Active ingredient in epiduo

What is Epiduo gel?

Epiduo gel contains adapalene 0.1% and benzoyl peroxide 2.5%.

It is only available on prescription in the UK.

Epiduo gel is only suitable for adults and children over 9 years old.

What is Epiduo gel used for?

Epiduo gel is a treatment for mild to moderate acne.

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How does Epiduo gel work?

Epiduo gel contains two active ingredients, adapalene 0.1% and benzoyl peroxide 2.5%.

Adapalene is a retinoid medicine that increases the turnover of skin cells. Benzoyl peroxide is a keratolytic that breaks down keratin, a protein that forms part of the skin structure. Both these ingredients increase the natural exfoliation of the surface layer of skin and help to unblock the pores and sebaceous glands (the glands that produce sebum, the skin’s natural oil), allowing the sebum to escape. They reduce the formation of blackheads and spots.

Adapalene also has an anti-inflammatory effect, reducing redness and swelling in the skin, while benzoyl peroxide also kills the bacteria associated with causing acne, Propionebacterium acnes. This common type of bacteria feeds on sebum and produces waste products and fatty acids that irritate the sebaceous glands, making them inflamed and causing spots. Benzoyl peroxide reduces the number of these bacteria on the skin.

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Key info to know about Epiduo gel

▪️ You can use Epiduo on your face, back or chest.

▪️ Apply Epiduo thinly to the whole area where you get acne once a day before going to bed.

▪️ Protect treated areas of skin from sunlight with suncream or clothing while using Epiduo, even on a bright but cloudy day. Do not use sunbeds or sunlamps.

▪️ The most common side effects are a mild burning sensation, redness, dryness and peeling of the treated areas of skin.

▪️ Epiduo gel can bleach hair and coloured fabrics, including clothing, towels and bed linen. Be careful to avoid getting the gel on these materials.

▪️ Although it starts to work straight away, and some people start to see results after a couple of weeks, most people will need to use Epiduo gel for at least a couple of months before their acne improves.

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Is it safe to use Epiduo gel if pregnant?

There is limited data available to show that it is safe to use Epiduo during pregnancy, for this reason women who are pregnant or trying to get pregnant should not use Epiduo gel. Stop using Epiduo if you think you could be pregnant.

Is it safe to use Epiduo if breastfeeding?

Epiduo can be used by women who are breastfeeding, as long as your doctor agrees. However, avoid applying it to your chest so your baby doesn’t come into contact with it.

How to use Epiduo gel

Epiduo gel should be applied thinly once a day before going to bed.

Clean and dry the skin thoroughly before applying Epiduo. Use a mild cleanser and pat rather than rub the skin dry. Using clean fingertips, apply enough Epiduo to thinly cover the area affected by acne (for example your whole face, not just individual spots or blackheads). Then wash your hands.

Don’t apply Epiduo to broken, sunburnt or sensitive areas of skin, or skin affected by eczema. Also take care to avoid getting it on your eyelids or lips, or in your eyes, nose or mouth. If you accidentally get the gel on these areas, wash it off with warm water.

If you want to apply moisturisers or cosmetics, wait until the Epiduo has been absorbed into your skin.

Don’t apply Epiduo more than once a day; this won’t make it any more effective or work any quicker. It may also make your skin very red, irritated or scaly.

What are the side effects of Epiduo gel?

Medicines and their possible side effects can affect people in different ways. The following are some of the side effects that may be associated with Epiduo gel. Just because a side effect is stated here doesn’t mean that all people using this acne treatment will experience that or any side effect.

Common side effects (affect between 1 in 10 and 1 in 100 people)

  • Burning sensation.
  • Skin irritation.
  • Redness of skin.
  • Dry or peeling skin.
  • Contact dermatitis.

These tend to improve after two to four weeks as your skin gets used to the treatment. You can use a non-oily moisturiser to help with any dryness. If your skin gets very irritated, try applying Epiduo gel less frequently or stop using it temporarily. If the irritation is more severe or doesn’t get better, you should stop using Epiduo gel completely and consult your doctor.

