc 100 gm/ton of diet. Long-term animal studies have not been performed to evaluate the effect on fertility of topical corticosteroids.

Pregnancy: Teratogenic Effects: Pregnancy Category C. Corticosteroids have been found to be teratogenic in rabbits when applied topically at concentrations of 0.5% on days 6 to 18 of gestation and in mice when applied topically at a concentration of 15% on days 10 to 13 of gestation. There are no adequate and well-controlled studies in pregnant women. CORTISPORIN Ophthalmic Ointment (neomycin and polymyxin b sulfates, bacitracin zinc, and hydrocortisone ophthalmic ) should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Nursing Mothers: It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk. Systemically administered corticosteroids appear in human milk and could suppress growth, interfere with endogenous corticosteroid production, or cause other untoward effects. Because of the potential for serious adverse reactions in nursing infants from CORTISPORIN Ophthalmic Ointment (neomycin and polymyxin b sulfates, bacitracin zinc, and hydrocortisone ophthalmic ) , a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Pediatric Use: Safety and effectiveness in children have not been established.

Geriatric Use: No overall differences in safety or effectiveness have been observed in between elderly and younger patients.

Neomycin, Polymyxin, and Bacitracin Ophthalmic

Ophthalmic neomycin, polymyxin, and bacitracin combination comes as an ointment to apply inside the lower lid of an infected eye. The ointment is usually applied to the eye every 3 to 4 hours for 7 to 10 days, as directed by your doctor. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use neomycin, polymyxin, and bacitracin ophthalmic ointment exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

Your eye or eyelid infection should begin getting better during the first few days of treatment with neomycin, polymyxin, and bacitracin combination. If your symptoms do not go away or get worse, call your doctor.

Continue to use neomycin, polymyxin, and bacitracin combination as directed, even if your symptoms improve. Do not stop using neomycin, polymyxin, and bacitracin combination without talking to your doctor. If you stop using this medication too soon or skip doses, your infection may not be completely cured and bacteria may become resistant to antibiotics.

This medication is for use in the eye only. Do not let neomycin, polymyxin, and bacitracin combination get into your nose or mouth, and do not swallow it.

Never share your tube of ophthalmic ointment, even with someone who was also prescribed this medication. If more than one person uses the same tube, infection may spread.

To apply the eye ointment, follow these steps:

  1. Wash your hands thoroughly with soap and water.
  2. Use a mirror or have someone else apply the ointment.
  3. Avoid touching the tip of the tube against your eye or anything else. The ointment must be kept clean.
  4. Tilt your head forward slightly.
  5. Holding the tube between your thumb and index finger, place the tube as near as possible to your eyelid without touching it.
  6. Brace the remaining fingers of that hand against your cheek or nose.
  7. With the index finger of your other hand, pull the lower lid of your eye down to form a pocket.
  8. Place a small amount of ointment into the pocket made by the lower lid and the eye. A 1/2-inch (1.25-centimeter) strip of ointment usually is enough unless otherwise directed by your doctor.
  9. Gently close your eyes and keep them closed for 1 to 2 minutes to allow the medication to be absorbed.
  10. Replace and tighten the cap right away.
  11. Wipe off any excess ointment from your eyelids and lashes with a clean tissue. Wash your hands again.

SIDE EFFECTS: Stinging/burning of the eyes for 1 to 2 minutes or temporary blurred vision may occur when this medication is applied. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Use of this medication for prolonged/repeated periods may result in a new fungal eye infection and may increase your risk for other eye problems (e.g., glaucoma, cataracts, delayed wound healing). Do not use this medication for longer than prescribed. Tell your doctor immediately if any of these unlikely but serious side effects occur: new or worsening eye symptoms (e.g., discharge, swelling, redness), vision problems, eye pain.A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using this medication, tell your doctor or pharmacist if you are allergic to neomycin, polymyxin, or dexamethasone; or to aminoglycoside antibiotics (e.g., gentamicin, tobramycin); or to corticosteroids (e.g., hydrocortisone, prednisone); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: other eye problems (e.g., glaucoma).After you apply this drug, your vision may become temporarily blurred. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is not known if this drug passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

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Bacitracin, neomycin, and polymyxin B ophthalmic

Medically reviewed by Drugs.com on Dec 30, 2019 – Written by Cerner Multum

  • Overview
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What is bacitracin, neomycin, and polymyxin B ophthalmic?

Bacitracin, neomycin, and polymyxin B are antibiotics that kill bacteria.

Bacitracin, neomycin, and polymyxin B ophthalmic (for the eyes) is a combination medicine used to treat bacterial infections of the eye or eyelid.

Bacitracin, neomycin, and polymyxin B ophthalmic may also be used for purposes not listed in this medication guide.

Important Information

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use this medicine if you are allergic to bacitracin, neomycin, or polymyxin B.

