1 or 2 benadryl

Getting High on Benadryl: How Much Is Safe?

Benadryl is a brand name over-the-counter antihistamine medication. Histamine is a substance produced by the body in response to the presence of allergens like pollen, animal hair, or dust. Histamine release underlies certain symptoms like sneezing, itchy eyes, scratchy feelings in the nose or throat, runny nose, and difficulty breathing. Antihistamines like Benadryl combat the actions of histamine. Some people may also take Benadryl to reduce similar symptoms when they have a cold. Diphenhydramine is the main ingredient in this drug, and the substance can be found in other over-the-counter medications, too.1

Although Benadryl is sold without a prescription, the drug can cause drowsiness and sedation. Misuse of the medication may occur because people do not properly read the directions, mix it with alcohol or other intoxicants, or take too much of it at once. Any form of misuse can be dangerous and may result in severe side effects or an overdose.1

Just like with a prescription drug, it is important to follow the instructions on the package and only take Benadryl in recommended doses for a short period of time.
Even when taken as directed, Benadryl can have some troublesome side effects, so it is important to know how much is safe in one dose and in one day, and what the signs of abuse or overdose may be.

What Is Benadryl? How Is It Taken Safely?

Benadryl was the first antihistamine to receive approval from the Food and Drug Administration (FDA). The brand name was acquired by Johnson & Johnson in 2007 and the medication remains a widely-used treatment for allergies and mild cold symptoms.1

Since the medication has been available for several decades, safe dosage and elimination time are well understood. Benadryl is available in a variety of formulations, including tablets, liquid gels, and chewables. The standard dose of diphenhydramine in brand name Benadryl is 25 mg per dose for adults and 12.5 mg per dose in children’s formulas. For the average healthy adult, elimination half-life ranges from 6.7 to 11.7 hours.2 So between 6 to 12 hours after taking Benadryl, half the drug will be eliminated from the body. Within two days, the drug will be completely gone from the body.

Several factors impact how quickly Benadryl is metabolized, including:3

  • Age: Adults over 65 years old and children younger than 12 years old metabolize diphenhydramine more slowly, so lower doses less often are safer.3
  • Liver problems: Since the active ingredient in Benadryl is processed through the liver, anyone with decreased hepatic function will have difficulty safely consuming this drug.
  • Kidney problems: The kidneys help to process toxins by passing them out through the bladder. People who have decreased renal function may have a tough time metabolizing Benadryl. Urinary pH can also impact how the body processes diphenhydramine.
  • Hydration: People who do not drink sufficient water may struggle to eliminate diphenhydramine from their system.
  • Low vs. high dose: Even healthy adults who take more than the recommended dose of Benadryl will experience consequences, such as taking longer to metabolize the drug. Taking the recommended dose of Benadryl for longer than recommended may also lead to tolerance as the drug builds up in the body, and that also might increase the medication’s elimination time.
  • Other medications: Taking prescription drugs, or other over the counter drugs, along with Benadryl may change how the body metabolizes all the substances together.
  • Body weight/mass: Different body types process different amounts of medication at different rates. This is true for prescription drugs, recreational substances like alcohol, and over the counter drugs like Benadryl.

Although Benadryl is sold over the counter without a prescription, the active ingredient is potent and has an impact on the body. In addition to eliminating symptoms of allergies or a cold, it also interacts with other organ systems.

Even when taken as directed, Benadryl can cause side effects which include:4

  • Drowsiness or sleepiness.
  • Dry mouth.
  • Dryness in the nose or throat.
  • Dizziness.
  • Nausea or stomach upset.
  • Headaches.
  • Jitteriness or restlessness.
  • Tightness in the chest.
  • Muscle weakness.
  • Loss of appetite.
  • Constipation.

When the recommended amount is consumed, effects peak after about two hours. Within four hours, most effects of the medication wear off. There are still metabolites from diphenhydramine’s breakdown in the body, so taking another dose of Benadryl before the full effects wear off may be dangerous.5

Additionally, some people take more than the recommended amount because they want to get high. Benadryl produces mild sedative effects, and in larger amounts, that can feel like intoxication.

However, taking more than 25 mg can be extremely dangerous and is more likely to cause harm than produce any euphoria.5

Benadryl Overdose

Too much Benadryl, whether taken accidentally or for recreational reasons, could lead to an overdose.