Uncommon side effects (affect between 1 in 100 and 1 in 1000 people)

  • Itching.
  • Sunburn.

You should read the patient information leaflet that is supplied with your medication for more information about side effects associated with Epiduo. You can find a copy of this here

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If you think you have experienced a side effect you can report this using the yellow card website?

Can I use Epiduo gel with other medicines?

Epiduo gel is unlikely to interact with oral medicines, as very little of the active ingredients are absorbed into the bloodstream.

You should not use other retinoids or products containing benzoyl peroxide while you’re using Epiduo gel.

You should avoid using peeling agents like salicylic acid or glycolic acid, abrasive cleansers, strong drying agents or acne products containing alcohol or astringents while you’re using Epiduo, as these are likely to have an additive drying or irritant effect on the skin.

Last updated: 26.11.2019

Rita Ghelani (BPharm, MRPharmS) Pharmacist A UK registered practising pharmacist with over 20 years’ experience, Rita is a member of the medical journalists’ association (MJA) and has a wealth of experience in community pharmacy.

Epiduo Gel 2.5% – Acne Cream (45g)

Buy Epiduo Gel Online UK

My Pharmacy is the Best Place to Buy Epiduo 2.5 Gel in the UK in 2019. To buy Epiduo Cream online in the UK you are required to have a prescription, which you can acquire with our free online consultation service.

Epiduo Gel 30g in the UK with Next Day Delivery

Through My Pharmacy you can Buy Epiduo Gel UK Next Day Delivery. Each treatment is sent out in secure and discreet packaging ensuring that you get your medicine on time and intact.

What is Epiduo Gel?

We are often asked “What Epiduo Gel?”

Epiduo is used for the treatment of mild to moderate acne, for use by patients as young as nine-years-old. It contains two active ingredients called Adapalene and Benzoyl peroxide, both working together to help and reduce the acne you currently have and prevents any you may get in the future.

Having both of the above ingredients included reduces the amount of treatment you may need to keep re-purchasing. Using the specified amount on the affected areas, refills will only be need once every three months.

Currently Epiduo is only available via prescription and there is no existing generic version available, however, the two active ingredients (Adapalene & Benzoyl peroxide) can be bought separately over the counter and as prescription medications.

For more general information about Acne,

Epiduo Gel Does it Work?

So the question is, Epiduo Gel does it work? Epiduo 2.5 gel works with the help of the active ingredients, Adapalene and Benzoyl peroxide. Both are acne-fighting ingredients, when combined, create one of the most effective methods of treating acne. It also helps tone down inflammation, particularly good news for people who tend to get red, inflamed pimples.

Firstly, Adapalene. Adapalene is a retinoid, acting specifically on the skin process that causes acne. It helps shed dead skin cells, keeping the pores from becoming blocked. This helps any future blemishes (mark, spot or discoloration) from reoccurring.

Benzoyl peroxide works differently. Benzoyl peroxide is something called an antimicrobial. These antimicrobials help fight the bacteria that cause acne outbreaks.

The amount of time it takes for Epiduo 2.5 gel to show any results usually takes eight to twelve weeks. If no improvement or signs of improvement have been procured, it is recommended to discontinue use and look for alternatives.

How Long Does it Take for Epiduo Gel to Work?

How long does it take for Epiduo Gel to work? Once treatment has been started, you may notice an initial flare up, this is common and can usually go worse before improving. The flare up can last up four weeks before improving.

This happens because the gel is making any current debris on the skin rise to the surface, this is usually not the case after eight weeks of continued appliance.

After the eight week mark, your skin should be showing signs of improvement, if this isn’t the case, consult with your doctor or dermatologist.

Adapalene Benzoyl Peroxide Epiduo 0.1 2.5 Gel

Epiduo 2.5 gel 30g contains two active ingredients called Adapalene and Benzoyl peroxide, both working together to help and reduce the acne you currently have and prevents any you may get in the future.