To make sure this medicine is safe for you, tell your doctor if you have ever had an allergic reaction to any antibiotic eye medication.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether this medicine passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.

Do not give this medicine to a child without medical advice.

How should I use bacitracin, neomycin, and polymyxin B ophthalmic?

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Wash your hands before using eye medication.

To apply the ointment:

  • Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the ointment tube with the tip pointing toward this pocket. Look up and away from the tip.

  • Squeeze out a ribbon of ointment into the lower eyelid pocket without touching the tip of the tube to your eye. Blink your eye gently and then keep it closed for 1 or 2 minutes.

  • Use a tissue to wipe excess ointment from your eyelashes.

  • After opening your eyes, you may have blurred vision for a short time. Avoid driving or doing anything that requires you to be able to see clearly.

Do not touch the tip of the ointment tube or place it directly on your eye. A contaminated tube tip can infect your eye, which could lead to serious vision problems.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics.

Call your doctor if your symptoms do not improve, or if they get worse while using this medicine.

Store at room temperature away from moisture and heat. Do not freeze. Keep the tube tightly closed when not in use.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

An overdose of bacitracin, neomycin, and polymyxin B ophthalmic is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

What should I avoid while using bacitracin, neomycin, and polymyxin B ophthalmic?

This medicine may cause blurred vision and may impair your reactions. Be careful if you drive or do anything that requires you to be able to see clearly.

Do not use other eye medications unless your doctor tells you to.

bacitracin, neomycin, and polymyxin B ophthalmic side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe itching or watering of your eyes;

  • eye pain; or

  • eye swelling, redness, severe discomfort, crusting or drainage (may be signs of infection);

Less serious side effects may be more likely, and you may have none at all.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Bacitracin, neomycin, and polymyxin B ophthalmic dosing information

Usual Adult Dose for Bacterial Conjunctivitis:

Apply to the affected eye(s) every 3 to 4 hours for 7 to 10 days.

-Dosing and duration depend on severity of infection.
Use: For the topical treatment of superficial infections of the external eye and its adnexa (including conjunctivitis, keratitis, keratoconjunctivitis, blepharitis, blepharoconjunctivitis) due to susceptible bacteria

Usual Adult Dose for Keratitis:

Apply to the affected eye(s) every 3 to 4 hours for 7 to 10 days.

-Dosing and duration depend on severity of infection.
Use: For the topical treatment of superficial infections of the external eye and its adnexa (including conjunctivitis, keratitis, keratoconjunctivitis, blepharitis, blepharoconjunctivitis) due to susceptible bacteria

Usual Adult Dose for Keratoconjunctivitis:

Apply to the affected eye(s) every 3 to 4 hours for 7 to 10 days.

-Dosing and duration depend on severity of infection.
Use: For the topical treatment of superficial infections of the external eye and its adnexa (including conjunctivitis, keratitis, keratoconjunctivitis, blepharitis, blepharoconjunctivitis) due to susceptible bacteria

Usual Adult Dose for Blepharitis:

Apply to the affected eye(s) every 3 to 4 hours for 7 to 10 days.

-Dosing and duration depend on severity of infection.
Use: For the topical treatment of superficial infections of the external eye and its adnexa (including conjunctivitis, keratitis, keratoconjunctivitis, blepharitis, blepharoconjunctivitis) due to susceptible bacteria

Usual Adult Dose for Blepharoconjunctivitis:

Apply to the affected eye(s) every 3 to 4 hours for 7 to 10 days.

-Dosing and duration depend on severity of infection.
Use: For the topical treatment of superficial infections of the external eye and its adnexa (including conjunctivitis, keratitis, keratoconjunctivitis, blepharitis, blepharoconjunctivitis) due to susceptible bacteria

What other drugs will affect bacitracin, neomycin, and polymyxin B ophthalmic?

It is not likely that other drugs you take orally or inject will have an effect on bacitracin, neomycin, and polymyxin B used in the eyes. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2018 Cerner Multum, Inc. Version: 5.01.

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More about bacitracin / neomycin / polymyxin b ophthalmic

  • Side Effects
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  • Pricing & Coupons
  • En Español
  • 1 Review
  • Drug class: ophthalmic anti-infectives
  • FDA Alerts (1)

Consumer resources

  • Bacitracin, Neomycin, and Polymyxin B (Ophthalmic)
  • Neomycin, polymyxin b, and bacitracin Ophthalmic (Advanced Reading)

Other brands: Neo-Polycin

Professional resources

  • Bacitracin, Neomycin, and Polymyxin B (Ophthalmic) (Wolters Kluwer)
  • … +1 more

Related treatment guides

  • Blepharitis
  • Blepharoconjunctivitis
  • Conjunctivitis, Bacterial
  • Hordeolum
  • Keratitis
  • Keratoconjunctivitis

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