Symptoms of a Benadryl overdose include:6

  • Enlarged pupils.
  • Very dry eyes.
  • Blurry vision.
  • Ringing in the ears (tinnitus).
  • Low blood pressure.
  • Rapid heart rate.
  • Agitation, rapid mood swings, or restlessness.
  • Confusion.
  • Seizures.
  • Delirium.
  • Intense, sudden depression.
  • Extreme drowsiness.
  • Passing out or falling asleep.
  • Nervousness or paranoia.
  • Physical tremors.
  • Unsteady gait, loss of balance, or inability to walk.
  • Dry, red skin.
  • Nausea or vomiting.
  • Inability to urinate.

Too much Benadryl can lead to an overdose and taking the drug with other potent substances can increase the risk of overdose. For example, taking other antihistamines that contain diphenhydramine can lead to an overdose. Substances like alcohol or benzodiazepines (e.g., Valium, Xanax, Klonopin, etc.) may dangerously increase Benadryl’s sedative effects. Muscle relaxants, sedative-hypnotic sleep medications like Ambien, tranquilizers, opioids, and other prescription drugs that are central nervous system (CNS) depressants can also adversely interact with Benadryl. In addition, some types of antidepressants called monoamine oxidase inhibitors (MAOIs) do not mix with antihistamines like Benadryl.3

Attempting to Get High on Benadryl Can Be Extremely Dangerous

Benadryl is not effective as an intoxicant.Taking more than the recommended dose is more likely to lead to an overdose and uncomfortable side effects rather than euphoria. More than 500 mg, which is more than 40 times the recommended dose, may lead to a state of delirium, hallucinations, and other overdose symptoms. Anecdotal evidence about diphenhydramine highs indicates that the effects are more often uncomfortable and unsettling instead of enjoyable.

Attempts at getting high on Benadryl may be indicative of larger issues with addiction or substance abuse. Because Benadryl is easy to acquire, it may be the first drug abused by an adolescent, or it could be a drug abused after struggling with other substances. Regardless, it is important to get help ending substance abuse.

Benadryl Dosage: How Much Diphenhydramine Can One Take?

Benadryl is a popular antihistamine that is often utilized to treat other conditions like insomnia as well. While the drug is generally safe and effective, it is essential to understand how Benadryl dosing works. Diphenhydramine dosage generally depends on the symptoms that will be treated with the medication, as well as the patient’s age. In some cases, the individual’s weight might be a contributing factor to the dosage as well. Benadryl dosage for children is also usually considerably lower than for adults. Overdosing on the medication can cause unpleasant side-effects that can, in some cases, be dangerous to a person’s health and require medical detoxification.

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Table of Contents

  • What Is Benadryl Adult Dose?
  • What Is Benadryl Dose For Pediatric Patients?
  • What Is Benadryl LD-50?
  • How To Take Benadryl Safely?

Benadryl Adults Dosage

Benadryl dosage for adults is higher than that allowed to be administered to children as an adult’s body can handle a larger dose of the medication. The higher dose may also provide more effective relief of certain symptoms. It should, however, be noted that even though adults are allowed a higher dose of the medication, this does not mean that adults are free to take any diphenhydramine HCL dosage. Precaution is noted due to an increased risk of diphenhydramine side-effects when the dosage limitations for certain conditions and symptoms are exceeded.


Benadryl dosage for adults by weight is a model that is not often utilized, as weight is mostly taken into close account when administering the drug to a child. Still, if an adult weighs less than 100 pounds, weight is something that might have to be taken into account.
Benadryl administration based on weight among adults are as follows:

The adult dose of Benadryl should be administered with at least four to six hours in between each dosage.

What Is Benadryl Max Dose For Adults?

Due to the high risk of side-effects when taking too much of this medication, it is important for people to realize how much Benadryl is too much. While the maximum dose for adults is higher than the highest dosage that may be provided to a child, this does not mean an adult individual can take an exceptional amount of tablets to relieve their symptoms.
It is important also to consider how long does Benadryl take to work? The drug may not act very quickly, which might cause a person to consider taking a second dose too soon. This also causes an increased risk of more serious side-effects associated with the active ingredient diphenhydramine.
The appropriate adult Benadryl dose will depend on factors such as the condition that is being treated. The maximum dose also depends on the method of administration.