Firstly, Adapalene. Adapalene is a retinoid, acting specifically on the skin process that causes acne. It helps shed dead skin cells, keeping the pores from becoming blocked. This helps any future blemishes (mark, spot or discoloration) from reoccurring. Furthermore, Adapalene helps the efficiency and penetration of any other topical acne medication, thus it’s combined with Benzoyl.

Benzoyl peroxide works differently. Benzoyl peroxide is something called an antimicrobial. These antimicrobials help fight the bacteria that cause acne outbreaks. It’s listed on the world health organization’s list of essential medicines, making it one of the most effective and safe medications available.

Epiduo Gel How to Apply

This is a general use guide on Epiduo Gel How to Apply, if your doctor has guided you to use it differently, follow his/her instructions.

  • Applying the Epiduo gel is simple, modestly apply a pea-sized amount over clean and dry skin, once a day at bedtime.
  • Avoid the eyes, lips and nostrils.
  • After using Epiduo gel, wash your hands thoroughly.
  • Your doctor will tell you the length of treatment, this can vary.
  • If the effects of Epiduo are too strong or weak, talk to your doctor or pharmacist for guidance.

Epiduo Gel Review

Epiduo Gel Review by user Kimzzz

“Epiduo has changed my life. I am a 30 year old women always suffered from acne breakouts especially at that time of the month. My doctor prescribed me Epiduo three months ago to use once a night he advised me it wouldn’t work over night and to give it time. Within four weeks my skin completely cleared up and I haven’t had another spot since. The first week I suffered red dry skin so I used Sudocrem and persevered, my skin soon got used to it and now I use it every night as part of my routine. I hardly have any dark red marks left and I’ve never been happier. Give it a go and give it time.” –

(User Reviews for Epiduo, 2019)

Epiduo Gel review by the user TMarie12

“I have been suffering from adult acne for over a year and finally plucked up the courage to see the dermatologist for the first time in my life and boy, am I glad I did! I have been using Epiduo paired with an oral antibiotic (Solodyn) for about 1 1/2 months and my skin already looks better. I did have the redness on my first application (like a sunburn) and there was a good amount of dryness around my mouth for the first few weeks, but if you stop applying to those dry areas, it gets better. I also experienced some burning – but only in the dry areas. I didn’t really have an initial breakout, just a few little pimples that were NOTHING like the huge cysts that I had been so used to getting. Another pro – my skin is SO SOFT now.” –

(User Reviews for Epiduo, 2019)

Buy Epiduo Gel UK next day delivery from My Pharmacy UK.

Duac Gel or Epiduo Gel

Here are some of the differences between Duac Gel and Epiduo Gel –

One of the first differences a lot of people notice is the significant increase in dryness when using Epiduo compared to Duac, with the former causing higher volumes of evaporative water loss on the skin.

Users testing the difference between the two also noted a higher frequency of adverse perceptions, including mild burning and stinging when using Epiduo Gel compared to Duac Gel.

Overall the two of them barely have any significant differences between them when comparing common side effects.

Another difference is that both use changed active ingredients. Epiduo gel contains Adapalene and Benzoyl peroxide, whilst Duac Gel contains Clindamycin and Benzoyl peroxide. Clindomycin works by slowing or stopping the growth of bacteria, treating certain types of bacterial infections, including the skin.

Duac Gel is available to be purchased from My Pharmacy UK,

Epiduo Acne Gel Side Effects

Like with all medicine, Epiduo 2.5 gel can have side effects, but these aren’t experienced by everyone.

Stop using this product and seek immediate medical attention if you develop throat tightness or swelling of the eyes, face, lips or tongue, feel faint, or have difficulty breathing. The frequency at which these side effects occur is not known. This could mean you have an adverse allergic reaction to the medicine.