The max dose advised for adults on a single administration of the medication is 50mg of diphenhydramine.

This dose can be taken in four-hour intervals. It is also not advised to take more than four doses of the medication in a single day. Furthermore, if a person finds that they need to use the medication consistently for more than four days per week, it is generally advised that the individual see a physician to obtain a drug that may be more effective for the treatment of their symptoms.
To avoid reaching a Benadryl overdose amount, a person should ensure they do not take more than 400mg of the drug for 24-hours.

Benadryl Adult Dosage For Extrapyramidal Reaction

Between 25mg and 50mg of the medication can be used to treat an extrapyramidal reaction. This dose can be taken up to four times each day. Parenteral administration of diphenhydramine can be provided in doses of up to 100mg at a time, with a maximum daily dose of 400mg. In such a case, the medication will be administered through IV or IM. Medical supervision is advised when using such high doses of the medication to assist in the treatment of an extrapyramidal reaction.

Benadryl Adult Dosage For Insomnia

The side-effects of the medication often sleepiness, which is why some people tend to opt for the drug to assist in the treatment of insomnia. When using the drug for insomnia, the advised dose depends on the type of diphenhydramine that is included in the capsule or tablet that a person will be taking.


When using diphenhydramine Citrate, the advised dose is a 75mg oral pill before going to bed. In the case where diphenhydramine Hydrochloride is used instead, then the recommended dose is 50mg before going to bed.
It should be noted that it is generally not advised to continue using the drug for too long as an aid to assist with insomnia. If a person finds that their symptoms do not improve within two weeks while using this medication, they should consult with a physician.

Benadryl Adult Dosage For Motion Sickness

When used to assist in treating motion sickness, the advised dose is between 25mg and 50mg of diphenhydramine up to four times per day. The patient should take the first dose of up to 50mg before they start with the trip. The final dose should be taken when their trip comes to an end. There should, however, be at least a four-hour period between each dose.

Benadryl Adult Dosage For Allergic Rhinitis

The dose of this drug for treating allergic rhinitis depends on the type of active ingredient used. If a patient is using diphenhydramine Citrate, then a dose between 38mg and 75mg can be taken through oral administration of a capsule at a time. The maximum daily dose of diphenhydramine Citrate should not exceed 456mg. When using diphenhydramine Hydrochloride, the maximum daily dose should be limited to 300mg, and up to 50mg can be taken as a single dose.

Benadryl Adult Dosage For Cold Symptoms

It is advised that adults take up to 75mg of diphenhydramine Citrate at a time to assist in relieving symptoms associated with a cold. A lower dose is recommended when diphenhydramine Hydrochloride is used instead, with a recommendation of up to 50mg at a time. There should be at least a four-hour period between two doses of the medication. When provided with a parenteral administration of diphenhydramine, up to 100mg may be given to the patient at a time.

Benadryl Adult Dosage For Pruritus

In the case of Pruritus, a patient can opt for either diphenhydramine Citrate or diphenhydramine Hydrochloride. Between 38mg and 76mg can be administered as a single dose every four to six hours when the individual utilizes a drug that contains diphenhydramine Citrate. A 25mg to 50mg dose is advised when rather using a diphenhydramine Hydrochloride drug. Parenteral administration of the drug for the treatment of Pruritus may reach up to 100mg during a single dose, but should not exceed an administration rate of more than 25mg per minute.

Benadryl Adult Dosage For Urticaria

The use of the drug for treating Urticaria may be provided at doses of up to 76mg when using diphenhydramine Citrate or up to 50mg when using diphenhydramine Hydrochloride.

This dosage should not be exceeded, and the person should wait four to six hours before taking another dose of the medication. The maximum daily dose for diphenhydramine Citrate is 456mg, and for diphenhydramine Hydrochloride is 300mg.

Benadryl Pediatric Dose

The use of this particular drug among children require careful administration and an appropriate dosage to ensure an overdose is not provided. Whether using Benadryl for hives, cold, or any other condition, it is crucial to follow the advised dosage instructions to assure the safety of the child that is being provided with this medication.

Children’s Benadryl dosage by weight is particularly important in the pediatric use of the medication. It is important not only to take a child’s age into account but also their current weight.

Here is a table of Benadryl dosage by weight for children:

Pediatric Dosage For Allergic Rhinitis

Child between the age of 6 and 12 can be provided with up to 38mg of diphenhydramine Citrate as a single dose or up to 6.25mg of Diphenhydramine Hydrochloride daily. When the child is older than 12, they can be provided with up to 76mg of diphenhydramine Citrate of up to 25mg of Diphenhydramine Hydrochloride in four-hour periods.

Pediatric Dosage For Cold Symptoms

Up to 38mg of Diphenhydramine Citrate can be provided or 25mg of Diphenhydramine Hydrochloride for children between 6 and 12. Older children may be provided with up to 76mg of Diphenhydramine Citrate or up to 50mg of Diphenhydramine Hydrochloride.

Pediatric Dosage For Motion Sickness

For treating motion sickness in children, Diphenhydramine Citrate can be used with a dose of up to 38mg before the start of the trip in children up to 12 or up to 76mg if the child is older than 12.

When using diphenhydramine Hydrochloride, the maximum dose for children under the age of 12 is 25mg, and for those over the age of 12, up to 50mg may be provided.

Pediatric Dosage For Insomnia

The drug should not be used for the treatment of insomnia in children under 12 years. Up to 76mg of diphenhydramine Citrate can be used in children over 12 and up to 50mg of Diphenhydramine Hydrochloride prior to going to bed.

Pediatric Dosage For Extrapyramidal Reaction

Up to 25mg can be provided to a child for a maximum of four times daily for the treatment of an extrapyramidal reaction.

Pediatric Dosage For Allergic Reaction

Up to 25mg of the drug can be used to help treat an allergic reaction in children. When using Benadryl by weight, up to five milligrams of the medication can be provided per one kilogram of body weight.

What Is Benadryl LD-50?

The LD-50 of Benadryl is considered to be around 500mg per one kilogram of body weight.

It is important to note that when mixing the drug with other substances, the likelihood of life-threatening complications become more likely.

For example, individuals should be wary of Benadryl and alcohol death and related complications. When it comes to looking at how much Benadryl it would take to result in more severe side-effects, it is also crucial to ask a question like how long does Benadryl last in the system? When taking multiple doses in short periods, it could lead to overdose symptoms. If OD on Benadryl took place the patient is advised to seek treatment in rehabilitation facility.

Taking Benadryl Safely

Excessive use of the drug, whether looking to use Benadryl for sleep dosage or another purpose, can lead to serious side-effects. Some people may also think that Benadryl dose for allergic reaction is much higher, but even when such a reaction is experienced, adhering to the max dose instructions is crucial. There are other types of drugs that are used to assist in treating an acute allergic reaction. It is also important to consider potential complications when using Benadryl while pregnant.


Some people who use the drug may experience diphenhydramine withdrawal if they become dependent on the medication to help with sleep and other issues that the product can assist with. In cases where a dependency occurs, the individual may need to opt for professional treatment.

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View Sources

  1. BENADRYL DOSING GUIDE, https://www.benadryl.com/benadryl-dosing-guide

Diphenhydramine – Benadryl etc – Dosage Table

Diphenhydramine (Benadryl, etc.) Dosage

Child’s weight 20 – 24 lbs. 25 – 37 lbs. 38 – 49 lbs. 50 – 99 lbs. Over 100 lbs.
Liquid 12.5 mg/5 milliliters (ml) 4 5 7.5 10
Chewable 12.5 mg 1 2 4
Tablets 25 mg ½ ½ 1 2
Capsules 25 mg 1 2

Indications:

Treatment of allergic reactions, nasal allergies, hives and itching.

Table Notes:

  • AGE LIMITS: For allergies, don’t use under 1 year of age (Reason: it’s a sedative). For colds, not recommended at any age (Reason: no proven benefits) and should be avoided if under 4 years old. Avoid multi-ingredient products in children under 6 years of age (Reason: FDA recommendations 10/2008).
  • DOSAGE: Determine by finding child’s weight in the top row of the dosage table
  • MEASURING the DOSAGE: Syringes and droppers are more accurate than teaspoons. If possible, use the syringe or dropper that comes with the medication. If not, medicine syringes are available at pharmacies. If you use a teaspoon, it should be a measuring spoon. Regular spoons are not reliable. Also, remember that 1 level teaspoon equals 5 ml and that ½ teaspoon equals 2.5 ml.
  • ADULT DOSAGE: 50 mg
  • FREQUENCY: Repeat every six hours as needed
  • CHILDREN’S BENADRYL FASTMELTS: Each fastmelt tablet contains the equivalent of 12.5 mg of Diphenhydramine HCL and dosed the same as chewable tablets.