Some of the common side effects include –

  • Scaling
  • Redness
  • Skin irritation
  • Burning sensation
  • Dry skin
  • Skin rash

Uncommon side effects include –

  • Itchy skin
  • Sunburn

For more information on the side effects of Epiduo Gel, please consult the patient information leaflet located here.

Alternatives to Epiduo Gel 30g

My Pharmacy UK is the best place to Buy Epiduo Gel UK.

If Epiduo isn’t viable for you, here are some alternatives to Epiduo Gel 30g –

  • Duac Gel
  • Zineryt Solution 30ml
  • Oxytetracycline Tablets
  • Differin Cream

1. What is Epiduo?

Epiduo is a topical acne treatment gel comprised of a fixed combination of two antibiotic-free medications, Adapalene (0.1%) and Benzoyl Peroxide (2.5%) Gel. It is commonly prescribed, once-a-day prescription that both treats existing pimples and prevents new ones from forming.

2. Is Epiduo more effective than Benzoyl Peroxide?
Regarding efficacy, it seems that the Epiduo has similar efficacy to Benzoyl Peroxide. This benefit comes with significantly higher irritation. In addition to the negative impacts of irritation on acne production, the side effects associated often result in reduced commitment to treatment, essentially making it “less effective” comparatively.

Oldschool and more generic formulations of Benzoyl Peroxide (particularly 5%) can also irritate and dry the skin. However, newer micronized forms of Benzoyl Peroxide available are equally (if not more effective) while causing less irritation, particularly when paired with anti-inflammatory ingredients (such as the natural boosters in MDacne products) and when used in the correct % for the skin type and acne severity of the specific user (typically 2.5%-5%)

3. What are the common side effects of Epiduo?

Skin redness, scaling, dryness, and stinging/burning may be experienced with the use of Epiduo gel. These are most likely to occur during the first four weeks of treatment, are mostly mild to moderate in intensity, and usually, lessen with continued use of the medication. However, irritant and allergic contact dermatitis may occur. Depending upon the severity of these adverse reactions, patients should be instructed to use a moisturizer, reduce the frequency of the application of Epiduo gel, or discontinue use altogether. The product should not be applied to cuts, abrasions, eczematous or sunburned skin. As with other retinoids, use of “waxing” as a depilatory method should be avoided on skin treated with Epiduo gel.

4. What products do you need to avoid while using Epiduo?

Users will also need to avoid concomitant use of other potentially irritating topical products (medicated or abrasive soaps and cleansers, soaps and cosmetics that have strong skin-drying effect and products with high concentrations of alcohol, astringents, spices, or limes).

5. Why is Epiduo more irritating than other acne treatments?

It seems the combination of Adapalene and Benzoyl Peroxide causes a much greater risk for irritation than each of the ingredients alone, which is why Epiduo users often experience greater irritation. Though some initial dryness and irritation are normal with most effective topical acne treatments, excessive and continuous irritation can actually make acne worse. Once the skin is over-irritated, the outer protective barrier of the skin is damaged, causing more inflammation, which slows down skin’s healing and increases the risk for acne breakouts.

6. Does Epiduo make you more sensitive to the sun?

Yes. Epiduo is contraindicated with ultraviolet light exposure (i.e. exposure to sunlight), including sunlamps. Patients with high levels of sun exposure and those with inherent sensitivity to the sun should exercise particular caution. Use of sunscreen and protective apparel, (e.g., hats, shirts) are recommended when exposure cannot be avoided. Weather extremes, such as wind or cold, may also be irritating to patients under treatment with Epiduo gel.

7. Does Epiduo also help with acne scarring?

The main ingredient in Epiduo is benzoyl peroxide. The purpose of this gel, as with all other topical anti-acne treatments, is to prevent the formation of new active acne pimples. Therefore it will not help with the treatment of existing deeper, pitted scars. Nevertheless, by preventing new breakouts, it will prevent the appearance of new acne scars and hyperpigmentation in the future. (update: if you struggle with post-acne hyperpigmentation, we recommend trying our new medicated dark spot remover)

8. What is the difference between Differin and Epiduo?

Differin (Adapalene) and Epiduo (which contains Adapalene) are 2 gels commonly used for acne treatment.