Author and Senior Reviewer: Barton D. Schmitt, M.D.
Content Set: Pediatric HouseCalls Symptom Checker
Pediatric HouseCalls Symptom Checker

Is it safe to give infants Benadryl?

Share on PinterestAntihistamines cause serious side effects for children under 2 years of age.

Over-the-counter Benadryl products are only suitable for some age groups:

  • Benadryl is generally not safe to give to babies or infants under 2 years old at home.
  • Sometimes, people can safely give infants aged 2 to 5 small doses of Benadryl, but only when a doctor advises them to do so.
  • Specific child-friendly Benadryl is available for children aged 6 and above.

However, a doctor or pediatrician may recommend giving Benadryl to very young children for certain conditions, such as an allergic reaction. It is essential to follow the doctor’s direction and dosage recommendations.

Uses of Benadryl

The active ingredient in Benadryl is an antihistamine called diphenhydramine. This ingredient is also found in many cough and cold products.

According to the U.S. Food and Drug Administration (FDA), cough and cold products containing decongestants or antihistamines, such as diphenhydramine, can cause severe and potentially fatal side effects in children under 2 years old, including convulsions and a rapid heart rate.

Doctors or pediatricians would never recommend giving a very young child a Benadryl-containing product for a cough or cold, although they might recommend it for an allergic reaction.

These cough and cold products do not help very much and can cause potentially dangerous side effects.

If your child has a cold, consider using other methods to relieve symptoms instead.

Benadryl may cause drowsiness in children, but caregivers must never use Benadryl to make a child sleepy.

Benadryl products for children

There is a variety of Benadryl allergy medications formulated for children aged 6 or over.

Products include Children’s Benadryl Dye-Free Allergy Liquid, Children’s Benadryl Allergy Plus Congestion, Children’s Benadryl Chewables, and Children’s Benadryl Allergy Liquid. These are usually safe to give to children aged 6 and above.

Never give children any medications, including Benadryl, that are designed for adults. Dosages in adult medicines are higher than in children’s medicines, so giving adult dosages to children might lead to an overdose.

It is usually safe for children aged 12 onwards to take adult Benadryl products, but always check the directions on the labels.

Don’t take Benadryl every day for allergies

Q. Is it OK to take Benadryl every day to treat my allergies?

A. It’s not a good idea. Benadryl Allergy (diphenhydramine and generic) and similar first-generation antihistamines used to treat allergy symptoms, such as chlorpheniramine (Chlor-Trimeton Allergy and generic), shouldn’t be taken for long periods of time. Besides having side effects including drowsiness, confusion, and urinary retention, a new study shows that frequent, long-term use of older antihistamines are associated with an increased risk of dementia and Alzheimer’s disease.

The study found that also to be true for certain drugs used to treat depression, asthma, overactive bladder, and Parkinson’s. Those types of drugs are known as anticholinergics, and they block the substance acetylcholine, which is involved in learning, memory, and muscle contractions.

The study, published online in the Journal of the American Medical Association (JAMA) in January, looked at 10 years’ worth of pharmacy data, including prescription and over-the-counter drugs, taken by 3,434 adults age 65 or older who didn’t have dementia at the beginning of the study. Researchers at the University of Washington School of Pharmacy then tracked them for about seven years. During that time, 797 participants (23 percent) developed dementia.

Researchers found that people who had regularly taken any type of anticholinergic, including the older antihistamines like chlorpheniramine and diphenhydramine, were more likely to develop the disease than those who had not, and those who’d taken the drugs for three years or more had an even higher risk.

Have you heard parents say, “Just give them some Benadryl®” when they refer to helping kids relax, calm down, sleep, etc.? Well, I can tell you I get many questions about this, so I thought it would help to list some common questions and answers about this drug. Diphenhydramine, brand name Benadryl®, is one of the oldest and most frequently used over-the-counter medications for children. Diphenhydramine, an anti-histamine, counteracts the effects of histamine throughout the body, which include itching, runny nose, sneezing and hives. It is not a very selective medication and has other unintended side effects, which often confuse parents. Here are some examples of common questions:

Can Benadryl make my child sleepy?

Yes, one of the main side effects is sedation. This can make many children very drowsy, to the point of falling asleep. In addition, sedation can cause lingering confusion and significantly impair gross motor and even affect learning abilities. This can be a big problem when it comes to school performance.

My child becomes hyperactive with Benadryl®. Is this normal?

Hyperactivity occurs in roughly 10-15% of children as sort of an opposite effect. The only way to know if your child will react this way is by giving it to them. Tip: Do not give them Benadryl® for the first time right before you board a plane or get in a car for a long road trip!

I often use Benadryl® to help my child go to sleep at night. Is this OK?

Not really. If your child is having difficulty sleeping, it is very important to discuss possible reasons with their doctor. Sleep aids, in general, are not effective as they don’t address the underlying problem causing insomnia. Now, if your child is itching so much from eczema or other causes then Benadryl® may be helpful to calm this down so they can rest.

I use Benadryl® for my child’s seasonal allergies. Is there a better option?

Absolutely. Newer 2nd generation over-the-counter antihistamines such as loratadine, cetirizine, and fexofenadine (Claritin®, Zyrtec®, and Allegra®) last much longer (18-24 hours compared with 4-6 hours for Benadryl®) and have much fewer side effects, most notably sedation.

My child’s runny nose got better after taking Benadryl®. Does this mean they have allergies?

Not at all. This is a prime example of how the side effects of Benadryl® can improve symptoms. Benadryl® can dry out secretions and mucous membranes. This can create problems not only in the eyes, nose and throat but throughout the rest of the body as well. Improvement in a runny nose during a cold is not due to the anti-histamine properties of the medication. In general, Benadryl® is not an effective medication to use during upper respiratory infections due to short duration of action and unfavorable side effect profile.

Can my child become tolerant to Benadryl®? Yes and no. If used excessively, the effectiveness may wear off over time. However, many other reasons for lack of efficacy exist, including using too low of a dose for their weight or using it to treat symptoms that it has no benefit towards.

Should I give Benadryl® for treatment of an allergic reaction?

First line treatment of any severe, rapidly progressive allergic reaction (anaphylaxis) is self-injectable epinephrine. This is prescribed for children who have known food allergies or history of anaphylaxis and is not necessary for everyone to have. However, for mild symptoms such as rash or localized swelling without any breathing problems or other symptoms, Benadryl® can be very effective at reducing symptoms.

This is, by no means, a comprehensive list of indications for use or possible side effects but hopefully will answer some of your questions. As always, please talk to your child’s doctor if you have any questions regarding Benadryl® or any other medications. If you have specific questions about your child’s allergies, contact the Nationwide Children’s Hospital Allergy & Immunology department.

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Benadryl

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 4/22/2019

Benadryl (diphenhydramine) is an antihistamine used to treat allergies, hives, insomnia, motion sickness, and mild cases of Parkinsonism. Benadryl is available in generic form and over-the-counter (OTC). Common side effects of Benadryl include:

  • drowsiness,
  • fatigue,
  • tiredness,
  • sleepiness,
  • dizziness,
  • disturbed coordination,
  • constipation,
  • dry mouth/nose/throat,
  • difficulty urinating or an enlarged prostate,
  • upset stomach,
  • blurred vision,
  • double vision,
  • tremor,
  • loss of appetite,
  • headache, or
  • nausea.

A typical dose of Benadryl is 25-50 mg every 4-6 hours. Benadryl may interact with monoamine oxidase inhibitors (MAOIs), other over-the-counter cough, cold, allergy, or insomnia medications, anxiety or sleep medicines, antidepressants, or any other medications that make you feel drowsy, sleepy, or relaxed. Tell your doctor all medications and supplements you use. Benadryl has not been adequately evaluated in pregnant women. Benadryl is secreted in breast milk. Because of the risk of stimulation and seizures in infants, especially newborns and premature infants, antihistamines should not be used by nursing mothers.

Our Benadryl Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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