Formulations: Differin is sold in 2 forms; Adapalene 0.1% which can be bought without a prescription (over the counter) and Adapalene 0.3%, which requires a prescription. Epiduo is a combination of Adapalene 0.1% and Benzoyl Peroxide 2.5%. Epiduo Forte is a combination of adapalene 0.3% and benzoyl peroxide 2.5%.

Use Case: The Differin gel 0.3% (like other topical retinoids) is most effective only on comedonal acne (blackheads and whiteheads), and only slightly inflammatory acne. However, Benzoyl Peroxide is effective on both comedones and inflammatory pimples. Therefore, the combination of Benzoyl Peroxide and Adapalene in the Epiduo gel allows it to cover both inflammatory acne (papules, pustules), and comedonal acne (blackheads and whiteheads).

*According to updated treatment guidelines of the American Academy of Dermatology, topical retinoids are recommended as monotherapy in primarily comedonal acne, or in combination with topical or oral antimicrobials in patients with mixed or primarily inflammatory acne lesions.

9. What’s the price of Epiduo?

As a prescription drug, Epiduo is quite a bit more expensive than Differin and other OTC topical acne treatments. For example, here’s how it stacks up against Differin at Walmart.

  • Differin 0.1% 45ml – Walmart $64

  • Differin 0.3% 45ml – Walmart $83

  • Epiduo 0.1%/2.5% 45ml – Walmart $119

  • Epiduo 0.3%/2.5% 45ml – Walmart $416

10. Is it good to use Epiduo and Clindamycin together?

Clindamycin is a topical antibiotic. Unfortunately, most acne bacteria are resistant to topical antibiotics (learn more about the risks of topical antibiotics for acne here), providing it limited efficacy on its own. However, because Clindamycin itself is not irritating, it can be used in combination with other topical treatments such as Epiduo or other products containing Benzoyl Peroxide, which will be the key ingredient for treating and preventing acne.



Clinical Studies Experience

Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in practice. During clinical trials, 1401 subjects were exposed to EPIDUO gel. A total of 1036 subjects with acne vulgaris, 12 years and older, were treated once daily for 12 weeks to 12 months. Related adverse events reported within 12 weeks of treatment and in at least 1% of subjects treated with EPIDUO gel and those reported in subjects treated with the vehicle gel are presented in Table 1:

Table 1 : Drug Related Adverse Events Reported in Clinical Trials by At Least 1% of Patients Treated For 12 Weeks

Local tolerability evaluations, presented in Table 2, were conducted at each study visit in clinical trials by assessment of erythema, scaling, dryness, burning, and stinging.

Table 2 : Incidence of Local Cutaneous Irritation in Controlled Clinical Trials (N = 553) Treatment Emergent Signs and Symptoms

Analysis over the 12-week period showed that local tolerability scores for erythema, scaling, dryness, and stinging/burning peaked at Week 1 of therapy and decreased thereafter.

During a pediatric clinical trial, 285 children with acne vulgaris, 9 to 11 years of age were treated with EPIDUO gel or with the vehicle gel once daily for 12 weeks. Overall, the safety profile of EPIDUO gel in these subjects is comparable to the safety profile observed in older subjects 12 years of age and above, both in the nature and frequency of the observed events.

Analysis of local tolerability evaluations shows similar incidence of treatment emergent signs and symptoms as in subjects 12 years of age and above, with local tolerability signs and symptoms peaking during the first week and decreasing over time.

Postmarketing Experience

The following adverse reactions have been identified during postapproval use of EPIDUO Gel: eyelid edema, sunburn, blister, pain of skin, pruritus, swelling face, conjunctivitis, skin discoloration, rash, eczema, throat tightness and allergic contact dermatitis. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Read the entire FDA prescribing information for Epiduo (Adapalene and Benzoyl Peroxide Gel)

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